DE69836272T2 - Versuchsanordnung zur bestimmung von analyten in körperflüssigkeiten - Google Patents
Versuchsanordnung zur bestimmung von analyten in körperflüssigkeiten Download PDFInfo
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- DE69836272T2 DE69836272T2 DE69836272T DE69836272T DE69836272T2 DE 69836272 T2 DE69836272 T2 DE 69836272T2 DE 69836272 T DE69836272 T DE 69836272T DE 69836272 T DE69836272 T DE 69836272T DE 69836272 T2 DE69836272 T2 DE 69836272T2
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- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/805—Test papers
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/81—Packaged device or kit
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/97—Test strip or test slide
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/805—Optical property
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/807—Apparatus included in process claim, e.g. physical support structures
- Y10S436/81—Tube, bottle, or dipstick
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
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- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
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- Microbiology (AREA)
- Pathology (AREA)
- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/874,468 US5948695A (en) | 1997-06-17 | 1997-06-17 | Device for determination of an analyte in a body fluid |
| PCT/US1998/011407 WO1998058260A1 (en) | 1997-06-17 | 1998-06-15 | Device for determination of an analyte in a body fluid |
| US874468 | 2001-06-04 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69836272D1 DE69836272D1 (de) | 2006-12-07 |
| DE69836272T2 true DE69836272T2 (de) | 2007-02-15 |
Family
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Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69836272T Expired - Fee Related DE69836272T2 (de) | 1997-06-17 | 1998-06-15 | Versuchsanordnung zur bestimmung von analyten in körperflüssigkeiten |
| DE19826957A Expired - Fee Related DE19826957C2 (de) | 1997-06-17 | 1998-06-17 | Vorrichtung zum Bestimmen eines Analyten in einem Körperfluid |
| DE29810858U Expired - Lifetime DE29810858U1 (de) | 1997-06-17 | 1998-06-17 | Vorrichtung zum Bestimmen eines Analyten in einem Körperfluid |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19826957A Expired - Fee Related DE19826957C2 (de) | 1997-06-17 | 1998-06-17 | Vorrichtung zum Bestimmen eines Analyten in einem Körperfluid |
| DE29810858U Expired - Lifetime DE29810858U1 (de) | 1997-06-17 | 1998-06-17 | Vorrichtung zum Bestimmen eines Analyten in einem Körperfluid |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US5948695A (enExample) |
| EP (1) | EP0993614B1 (enExample) |
| JP (1) | JP2002510392A (enExample) |
| AU (1) | AU8253098A (enExample) |
| DE (3) | DE69836272T2 (enExample) |
| GB (1) | GB2323666B (enExample) |
| WO (1) | WO1998058260A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3686597A1 (en) * | 2014-09-30 | 2020-07-29 | Siemens Healthcare Diagnostics Inc. | Device for determining the amount of hemoglobin in a plasma fraction |
Families Citing this family (160)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020010406A1 (en) | 1996-05-17 | 2002-01-24 | Douglas Joel S. | Methods and apparatus for expressing body fluid from an incision |
| US7828749B2 (en) | 1996-05-17 | 2010-11-09 | Roche Diagnostics Operations, Inc. | Blood and interstitial fluid sampling device |
| US7235056B2 (en) | 1996-05-17 | 2007-06-26 | Amira Medical | Body fluid sampling device and methods of use |
| EP1579814A3 (en) | 1996-05-17 | 2006-06-14 | Roche Diagnostics Operations, Inc. | Methods and apparatus for sampling and analyzing body fluid |
| US5948695A (en) * | 1997-06-17 | 1999-09-07 | Mercury Diagnostics, Inc. | Device for determination of an analyte in a body fluid |
| AU2005399A (en) * | 1997-12-19 | 1999-07-12 | Amira Medical | Embossed test strip system |
| US6656697B1 (en) * | 1998-09-28 | 2003-12-02 | Lifescan, Inc. | Diagnostics based on tetrazolium compounds |
| US6036659A (en) | 1998-10-09 | 2000-03-14 | Flexsite Diagnostics, Inc. | Collection device for biological samples and methods of use |
| FR2792333B1 (fr) * | 1999-04-14 | 2003-01-24 | Labonord | Dispositif de depot de cellules sur une plaque d'analyse |
| ATE418387T1 (de) * | 1999-10-22 | 2009-01-15 | Ngk Insulators Ltd | Flüssigkeitsspender und verfahren zur herstellung von dna chip |
| US6696240B1 (en) * | 1999-10-26 | 2004-02-24 | Micronix, Inc. | Capillary test strip to separate particulates |
| GB2357143A (en) * | 1999-12-10 | 2001-06-13 | Surescreen Diagnostics Ltd | Analytical test device |
| US6627057B1 (en) | 1999-12-23 | 2003-09-30 | Roche Diagnostic Corporation | Microsphere containing sensor |
| BR0114778A (pt) * | 2000-10-18 | 2005-02-09 | Clarity Technologies Inc | Processo e dispositivo para diluir um fluido e detectar analitos em um fluido diluìdo |
| US6540890B1 (en) * | 2000-11-01 | 2003-04-01 | Roche Diagnostics Corporation | Biosensor |
| US6583722B2 (en) | 2000-12-12 | 2003-06-24 | Kimberly-Clark Worldwide, Inc. | Wetness signaling device |
| US6603403B2 (en) | 2000-12-12 | 2003-08-05 | Kimberly-Clark Worldwide, Inc. | Remote, wetness signaling system |
| US6833111B2 (en) * | 2001-04-13 | 2004-12-21 | Varian, Inc. | Multiple analyte assaying device with a multiple sample introduction system |
| US6565808B2 (en) | 2001-05-18 | 2003-05-20 | Acon Laboratories | Line test device and methods of use |
| US6890484B2 (en) | 2001-05-18 | 2005-05-10 | Acon Laboratories, Inc. | In line test device and methods of use |
| EP2290358B1 (en) * | 2001-07-27 | 2015-11-11 | ARKRAY, Inc. | Analyzing instrument |
| KR100550707B1 (ko) * | 2001-08-09 | 2006-02-08 | 마츠시타 덴끼 산교 가부시키가이샤 | 바이오센서 및 측정방법 |
| US20040229347A1 (en) * | 2001-09-17 | 2004-11-18 | Perez Edward P. | Embossed test strip system |
| WO2003026721A2 (en) * | 2001-09-24 | 2003-04-03 | Fukunaga Atsuo F | Breathing circuits having unconventional respiratory conduits and systems and methods for optimising utilisation of fresh gases |
| CA2461370A1 (en) | 2001-09-26 | 2003-05-15 | F. Hoffmann-La Roche Ag | Method and apparatus for sampling bodily fluid |
| USD467665S1 (en) | 2001-09-28 | 2002-12-24 | Orasure Technologies, Inc. | Test device |
| USD631553S1 (en) | 2001-09-28 | 2011-01-25 | Orasure Technologies, Inc. | Test device |
| US6989891B2 (en) | 2001-11-08 | 2006-01-24 | Optiscan Biomedical Corporation | Device and method for in vitro determination of analyte concentrations within body fluids |
| US7244393B2 (en) * | 2001-12-21 | 2007-07-17 | Kimberly-Clark Worldwide, Inc. | Diagnostic device and system |
| US7004928B2 (en) | 2002-02-08 | 2006-02-28 | Rosedale Medical, Inc. | Autonomous, ambulatory analyte monitor or drug delivery device |
| EP1492448A4 (en) * | 2002-04-05 | 2008-03-19 | Eyelab Group Llc | MONITORING OF BLOOD SUBSTANCES USING SELF-COLLECTED TISSUES |
| US6759190B2 (en) * | 2002-06-15 | 2004-07-06 | Acon Laboratories, Inc. | Test strip for detection of analyte and methods of use |
| US7501053B2 (en) * | 2002-10-23 | 2009-03-10 | Abbott Laboratories | Biosensor having improved hematocrit and oxygen biases |
| DE10251669B3 (de) * | 2002-11-06 | 2004-06-17 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Kapillarsubstrat zur Tieftemperaturspeicherung von Suspensionsproben |
| US7560272B2 (en) | 2003-01-04 | 2009-07-14 | Inverness Medical Switzerland Gmbh | Specimen collection and assay container |
| US6983177B2 (en) * | 2003-01-06 | 2006-01-03 | Optiscan Biomedical Corporation | Layered spectroscopic sample element with microporous membrane |
| US20040131088A1 (en) * | 2003-01-08 | 2004-07-08 | Adtran, Inc. | Shared T1/E1 signaling bit processor |
| EP1447665B1 (en) * | 2003-02-11 | 2016-06-29 | Bayer HealthCare LLC | Method for reducing effect of hematocrit on measurement of an analyte in whole blood |
| US6900058B2 (en) * | 2003-03-11 | 2005-05-31 | Bionostics, Inc. | Control solution for photometric analysis |
| US7052652B2 (en) * | 2003-03-24 | 2006-05-30 | Rosedale Medical, Inc. | Analyte concentration detection devices and methods |
| AU2004203280A1 (en) | 2003-07-28 | 2005-02-17 | Bayer Healthcare Llc | Swing Lance with Integrated Sensor |
| BRPI0415886A (pt) * | 2003-10-29 | 2007-01-09 | Mec Dynamics Corp | tiras descartáveis e método de determinação da porcentagem de hbalc na hemoglobina |
| CA2545125A1 (en) * | 2003-11-14 | 2005-06-02 | Oakville Hong Kong Co., Limited | Rapid sample collection and analysis device and methods of use |
| US7510849B2 (en) * | 2004-01-29 | 2009-03-31 | Glucolight Corporation | OCT based method for diagnosis and therapy |
| US20070207554A1 (en) * | 2004-02-26 | 2007-09-06 | Lin Alex C C | Medical System and Method for Determining Parameters |
| WO2005111580A1 (en) * | 2004-05-07 | 2005-11-24 | Optiscan Biomedical Corporation | Sample element with fringing-reduction capabilities |
| JP5065013B2 (ja) * | 2004-05-14 | 2012-10-31 | バイエル・ヘルスケア・エルエルシー | グルコースアッセイにおいてヘマトクリットの調整を行う方法、およびそのための装置 |
| US7695676B2 (en) * | 2004-08-11 | 2010-04-13 | Hans Kloepfer | Methods and apparatus for analyzing an analysis fluid |
| US7254429B2 (en) | 2004-08-11 | 2007-08-07 | Glucolight Corporation | Method and apparatus for monitoring glucose levels in a biological tissue |
| US8036727B2 (en) | 2004-08-11 | 2011-10-11 | Glt Acquisition Corp. | Methods for noninvasively measuring analyte levels in a subject |
| WO2006034102A2 (en) * | 2004-09-20 | 2006-03-30 | Bayer Healthcare Llc | Biological test strip |
| US7442557B1 (en) | 2004-10-22 | 2008-10-28 | Idexx Laboratories, Inc. | Bi-directional flow assay device with reagent bridge |
| US8475735B2 (en) * | 2004-11-01 | 2013-07-02 | Uma Mahesh Babu | Disposable immunodiagnostic test system |
| US7387890B2 (en) * | 2004-12-16 | 2008-06-17 | Chembio Diagnostic Systems, Inc. | Immunoassay devices and use thereof |
| US7432111B2 (en) * | 2005-02-02 | 2008-10-07 | Standard Diagnostics, Inc. | Non-continuous immunoassay device and immunoassay method using the same |
| US20060195058A1 (en) | 2005-02-14 | 2006-08-31 | Gable Jennifer H | Methods and apparatus for extracting and analyzing a bodily fluid |
| US7189522B2 (en) | 2005-03-11 | 2007-03-13 | Chembio Diagnostic Systems, Inc. | Dual path immunoassay device |
| WO2006098804A2 (en) | 2005-03-11 | 2006-09-21 | Chembio Diagnostic Systems, Inc. | Dual path immunoassay device |
| WO2006110859A2 (en) | 2005-04-13 | 2006-10-19 | Glucolight Corporation | Method for data reduction and calibration of an oct-based blood glucose monitor |
| US20060281187A1 (en) | 2005-06-13 | 2006-12-14 | Rosedale Medical, Inc. | Analyte detection devices and methods with hematocrit/volume correction and feedback control |
