DE69839227T2 - Verfahren zur in vitro-Diagnose von Infektionen durch Schweinecircovirus vom Typ II und diagnostische Reagenzien - Google Patents

Verfahren zur in vitro-Diagnose von Infektionen durch Schweinecircovirus vom Typ II und diagnostische Reagenzien Download PDF

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Publication number
DE69839227T2
DE69839227T2 DE69839227T DE69839227T DE69839227T2 DE 69839227 T2 DE69839227 T2 DE 69839227T2 DE 69839227 T DE69839227 T DE 69839227T DE 69839227 T DE69839227 T DE 69839227T DE 69839227 T2 DE69839227 T2 DE 69839227T2
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Germany
Prior art keywords
type
porcine circovirus
pcv
antigen
antibodies
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Expired - Lifetime
Application number
DE69839227T
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German (de)
English (en)
Other versions
DE69839227D1 (de
Inventor
Gordon Allan
Brian Meehan
Edward Clark
John Saskatoon Ellis
Deborah Saskatoon Haines
Lori Saskatoon Hassard
John Harding
Catherine Elisabeth Atlanta Charreyre
Gilles Emile Chappuis
Francis Mc Neilly
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Saskatchewan
Boehringer Ingelheim Animal Health France SAS
Queens University of Belfast
Original Assignee
University of Saskatchewan
Merial SAS
Queens University of Belfast
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Priority claimed from FR9712382A external-priority patent/FR2769321B1/fr
Priority claimed from FR9800873A external-priority patent/FR2769322B1/fr
Priority claimed from FR9803707A external-priority patent/FR2776294B1/fr
Application filed by University of Saskatchewan, Merial SAS, Queens University of Belfast filed Critical University of Saskatchewan
Publication of DE69839227D1 publication Critical patent/DE69839227D1/de
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Publication of DE69839227T2 publication Critical patent/DE69839227T2/de
Anticipated expiration legal-status Critical
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23CDAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
    • A23C19/00Cheese; Cheese preparations; Making thereof
    • A23C19/02Making cheese curd
    • A23C19/032Making cheese curd characterised by the use of specific microorganisms, or enzymes of microbial origin
    • A23C19/0321Propionic acid bacteria
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23CDAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
    • A23C19/00Cheese; Cheese preparations; Making thereof
    • A23C19/02Making cheese curd
    • A23C19/032Making cheese curd characterised by the use of specific microorganisms, or enzymes of microbial origin
    • A23C19/0323Making cheese curd characterised by the use of specific microorganisms, or enzymes of microbial origin using only lactic acid bacteria, e.g. Pediococcus and Leuconostoc species; Bifidobacteria; Microbial starters in general
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N7/00Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525Virus
    • A61K2039/5252Virus inactivated (killed)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/55Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A61K2039/552Veterinary vaccine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55566Emulsions, e.g. Freund's adjuvant, MF59
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C12N2710/00011Details
    • C12N2710/10011Adenoviridae
    • C12N2710/10311Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10341Use of virus, viral particle or viral elements as a vector
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    • C12N2710/00011Details
    • C12N2710/16011Herpesviridae
    • C12N2710/16711Varicellovirus, e.g. human herpesvirus 3, Varicella Zoster, pseudorabies
    • C12N2710/16741Use of virus, viral particle or viral elements as a vector
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    • C12N2710/00011Details
    • C12N2710/24011Poxviridae
    • C12N2710/24041Use of virus, viral particle or viral elements as a vector
    • C12N2710/24043Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2750/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011Details
    • C12N2750/10011Circoviridae
    • C12N2750/10021Viruses as such, e.g. new isolates, mutants or their genomic sequences
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    • C12N2750/00011Details
    • C12N2750/10011Circoviridae
    • C12N2750/10022New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • CCHEMISTRY; METALLURGY
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    • C12N2750/00011Details
    • C12N2750/10011Circoviridae
    • C12N2750/10034Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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    • C12N2750/10011Circoviridae
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    • C12N2750/00011Details
    • C12N2750/10011Circoviridae
    • C12N2750/10061Methods of inactivation or attenuation
    • C12N2750/10064Methods of inactivation or attenuation by serial passage

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DE69839227T 1997-10-03 1998-10-01 Verfahren zur in vitro-Diagnose von Infektionen durch Schweinecircovirus vom Typ II und diagnostische Reagenzien Expired - Lifetime DE69839227T2 (de)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
FR9712382A FR2769321B1 (fr) 1997-10-03 1997-10-03 Nouveaux circovirus porcins, vaccins et reactifs de diagnostics
FR9712382 1997-10-03
FR9800873A FR2769322B1 (fr) 1997-10-03 1998-01-22 Nouveaux circovirus porcins, vaccins et reactifs de diagnostic
FR9800873 1998-01-22
FR9803707A FR2776294B1 (fr) 1998-03-20 1998-03-20 Nouveaux circovirus porcins ; vaccins et reactifs de diagnostic
FR9803707 1998-03-20

Publications (2)

Publication Number Publication Date
DE69839227D1 DE69839227D1 (de) 2008-04-17
DE69839227T2 true DE69839227T2 (de) 2009-03-12

Family

ID=27253376

Family Applications (7)

Application Number Title Priority Date Filing Date
DE05014998T Pending DE05014998T1 (de) 1997-10-03 1998-10-01 Schweinecircoviren, Nukleinsäuren, Polypeptide und Impfstoffe
DE69839227T Expired - Lifetime DE69839227T2 (de) 1997-10-03 1998-10-01 Verfahren zur in vitro-Diagnose von Infektionen durch Schweinecircovirus vom Typ II und diagnostische Reagenzien
DE69830858A Expired - Lifetime DE69830858D1 (de) 1997-10-03 1998-10-01 Schweinecircoviren
DE69830858T Expired - Lifetime DE69830858T4 (de) 1997-10-03 1998-10-01 Schweinecircoviren
DE200512000009 Pending DE122005000009I1 (de) 1997-10-03 1998-10-01 Schweinecircoviren abgeleitete Impfstoffe.
DE69816460T Expired - Lifetime DE69816460T2 (de) 1997-10-03 1998-10-01 Schweinecircoviren abgeleitete impfstoffe
DE122008000069C Pending DE122008000069I1 (de) 1997-10-03 1998-10-01 Schweinecircoviren abgeleitete impfstoffe

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE05014998T Pending DE05014998T1 (de) 1997-10-03 1998-10-01 Schweinecircoviren, Nukleinsäuren, Polypeptide und Impfstoffe

Family Applications After (5)

Application Number Title Priority Date Filing Date
DE69830858A Expired - Lifetime DE69830858D1 (de) 1997-10-03 1998-10-01 Schweinecircoviren
DE69830858T Expired - Lifetime DE69830858T4 (de) 1997-10-03 1998-10-01 Schweinecircoviren
DE200512000009 Pending DE122005000009I1 (de) 1997-10-03 1998-10-01 Schweinecircoviren abgeleitete Impfstoffe.
DE69816460T Expired - Lifetime DE69816460T2 (de) 1997-10-03 1998-10-01 Schweinecircoviren abgeleitete impfstoffe
DE122008000069C Pending DE122008000069I1 (de) 1997-10-03 1998-10-01 Schweinecircoviren abgeleitete impfstoffe

Country Status (21)

Country Link
US (1) US6368601B1 (hu)
EP (4) EP1019510B1 (hu)
JP (5) JP5008218B2 (hu)
KR (4) KR100854615B1 (hu)
CN (2) CN100584948C (hu)
AT (3) ATE245191T1 (hu)
AU (1) AU756554C (hu)
BR (1) BR9812845B1 (hu)
CA (1) CA2305623C (hu)
CY (3) CY1110359T1 (hu)
DE (7) DE05014998T1 (hu)
DK (4) DK1386617T3 (hu)
ES (4) ES2302885T3 (hu)
FR (1) FR05C0021I2 (hu)
HK (1) HK1095161A1 (hu)
HU (2) HU230340B1 (hu)
NL (1) NL300326I2 (hu)
PL (1) PL198506B1 (hu)
PT (4) PT1741785E (hu)
UA (1) UA78180C2 (hu)
WO (1) WO1999018214A1 (hu)

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US7211379B2 (en) * 1997-10-03 2007-05-01 Merial Sas Prevention of myocarditis, abortion and intrauterine infection associated with porcine circovirus-2
US20060029617A1 (en) * 1997-10-03 2006-02-09 Charreyre Catherine E Porcine circovirus and Helicobacter combination vaccines and methods of use
US6517843B1 (en) 1999-08-31 2003-02-11 Merial Reduction of porcine circovirus-2 viral load with inactivated PCV-2
FR2781159B1 (fr) * 1998-07-06 2000-10-06 Merial Sas Vaccin circovirus et parvovirus porcin
US20040062775A1 (en) * 1997-12-05 2004-04-01 Agence Francaise De Securite Sanitaire Des Aliments Circovirus sequences associated with piglet weight loss disease (PWD)
FR2772047B1 (fr) * 1997-12-05 2004-04-09 Ct Nat D Etudes Veterinaires E Sequence genomique et polypeptides de circovirus associe a la maladie de l'amaigrissement du porcelet (map), applications au diagnostic et a la prevention et/ou au traitement de l'infection
CA2313806A1 (en) * 1997-12-11 1999-06-17 University Of Saskatchewan Postweaning multisystemic wasting syndrome virus from pigs
EP1816200B1 (en) 1997-12-11 2016-03-09 Merial Postweaning multisystemic wasting syndrome virus for pigs
US6497883B1 (en) * 1999-06-10 2002-12-24 Merial Porcine circovirus recombinant poxvirus vaccine
US6943152B1 (en) * 1999-06-10 2005-09-13 Merial DNA vaccine-PCV
ES2170622B1 (es) * 1999-12-03 2004-05-16 Consejo Superior De Investigaciones Cientificas Clones y vectores infectivos derivados de coronavirus y sus aplicaciones.
AU2001266940A1 (en) * 2000-06-15 2001-12-24 Purdue Research Foundation Vaccine for congenital tremors in pigs
US7018638B2 (en) * 2000-12-19 2006-03-28 Wyeth Mycoplasma hyopneumoniae bacterin vaccine
UA82647C2 (uk) 2001-03-27 2008-05-12 Юниверсити Оф Саскачеван Спосіб культивування цирковірусу ссавця
NZ531025A (en) 2001-07-20 2005-08-26 Univ Georgia Res Found Vaccine comprising a mutant rabies virus N protein which has an amino acid other than serine at position 389 and possibly one or more other mutations within the N protein
US7279166B2 (en) 2001-12-12 2007-10-09 Virginia Tech Intellectual Properties, Inc. Chimeric infectious DNA clones, chimeric porcine circoviruses and uses thereof
US7276353B2 (en) 2001-12-12 2007-10-02 Virginia Tech Intellectual Properties, Inc. Chimeric infectious DNA clones, chimeric porcine circoviruses and uses thereof
MXPA05002255A (es) * 2002-08-26 2005-06-08 Pfizer Prod Inc Vacunas para infecciones del sistema respiratorio y reproductor en ganado.
KR20040021988A (ko) * 2002-09-06 2004-03-11 서상희 바이러스 증식용 돼지 신장 상피 세포주, 및 이의 용도
UA95602C2 (ru) 2004-12-30 2011-08-25 Берингер Ингельхейм Ветмедика, Инк. Иммуногенная композиция цвс2 и способы приготовления такой композиции
US7833707B2 (en) * 2004-12-30 2010-11-16 Boehringer Ingelheim Vetmedica, Inc. Methods of overexpression and recovery of porcine circovirus type 2 ORF2
US7700285B1 (en) 2005-12-29 2010-04-20 Boehringer Ingelheim Vetmedica, Inc. PCV2 immunogenic compositions and methods of producing such compositions
US8834891B2 (en) 2005-03-14 2014-09-16 Boehringer Ingelheim Vetmedica, Inc. Immunogenic compositions comprising Lawsonia intracellularis
JP5408998B2 (ja) * 2005-04-13 2014-02-05 メリアル リミテッド ブタサーコウイルス産生アッセイ
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