DE69924026T2 - Coenzym zur herstellung von l-carnitin - Google Patents

Coenzym zur herstellung von l-carnitin Download PDF

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Publication number
DE69924026T2
DE69924026T2 DE69924026T DE69924026T DE69924026T2 DE 69924026 T2 DE69924026 T2 DE 69924026T2 DE 69924026 T DE69924026 T DE 69924026T DE 69924026 T DE69924026 T DE 69924026T DE 69924026 T2 DE69924026 T2 DE 69924026T2
Authority
DE
Germany
Prior art keywords
carnitine
coenzyme
crotonobetainyl
crotonobetaine
synthesis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69924026T
Other languages
German (de)
English (en)
Other versions
DE69924026D1 (de
Inventor
Thomas Elssner
Hans-Peter Kleber
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sigma Tau Industrie Farmaceutiche Riunite SpA
Original Assignee
Sigma Tau Industrie Farmaceutiche Riunite SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE1998150426 external-priority patent/DE19850426A1/de
Priority claimed from DE1998150433 external-priority patent/DE19850433A1/de
Application filed by Sigma Tau Industrie Farmaceutiche Riunite SpA filed Critical Sigma Tau Industrie Farmaceutiche Riunite SpA
Priority to DE69924026T priority Critical patent/DE69924026T2/de
Application granted granted Critical
Publication of DE69924026D1 publication Critical patent/DE69924026D1/de
Publication of DE69924026T2 publication Critical patent/DE69924026T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/007—Carnitine; Butyrobetaine; Crotonobetaine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/001—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by metabolizing one of the enantiomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DE69924026T 1998-10-27 1999-10-22 Coenzym zur herstellung von l-carnitin Expired - Fee Related DE69924026T2 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE69924026T DE69924026T2 (de) 1998-10-27 1999-10-22 Coenzym zur herstellung von l-carnitin

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
DE1998150426 DE19850426A1 (de) 1998-10-27 1998-10-27 gamma-Butyrobetainyl-Coenzym A und Verfahren zu seiner Herstellung
DE19850426 1998-10-27
DE19850433 1998-10-27
DE1998150433 DE19850433A1 (de) 1998-10-27 1998-10-27 Crotonobetainyl-Coenzym A, Verfahren zu seiner Herstellung
PCT/IT1999/000339 WO2000024919A1 (en) 1998-10-27 1999-10-22 Coenzymes useful for the synthesis of l-carnitine
DE69924026T DE69924026T2 (de) 1998-10-27 1999-10-22 Coenzym zur herstellung von l-carnitin

Publications (2)

Publication Number Publication Date
DE69924026D1 DE69924026D1 (de) 2005-04-07
DE69924026T2 true DE69924026T2 (de) 2006-02-09

Family

ID=26049898

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69924026T Expired - Fee Related DE69924026T2 (de) 1998-10-27 1999-10-22 Coenzym zur herstellung von l-carnitin

Country Status (11)

Country Link
US (2) US6379936B1 (https=)
EP (2) EP1452604A3 (https=)
JP (1) JP2002528468A (https=)
AT (1) ATE290096T1 (https=)
AU (1) AU1075400A (https=)
DE (1) DE69924026T2 (https=)
DK (1) DK1151130T3 (https=)
ES (1) ES2237954T3 (https=)
PT (1) PT1151130E (https=)
SI (1) SI1151130T1 (https=)
WO (1) WO2000024919A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1274858A1 (de) * 2000-04-17 2003-01-15 Befa Handelsgesellschaft mbH Verfahren zur bestimmung der konzentration von carnitin in flüssigen substanzen
US7407778B2 (en) * 2002-02-07 2008-08-05 Pettegrew Jay W Compounds, compositions and methods for treating neuropsychiatric disorders
US7700074B2 (en) * 2002-02-07 2010-04-20 Pettegrew Jay W Method and system for diagnosis of neuropsychiatric disorders including chronic alcoholism
US7815894B2 (en) * 2003-05-29 2010-10-19 Jay W. Pettegrew Compounds, compositions and methods for medical imaging of neuropsychiatric disorders
US20060257842A1 (en) * 2003-05-29 2006-11-16 Pettegrew Jay W Cryopreservation media and molecules
US20050232911A1 (en) * 2004-04-19 2005-10-20 Schreiber Brian D Prevention and treatment of metabolic abnormalities associated with excess intramyocellular lipid
KR100713104B1 (ko) * 2005-07-07 2007-05-02 씨제이 주식회사 뉴로스포라 크라사 유래의ｓ-아데노실메티오닌-6-ｎ-라이신-메틸트란스퍼라제, 그를코딩하는 폴리뉴클레오티드, 상기 폴리뉴클레오티드를포함하는 벡터 및 숙주세포 및 상기 숙주세포를 이용하여트리메틸라이신을 생산하는 방법

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1142201B (it) 1980-06-24 1986-10-08 Sigma Tau Ind Farmaceuti Procedimento per la produzione enzimatica di l-carnitina
DD221905B1 (de) 1983-11-03 1987-03-18 Univ Leipzig Verfahren zur herstellung von l(-)-carnitin und seinen derivaten
EP0320460B1 (en) 1987-10-26 1994-04-27 Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. Process for isolating the enzyme carnitinehydrolyase from strains belonging to the family enterobacteriaceae and use of the immobilized enzyme for producing L(-)-carnitine
IT1240833B (it) 1990-05-14 1993-12-17 Sigma Tau Ind Farmaceuti Procedimento biocatalitico per la produzione di l-(-)- carnitina da crotonilbetaina e ceppi di proteeae per l'uso in tale procedimento
WO1995010613A1 (de) * 1993-10-08 1995-04-20 Lonza Ag Gene für den butyrobetain/crotonobetain-l-carnitin-stoffwechsel und ihre verwendung zur mikrobiologischen herstellung von l-carnitin
FR2715167B1 (fr) * 1994-01-20 1996-04-12 Inst Nat Sciences Appliq Lyon Procédé de production de la L-carnitine par voie microbiologique.
DE4402127A1 (de) * 1994-01-21 1995-07-27 Univ Leipzig Carnitinracemase und Verfahren zu ihrer Herstellung

Also Published As

Publication number Publication date
EP1452604A2 (en) 2004-09-01
US20020146787A1 (en) 2002-10-10
EP1452604A3 (en) 2005-03-30
WO2000024919A1 (en) 2000-05-04
ATE290096T1 (de) 2005-03-15
EP1151130B1 (en) 2005-03-02
US6562608B2 (en) 2003-05-13
JP2002528468A (ja) 2002-09-03
ES2237954T3 (es) 2005-08-01
DK1151130T3 (da) 2005-06-20
DE69924026D1 (de) 2005-04-07
PT1151130E (pt) 2005-06-30
SI1151130T1 (en) 2005-06-30
AU1075400A (en) 2000-05-15
US6379936B1 (en) 2002-04-30
EP1151130A1 (en) 2001-11-07

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee