DE69938170T2 - Mischverfahren - Google Patents
Mischverfahren Download PDFInfo
- Publication number
- DE69938170T2 DE69938170T2 DE69938170T DE69938170T DE69938170T2 DE 69938170 T2 DE69938170 T2 DE 69938170T2 DE 69938170 T DE69938170 T DE 69938170T DE 69938170 T DE69938170 T DE 69938170T DE 69938170 T2 DE69938170 T2 DE 69938170T2
- Authority
- DE
- Germany
- Prior art keywords
- capillary
- liquid
- reagent
- recess
- mixing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000002156 mixing Methods 0.000 title claims abstract description 45
- 238000000034 method Methods 0.000 title claims abstract description 35
- 239000007788 liquid Substances 0.000 claims abstract description 62
- 239000003153 chemical reaction reagent Substances 0.000 claims description 46
- 238000004458 analytical method Methods 0.000 claims description 9
- 238000005259 measurement Methods 0.000 claims description 8
- 230000003287 optical effect Effects 0.000 claims description 8
- 108010088751 Albumins Proteins 0.000 claims description 7
- 102000009027 Albumins Human genes 0.000 claims description 7
- 238000004090 dissolution Methods 0.000 claims description 6
- 102000004169 proteins and genes Human genes 0.000 claims description 6
- 108090000623 proteins and genes Proteins 0.000 claims description 6
- 229920002521 macromolecule Polymers 0.000 claims description 4
- 108010074051 C-Reactive Protein Proteins 0.000 claims description 3
- 102100032752 C-reactive protein Human genes 0.000 claims description 3
- 150000001720 carbohydrates Chemical class 0.000 claims description 3
- 239000000427 antigen Substances 0.000 claims description 2
- 102000004856 Lectins Human genes 0.000 claims 2
- 108090001090 Lectins Proteins 0.000 claims 2
- 239000002523 lectin Substances 0.000 claims 2
- 108010017384 Blood Proteins Proteins 0.000 claims 1
- 102000004506 Blood Proteins Human genes 0.000 claims 1
- 239000012528 membrane Substances 0.000 abstract description 12
- 239000000523 sample Substances 0.000 description 45
- 238000005070 sampling Methods 0.000 description 8
- 239000010409 thin film Substances 0.000 description 8
- 239000008280 blood Substances 0.000 description 6
- 210000004369 blood Anatomy 0.000 description 6
- 238000006243 chemical reaction Methods 0.000 description 5
- 239000000203 mixture Substances 0.000 description 5
- 230000035559 beat frequency Effects 0.000 description 4
- 210000004379 membrane Anatomy 0.000 description 4
- 239000006249 magnetic particle Substances 0.000 description 3
- 210000002700 urine Anatomy 0.000 description 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- 102000001554 Hemoglobins Human genes 0.000 description 2
- 108010054147 Hemoglobins Proteins 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 239000008103 glucose Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 241001295925 Gegenes Species 0.000 description 1
- 102000008100 Human Serum Albumin Human genes 0.000 description 1
- 108091006905 Human Serum Albumin Proteins 0.000 description 1
- 239000008118 PEG 6000 Substances 0.000 description 1
- 229920002584 Polyethylene Glycol 6000 Polymers 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 239000012491 analyte Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 239000010419 fine particle Substances 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 238000011002 quantification Methods 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 125000006850 spacer group Chemical group 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000009827 uniform distribution Methods 0.000 description 1
