DE69925267D1 - Verbesserung der enzymatischen synthese von chiralen aminen - Google Patents

Verbesserung der enzymatischen synthese von chiralen aminen

Info

Publication number
DE69925267D1
DE69925267D1 DE69925267T DE69925267T DE69925267D1 DE 69925267 D1 DE69925267 D1 DE 69925267D1 DE 69925267 T DE69925267 T DE 69925267T DE 69925267 T DE69925267 T DE 69925267T DE 69925267 D1 DE69925267 D1 DE 69925267D1
Authority
DE
Germany
Prior art keywords
aminopropane
improvement
enzymatic synthesis
transaminase
chiral amines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69925267T
Other languages
English (en)
Other versions
DE69925267T2 (de
Inventor
Wei Wu
B Bhatia
M Lewis
Wei Lang
Alice Wang
W Matcham
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Celgro
Original Assignee
Celgro
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celgro filed Critical Celgro
Application granted granted Critical
Publication of DE69925267D1 publication Critical patent/DE69925267D1/de
Publication of DE69925267T2 publication Critical patent/DE69925267T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/001—Amines; Imines
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/005—Amino acids other than alpha- or beta amino acids, e.g. gamma amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/06—Alanine; Leucine; Isoleucine; Serine; Homoserine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/12—Methionine; Cysteine; Cystine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/006—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE69925267T 1998-03-11 1999-03-10 Verbesserung der enzymatischen synthese von chiralen aminen Expired - Fee Related DE69925267T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US7752098P 1998-03-11 1998-03-11
US77520P 1998-03-11
PCT/US1999/005150 WO1999046398A1 (en) 1998-03-11 1999-03-10 Improvements in the enzymatic synthesis of chiral amines

Publications (2)

Publication Number Publication Date
DE69925267D1 true DE69925267D1 (de) 2005-06-16
DE69925267T2 DE69925267T2 (de) 2006-01-26

Family

ID=22138554

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69925267T Expired - Fee Related DE69925267T2 (de) 1998-03-11 1999-03-10 Verbesserung der enzymatischen synthese von chiralen aminen

Country Status (24)

Country Link
EP (1) EP1075534B8 (de)
JP (1) JP2002505884A (de)
KR (1) KR20010034561A (de)
CN (1) CN1154746C (de)
AT (1) ATE295424T1 (de)
AU (1) AU753904B2 (de)
BR (1) BR9908797A (de)
CA (1) CA2322605A1 (de)
CZ (1) CZ295882B6 (de)
DE (1) DE69925267T2 (de)
ES (1) ES2243051T3 (de)
FI (1) FI20001805A (de)
HK (1) HK1035000A1 (de)
HU (1) HUP0101056A3 (de)
MX (1) MXPA00008573A (de)
NO (1) NO319671B1 (de)
NZ (1) NZ506405A (de)
PL (1) PL342882A1 (de)
PT (1) PT1075534E (de)
RU (1) RU2213142C2 (de)
SK (1) SK284352B6 (de)
TR (1) TR200002604T2 (de)
UA (1) UA64784C2 (de)
WO (1) WO1999046398A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE277170T1 (de) 1999-03-19 2004-10-15 Sumitomo Chemical Co Stereoselektive transaminase, deren kodierende gen und deren verwendungen
JP2001190298A (ja) * 2000-01-13 2001-07-17 Kanegafuchi Chem Ind Co Ltd 光学活性ｎ−メチルアミノ酸の製造方法
EP1818411A1 (de) * 2006-02-13 2007-08-15 Lonza AG Verfahren zur Herstellung von optisch aktiven chiralen Aminen
DE102007042600A1 (de) 2007-09-07 2009-03-12 Evonik Degussa Gmbh Verfahren zur Herstellung von enantiomerenangereichten Aminen
HUE036104T2 (hu) 2009-01-08 2018-06-28 Codexis Inc Transzamináz polipeptidek
WO2010099501A2 (en) 2009-02-26 2010-09-02 Codexis, Inc. Transaminase biocatalysts
EP2446026B1 (de) 2009-06-22 2017-08-09 Codexis, Inc. Transaminasereaktionen
SG178842A1 (en) * 2009-09-02 2012-04-27 Lonza Ag A process for the identification and preparation of a (r)-specific omega-transaminase
EP2582799B1 (de) 2010-06-17 2017-12-20 Codexis, Inc. Biokatalysatoren und verfahren zur synthese von (s)-3-(1-aminoethyl)-phenol
US8932836B2 (en) 2010-08-16 2015-01-13 Codexis, Inc. Biocatalysts and methods for the synthesis of (1R,2R)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine
WO2013024453A1 (en) * 2011-08-16 2013-02-21 Embio Limited Enzymatic synthesis of optically active chiral amines
CN104630170A (zh) * 2013-11-08 2015-05-20 中国科学院天津工业生物技术研究所 一种来源于里氏木霉的新(r)-转氨酶及其应用
CN114134126B (zh) * 2021-10-28 2023-12-05 浙江大学杭州国际科创中心 转氨酶及其突变体在制备(s)-1-甲氧基-2-丙胺中的应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5300437A (en) * 1989-06-22 1994-04-05 Celgene Corporation Enantiomeric enrichment and stereoselective synthesis of chiral amines
WO1997015682A1 (fr) * 1995-10-23 1997-05-01 Kaneka Corporation Procede de production de composes amines actifs sur le plan optique

Also Published As

Publication number Publication date
HUP0101056A2 (hu) 2001-07-30
ATE295424T1 (de) 2005-05-15
HK1035000A1 (en) 2001-11-09
CA2322605A1 (en) 1999-09-16
FI20001805A (fi) 2000-08-15
NZ506405A (en) 2003-08-29
SK13382000A3 (sk) 2001-05-10
EP1075534A4 (de) 2003-07-09
DE69925267T2 (de) 2006-01-26
PT1075534E (pt) 2005-09-30
EP1075534B8 (de) 2005-07-06
PL342882A1 (en) 2001-07-16
NO20004036L (no) 2000-10-27
CZ295882B6 (cs) 2005-11-16
NO20004036D0 (no) 2000-08-11
CN1292828A (zh) 2001-04-25
CZ20003177A3 (cs) 2000-12-13
SK284352B6 (sk) 2005-02-04
WO1999046398A1 (en) 1999-09-16
JP2002505884A (ja) 2002-02-26
AU753904B2 (en) 2002-10-31
UA64784C2 (en) 2004-03-15
BR9908797A (pt) 2000-12-12
NO319671B1 (no) 2005-09-05
TR200002604T2 (tr) 2000-11-21
HUP0101056A3 (en) 2006-03-28
AU2993899A (en) 1999-09-27
ES2243051T3 (es) 2005-11-16
EP1075534B1 (de) 2005-05-11
EP1075534A1 (de) 2001-02-14
MXPA00008573A (es) 2003-07-14
CN1154746C (zh) 2004-06-23
RU2213142C2 (ru) 2003-09-27
KR20010034561A (ko) 2001-04-25

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Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: CELGRO, SUMMIT, N.J., US

8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee