DK0467331T3 - O-methylderivater af azithromycin A, fremgangsmåde og mellemprodukter til fremstilling deraf og anve ndelse deraf ved fremstilling af lægemidler - Google Patents

O-methylderivater af azithromycin A, fremgangsmåde og mellemprodukter til fremstilling deraf og anve ndelse deraf ved fremstilling af lægemidler

Info

Publication number
DK0467331T3
DK0467331T3 DK91111948.5T DK91111948T DK0467331T3 DK 0467331 T3 DK0467331 T3 DK 0467331T3 DK 91111948 T DK91111948 T DK 91111948T DK 0467331 T3 DK0467331 T3 DK 0467331T3
Authority
DK
Denmark
Prior art keywords
azithromycin
methyl derivatives
co2ch2c6h5
derivatives
methyl
Prior art date
Application number
DK91111948.5T
Other languages
Danish (da)
English (en)
Inventor
Gabrijela Kobrehel
Slobodan Djokic
Gorjana Lazarevski
Original Assignee
Pliva Pharm & Chem Works
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pliva Pharm & Chem Works filed Critical Pliva Pharm & Chem Works
Application granted granted Critical
Publication of DK0467331T3 publication Critical patent/DK0467331T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DK91111948.5T 1990-07-18 1991-07-17 O-methylderivater af azithromycin A, fremgangsmåde og mellemprodukter til fremstilling deraf og anve ndelse deraf ved fremstilling af lægemidler DK0467331T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
YU140990 1990-07-18

Publications (1)

Publication Number Publication Date
DK0467331T3 true DK0467331T3 (da) 1996-02-05

Family

ID=25554060

Family Applications (1)

Application Number Title Priority Date Filing Date
DK91111948.5T DK0467331T3 (da) 1990-07-18 1991-07-17 O-methylderivater af azithromycin A, fremgangsmåde og mellemprodukter til fremstilling deraf og anve ndelse deraf ved fremstilling af lægemidler

Country Status (20)

Country Link
US (1) US5250518A (ro)
EP (1) EP0467331B1 (ro)
JP (1) JP2657132B2 (ro)
CN (1) CN1029738C (ro)
AT (1) ATE129715T1 (ro)
BG (1) BG60593B1 (ro)
CA (1) CA2046956C (ro)
CZ (1) CZ280640B6 (ro)
DE (1) DE69114198T2 (ro)
DK (1) DK0467331T3 (ro)
ES (1) ES2081397T3 (ro)
GR (1) GR3018330T3 (ro)
HR (1) HRP920491B1 (ro)
HU (4) HU221803B1 (ro)
PL (1) PL166379B1 (ro)
RO (1) RO109338B1 (ro)
RU (1) RU2045533C1 (ro)
SI (1) SI9011409A (ro)
SK (1) SK279075B6 (ro)
UA (1) UA27105A1 (ro)