- 238000003805 vibration mixing Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N21/03—Cuvette constructions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/30—Micromixers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/02—Adapting objects or devices to another
- B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0825—Test strips
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0457—Moving fluids with specific forces or mechanical means specific forces passive flow or gravitation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N21/03—Cuvette constructions
- G01N2021/0325—Cells for testing reactions, e.g. containing reagents
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N21/03—Cuvette constructions
- G01N2021/0325—Cells for testing reactions, e.g. containing reagents
- G01N2021/0328—Arrangement of two or more cells having different functions for the measurement of reactions
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N21/03—Cuvette constructions
- G01N2021/0346—Capillary cells; Microcells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N21/11—Filling or emptying of cuvettes
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/827—Lectins
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Pathology (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Dispersion Chemistry (AREA)
- Biochemistry (AREA)
- Clinical Laboratory Science (AREA)
- Sampling And Sample Adjustment (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Optical Measuring Cells (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Processing Of Solid Wastes (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9800070 | 1998-01-14 | ||
| SE9800070A SE9800070D0 (sv) | 1998-01-14 | 1998-01-14 | Blandningsmetod |
| PCT/SE1999/000046 WO1999036765A1 (en) | 1998-01-14 | 1999-01-14 | Mixing method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69938170D1 DE69938170D1 (de) | 2008-04-03 |
| DE69938170T2 true DE69938170T2 (de) | 2009-02-26 |
Family
ID=20409855
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69938170T Expired - Lifetime DE69938170T2 (de) | 1998-01-14 | 1999-01-14 | Mischverfahren |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6468807B1 (enExample) |
| EP (1) | EP1055112B1 (enExample) |
| JP (2) | JP4502504B2 (enExample) |
| CN (1) | CN1130558C (enExample) |
| AT (1) | ATE386930T1 (enExample) |
| AU (1) | AU2195699A (enExample) |
| DE (1) | DE69938170T2 (enExample) |
| DK (1) | DK1055112T3 (enExample) |
| ES (1) | ES2299239T3 (enExample) |
| SE (1) | SE9800070D0 (enExample) |
| WO (1) | WO1999036765A1 (enExample) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19933458B4 (de) * | 1999-07-15 | 2015-08-20 | Eppendorf Ag | Einrichtungen und Systeme zum Handhaben von Flüssigkeitsproben |
| JP3621617B2 (ja) * | 2000-01-21 | 2005-02-16 | ブラザー工業株式会社 | グルコース濃度測定用のキャピラリー装置、グルコース濃度の非侵襲的モニター方法及び血糖値の非侵襲的モニター方法 |
| US7029628B2 (en) | 2000-12-28 | 2006-04-18 | Stat-Chem Inc. | Portable co-oximeter |
| CA2523124A1 (en) * | 2003-03-20 | 2004-10-07 | Gary D. Niehaus | Self-contained assay device for rapid detection of biohazardous agents |
| AU2005233571B2 (en) | 2004-04-07 | 2008-10-09 | Levine, Robert A. | Disposable chamber for analyzing biologic fluids |
| SE528697C2 (sv) * | 2005-03-11 | 2007-01-30 | Hemocue Ab | Volymetrisk bestämning av antalet vita blodkroppar i ett blodprov |
