DE69222444D1 - Substituierte 1,2,3,4-Tetrahydrocyclopent[b]indole, 1,2,3,3a,4,8a-Hexahydrocyclopent[b]indole und verwandte Verbindungen, Zwischenprodukte und ein Verfahren zur Herstellung derselben und ihre Verwendung als Medikamente - Google Patents
Substituierte 1,2,3,4-Tetrahydrocyclopent[b]indole, 1,2,3,3a,4,8a-Hexahydrocyclopent[b]indole und verwandte Verbindungen, Zwischenprodukte und ein Verfahren zur Herstellung derselben und ihre Verwendung als MedikamenteInfo
- Publication number
- DE69222444D1 DE69222444D1 DE69222444T DE69222444T DE69222444D1 DE 69222444 D1 DE69222444 D1 DE 69222444D1 DE 69222444 T DE69222444 T DE 69222444T DE 69222444 T DE69222444 T DE 69222444T DE 69222444 D1 DE69222444 D1 DE 69222444D1
- Authority
- DE
- Germany
- Prior art keywords
- indoles
- intermediates
- preparation
- hexahydrocyclopent
- tetrahydrocyclopent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/642,952 US5100891A (en) | 1991-01-18 | 1991-01-18 | Substituted 1,2,3,4-tetrahydrocyclopent[b]indoles, 1,2,3,3a,4,8a-hexahydrocyclopent[B]indoles and related compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69222444D1 true DE69222444D1 (de) | 1997-11-06 |
DE69222444T2 DE69222444T2 (de) | 1998-06-04 |
Family
ID=24578739
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69222444T Expired - Lifetime DE69222444T2 (de) | 1991-01-18 | 1992-01-18 | Substituierte 1,2,3,4-Tetrahydrocyclopent[b]indole, 1,2,3,3a,4,8a-Hexahydrocyclopent[b]indole und verwandte Verbindungen, Zwischenprodukte und ein Verfahren zur Herstellung derselben und ihre Verwendung als Medikamente |
Country Status (26)
Country | Link |
---|---|
US (1) | US5100891A (de) |
EP (1) | EP0496314B1 (de) |
JP (1) | JP2665422B2 (de) |
KR (1) | KR100230881B1 (de) |
AT (1) | ATE158790T1 (de) |
AU (1) | AU650315B2 (de) |
BR (1) | BR9200171A (de) |
CA (1) | CA2059610C (de) |
CZ (1) | CZ282732B6 (de) |
DE (1) | DE69222444T2 (de) |
DK (1) | DK0496314T3 (de) |
ES (1) | ES2109953T3 (de) |
FI (2) | FI102174B (de) |
GR (1) | GR3025318T3 (de) |
HU (1) | HUT67027A (de) |
IE (1) | IE920149A1 (de) |
IL (1) | IL100693A0 (de) |
MX (1) | MX9200206A (de) |
NO (1) | NO178397C (de) |
NZ (1) | NZ241305A (de) |
PH (1) | PH31429A (de) |
PL (2) | PL167465B1 (de) |
RO (1) | RO112505B1 (de) |
RU (1) | RU2077530C1 (de) |
TW (1) | TW198024B (de) |
ZA (1) | ZA92341B (de) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5298626A (en) * | 1991-01-18 | 1994-03-29 | Hoechst-Roussel Pharmaceuticals Incorporated | Select cyclopent[b]indoles |
US5350762A (en) * | 1993-03-08 | 1994-09-27 | Hoechst-Roussel Pharmaceuticals Incorporated | Tetrahydrocyclopent[B]indole methanamines and related compounds |
ES2149742T1 (es) * | 1997-07-03 | 2000-11-16 | Asahi Chemical Ind | Nuevos compuestos triciclicos que tienen anillos saturados y composiciones medicinales que contienen los mismos. |
UA70334C2 (en) * | 1998-10-06 | 2004-10-15 | Janssen Pharmaceutica N V Jans | BENZOTHIENO[3,2-c]PYRIDINES AS a2 ANTAGONISTS BENZOTHIENO[3,2-c]PYRIDINES AS a2 ANTAGONISTS |
ID28451A (id) * | 1998-10-06 | 2001-05-24 | Janssen Pharmaceutica Nv | Trisiklik piperidin-δ3 sebagai bahan farmasi |
UA69420C2 (uk) * | 1998-10-06 | 2004-09-15 | Янссен Фармацевтика Н.В. | ТРИЦИКЛІЧНІ <font face="Symbol">D3</font>-ПІПЕРИДИНИ ЯК <font face="Symbol">a<sub></font>2</sub>-АНТАГОНІСТИ |
IT1317926B1 (it) * | 2000-11-03 | 2003-07-15 | Sigma Tau Ind Farmaceuti | Derivati triciclici dell'indolo ad attivita' antiangiogenica. |
AU2004247676A1 (en) | 2003-06-10 | 2004-12-23 | Smithkline Beecham Corporation | Tetrahydrocarbazole derivatives and their pharmaceutical use |
BRPI0411245A (pt) | 2003-06-12 | 2006-07-18 | Smithkline Beecham Corp | composto, composição farmacêutica, uso de um composto, e, métodos para tratamento ou profilaxia de vìrus oncogênicos e para tratamento ou profilaxia de condições ou distúrbios devidos a infecção por hpv |