| US7887494B2 (en) * | 2005-09-30 | 2011-02-15 | Intuity Medical, Inc. | Fluid sample transport devices and methods |
| US8801631B2 (en) | 2005-09-30 | 2014-08-12 | Intuity Medical, Inc. | Devices and methods for facilitating fluid transport |
| EP1928316B1 (en) | 2005-09-30 | 2014-02-26 | Intuity Medical, Inc. | Multi-site body fluid sampling and analysis cartridge |
| US9561001B2 (en) | 2005-10-06 | 2017-02-07 | Optiscan Biomedical Corporation | Fluid handling cassette system for body fluid analyzer |
| US8133741B2 (en) | 2005-10-26 | 2012-03-13 | General Electric Company | Methods and systems for delivery of fluidic samples to sensor arrays |
| US7723120B2 (en) * | 2005-10-26 | 2010-05-25 | General Electric Company | Optical sensor array system and method for parallel processing of chemical and biochemical information |
| WO2007062575A1 (en) * | 2005-11-30 | 2007-06-07 | Inverness Medical Switzerland Gmbh | A device for detecting the presence or amount of an analyte in a fluid sample and method thereof |
| JP4681052B2 (ja) * | 2006-06-26 | 2011-05-11 | 日本電信電話株式会社 | フローセルおよびその製造方法 |
| WO2008014709A1 (en) * | 2006-07-26 | 2008-02-07 | Abon Biopharm (Hangzhou) Co., Ltd. | Analysis device for biologicla sample |
| US8797644B2 (en) * | 2006-08-11 | 2014-08-05 | The Regents Of The University Of California | Capillary-based cell and tissue acquisition system (CTAS) |
| WO2008049011A2 (en) * | 2006-10-18 | 2008-04-24 | Research Development Foundation | Alpha-msh therapies for treatment of autoimmune disease |
| ES2453379T3 (es) * | 2007-04-25 | 2014-04-07 | 3M Innovative Properties Company | Reactivos soportados, métodos y dispositivos |
| WO2008134466A1 (en) * | 2007-04-25 | 2008-11-06 | 3M Innovative Properties Company | Chemical component and processing device assembly |
| US7883898B2 (en) * | 2007-05-07 | 2011-02-08 | General Electric Company | Method and apparatus for measuring pH of low alkalinity solutions |
| US8417311B2 (en) | 2008-09-12 | 2013-04-09 | Optiscan Biomedical Corporation | Fluid component analysis system and method for glucose monitoring and control |
| KR101067803B1 (ko) * | 2007-07-20 | 2011-09-27 | 아크레이 가부시키가이샤 | 검체 공급 툴 및 이를 이용한 검체 분석용 툴 |
| EP3868284A1 (en) | 2007-10-10 | 2021-08-25 | Optiscan Biomedical Corporation | Fluid component analysis system and method for glucose monitoring and control |
| US20100209927A1 (en) * | 2007-11-06 | 2010-08-19 | Menon Vinod P | Processing device tablet |
| US8571617B2 (en) | 2008-03-04 | 2013-10-29 | Glt Acquisition Corp. | Flowometry in optical coherence tomography for analyte level estimation |
| EP2293719B1 (en) | 2008-05-30 | 2015-09-09 | Intuity Medical, Inc. | Body fluid sampling device -- sampling site interface |
| CA3095014A1 (en) | 2008-06-06 | 2009-12-10 | Intuity Medical, Inc. | Detection meter and mode of operation |
| EP2299904B1 (en) | 2008-06-06 | 2019-09-11 | Intuity Medical, Inc. | Medical measurement method |
| US20100022916A1 (en) | 2008-07-24 | 2010-01-28 | Javanbakhsh Esfandiari | Method and Apparatus for Collecting and Preparing Biological Samples for Testing |
| US7959598B2 (en) | 2008-08-20 | 2011-06-14 | Asante Solutions, Inc. | Infusion pump systems and methods |
| CN102422164B (zh) * | 2009-05-15 | 2015-12-16 | 柯尼卡美能达株式会社 | 微芯片 |
| EP2456355B1 (en) | 2009-07-20 | 2016-09-14 | Optiscan Biomedical Corporation | Adjustable connector and dead space reduction |
| US9554742B2 (en) | 2009-07-20 | 2017-01-31 | Optiscan Biomedical Corporation | Fluid analysis system |
| US8012770B2 (en) | 2009-07-31 | 2011-09-06 | Invisible Sentinel, Inc. | Device for detection of antigens and uses thereof |
| WO2011044574A1 (en) | 2009-10-09 | 2011-04-14 | Invisible Sentinel | Device for detection of antigens and uses thereof |
| EP2496941B1 (en) | 2009-11-04 | 2016-07-13 | Thomas M. Buchanan | Methods and devices to enhance sensitivity and evaluate sample adequacy and reagent reactivity in rapid lateral flow immunoassays |
| US8919605B2 (en) | 2009-11-30 | 2014-12-30 | Intuity Medical, Inc. | Calibration material delivery devices and methods |
| CN105044320B (zh) | 2010-03-25 | 2017-02-22 | 艾博生物医药(杭州)有限公司 | 测试液体样本中被分析物的检测装置 |
| WO2011156522A1 (en) | 2010-06-09 | 2011-12-15 | Optiscan Biomedical Corporation | Measuring analytes in a fluid sample drawn from a patient |
| CA2803797A1 (en) | 2010-06-25 | 2011-12-29 | Intuity Medical, Inc. | Analyte monitoring methods and systems |
| AU2012211141B2 (en) | 2011-01-27 | 2016-11-03 | Invisible Sentinel, Inc. | Analyte detection devices, multiplex and tabletop devices for detection of analytes, and uses thereof |
| US8603835B2 (en) | 2011-02-10 | 2013-12-10 | Chembio Diagnostic Systems, Inc. | Reduced step dual path immunoassay device and method |
| WO2013006716A1 (en) | 2011-07-06 | 2013-01-10 | Optiscan Biomedical Corporation | Sample cell for fluid analysis system |
| CA2843945C (en) | 2011-08-03 | 2022-06-21 | Intuity Medical, Inc. | Devices and methods for body fluid sampling and analysis |
| JP2015508493A (ja) * | 2011-12-22 | 2015-03-19 | ディーエスエム アイピー アセッツ ビー.ブイ. | 多層織物製品および乾燥マトリックススポット用途用担体としての多層織物製品の使用 |
| US9451914B2 (en) * | 2012-01-03 | 2016-09-27 | Charleston Area Medical Center, Inc. | Integrated needle and test strip assembly and method of use |
| CN104160277B (zh) * | 2012-01-11 | 2017-05-17 | 嘉泉大学校产学协力团 | 用于测量血糖水平的单元、包含该单元的系统以及用于测量血糖水平的方法 |