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HRP931480B1 (en) * 1993-12-08 1997-08-31 Sour Pliva 9a-N-(N'-CARBAMONYL) and 9a-N-(N'-THIOCARBAMONYL) DERIVATES OF 9-DEOXO-9a-HOMOERYTHROMYCIN A
US5605889A (en) * 1994-04-29 1997-02-25 Pfizer Inc. Method of administering azithromycin
DE69824201T2 (de) * 1997-10-16 2005-09-22 Pliva - Istrazivacki Institut D.O.O. Neue 9a-azalide
US6861411B1 (en) 1997-12-02 2005-03-01 Pfizer, Inc. Method of treating eye infections with azithromycin
TW546302B (en) * 1998-05-08 2003-08-11 Biochemie Sa Improvements in macrolide production
UA70972C2 (uk) 1998-11-20 2004-11-15 Пфайзер Продактс Інк. 13-членні азаліди і їх застосування як антибіотиків
HRP980646B1 (en) * 1998-12-30 2008-02-29 GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. Novel oleandomycin derivatives
US6239113B1 (en) 1999-03-31 2001-05-29 Insite Vision, Incorporated Topical treatment or prevention of ocular infections
US7056893B2 (en) 1999-03-31 2006-06-06 Insite Vision, Inc. Topical treatment for prevention of ocular infections
HRP990116B1 (en) * 1999-04-20 2007-10-31 GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. NOVEL 8a AND 9a- 15-MEMBERED LACTAMES
US6465437B1 (en) * 1999-06-30 2002-10-15 Pfizer Inc. Diphosphate salt of a 4″-substituted-9-deoxo-9A-AZA-9A- homoerythromycin derivative and its pharmaceutical composition
US6787342B2 (en) 2000-02-16 2004-09-07 Merial Limited Paste formulations
CA2419873A1 (en) 2000-08-23 2002-02-28 Wockhardt Limited Process for preparation of anhydrous azithromycin
HRP20010301A2 (en) * 2001-04-27 2001-12-31 Pliva D D New therapeutic indication for azithromycin in the treatment of non-infective inflammatory diseases
NZ535354A (en) 2002-02-15 2008-01-31 Merckle Gmbh Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof
US20060099660A1 (en) 2002-02-15 2006-05-11 Synovo Gmbh Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof
AU2003211113B2 (en) 2002-02-15 2007-08-09 Merckle Gmbh Antibiotic conjugates
ITMI20022292A1 (it) * 2002-10-29 2004-04-30 Zambon Spa 9a-azalidi ad attivita' antiinfiammatoria.
US7435805B2 (en) * 2003-05-30 2008-10-14 Glaxpsmithkline Istrazivacki O-alkyl macrolide and azalide derivatives and regioselective process for their preparation
WO2004106353A1 (en) * 2003-05-30 2004-12-09 Pliva - Istrazivacki Institut D.O.O. Process for selective alkylation of macrolide and azalide derivatives
WO2005021567A1 (en) * 2003-09-02 2005-03-10 Pliva - Istrazivacki Institut D.O.O. O-alkyl macrolide and azalide derivatives and regioselective process for their preparation
US7468428B2 (en) 2004-03-17 2008-12-23 App Pharmaceuticals, Llc Lyophilized azithromycin formulation
RS51479B (en) * 2005-01-13 2011-04-30 Glaxo Group Limited MACROLIDES WITH ANTI-INFLAMMATORY ACTION
US8362086B2 (en) 2005-08-19 2013-01-29 Merial Limited Long acting injectable formulations
US20110281812A1 (en) 2009-01-30 2011-11-17 Sulejman Alihodzic Compounds
AR075340A1 (es) 2009-01-30 2011-03-23 Glaxosmithkline Zagreb 3'-n-desmetil-4''-o-(2-dietilaminoetanoil)-6-o-metil-9a-aza-9a-homoeritromicina a,formas cristalinas 1, 2 y 3, proceso para su preparacion, composicion farmaceutica que lo comprende y su uso para la preparacion de un medicamento util para el tratamiento de enfermedades inflamatorias
CN101830949B (zh) * 2009-03-13 2012-05-23 上海医药工业研究院 一种阿奇霉素衍生物、其中间体及其制备方法和应用
WO2011131749A1 (en) 2010-04-23 2011-10-27 Glaxo Group Limited New 14 and 15 membered macrolides for the treatment of neutrophil dominated inflammatory diseases
CN102952166A (zh) * 2011-08-28 2013-03-06 山东方明药业集团股份有限公司 聚合物支载硼氢阴离子还原剂合成阿奇霉素中间体的方法
CA2869461A1 (en) * 2012-03-27 2013-10-03 Michael W. BURNET Anti-inflammatory macrolides
GB201608236D0 (en) 2016-05-11 2016-06-22 Fidelta D O O Seco macrolide compounds
WO2018193117A1 (en) * 2017-04-20 2018-10-25 Novintum Biotechnology Gmbh Azithromycin derivatives containing a phosphonium ion as anticancer agents
WO2018193125A1 (en) * 2017-04-20 2018-10-25 Novintum Biotechnology Gmbh Azithromycin derivatives containing a phosphonium ion as anticancer agents
US11197872B2 (en) 2017-04-21 2021-12-14 Lunella Biotech, Inc. Vitamin C and doxycycline: a synthetic lethal combination therapy for eradicating cancer stem cells (CSCs)
WO2018195446A1 (en) 2017-04-21 2018-10-25 Lisanti Michael P Targeting hypoxic cancer stem cells (cscs) with doxycycline: implications for improving anti-angiogenic therapy
CR20190524A (es) 2017-05-19 2020-01-10 Lunella Biotech Inc Antimitoscinas: inhibidores específicos de la biogénesis mitocondrial para erradicar células madre cancerosas
CA3063450A1 (en) 2017-05-19 2018-11-22 Lunella Biotech, Inc. Companion diagnostics for mitochondrial inhibitors
MX2019014806A (es) 2017-06-26 2020-02-10 Lunella Biotech Inc Mitocetoscinas: agentes terapeuticos basados en mitocondrias que fijan como objetivo el metabolismo de cetonas en celulas cancerosas.

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US4474768A (en) * 1982-07-19 1984-10-02 Pfizer Inc. N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor
JPS61103890A (ja) * 1984-10-26 1986-05-22 Taisho Pharmaceut Co Ltd ６−０−メチルエリスロマイシンａ誘導体
EP0184921A3 (en) * 1984-12-08 1986-10-29 Beecham Group Plc Erythromycin derivatives
JPS63107994A (ja) * 1986-05-02 1988-05-12 Taisho Pharmaceut Co Ltd エリスロマイシン誘導体
WO1989002271A1 (en) * 1987-09-10 1989-03-23 Pfizer Azithromycin and derivatives as antiprotozoal agents

Also Published As

Publication number Publication date
ES2081397T3 (es) 1996-03-01
CZ280640B6 (cs) 1996-03-13
PL291130A1 (en) 1992-11-16
CN1059728A (zh) 1992-03-25
CA2046956C (en) 1999-01-05
ATE129715T1 (de) 1995-11-15
HUT62307A (en) 1993-04-28
JPH05132497A (ja) 1993-05-28
RU2045533C1 (ru) 1995-10-10
DE69114198T2 (de) 1996-06-27
HRP920491A2 (en) 1994-08-31
EP0467331B1 (en) 1995-11-02
GR3018330T3 (en) 1996-03-31
SK279075B6 (sk) 1998-06-03
HU211659A9 (en) 1995-12-28
HUT59935A (en) 1992-07-28
HU221803B1 (hu) 2003-01-28
SI9011409A (en) 1995-10-31
HU9202619D0 (en) 1992-12-28
BG60593B1 (bg) 1995-09-29
CN1029738C (zh) 1995-09-13
DE69114198D1 (de) 1995-12-07
UA27105A1 (uk) 2000-02-28
CA2046956A1 (en) 1992-01-19
US5250518A (en) 1993-10-05
HRP920491B1 (en) 1998-10-31
RO109338B1 (ro) 1995-01-30
HU9802439D0 (en) 1998-12-28
HU215158B (hu) 1998-12-28
HU912408D0 (en) 1991-12-30
JP2657132B2 (ja) 1997-09-24
EP0467331A1 (en) 1992-01-22
PL166379B1 (en) 1995-05-31
BG94837A (bg) 1993-12-24
CS219591A3 (en) 1992-03-18

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