DE69527429T2 - Verfahren zur herstellung von wasserfreien und hydrat-formen von antihistaminischen piperinderivaten, polymerphe und pseudomorphe davon - Google Patents

Verfahren zur herstellung von wasserfreien und hydrat-formen von antihistaminischen piperinderivaten, polymerphe und pseudomorphe davon

Info

Publication number
DE69527429T2
DE69527429T2 DE69527429T DE69527429T DE69527429T2 DE 69527429 T2 DE69527429 T2 DE 69527429T2 DE 69527429 T DE69527429 T DE 69527429T DE 69527429 T DE69527429 T DE 69527429T DE 69527429 T2 DE69527429 T2 DE 69527429T2
Authority
DE
Germany
Prior art keywords
derivatives
pseudomorphe
polymerphe
piperin
antihistaminic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69527429T
Other languages
English (en)
Other versions
DE69527429D1 (de
Inventor
R Henton
J Mccarty
I Tripp
E Dewitt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Aventis Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26937420&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69527429(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Aventis Pharmaceuticals Inc filed Critical Aventis Pharmaceuticals Inc
Publication of DE69527429D1 publication Critical patent/DE69527429D1/de
Application granted granted Critical
Publication of DE69527429T2 publication Critical patent/DE69527429T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Peptides Or Proteins (AREA)
DE69527429T 1994-05-18 1995-04-28 Verfahren zur herstellung von wasserfreien und hydrat-formen von antihistaminischen piperinderivaten, polymerphe und pseudomorphe davon Expired - Lifetime DE69527429T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US24573194A 1994-05-18 1994-05-18
US41716195A 1995-04-11 1995-04-11
PCT/US1995/004942 WO1995031437A1 (en) 1994-05-18 1995-04-28 Processes for preparing anhydrous and hydrate forms of antihistaminic piperidine derivatives, polymorphs and pseudormophs thereof

Publications (2)

Publication Number Publication Date
DE69527429D1 DE69527429D1 (de) 2002-08-22
DE69527429T2 true DE69527429T2 (de) 2003-03-20

Family

ID=26937420

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69527429T Expired - Lifetime DE69527429T2 (de) 1994-05-18 1995-04-28 Verfahren zur herstellung von wasserfreien und hydrat-formen von antihistaminischen piperinderivaten, polymerphe und pseudomorphe davon

Country Status (18)

Country Link
US (12) US20010025106A1 (de)
EP (3) EP1178041A1 (de)
JP (7) JPH10500134A (de)
CN (3) CN1148849A (de)
AT (1) ATE220667T1 (de)
AU (1) AU693892B2 (de)
CA (3) CA2449419C (de)
DE (1) DE69527429T2 (de)
DK (1) DK0766668T3 (de)
ES (1) ES2176329T3 (de)
FI (1) FI964565A (de)
HK (2) HK1098467A1 (de)
HU (1) HU227676B1 (de)
IL (3) IL134917A (de)
MX (1) MX9605613A (de)
NO (1) NO315319B1 (de)
PT (1) PT766668E (de)
WO (1) WO1995031437A1 (de)

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CZ295461B6 (cs) * 1997-08-26 2005-08-17 Aventis Pharmaceuticals Inc. Farmaceutický prostředek ve formě dvouvrstvé tablety
IN191492B (de) * 1999-05-25 2003-12-06 Ranbaxy Lab Ltd
US6613906B1 (en) 2000-06-06 2003-09-02 Geneva Pharmaceuticals, Inc. Crystal modification
CH695216A5 (de) * 2001-02-23 2006-01-31 Cilag Ag Verfahren zur Herstellung eines nicht hydratisierten Salzes eines Piperidinderivats und eine so erhältliche neue kristalline Form eines solchen Salzes.
US20030021849A1 (en) * 2001-04-09 2003-01-30 Ben-Zion Dolitzky Polymorphs of fexofenadine hydrochloride
SK13822003A3 (sk) * 2001-04-09 2004-09-08 Teva Pharmaceutical Industries Ltd. Polymorfné formy chloridu fexofenadínu
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US7700779B2 (en) * 2001-06-18 2010-04-20 Dr. Reddy's Laboratories Limited Crystalline forms of fexofenadine and its hydrochloride
ATE389405T1 (de) * 2001-07-31 2008-04-15 Texcontor Ets Fexofenadine hydrochlorid polymorph
US20030158227A1 (en) * 2001-11-08 2003-08-21 Barnaba Krochmal Polymorphs of fexofenadine base
JP2005532356A (ja) * 2002-06-10 2005-10-27 テバ ファーマシューティカル インダストリーズ リミティド 塩酸フェキソフェナジンの多型体ｘｖｉ
JP3910907B2 (ja) * 2002-10-29 2007-04-25 新光電気工業株式会社 キャパシタ素子及びこの製造方法、半導体装置用基板、並びに半導体装置
WO2005005447A2 (en) 2003-07-03 2005-01-20 Teva Pharmaceutical Industries Ltd. Zoledronic acid crystal forms, zoledronate sodium salt crystal forms, amorphous zoledronate sodium salt, and processes for their preparation
GB0319935D0 (en) * 2003-08-26 2003-09-24 Cipla Ltd Polymorphs
WO2005102999A2 (en) * 2004-04-26 2005-11-03 Teva Pharmaceutical Industries Ltd. Crystalline forms of fexofenadine hydrochloride and processes for their preparation
ITMI20041143A1 (it) * 2004-06-08 2004-09-08 Dipharma Spa Polimorfi di fexofenadina e procedimento per la loro preparazione
EP1616861A3 (de) * 2004-06-15 2006-02-08 Dipharma S.p.A. Verfahren zur Herstellung von Keto-Verbindungen
ITMI20041568A1 (it) * 2004-07-30 2004-10-30 Dipharma Spa "polimorfi di fexofenadina base"
WO2006037042A1 (en) * 2004-09-28 2006-04-06 Teva Pharmaceutical Industries Ltd. Fexofenadine crystal form and processes for its preparation thereof
DOP2006000274A (es) * 2005-12-14 2007-10-15 Sanofi Aventis Us Llc Formulación de suspensión de fexofenadina
AU2007272951A1 (en) * 2006-07-11 2008-01-17 Mutual Pharmaceutical Company, Inc. Controlled-release formulations
US20090076080A1 (en) * 2007-09-19 2009-03-19 Protia, Llc Deuterium-enriched fexofenadine
EP2105134A1 (de) 2008-03-24 2009-09-30 Ranbaxy Laboratories Limited Stabiles und amorphes Fexofenadin-Hydrochlorid
WO2010083360A2 (en) * 2009-01-16 2010-07-22 Mutual Pharmaceutical Company, Inc. Controlled-release formulations
JP2013510113A (ja) 2009-11-06 2013-03-21 ビーエーエスエフ ソシエタス・ヨーロピア ４−ヒドロキシ安息香酸及び選択された殺有害生物剤の結晶複合体
IT1400965B1 (it) * 2010-06-15 2013-07-05 Dipharma Francis Srl Polimorfi di fexofenadina
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CN104072402B (zh) * 2014-07-16 2016-08-17 昆山龙灯瑞迪制药有限公司 一种新结晶形式的盐酸非索非那定化合物及其制备方法