| SE529643C3 (sv) | 2005-07-08 | 2007-11-06 | Hemocue Ab | En kuvett och en metod och ett verktyg för tillverkning därav |
| US7731901B2 (en) | 2005-10-19 | 2010-06-08 | Abbott Laboratories | Apparatus and method for performing counts within a biologic fluid sample |
| WO2008002462A2 (en) * | 2006-06-23 | 2008-01-03 | Micronics, Inc. | Methods and devices for microfluidic point-of-care immunoassays |
| US9056291B2 (en) | 2005-11-30 | 2015-06-16 | Micronics, Inc. | Microfluidic reactor system |
| US7763453B2 (en) | 2005-11-30 | 2010-07-27 | Micronics, Inc. | Microfluidic mixing and analytic apparatus |
| JP4331789B2 (ja) | 2006-08-21 | 2009-09-16 | パナソニック株式会社 | 測定デバイス、測定装置及び測定方法 |
| EP2274613B1 (en) * | 2008-04-02 | 2014-06-04 | Abbott Point Of Care, Inc. | Method for serologic agglutination assays performed in a thin film fluid sample |
| US7947492B2 (en) * | 2008-08-20 | 2011-05-24 | Northeastern Ohio Universities College Of Medicine | Device improving the detection of a ligand |
| WO2010122464A1 (en) | 2009-04-23 | 2010-10-28 | Koninklijke Philips Electronics N.V. | Mixer with zero dead volume and method for mixing |
| JP5709894B2 (ja) | 2009-12-18 | 2015-04-30 | アボット ポイント オブ ケア インコーポレイテッド | 生物学的液体分析カートリッジ |
| EP2528687B1 (en) | 2010-01-29 | 2018-08-22 | Micronics, Inc. | System comprising a host instrument and a microfluidic cartridge for assays |
| US10114020B2 (en) | 2010-10-11 | 2018-10-30 | Mbio Diagnostics, Inc. | System and device for analyzing a fluidic sample |
| CN103282123B (zh) | 2010-12-30 | 2015-05-06 | 艾博特健康公司 | 带有样品处理区和分析室区的生物液体分析卡式盒 |
| US9157903B2 (en) * | 2011-02-25 | 2015-10-13 | Honeywell International Inc. | Microfluidic separation of plasma for colormetric assay |
| CN103890590B (zh) | 2011-08-24 | 2016-03-09 | 艾博特健康公司 | 生物流体样品分析盒 |
| WO2013106458A2 (en) | 2012-01-09 | 2013-07-18 | Micronics, Inc. | Microfluidic reactor system |
| EP2911791A4 (en) | 2012-10-29 | 2016-11-02 | Mbio Diagnostics Inc | BIOPARTICLE IDENTIFICATION SYSTEM, CARTRIDGE AND RELATED METHODS |
| US20150346097A1 (en) | 2012-12-21 | 2015-12-03 | Micronics, Inc. | Portable fluorescence detection system and microassay cartridge |
| KR102102123B1 (ko) | 2012-12-21 | 2020-04-20 | 퍼킨엘머 헬스 사이언시즈, 아이엔씨. | 유체 공학 회로 및 관련 제조 방법 |
| CN107824233B (zh) | 2012-12-21 | 2020-06-30 | 珀金埃尔默健康科学有限公司 | 用于微流体用途的低弹性膜 |
| US10386377B2 (en) | 2013-05-07 | 2019-08-20 | Micronics, Inc. | Microfluidic devices and methods for performing serum separation and blood cross-matching |
| JP6472788B2 (ja) | 2013-05-07 | 2019-02-20 | マイクロニクス， インコーポレイテッド | 粘土鉱物およびアルカリ性溶液を使用して核酸含有試料を調製するための方法 |
| US10087440B2 (en) | 2013-05-07 | 2018-10-02 | Micronics, Inc. | Device for preparation and analysis of nucleic acids |
| GB2555403B (en) * | 2016-10-24 | 2021-03-24 | Entia Ltd | A Cuvette |
| EP3669179B1 (en) | 2017-08-17 | 2023-07-19 | Abbott Point Of Care Inc | Systems for performing optical and electrochemical assays |
| WO2019035077A1 (en) | 2017-08-17 | 2019-02-21 | Abbott Point Of Care Inc. | DEVICES, SYSTEMS AND METHODS FOR PERFORMING OPTICAL ASSAYS |
| GB2607337B (en) | 2021-06-04 | 2025-04-02 | Entia Ltd | A cuvette |
| GB2616668A (en) | 2022-03-18 | 2023-09-20 | Entia Ltd | A method of obtaining an image of a biological sample in a cuvette |
| GB2616667A (en) | 2022-03-18 | 2023-09-20 | Entia Ltd | A composition for coating a cuvette and a method of making a composition for coating a cuvette |
| GB2616840A (en) | 2022-03-18 | 2023-09-27 | Entia Ltd | A cuvette for analysing biological samples |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE107783C (enExample) | ||||
| US3898982A (en) * | 1972-11-13 | 1975-08-12 | Jintan Terumo Co | Capillary tube for blood examination |
| DD107783A1 (enExample) * | 1973-12-03 | 1974-08-12 | ||
| JPS51114767A (en) * | 1975-03-31 | 1976-10-08 | Fujirebio Inc | Vibrator |
| SE399768B (sv) * | 1975-09-29 | 1978-02-27 | Lilja Jan E | Kyvett for provtagning, blandning av, provet med ett reagensmedel och direkt utforande av, serskilt optisk, analys av det med reagensmedlet blandade provet |
| EP0018435B1 (de) * | 1979-10-16 | 1984-03-07 | Winfried Dr. med. Stöcker | Vorrichtung zur Durchführung von Mikroanalysen |
| EP0075605B1 (de) * | 1981-09-25 | 1987-01-21 | Winfried Dr. med. Stöcker | Vorrichtung für photometrische Analysen |
| SE452512B (sv) * | 1984-09-11 | 1987-11-30 | Biolabimex Ab | Forfarande for minskning av de elektrostatiska krafterna, t ex ytspenning, i en vetska , i synnerhet blod eller blodlosning |
| US4756884A (en) * | 1985-08-05 | 1988-07-12 | Biotrack, Inc. | Capillary flow device |
| ATE138475T1 (de) * | 1985-09-30 | 1996-06-15 | Molecular Devices Corp | Photometrisches vielortmesssystem mit einer quelle |
| SE8601528D0 (sv) | 1986-04-07 | 1986-04-07 | Leo Ab | Mixing apparatus and method |
| US4849340A (en) * | 1987-04-03 | 1989-07-18 | Cardiovascular Diagnostics, Inc. | Reaction system element and method for performing prothrombin time assay |
| CA1315181C (en) * | 1987-04-13 | 1993-03-30 | Joel M. Blatt | Test strip device with volume metering capillary gap |
| JPH0217426A (ja) * | 1988-07-05 | 1990-01-22 | Kiyouseki Seihin Gijutsu Kenkyusho:Kk | 液体試料用の分析セル |
| US5286454A (en) * | 1989-04-26 | 1994-02-15 | Nilsson Sven Erik | Cuvette |
| JP2832117B2 (ja) * | 1991-11-29 | 1998-12-02 | キヤノン株式会社 | サンプル測定デバイス及びサンプル測定システム |
| SE504193C2 (sv) | 1995-04-21 | 1996-12-02 | Hemocue Ab | Kapillär mikrokyvett |
| US6001307A (en) * | 1996-04-26 | 1999-12-14 | Kyoto Daiichi Kagaku Co., Ltd. | Device for analyzing a sample |
-
1998
- 1998-01-14 SE SE9800070A patent/SE9800070D0/xx unknown
-
1999
- 1999-01-14 DK DK99902025T patent/DK1055112T3/da active
- 1999-01-14 DE DE69938170T patent/DE69938170T2/de not_active Expired - Lifetime
- 1999-01-14 JP JP2000540426A patent/JP4502504B2/ja not_active Expired - Fee Related
- 1999-01-14 EP EP99902025A patent/EP1055112B1/en not_active Expired - Lifetime
- 1999-01-14 AT AT99902025T patent/ATE386930T1/de active
- 1999-01-14 CN CN99802180A patent/CN1130558C/zh not_active Expired - Fee Related
- 1999-01-14 WO PCT/SE1999/000046 patent/WO1999036765A1/en not_active Ceased
- 1999-01-14 ES ES99902025T patent/ES2299239T3/es not_active Expired - Lifetime
- 1999-01-14 AU AU21956/99A patent/AU2195699A/en not_active Abandoned
-
2000
- 2000-07-07 US US09/612,273 patent/US6468807B1/en not_active Expired - Lifetime
-
2008
- 2008-09-29 JP JP2008249582A patent/JP4491032B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN1130558C (zh) | 2003-12-10 |
| JP2002509247A (ja) | 2002-03-26 |
| AU2195699A (en) | 1999-08-02 |
| SE9800070D0 (sv) | 1998-01-14 |
| US6468807B1 (en) | 2002-10-22 |
| EP1055112B1 (en) | 2008-02-20 |
| JP4491032B2 (ja) | 2010-06-30 |
| JP2009053201A (ja) | 2009-03-12 |
| ATE386930T1 (de) | 2008-03-15 |
| WO1999036765A1 (en) | 1999-07-22 |
| JP4502504B2 (ja) | 2010-07-14 |
| EP1055112A1 (en) | 2000-11-29 |
| CN1288517A (zh) | 2001-03-21 |
| DE69938170D1 (de) | 2008-04-03 |
| ES2299239T3 (es) | 2008-05-16 |
| DK1055112T3 (da) | 2008-04-14 |
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