| AU2013230917C1 (en) | 2012-03-09 | 2021-09-16 | Invisible Sentinel, Inc. | Methods and compositions for detecting multiple analytes with a single signal |
| USD713973S1 (en) * | 2012-09-25 | 2014-09-23 | PDx BioTech | Diagnostic test device |
| CN105283757B (zh) | 2013-03-15 | 2019-04-23 | 豪夫迈·罗氏有限公司 | 对分析物的电化学测量进行防故障的方法以及结合该方法的设备、装置和系统 |
| CA2900572C (en) | 2013-03-15 | 2018-02-13 | F. Hoffmann-La Roche Ag | Methods of detecting high antioxidant levels during electrochemical measurements and failsafing an analyte concentration therefrom as well as devices, apparatuses and systems incorporting the same |
| WO2014140164A1 (en) | 2013-03-15 | 2014-09-18 | Roche Diagnostics Gmbh | Methods of using information from recovery pulses in electrochemical analyte measurements as well as devices, apparatuses and systems incorporating the same |
| EP3385706A1 (en) | 2013-03-15 | 2018-10-10 | Roche Diabetes Care GmbH | Methods of scaling data used to construct biosensor algorithms as well as devices, apparatuses and systems incorporating the same |
| EP3011544A4 (en) | 2013-06-21 | 2017-02-22 | Intuity Medical, Inc. | Analyte monitoring system with audible feedback |
| WO2015005504A1 (ko) * | 2013-07-08 | 2015-01-15 | 가천대학교 산학협력단 | 혈당측정용 바이오칩 및 그를 포함하는 스마트폰용 혈당측정기 |
| US9561324B2 (en) | 2013-07-19 | 2017-02-07 | Bigfoot Biomedical, Inc. | Infusion pump system and method |
| GB2523989B (en) | 2014-01-30 | 2020-07-29 | Insulet Netherlands B V | Therapeutic product delivery system and method of pairing |
| BR112016022829B1 (pt) | 2014-04-02 | 2022-03-03 | Chembio Diagnostic Systems, Inc | Dispositivo de teste para determinar a presença de um primeiro ligante em uma amostra líquida, e método para testar uma amostra quanto à presença de um primeiro ligante |
| JP6359348B2 (ja) * | 2014-06-06 | 2018-07-18 | キヤノンメディカルシステムズ株式会社 | センサチップ及びセンサチップへの液体供給方法 |
| US9901922B2 (en) | 2014-07-25 | 2018-02-27 | General Electric Company | Sample collection and transfer device |
| US9480981B2 (en) | 2014-07-25 | 2016-11-01 | General Electric Company | Sample collection and transfer device |
| US20160116466A1 (en) | 2014-10-27 | 2016-04-28 | Chembio Diagnostic Systems, Inc. | Rapid Screening Assay for Qualitative Detection of Multiple Febrile Illnesses |
| CN111905188B (zh) | 2015-02-18 | 2022-07-22 | 英赛罗公司 | 流体输送和输注装置及其使用方法 |
| WO2017123525A1 (en) | 2016-01-13 | 2017-07-20 | Bigfoot Biomedical, Inc. | User interface for diabetes management system |
| EP3402548B1 (en) | 2016-01-14 | 2025-03-12 | Insulet Corporation | Occlusion resolution in medication delivery devices, systems, and methods |
| JP6876046B2 (ja) | 2016-01-14 | 2021-05-26 | ビッグフット バイオメディカル インコーポレイテッドBigfoot Biomedical, Inc. | インスリン・デリバリ量の調節 |
| US12383166B2 (en) | 2016-05-23 | 2025-08-12 | Insulet Corporation | Insulin delivery system and methods with risk-based set points |
| US10765807B2 (en) | 2016-09-23 | 2020-09-08 | Insulet Corporation | Fluid delivery device with sensor |
| PL3523639T3 (pl) | 2016-10-05 | 2025-03-17 | F. Hoffmann-La Roche Ag | Odczynniki wykrywające i układy elektrod do elementów diagnostycznych testów wieloanalitowych oraz sposoby ich zastosowania |
| CA3041623A1 (en) | 2016-10-24 | 2018-05-03 | F. Hoffmann-La Roche Ag | Methods of correcting for uncompensated resistances in the conductive elements of biosensors, as well as devices and systems |
| CA3037432A1 (en) | 2016-12-12 | 2018-06-21 | Bigfoot Biomedical, Inc. | Alarms and alerts for medication delivery devices and related systems and methods |
| US10500334B2 (en) | 2017-01-13 | 2019-12-10 | Bigfoot Biomedical, Inc. | System and method for adjusting insulin delivery |
| US10758675B2 (en) | 2017-01-13 | 2020-09-01 | Bigfoot Biomedical, Inc. | System and method for adjusting insulin delivery |
| EP3568860B1 (en) | 2017-01-13 | 2025-12-10 | Insulet Corporation | Insulin delivery methods, systems and devices |
| WO2018132754A1 (en) | 2017-01-13 | 2018-07-19 | Mazlish Bryan | System and method for adjusting insulin delivery |
| EP3568859B1 (en) | 2017-01-13 | 2025-12-10 | Insulet Corporation | Insulin delivery methods, systems and devices |
| USD928199S1 (en) | 2018-04-02 | 2021-08-17 | Bigfoot Biomedical, Inc. | Medication delivery device with icons |
| US11565043B2 (en) | 2018-05-04 | 2023-01-31 | Insulet Corporation | Safety constraints for a control algorithm based drug delivery system |
| CN112789070A (zh) | 2018-09-28 | 2021-05-11 | 英赛罗公司 | 人造胰腺系统的活动模式 |
| US11565039B2 (en) | 2018-10-11 | 2023-01-31 | Insulet Corporation | Event detection for drug delivery system |
| USD920343S1 (en) | 2019-01-09 | 2021-05-25 | Bigfoot Biomedical, Inc. | Display screen or portion thereof with graphical user interface associated with insulin delivery |
| KR102079783B1 (ko) * | 2019-07-03 | 2020-02-21 | 주식회사 원드롭 | 생체 물질을 측정하기 위한 스트립 |
| US11801344B2 (en) | 2019-09-13 | 2023-10-31 | Insulet Corporation | Blood glucose rate of change modulation of meal and correction insulin bolus quantity |
| US11935637B2 (en) | 2019-09-27 | 2024-03-19 | Insulet Corporation | Onboarding and total daily insulin adaptivity |
| KR102168919B1 (ko) | 2019-10-25 | 2020-10-22 | 주식회사 원드롭 | 정량 채취가 가능한 시료 수집 장치 |
| EP4354455B1 (en) | 2019-12-06 | 2025-10-29 | Insulet Corporation | Techniques and devices providing adaptivity and personalization in diabetes treatment |
