SI1151130T1 - Coenzyme useful for the synthesis of l-carnitine - Google Patents
Coenzyme useful for the synthesis of l-carnitineInfo
- Publication number
- SI1151130T1 SI1151130T1 SI9930765T SI9930765T SI1151130T1 SI 1151130 T1 SI1151130 T1 SI 1151130T1 SI 9930765 T SI9930765 T SI 9930765T SI 9930765 T SI9930765 T SI 9930765T SI 1151130 T1 SI1151130 T1 SI 1151130T1
- Authority
- SI
- Slovenia
- Prior art keywords
- carnitine
- synthesis
- coenzyme
- useful
- coenzyme useful
- Prior art date
Links
- PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical compound C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 title abstract 3
- 230000015572 biosynthetic process Effects 0.000 title abstract 2
- 239000005515 coenzyme Substances 0.000 title abstract 2
- 229960001518 levocarnitine Drugs 0.000 title abstract 2
- 238000003786 synthesis reaction Methods 0.000 title abstract 2
- 239000005516 coenzyme A Substances 0.000 abstract 2
- 229940093530 coenzyme a Drugs 0.000 abstract 2
- GUYHPGUANSLONG-SNAWJCMRSA-N (E)-4-(trimethylammonio)but-2-enoate Chemical compound C[N+](C)(C)C\C=C\C([O-])=O GUYHPGUANSLONG-SNAWJCMRSA-N 0.000 abstract 1
- RGJOEKWQDUBAIZ-IBOSZNHHSA-N CoASH Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCS)O[C@H]1N1C2=NC=NC(N)=C2N=C1 RGJOEKWQDUBAIZ-IBOSZNHHSA-N 0.000 abstract 1
- PHIQHXFUZVPYII-UHFFFAOYSA-N carnitine Chemical compound C[N+](C)(C)CC(O)CC([O-])=O PHIQHXFUZVPYII-UHFFFAOYSA-N 0.000 abstract 1
- RGJOEKWQDUBAIZ-UHFFFAOYSA-N coenzime A Natural products OC1C(OP(O)(O)=O)C(COP(O)(=O)OP(O)(=O)OCC(C)(C)C(O)C(=O)NCCC(=O)NCCS)OC1N1C2=NC=NC(N)=C2N=C1 RGJOEKWQDUBAIZ-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- KDTSHFARGAKYJN-UHFFFAOYSA-N dephosphocoenzyme A Natural products OC1C(O)C(COP(O)(=O)OP(O)(=O)OCC(C)(C)C(O)C(=O)NCCC(=O)NCCS)OC1N1C2=NC=NC(N)=C2N=C1 KDTSHFARGAKYJN-UHFFFAOYSA-N 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/007—Carnitine; Butyrobetaine; Crotonobetaine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/001—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by metabolizing one of the enantiomers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Compounds Of Unknown Constitution (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE1998150426 DE19850426A1 (de) | 1998-10-27 | 1998-10-27 | gamma-Butyrobetainyl-Coenzym A und Verfahren zu seiner Herstellung |
| DE1998150433 DE19850433A1 (de) | 1998-10-27 | 1998-10-27 | Crotonobetainyl-Coenzym A, Verfahren zu seiner Herstellung |
| EP99954351A EP1151130B1 (en) | 1998-10-27 | 1999-10-22 | Coenzyme useful for the synthesis of l-carnitine |
| PCT/IT1999/000339 WO2000024919A1 (en) | 1998-10-27 | 1999-10-22 | Coenzymes useful for the synthesis of l-carnitine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI1151130T1 true SI1151130T1 (en) | 2005-06-30 |
Family
ID=26049898
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI9930765T SI1151130T1 (en) | 1998-10-27 | 1999-10-22 | Coenzyme useful for the synthesis of l-carnitine |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US6379936B1 (https=) |
| EP (2) | EP1452604A3 (https=) |
| JP (1) | JP2002528468A (https=) |
| AT (1) | ATE290096T1 (https=) |
| AU (1) | AU1075400A (https=) |
| DE (1) | DE69924026T2 (https=) |
| DK (1) | DK1151130T3 (https=) |
| ES (1) | ES2237954T3 (https=) |
| PT (1) | PT1151130E (https=) |
| SI (1) | SI1151130T1 (https=) |
| WO (1) | WO2000024919A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1274858A1 (de) * | 2000-04-17 | 2003-01-15 | Befa Handelsgesellschaft mbH | Verfahren zur bestimmung der konzentration von carnitin in flüssigen substanzen |
| US7407778B2 (en) * | 2002-02-07 | 2008-08-05 | Pettegrew Jay W | Compounds, compositions and methods for treating neuropsychiatric disorders |