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Also Published As

Publication number Publication date
HK1137742A1 (en) 2010-08-06
EP1178041A1 (de) 2002-02-06
HK1098467A1 (en) 2007-07-20
US7662835B2 (en) 2010-02-16
US7138524B2 (en) 2006-11-21
CA2449419C (en) 2011-09-06
US20040014976A1 (en) 2004-01-22
CN1907967A (zh) 2007-02-07
JP2002255936A (ja) 2002-09-11
US20020193601A1 (en) 2002-12-19
FI964565A0 (fi) 1996-11-14
HUT76134A (en) 1997-06-30
CA2189007A1 (en) 1995-11-23
EP0766668A1 (de) 1997-04-09
US20020193603A1 (en) 2002-12-19
ES2176329T3 (es) 2002-12-01
US20030045721A1 (en) 2003-03-06
CA2585705A1 (en) 1995-11-23
US20070021462A1 (en) 2007-01-25
US20010012896A1 (en) 2001-08-09
NO964859L (no) 1996-11-15
CA2585705C (en) 2012-04-17
EP0766668B1 (de) 2002-07-17
PT766668E (pt) 2002-11-29
US7135571B2 (en) 2006-11-14
US20080167469A1 (en) 2008-07-10
US7666881B2 (en) 2010-02-23
WO1995031437A1 (en) 1995-11-23
IL134917A0 (en) 2001-05-20
DE69527429D1 (de) 2002-08-22
JP4503909B2 (ja) 2010-07-14
JP4503907B2 (ja) 2010-07-14
CA2189007C (en) 2004-03-02
HU9603167D0 (en) 1997-01-28
CN1907967B (zh) 2012-07-04
US20010025106A1 (en) 2001-09-27
US20070021461A1 (en) 2007-01-25
AU693892B2 (en) 1998-07-09
JP2010120969A (ja) 2010-06-03
JPH10500134A (ja) 1998-01-06
AU2426595A (en) 1995-12-05
US20080167471A1 (en) 2008-07-10
ATE220667T1 (de) 2002-08-15
US20010014741A1 (en) 2001-08-16
CN1623985A (zh) 2005-06-08
US20020193600A1 (en) 2002-12-19
CA2449419A1 (en) 1995-11-23
JP2002255935A (ja) 2002-09-11
CN1148849A (zh) 1997-04-30
IL113747A (en) 2001-05-20
MX9605613A (es) 1998-05-31
EP2354125A1 (de) 2011-08-10
JP2002308849A (ja) 2002-10-23
NO964859D0 (no) 1996-11-15
DK0766668T3 (da) 2002-10-28
IL134917A (en) 2001-07-24
IL113747A0 (en) 1995-08-31
JP4503908B2 (ja) 2010-07-14
HU227676B1 (en) 2011-11-28
JP2002316978A (ja) 2002-10-31
NO315319B1 (no) 2003-08-18
FI964565A (fi) 1996-11-14
JP2002308850A (ja) 2002-10-23

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Legal Events

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8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: AVENTIS HOLDINGS INC., GREENVILLE, DEL., US

8327 Change in the person/name/address of the patent owner

Owner name: AVENTISUB II INC., GREENVILLE, DEL., US