EP1817025A2 (de) * | 2004-11-23 | 2007-08-15 | PTC Therapeutics, Inc. | Tetrahydrocarbazole als aktivwirkstoffe zur hemmung der vegf-produktion durch translationskontrolle |
GB2422828A (en) * | 2005-02-03 | 2006-08-09 | Hunter Fleming Ltd | Tricyclic cytoprotective compounds comprising an indole residue |
WO2013139929A1 (en) * | 2012-03-22 | 2013-09-26 | Ludwig-Maximilians-Universität München | Novel means and methods for treating diseases of the central nervous system, metabolic and cardiac diseases and aging |
KR20140013471A (ko) | 2012-07-24 | 2014-02-05 | 주식회사 쎄코 | 진공증착용 발열조립체 및 이를 구비하는 진공증착장치 |
US10882821B1 (en) | 2017-09-26 | 2021-01-05 | The Board Of Trustees Of The Leland Stanford Junior University | Enantiomeric compound for the reduction of the deleterious activity of extended nucleotide repeat containing genes |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3514462A (en) * | 1966-10-21 | 1970-05-26 | Upjohn Co | 1 and 2 ethoxy 3,4,5,10 - tetrahydroazepino(3,4-b) and (2,3-b)indoles and corresponding amino derivatives thereof |
US3595874A (en) * | 1969-02-28 | 1971-07-27 | Upjohn Co | 3,4,5,10-tetrahydroazepino(2,3-b)indol-5a (2h)-ols |
BE787537A (fr) * | 1971-08-16 | 1973-02-14 | Sterling Drug Inc | Tetrahydrocarbazoles |
SU482086A1 (ru) * | 1973-11-30 | 1976-03-15 | Всесоюзный Научно-Исследовательски% Химико-Фармацевтический Институт Им.С.Орджоникидзе | Способ получени производных 1- -амино1,2,3,4-тетрагидрокарбазола |
JPS5111760A (de) * | 1974-06-18 | 1976-01-30 | Ayerst Mckenna & Harrison | |
US4254134A (en) * | 1978-03-17 | 1981-03-03 | Endo Laboratories, Inc. | Antidepressant 2-amino- and -2-(substituted amino)-cis-hexahydro-carbazoles |
-
1991
- 1991-01-18 US US07/642,952 patent/US5100891A/en not_active Expired - Lifetime
-
1992
- 1992-01-15 RO RO149168A patent/RO112505B1/ro unknown
- 1992-01-15 NZ NZ241305A patent/NZ241305A/en unknown
- 1992-01-16 FI FI920192A patent/FI102174B/fi active
- 1992-01-16 PL PL92296651A patent/PL167465B1/pl unknown
- 1992-01-16 KR KR1019920000543A patent/KR100230881B1/ko not_active IP Right Cessation
- 1992-01-16 PL PL92293209A patent/PL169417B1/pl unknown
- 1992-01-16 CZ CS92129A patent/CZ282732B6/cs not_active IP Right Cessation
- 1992-01-17 HU HU9200172A patent/HUT67027A/hu unknown
- 1992-01-17 IL IL100693A patent/IL100693A0/xx unknown
- 1992-01-17 NO NO920235A patent/NO178397C/no unknown
- 1992-01-17 CA CA002059610A patent/CA2059610C/en not_active Expired - Lifetime
- 1992-01-17 IE IE014992A patent/IE920149A1/en not_active IP Right Cessation
- 1992-01-17 MX MX9200206A patent/MX9200206A/es unknown
- 1992-01-17 ZA ZA92341A patent/ZA92341B/xx unknown
- 1992-01-17 RU SU925010763A patent/RU2077530C1/ru active
- 1992-01-17 JP JP4006681A patent/JP2665422B2/ja not_active Expired - Lifetime
- 1992-01-17 AU AU10279/92A patent/AU650315B2/en not_active Ceased
- 1992-01-18 DE DE69222444T patent/DE69222444T2/de not_active Expired - Lifetime
- 1992-01-18 DK DK92100816.5T patent/DK0496314T3/da active
- 1992-01-18 ES ES92100816T patent/ES2109953T3/es not_active Expired - Lifetime
- 1992-01-18 AT AT92100816T patent/ATE158790T1/de not_active IP Right Cessation
- 1992-01-18 EP EP92100816A patent/EP0496314B1/de not_active Expired - Lifetime
- 1992-01-21 BR BR929200171A patent/BR9200171A/pt not_active Application Discontinuation
- 1992-02-20 TW TW081101228A patent/TW198024B/zh active
- 1992-11-20 PH PH43793A patent/PH31429A/en unknown
-
1997
- 1997-11-07 GR GR970402960T patent/GR3025318T3/el unknown
-
2000
- 2000-08-10 FI FI20001775A patent/FI107919B/fi active
Also Published As
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |