JP2009053201A - 混合方法 - Google Patents
混合方法 Download PDFInfo
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- JP2009053201A JP2009053201A JP2008249582A JP2008249582A JP2009053201A JP 2009053201 A JP2009053201 A JP 2009053201A JP 2008249582 A JP2008249582 A JP 2008249582A JP 2008249582 A JP2008249582 A JP 2008249582A JP 2009053201 A JP2009053201 A JP 2009053201A
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N21/03—Cuvette constructions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/30—Micromixers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/02—Adapting objects or devices to another
- B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0825—Test strips
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0457—Moving fluids with specific forces or mechanical means specific forces passive flow or gravitation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N21/03—Cuvette constructions
- G01N2021/0325—Cells for testing reactions, e.g. containing reagents
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N21/03—Cuvette constructions
- G01N2021/0325—Cells for testing reactions, e.g. containing reagents
- G01N2021/0328—Arrangement of two or more cells having different functions for the measurement of reactions
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N21/03—Cuvette constructions
- G01N2021/0346—Capillary cells; Microcells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N21/11—Filling or emptying of cuvettes
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/827—Lectins
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Clinical Laboratory Science (AREA)
- Physics & Mathematics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Dispersion Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Hematology (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Sampling And Sample Adjustment (AREA)
- Optical Measuring Cells (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Processing Of Solid Wastes (AREA)
Abstract
【解決手段】本発明の方法は、互いから毛管距離のところにある実質的に平行な壁と壁の間に配置された液体薄層内で混合を実施する。混合は、壁を実質的に液体層の平面内で運動させ、前記運動を液体に接した壁によって生じた毛管力と釣り合わせ、液体層と周囲の媒体の間の界面をこの界面が弾性膜として機能するように選択することによって行われる。
【選択図】図1
Description
−定量する成分を含む試料を、前記成分用の乾性試薬を少なくとも含む使い捨て装置に挿入する段階であって、この装置には、実質的に面平行な2つの壁によって画定された毛管空洞内の入口を通して毛管力の作用下で試料を吸い込むことができる段階、
−試薬の溶解および液体薄層内での試薬と試料の混合を促進するために装置を運動させる段階であって、前記層が、空洞を画定する面平行な壁と壁の間に形成され、前記運動が実質的に液体層の平面内で起こり、壁によって液体に及ぼされる毛管力と釣合いがとられ、液体層と周囲の媒体の間の界面が弾性膜として機能するよう界面が選択される段階、および
−その結果得られた混合物を測定領域内での測定にかける段階
を含む。
2 毛管入口
3 毛管入口
4 空洞
Claims (10)
- 使い捨て装置内の液体薄層内で混合を実施する方法であって、この装置(1)が、液体試料中の成分を分析させるために、入口(2,3)と、2つの面平行な壁により画定された毛管空洞とを有し、乾燥試薬を含み、前記入口(2,3)が前記毛管空洞を、使い捨て装置(1)外の周囲媒体に接続し、この入口(2,3)が、前記面平行な壁間の距離の少なくとも5倍、好ましくは少なくとも10倍である長さを有し、或いは、使い捨て装置(1)が、前記毛管空洞に隣接して配置した非毛管空洞(4)を含む方法において、
定量する前記成分を含む液体試料を、毛管力作用で使い捨て装置(1)内へ吸い込んで、この使い捨て装置(1)の毛管空洞内に液体薄層を形成する段階と、
使い捨て装置(1)を実質的に前記液体薄層の平面内で運動させ、この運動を、前記面平行な壁が該液体薄層へ及ぼす毛管力と釣り合わせて、該液体薄層と周囲媒体の間の界面を弾性膜として動かし、前記毛管空洞の液体薄層内で前記乾燥試薬の溶解と、該乾燥試薬と前記液体試料の混合とを促進する段階とを含む方法。 - 請求項1に記載の方法において、前記動きが、実質的に往復動である、方法。
- 請求項1または2に記載の方法において、前記面平行な壁間の距離が最大で1000μm、好ましくは400μmから600μmである、方法。
- 請求項1から3のいずれか一項に記載の方法において、前記面平行な壁が透明で、実質的に非弾性である、方法。
- 請求項1から4のいずれか一項に記載の方法において、前記分析が光学測定である、方法。
- 請求項5に記載の方法において、前記光学測定が比濁測定またはネフェロ測定である、方法。
- 請求項1に記載の方法において、前記成分が、タンパク質や炭化水素などの高分子化合物である、方法。
- 請求項1に記載の方法において、前記試薬が抗体またはレクチンである、方法。
- 請求項7または8に記載の方法において、混合時に、前記試薬と高分子化合物が、抗体−抗原複合体またはレクチン−炭水化合物複合体から成る凝集体を形成する、方法。
- 請求項2に記載の方法において、前記高分子化合物が、アルブミン、C反応性タンパク質などの血漿タンパク質から成る、方法。
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9800070A SE9800070D0 (sv) | 1998-01-14 | 1998-01-14 | Blandningsmetod |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2000540426A Division JP4502504B2 (ja) | 1998-01-14 | 1999-01-14 | 混合方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2009053201A true JP2009053201A (ja) | 2009-03-12 |
JP4491032B2 JP4491032B2 (ja) | 2010-06-30 |
Family
ID=20409855
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2000540426A Expired - Fee Related JP4502504B2 (ja) | 1998-01-14 | 1999-01-14 | 混合方法 |
JP2008249582A Expired - Fee Related JP4491032B2 (ja) | 1998-01-14 | 2008-09-29 | 混合方法 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2000540426A Expired - Fee Related JP4502504B2 (ja) | 1998-01-14 | 1999-01-14 | 混合方法 |
Country Status (11)
Country | Link |
---|---|
US (1) | US6468807B1 (ja) |
EP (1) | EP1055112B1 (ja) |
JP (2) | JP4502504B2 (ja) |
CN (1) | CN1130558C (ja) |
AT (1) | ATE386930T1 (ja) |
AU (1) | AU2195699A (ja) |
DE (1) | DE69938170T2 (ja) |
DK (1) | DK1055112T3 (ja) |
ES (1) | ES2299239T3 (ja) |
SE (1) | SE9800070D0 (ja) |
WO (1) | WO1999036765A1 (ja) |
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JP3621617B2 (ja) * | 2000-01-21 | 2005-02-16 | ブラザー工業株式会社 | グルコース濃度測定用のキャピラリー装置、グルコース濃度の非侵襲的モニター方法及び血糖値の非侵襲的モニター方法 |
US7029628B2 (en) | 2000-12-28 | 2006-04-18 | Stat-Chem Inc. | Portable co-oximeter |
CA2523124A1 (en) * | 2003-03-20 | 2004-10-07 | Gary D. Niehaus | Self-contained assay device for rapid detection of biohazardous agents |
WO2005100539A2 (en) | 2004-04-07 | 2005-10-27 | Levine, Robert, A. | Disposable chamber for analyzing biologic fluids |
SE528697C2 (sv) * | 2005-03-11 | 2007-01-30 | Hemocue Ab | Volymetrisk bestämning av antalet vita blodkroppar i ett blodprov |
SE529643C3 (sv) | 2005-07-08 | 2007-11-06 | Hemocue Ab | En kuvett och en metod och ett verktyg för tillverkning därav |
US7731901B2 (en) | 2005-10-19 | 2010-06-08 | Abbott Laboratories | Apparatus and method for performing counts within a biologic fluid sample |
US7763453B2 (en) | 2005-11-30 | 2010-07-27 | Micronics, Inc. | Microfluidic mixing and analytic apparatus |
US9056291B2 (en) | 2005-11-30 | 2015-06-16 | Micronics, Inc. | Microfluidic reactor system |
EP2041573B1 (en) * | 2006-06-23 | 2019-09-04 | PerkinElmer Health Sciences, Inc. | Methods and devices for microfluidic point-of-care immunoassays |
EP2056109B1 (en) | 2006-08-21 | 2011-06-15 | Panasonic Corporation | Measuring device, measuring apparatus measuring method |
CN102027370B (zh) * | 2008-04-02 | 2016-06-08 | 艾博特健康公司 | 用于对包括全血的生物流体执行免疫测定的配体分析中的结合标记和游离标记的虚拟分离 |
US7947492B2 (en) * | 2008-08-20 | 2011-05-24 | Northeastern Ohio Universities College Of Medicine | Device improving the detection of a ligand |
JP5551763B2 (ja) | 2009-04-23 | 2014-07-16 | コーニンクレッカ フィリップス エヌ ヴェ | ゼロデッドボリュームを有するミキサ |
WO2011075667A2 (en) | 2009-12-18 | 2011-06-23 | Abbott Point Of Care, Inc. | Biologic fluid analysis cartridge |
KR101851117B1 (ko) | 2010-01-29 | 2018-04-23 | 마이크로닉스 인코포레이티드. | 샘플-투-앤서 마이크로유체 카트리지 |
US10114020B2 (en) | 2010-10-11 | 2018-10-30 | Mbio Diagnostics, Inc. | System and device for analyzing a fluidic sample |
EP2658653B1 (en) | 2010-12-30 | 2015-03-04 | Abbott Point Of Care, Inc. | Biologic fluid analysis cartridge with sample handling portion and analysis chamber portion |
US9157903B2 (en) * | 2011-02-25 | 2015-10-13 | Honeywell International Inc. | Microfluidic separation of plasma for colormetric assay |
EP2748618A1 (en) | 2011-08-24 | 2014-07-02 | Abbott Point of Care Inc. | Biologic fluid sample analysis cartridge |
JP6190822B2 (ja) | 2012-01-09 | 2017-08-30 | マイクロニクス, インコーポレイテッド | マイクロ流体リアクタシステム |
US9739714B2 (en) | 2012-10-29 | 2017-08-22 | Mbio Diagnostics, Inc. | Particle identification system, cartridge and associated methods |
US10065186B2 (en) | 2012-12-21 | 2018-09-04 | Micronics, Inc. | Fluidic circuits and related manufacturing methods |
WO2014100725A1 (en) | 2012-12-21 | 2014-06-26 | Micronics, Inc. | Portable fluorescence detection system and microassay cartridge |
EP3549674B1 (en) | 2012-12-21 | 2020-08-12 | PerkinElmer Health Sciences, Inc. | Low elasticity films for microfluidic use |
JP6484222B2 (ja) | 2013-05-07 | 2019-03-13 | マイクロニクス, インコーポレイテッド | 核酸の調製および分析のためのデバイス |
EP2994750B1 (en) | 2013-05-07 | 2020-08-12 | PerkinElmer Health Sciences, Inc. | Microfluidic devices and methods for performing serum separation and blood cross-matching |
JP6472788B2 (ja) | 2013-05-07 | 2019-02-20 | マイクロニクス, インコーポレイテッド | 粘土鉱物およびアルカリ性溶液を使用して核酸含有試料を調製するための方法 |
GB2555403B (en) * | 2016-10-24 | 2021-03-24 | Entia Ltd | A Cuvette |
GB2607337A (en) | 2021-06-04 | 2022-12-07 | Entia Ltd | A cuvette |
GB2616667A (en) | 2022-03-18 | 2023-09-20 | Entia Ltd | A composition for coating a cuvette and a method of making a composition for coating a cuvette |
GB2616840A (en) | 2022-03-18 | 2023-09-27 | Entia Ltd | A cuvette for analysing biological samples |
GB2616668A (en) | 2022-03-18 | 2023-09-20 | Entia Ltd | A method of obtaining an image of a biological sample in a cuvette |
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JPH0217426A (ja) * | 1988-07-05 | 1990-01-22 | Kiyouseki Seihin Gijutsu Kenkyusho:Kk | 液体試料用の分析セル |
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JPH0694723A (ja) * | 1985-08-05 | 1994-04-08 | Biotrack Inc | 流体流れ制御装置 |
JPH07167777A (ja) * | 1985-09-30 | 1995-07-04 | Mol Devices Corp | 多ビームによる光度測定装置 |
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DE107783C (ja) | ||||
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-
1998
- 1998-01-14 SE SE9800070A patent/SE9800070D0/xx unknown
-
1999
- 1999-01-14 CN CN99802180A patent/CN1130558C/zh not_active Expired - Fee Related
- 1999-01-14 WO PCT/SE1999/000046 patent/WO1999036765A1/en active IP Right Grant
- 1999-01-14 DK DK99902025T patent/DK1055112T3/da active
- 1999-01-14 JP JP2000540426A patent/JP4502504B2/ja not_active Expired - Fee Related
- 1999-01-14 AT AT99902025T patent/ATE386930T1/de active
- 1999-01-14 EP EP99902025A patent/EP1055112B1/en not_active Expired - Lifetime
- 1999-01-14 ES ES99902025T patent/ES2299239T3/es not_active Expired - Lifetime
- 1999-01-14 DE DE69938170T patent/DE69938170T2/de not_active Expired - Lifetime
- 1999-01-14 AU AU21956/99A patent/AU2195699A/en not_active Abandoned
-
2000
- 2000-07-07 US US09/612,273 patent/US6468807B1/en not_active Expired - Lifetime
-
2008
- 2008-09-29 JP JP2008249582A patent/JP4491032B2/ja not_active Expired - Fee Related
Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3898982A (en) * | 1972-11-13 | 1975-08-12 | Jintan Terumo Co | Capillary tube for blood examination |
JPS51114767A (en) * | 1975-03-31 | 1976-10-08 | Fujirebio Inc | Vibrator |
JPS62500196A (ja) * | 1984-09-11 | 1987-01-22 | バイオラビメツクス ア−ベ− | 毛細管中の血液と他の流体との運動および混合を向上させるポリプロピレングリコ−ルの使用方法 |
JPH0694723A (ja) * | 1985-08-05 | 1994-04-08 | Biotrack Inc | 流体流れ制御装置 |
JPH07167777A (ja) * | 1985-09-30 | 1995-07-04 | Mol Devices Corp | 多ビームによる光度測定装置 |
JPH0217426A (ja) * | 1988-07-05 | 1990-01-22 | Kiyouseki Seihin Gijutsu Kenkyusho:Kk | 液体試料用の分析セル |
JPH05240872A (ja) * | 1991-11-29 | 1993-09-21 | Canon Inc | サンプル測定デバイス及びサンプル測定システム |
WO1996033399A1 (en) * | 1995-04-21 | 1996-10-24 | Hemocue Ab | Capillary microcuvette |
Also Published As
Publication number | Publication date |
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ES2299239T3 (es) | 2008-05-16 |
DE69938170D1 (de) | 2008-04-03 |
SE9800070D0 (sv) | 1998-01-14 |
JP2002509247A (ja) | 2002-03-26 |
DK1055112T3 (da) | 2008-04-14 |
CN1130558C (zh) | 2003-12-10 |
CN1288517A (zh) | 2001-03-21 |
JP4502504B2 (ja) | 2010-07-14 |
US6468807B1 (en) | 2002-10-22 |
EP1055112B1 (en) | 2008-02-20 |
JP4491032B2 (ja) | 2010-06-30 |
AU2195699A (en) | 1999-08-02 |
EP1055112A1 (en) | 2000-11-29 |
DE69938170T2 (de) | 2009-02-26 |
WO1999036765A1 (en) | 1999-07-22 |
ATE386930T1 (de) | 2008-03-15 |
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