| US11833329B2 (en) | 2019-12-20 | 2023-12-05 | Insulet Corporation | Techniques for improved automatic drug delivery performance using delivery tendencies from past delivery history and use patterns |
| EP4088286A1 (en) | 2020-01-06 | 2022-11-16 | Insulet Corporation | Prediction of meal and/or exercise events based on persistent residuals |
| EP4100958A1 (en) | 2020-02-03 | 2022-12-14 | Insulet Corporation | Use of fuzzy logic in predicting user behavior affecting blood glucose concentration |
| US11551802B2 (en) | 2020-02-11 | 2023-01-10 | Insulet Corporation | Early meal detection and calorie intake detection |
| US11547800B2 (en) | 2020-02-12 | 2023-01-10 | Insulet Corporation | User parameter dependent cost function for personalized reduction of hypoglycemia and/or hyperglycemia in a closed loop artificial pancreas system |
| US11986630B2 (en) | 2020-02-12 | 2024-05-21 | Insulet Corporation | Dual hormone delivery system for reducing impending hypoglycemia and/or hyperglycemia risk |
| US11324889B2 (en) | 2020-02-14 | 2022-05-10 | Insulet Corporation | Compensation for missing readings from a glucose monitor in an automated insulin delivery system |
| US11607493B2 (en) | 2020-04-06 | 2023-03-21 | Insulet Corporation | Initial total daily insulin setting for user onboarding |
| WO2022020197A1 (en) | 2020-07-22 | 2022-01-27 | Insulet Corporation | Open-loop insulin delivery basal parameters based on insulin delivery records |
| US11684716B2 (en) | 2020-07-31 | 2023-06-27 | Insulet Corporation | Techniques to reduce risk of occlusions in drug delivery systems |
| GB202013085D0 (en) * | 2020-08-21 | 2020-10-07 | Vidya Holdings Ltd | Improvements in or relating to a device for analysing a sample |
| US12128215B2 (en) | 2020-09-30 | 2024-10-29 | Insulet Corporation | Drug delivery device with integrated optical-based glucose monitor |
| WO2022072618A1 (en) | 2020-09-30 | 2022-04-07 | Insulet Corporation | Secure wireless communications between a glucose monitor and other devices |
| US11160925B1 (en) | 2021-01-29 | 2021-11-02 | Insulet Corporation | Automatic drug delivery system for delivery of a GLP-1 therapeutic |
| US11904140B2 (en) | 2021-03-10 | 2024-02-20 | Insulet Corporation | Adaptable asymmetric medicament cost component in a control system for medicament delivery |
| US12431229B2 (en) | 2021-03-10 | 2025-09-30 | Insulet Corporation | Medicament delivery device with an adjustable and piecewise analyte level cost component to address persistent positive analyte level excursions |
| US12406760B2 (en) | 2021-06-07 | 2025-09-02 | Insulet Corporation | Exercise safety prediction based on physiological conditions |
| WO2023049900A1 (en) | 2021-09-27 | 2023-03-30 | Insulet Corporation | Techniques enabling adaptation of parameters in aid systems by user input |
| US11439754B1 (en) | 2021-12-01 | 2022-09-13 | Insulet Corporation | Optimizing embedded formulations for drug delivery |
| CA3275991A1 (en) | 2023-01-06 | 2024-07-11 | Insulet Corp | Automatic or manual administration of meal boluses with subsequent automatic relaxation of safety constraints |
Family Cites Families (133)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3092465A (en) * | 1960-03-25 | 1963-06-04 | Miles Lab | Diagnostic test device for blood sugar |
| US3298789A (en) * | 1964-12-14 | 1967-01-17 | Miles Lab | Test article for the detection of glucose |
| DE1598153C3 (de) * | 1966-11-22 | 1973-11-22 | Boehringer Mannheim Gmbh, 6800 Mannheim | Diagnostisches Mittel zum Nach weis der Inhaltsstoffe von Korperflus sigkeiten |
| US3552928A (en) * | 1967-07-19 | 1971-01-05 | Miles Lab | Whole blood separation means and test system using same |
| US3607093A (en) * | 1968-02-15 | 1971-09-21 | Schering Corp | Devices for testing biological liquids |
| US3992158A (en) * | 1973-08-16 | 1976-11-16 | Eastman Kodak Company | Integral analytical element |
| US4042335A (en) * | 1975-07-23 | 1977-08-16 | Eastman Kodak Company | Integral element for analysis of liquids |
| DE2611721B2 (de) * | 1976-03-19 | 1978-10-26 | R. Geerd Dr.Med. 6108 Weiterstadt Hamer | Vakuum-Sauggerät zum Absaugen von Gewebeserum |
| CA1095819A (en) * | 1977-01-14 | 1981-02-17 | Eastman Kodak Company | Element for analysis of liquids |
| DD137384B1 (de) * | 1977-11-04 | 1981-07-29 | Kallies Karl Heinz | Indikator-kapillar-roehrchen zur harnstoff-bestimmung |
| USD254444S (en) * | 1977-09-01 | 1980-03-11 | Levine Robert A | Blood sampling needle |
| US4258001A (en) * | 1978-12-27 | 1981-03-24 | Eastman Kodak Company | Element, structure and method for the analysis or transport of liquids |
| US4360016A (en) * | 1980-07-01 | 1982-11-23 | Transidyne General Corp. | Blood collecting device |
| DE3029579C2 (de) * | 1980-08-05 | 1985-12-12 | Boehringer Mannheim Gmbh, 6800 Mannheim | Verfahren und Mittel zur Abtrennung von Plasma oder Serum aus Vollblut |
| GB2090659A (en) * | 1981-01-02 | 1982-07-14 | Instrumentation Labor Inc | Analytical device |
| US4503856A (en) * | 1981-06-29 | 1985-03-12 | Sherwood Medical Company | Lancet injector |
| US5073484A (en) * | 1982-03-09 | 1991-12-17 | Bio-Metric Systems, Inc. | Quantitative analysis apparatus and method |
| CA1205731A (en) * | 1982-11-01 | 1986-06-10 | Roger C. Phillips | Test device and method for measurement of analyte levels in colored aqueous fluids |
| US4517978A (en) * | 1983-01-13 | 1985-05-21 | Levin Paul D | Blood sampling instrument |
| CA1226036A (en) * | 1983-05-05 | 1987-08-25 | Irving J. Higgins | Analytical equipment and sensor electrodes therefor |
| US4900666A (en) * | 1983-07-12 | 1990-02-13 | Lifescan, Inc. | Colorimetric ethanol analysis method and test device |
| US4734360A (en) * | 1983-07-12 | 1988-03-29 | Lifescan, Inc. | Colorimetric ethanol analysis method and test device |
| AU3552284A (en) * | 1983-10-17 | 1985-05-07 | Inomedix Inc. | Device for rapid quantitative analysis of a fluid |
| US4637978A (en) * | 1983-10-28 | 1987-01-20 | Eastman Kodak Company | Assay for analysis of whole blood |
| DE3407359A1 (de) * | 1984-02-29 | 1985-08-29 | Bayer Ag, 5090 Leverkusen | Testvorrichtung und methode zum nachweis einer komponente einer fluessigen probe |
| US4622974A (en) * | 1984-03-07 | 1986-11-18 | University Of Tennessee Research Corporation | Apparatus and method for in-vivo measurements of chemical concentrations |
| GB8406154D0 (en) | 1984-03-09 | 1984-04-11 | Palmer G C | Sampling fluid |
| NL8401536A (nl) * | 1984-05-11 | 1985-12-02 | Medscan B V I O | Bloedbemonsteringseenheid. |
| US4826759A (en) * | 1984-10-04 | 1989-05-02 | Bio-Metric Systems, Inc. | Field assay for ligands |
| US4653511A (en) * | 1984-10-05 | 1987-03-31 | Goch Thomas A | Microsample blood collecting device |
| US5279294A (en) * | 1985-04-08 | 1994-01-18 | Cascade Medical, Inc. | Medical diagnostic system |
| US4627445A (en) * | 1985-04-08 | 1986-12-09 | Garid, Inc. | Glucose medical monitoring system |
| US4787398A (en) * | 1985-04-08 | 1988-11-29 | Garid, Inc. | Glucose medical monitoring system |
| US4678757A (en) * | 1985-04-11 | 1987-07-07 | Smithkline Diagnostics, Inc. | Device and method for whole blood separation and analysis |
| US4653513A (en) * | 1985-08-09 | 1987-03-31 | Dombrowski Mitchell P | Blood sampler |
| US4839296A (en) * | 1985-10-18 | 1989-06-13 | Chem-Elec, Inc. | Blood plasma test method |
| US4658821A (en) * | 1986-01-08 | 1987-04-21 | Packaging Corporation International A/K/A/ Medicore | Ejector for an automatic lancet arm |
| DE3708031A1 (de) | 1986-03-20 | 1987-11-12 | Wolfgang Dr Med Wagner | Messeinrichtung oder induktionseinrichtung mit messeinrichtung oder vorrichtung zur materialgewinnung fuer eine messvorrichtung fuer stoffwechselzustaende im blut mittels punktion unter anwendung von unterdruck innerhalb einer saugglocke bei verlagerung der messzone ausserhalb des spitzenbereiches des punktionsgeraetes |
| US4906439A (en) * | 1986-03-25 | 1990-03-06 | Pb Diagnostic Systems, Inc. | Biological diagnostic device and method of use |
| US4685463A (en) * | 1986-04-03 | 1987-08-11 | Williams R Bruce | Device for continuous in vivo measurement of blood glucose concentrations |
| US4994167A (en) * | 1986-04-15 | 1991-02-19 | Markwell Medical Institute, Inc. | Biological fluid measuring device |
| US5029583A (en) * | 1986-07-22 | 1991-07-09 | Personal Diagnostics, Inc. | Optical analyzer |
| US4873993A (en) * | 1986-07-22 | 1989-10-17 | Personal Diagnostics, Inc. | Cuvette |
| US5049487A (en) * | 1986-08-13 | 1991-09-17 | Lifescan, Inc. | Automated initiation of timing of reflectance readings |
| US4935346A (en) * | 1986-08-13 | 1990-06-19 | Lifescan, Inc. | Minimum procedure system for the determination of analytes |
| US4790979A (en) * | 1986-08-29 | 1988-12-13 | Technimed Corporation | Test strip and fixture |
| US5178831A (en) * | 1986-10-08 | 1993-01-12 | Dai Nippon Insatsu Kab Ushiki Kaisha | Device for testing body fluids |
| US4774192A (en) * | 1987-01-28 | 1988-09-27 | Technimed Corporation | A dry reagent delivery system with membrane having porosity gradient |
| US5002054A (en) * | 1987-02-25 | 1991-03-26 | Ash Medical Systems, Inc. | Interstitial filtration and collection device and method for long-term monitoring of physiological constituents of the body |
| US4999287A (en) * | 1988-05-19 | 1991-03-12 | Chemtrak Corporation | Direct measuring assay strip and method of use thereof |
| US4805623A (en) * | 1987-09-04 | 1989-02-21 | Vander Corporation | Spectrophotometric method for quantitatively determining the concentration of a dilute component in a light- or other radiation-scattering environment |
| US4850973A (en) * | 1987-10-16 | 1989-07-25 | Pavel Jordon & Associates | Plastic device for injection and obtaining blood samples |
| US4818677A (en) * | 1987-12-03 | 1989-04-04 | Monoclonal Antibodies, Inc. | Membrane assay using focused sample application |
| US5014718A (en) * | 1988-01-22 | 1991-05-14 | Safety Diagnostics, Inc. | Blood collection and testing method |
| US5070886A (en) * | 1988-01-22 | 1991-12-10 | Safety Diagnostice, Inc. | Blood collection and testing means |
| US4883068A (en) * | 1988-03-14 | 1989-11-28 | Dec In Tech, Inc. | Blood sampling device and method |
| US5164294A (en) * | 1988-05-17 | 1992-11-17 | Syntex (U.S.A.) Inc. | Method for immunochromatographic analysis |
| US4994238A (en) * | 1988-06-09 | 1991-02-19 | Daffern George M | Constant volume chemical analysis test device |
| US4924879A (en) * | 1988-10-07 | 1990-05-15 | Brien Walter J O | Blood lancet device |
| US4995402A (en) * | 1988-10-12 | 1991-02-26 | Thorne, Smith, Astill Technologies, Inc. | Medical droplet whole blood and like monitoring |
| US4920977A (en) * | 1988-10-25 | 1990-05-01 | Becton, Dickinson And Company | Blood collection assembly with lancet and microcollection tube |
| US5202268A (en) * | 1988-12-30 | 1993-04-13 | Environmental Diagnostics, Inc. | Multi-layered test card for the determination of substances in liquids |
| US5035704A (en) * | 1989-03-07 | 1991-07-30 | Lambert Robert D | Blood sampling mechanism |
| US5054499A (en) * | 1989-03-27 | 1991-10-08 | Swierczek Remi D | Disposable skin perforator and blood testing device |
| US4953552A (en) * | 1989-04-21 | 1990-09-04 | Demarzo Arthur P | Blood glucose monitoring system |
| US5100620A (en) * | 1989-05-15 | 1992-03-31 | Miles, Inc. | Capillary tube/gap reagent format |
| ATE117804T1 (de) * | 1989-06-05 | 1995-02-15 | Janssen Pharmaceutica Nv | Festphasen-test zur verwendung mit einem physikalischen entwickler. |
| US4976724A (en) * | 1989-08-25 | 1990-12-11 | Lifescan, Inc. | Lancet ejector mechanism |
| US5306623A (en) * | 1989-08-28 | 1994-04-26 | Lifescan, Inc. | Visual blood glucose concentration test strip |
| AU640162B2 (en) * | 1989-08-28 | 1993-08-19 | Lifescan, Inc. | Blood separation and analyte detection techniques |
| US5620863A (en) * | 1989-08-28 | 1997-04-15 | Lifescan, Inc. | Blood glucose strip having reduced side reactions |
| US4994068A (en) * | 1989-11-24 | 1991-02-19 | Unidex, Inc. | Combination sterile pad support and lancet containing lancet disposal element |
| US5252496A (en) * | 1989-12-18 | 1993-10-12 | Princeton Biomeditech Corporation | Carbon black immunochemical label |
| US5223220A (en) * | 1990-03-27 | 1993-06-29 | Pacific Biotech, Inc. | Solid phase immunoassay device and method of making same |
| US5161532A (en) * | 1990-04-19 | 1992-11-10 | Teknekron Sensor Development Corporation | Integral interstitial fluid sensor |
| DE4015590A1 (de) * | 1990-05-15 | 1991-11-21 | Boehringer Mannheim Gmbh | Testtraeger zur bestimmung von ionen |
| US5066859A (en) * | 1990-05-18 | 1991-11-19 | Karkar Maurice N | Hematocrit and oxygen saturation blood analyzer |
| US5096833A (en) * | 1990-05-29 | 1992-03-17 | Miles Inc. | Method and device for determining protein using carrier matrix composed of urethane, water insouble inorganic compound and insoluble organic compound and method of making the device |
| US5187100A (en) * | 1990-05-29 | 1993-02-16 | Lifescan, Inc. | Dispersion to limit penetration of aqueous solutions into a membrane |
| US5208163A (en) * | 1990-08-06 | 1993-05-04 | Miles Inc. | Self-metering fluid analysis device |
| US5147606A (en) * | 1990-08-06 | 1992-09-15 | Miles Inc. | Self-metering fluid analysis device |
| US5565170A (en) * | 1990-08-30 | 1996-10-15 | Kyoto Daiichi Kagaku Co., Ltd. | Multilayer analytical element for assaying fructosamine |
| JPH06500174A (ja) * | 1990-10-30 | 1994-01-06 | ハイポガード(ユーケイ)リミテッド | 収集及び表示装置 |
| DE4117847A1 (de) * | 1991-05-31 | 1992-12-03 | Lre Relais & Elektronik Gmbh | Verfahren zum auswerten binaerer informationen |
| US5402798A (en) * | 1991-07-18 | 1995-04-04 | Swierczek; Remi | Disposable skin perforator and blood testing device |
| US5163442A (en) * | 1991-07-30 | 1992-11-17 | Harry Ono | Finger tip blood collector |
| FR2688311B1 (fr) * | 1991-11-12 | 1995-03-10 | Boy Inst Jacques | Procede pour la mise en evidence d'agglutinats erythrocytaires. |
| US5231993A (en) * | 1991-11-20 | 1993-08-03 | Habley Medical Technology Corporation | Blood sampler and component tester with guide member |
| US5334502A (en) * | 1991-11-27 | 1994-08-02 | Osborn Laboratories, Inc. | Method of collecting, identifying, and quantifying saliva |
| DE4202850A1 (de) * | 1992-01-31 | 1993-08-05 | Boehringer Mannheim Gmbh | Analysenelement fuer immunoassays |
| JP2572823Y2 (ja) * | 1992-02-13 | 1998-05-25 | 株式会社アドバンス | 簡易採血器 |
| US5165418B1 (en) * | 1992-03-02 | 1999-12-14 | Nikola I Tankovich | Blood sampling device and method using a laser |
| DE4212315A1 (de) * | 1992-04-13 | 1993-10-14 | Boehringer Mannheim Gmbh | Blutlanzettenvorrichtung zur Entnahme von Blut für Diagnosezwecke |
| US5318583A (en) * | 1992-05-05 | 1994-06-07 | Ryder International Corporation | Lancet actuator mechanism |
| DE4217733A1 (de) * | 1992-05-29 | 1993-12-02 | Boehringer Mannheim Gmbh | Testträger zur Analytbestimmung sowie Verfahren zu dessen Herstellung |
| US5217480A (en) * | 1992-06-09 | 1993-06-08 | Habley Medical Technology Corporation | Capillary blood drawing device |
| US5277198A (en) * | 1992-07-27 | 1994-01-11 | Ryder International Corporation | Blood sampling syringe |
| US5354692A (en) * | 1992-09-08 | 1994-10-11 | Pacific Biotech, Inc. | Analyte detection device including a hydrophobic barrier for improved fluid flow |
| US5569212A (en) * | 1994-07-22 | 1996-10-29 | Raya Systems, Inc. | Apparatus for electrically determining injection doses in syringes |
| US5395387A (en) * | 1993-02-26 | 1995-03-07 | Becton Dickinson And Company | Lancet blade designed for reduced pain |
| JP2630197B2 (ja) * | 1993-04-28 | 1997-07-16 | 株式会社ニッショー | 血液吸出器具 |
| US5843691A (en) | 1993-05-15 | 1998-12-01 | Lifescan, Inc. | Visually-readable reagent test strip |
| CA2127172C (en) * | 1993-08-05 | 1998-07-14 | Amy H. Chu | Analyte detection device and process |
| AU7563294A (en) * | 1993-08-24 | 1995-03-21 | Metrika Laboratories, Inc. | Novel disposable electronic assay device |
| US5522255A (en) * | 1993-08-31 | 1996-06-04 | Boehringer Mannheim Corporation | Fluid dose, flow and coagulation sensor for medical instrument |
| US5582184A (en) * | 1993-10-13 | 1996-12-10 | Integ Incorporated | Interstitial fluid collection and constituent measurement |
| CA2175056A1 (en) * | 1993-10-28 | 1995-05-04 | Imants R. Lauks | Fluid sample collection and introduction device |
| US5456835A (en) * | 1993-11-08 | 1995-10-10 | Hemasure, Inc. | Device and process for removing free hemoglobin from blood |
| US5725831A (en) * | 1994-03-14 | 1998-03-10 | Becton Dickinson And Company | Nucleic acid amplification apparatus |
| US5556761A (en) * | 1994-04-26 | 1996-09-17 | Phillips; Kevin J. | Test strip for blood glucose testing |
| DE4415896A1 (de) * | 1994-05-05 | 1995-11-09 | Boehringer Mannheim Gmbh | Analysesystem zur Überwachung der Konzentration eines Analyten im Blut eines Patienten |
| US5700695A (en) * | 1994-06-30 | 1997-12-23 | Zia Yassinzadeh | Sample collection and manipulation method |
| US5547702A (en) * | 1994-07-08 | 1996-08-20 | Polymer Technology International Corporation | Method for continuous manufacture of diagnostic test strips |
| US5518006A (en) * | 1994-08-09 | 1996-05-21 | International Technidyne Corp. | Blood sampling device |
| US5515170A (en) * | 1994-09-08 | 1996-05-07 | Lifescan, Inc. | Analyte detection device having a serpentine passageway for indicator strips |
| US5563031A (en) * | 1994-09-08 | 1996-10-08 | Lifescan, Inc. | Highly stable oxidative coupling dye for spectrophotometric determination of analytes |
| US5526120A (en) * | 1994-09-08 | 1996-06-11 | Lifescan, Inc. | Test strip with an asymmetrical end insuring correct insertion for measuring |
| US5597532A (en) * | 1994-10-20 | 1997-01-28 | Connolly; James | Apparatus for determining substances contained in a body fluid |
| US5668017A (en) * | 1995-02-10 | 1997-09-16 | Path | Radial absorption device |
| US5628764A (en) * | 1995-03-21 | 1997-05-13 | Schraga; Steven | Collar lancet device |
| AU706456B2 (en) * | 1995-03-27 | 1999-06-17 | Lifescan, Inc. | Chemical timer for a direct-reading reagent test strip |
| US5712172A (en) * | 1995-05-18 | 1998-01-27 | Wyntek Diagnostics, Inc. | One step immunochromatographic device and method of use |
| NZ299104A (en) * | 1995-08-03 | 1998-04-27 | Lifescan Inc | Reagent test strip |
| US5682233A (en) * | 1995-09-08 | 1997-10-28 | Integ, Inc. | Interstitial fluid sampler |
| AU722471B2 (en) * | 1995-10-17 | 2000-08-03 | Lifescan, Inc. | Blood glucose strip having reduced sensitivity to hematocrit |
| US5628309A (en) | 1996-01-25 | 1997-05-13 | Raya Systems, Inc. | Meter for electrically measuring and recording injection syringe doses |
| IL120587A (en) * | 1996-04-04 | 2000-10-31 | Lifescan Inc | Reagent test strip for determination of blood glucose |
| US5962215A (en) * | 1996-04-05 | 1999-10-05 | Mercury Diagnostics, Inc. | Methods for testing the concentration of an analyte in a body fluid |
| WO1997042888A1 (en) * | 1996-05-17 | 1997-11-20 | Mercury Diagnostics Inc. | Blood and interstitial fluid sampling device |
| WO1997043962A1 (en) | 1996-05-17 | 1997-11-27 | Mercury Diagnostics, Inc. | Methods and apparatus for expressing body fluid from an incision |
| WO1998019159A1 (en) * | 1996-10-30 | 1998-05-07 | Mercury Diagnostics, Inc. | Synchronized analyte testing system |
| US5948695A (en) * | 1997-06-17 | 1999-09-07 | Mercury Diagnostics, Inc. | Device for determination of an analyte in a body fluid |
| AU2005399A (en) * | 1997-12-19 | 1999-07-12 | Amira Medical | Embossed test strip system |
-
1997
- 1997-06-17 US US08/874,468 patent/US5948695A/en not_active Expired - Fee Related
-
1998
- 1998-06-15 EP EP98932712A patent/EP0993614B1/en not_active Expired - Lifetime
- 1998-06-15 WO PCT/US1998/011407 patent/WO1998058260A1/en not_active Ceased
- 1998-06-15 JP JP50448299A patent/JP2002510392A/ja not_active Ceased
- 1998-06-15 DE DE69836272T patent/DE69836272T2/de not_active Expired - Fee Related
- 1998-06-15 AU AU82530/98A patent/AU8253098A/en not_active Abandoned
- 1998-06-16 GB GB9813023A patent/GB2323666B/en not_active Expired - Fee Related
- 1998-06-17 DE DE19826957A patent/DE19826957C2/de not_active Expired - Fee Related
- 1998-06-17 DE DE29810858U patent/DE29810858U1/de not_active Expired - Lifetime
-
1999
- 1999-05-07 US US09/306,994 patent/US6271045B1/en not_active Expired - Fee Related
-
2001
- 2001-06-07 US US09/875,297 patent/US6780651B2/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3686597A1 (en) * | 2014-09-30 | 2020-07-29 | Siemens Healthcare Diagnostics Inc. | Device for determining the amount of hemoglobin in a plasma fraction |
| EP4465017A3 (en) * | 2014-09-30 | 2025-01-22 | Siemens Healthcare Diagnostics Inc. | System for determining the amount of hemoglobin in a plasma fraction |
Also Published As
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|---|---|
| GB2323666B (en) | 1999-09-22 |
| JP2002510392A (ja) | 2002-04-02 |
| US5948695A (en) | 1999-09-07 |
| GB2323666A (en) | 1998-09-30 |
| US6780651B2 (en) | 2004-08-24 |
| DE29810858U1 (de) | 1998-09-24 |
| US20020052050A1 (en) | 2002-05-02 |
| WO1998058260A1 (en) | 1998-12-23 |
| EP0993614B1 (en) | 2006-10-25 |
| AU8253098A (en) | 1999-01-04 |
| EP0993614A4 (en) | 2004-10-13 |
| DE19826957C2 (de) | 2001-11-08 |
| DE19826957A1 (de) | 1998-12-24 |
| GB9813023D0 (en) | 1998-08-12 |
| EP0993614A1 (en) | 2000-04-19 |
| DE69836272D1 (de) | 2006-12-07 |
| US6271045B1 (en) | 2001-08-07 |
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