| US7700074B2 (en) * | 2002-02-07 | 2010-04-20 | Pettegrew Jay W | Method and system for diagnosis of neuropsychiatric disorders including chronic alcoholism |
| US7815894B2 (en) * | 2003-05-29 | 2010-10-19 | Jay W. Pettegrew | Compounds, compositions and methods for medical imaging of neuropsychiatric disorders |
| US20060257842A1 (en) * | 2003-05-29 | 2006-11-16 | Pettegrew Jay W | Cryopreservation media and molecules |
| US20050232911A1 (en) * | 2004-04-19 | 2005-10-20 | Schreiber Brian D | Prevention and treatment of metabolic abnormalities associated with excess intramyocellular lipid |
| KR100713104B1 (ko) * | 2005-07-07 | 2007-05-02 | 씨제이 주식회사 | 뉴로스포라 크라사 유래의ｓ-아데노실메티오닌-6-ｎ-라이신-메틸트란스퍼라제, 그를코딩하는 폴리뉴클레오티드, 상기 폴리뉴클레오티드를포함하는 벡터 및 숙주세포 및 상기 숙주세포를 이용하여트리메틸라이신을 생산하는 방법 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1142201B (it) | 1980-06-24 | 1986-10-08 | Sigma Tau Ind Farmaceuti | Procedimento per la produzione enzimatica di l-carnitina |
| DD221905B1 (de) | 1983-11-03 | 1987-03-18 | Univ Leipzig | Verfahren zur herstellung von l(-)-carnitin und seinen derivaten |
| EP0320460B1 (en) | 1987-10-26 | 1994-04-27 | Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. | Process for isolating the enzyme carnitinehydrolyase from strains belonging to the family enterobacteriaceae and use of the immobilized enzyme for producing L(-)-carnitine |
| IT1240833B (it) | 1990-05-14 | 1993-12-17 | Sigma Tau Ind Farmaceuti | Procedimento biocatalitico per la produzione di l-(-)- carnitina da crotonilbetaina e ceppi di proteeae per l'uso in tale procedimento |
| WO1995010613A1 (de) * | 1993-10-08 | 1995-04-20 | Lonza Ag | Gene für den butyrobetain/crotonobetain-l-carnitin-stoffwechsel und ihre verwendung zur mikrobiologischen herstellung von l-carnitin |
| FR2715167B1 (fr) * | 1994-01-20 | 1996-04-12 | Inst Nat Sciences Appliq Lyon | Procédé de production de la L-carnitine par voie microbiologique. |
| DE4402127A1 (de) * | 1994-01-21 | 1995-07-27 | Univ Leipzig | Carnitinracemase und Verfahren zu ihrer Herstellung |
-
1999
- 1999-10-22 JP JP2000578471A patent/JP2002528468A/ja active Pending
- 1999-10-22 PT PT99954351T patent/PT1151130E/pt unknown
- 1999-10-22 DE DE69924026T patent/DE69924026T2/de not_active Expired - Fee Related
- 1999-10-22 AU AU10754/00A patent/AU1075400A/en not_active Abandoned
- 1999-10-22 EP EP04007026A patent/EP1452604A3/en not_active Withdrawn
- 1999-10-22 SI SI9930765T patent/SI1151130T1/xx unknown
- 1999-10-22 DK DK99954351T patent/DK1151130T3/da active
- 1999-10-22 AT AT99954351T patent/ATE290096T1/de not_active IP Right Cessation
- 1999-10-22 EP EP99954351A patent/EP1151130B1/en not_active Expired - Lifetime
- 1999-10-22 WO PCT/IT1999/000339 patent/WO2000024919A1/en not_active Ceased
- 1999-10-22 ES ES99954351T patent/ES2237954T3/es not_active Expired - Lifetime
-
2001
- 2001-11-26 US US09/992,005 patent/US6379936B1/en not_active Expired - Fee Related
-
2002
- 2002-03-26 US US10/105,318 patent/US6562608B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP1452604A2 (en) | 2004-09-01 |
| US20020146787A1 (en) | 2002-10-10 |
| EP1452604A3 (en) | 2005-03-30 |
| WO2000024919A1 (en) | 2000-05-04 |
| ATE290096T1 (de) | 2005-03-15 |
| DE69924026T2 (de) | 2006-02-09 |
| EP1151130B1 (en) | 2005-03-02 |
| US6562608B2 (en) | 2003-05-13 |
| JP2002528468A (ja) | 2002-09-03 |
| ES2237954T3 (es) | 2005-08-01 |
| DK1151130T3 (da) | 2005-06-20 |
| DE69924026D1 (de) | 2005-04-07 |
| PT1151130E (pt) | 2005-06-30 |
| AU1075400A (en) | 2000-05-15 |
| US6379936B1 (en) | 2002-04-30 |
| EP1151130A1 (en) | 2001-11-07 |
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