CN111905188B - 流体输送和输注装置及其使用方法 - Google Patents

流体输送和输注装置及其使用方法 Download PDF

Info

Publication number
CN111905188B
CN111905188B CN202010932203.XA CN202010932203A CN111905188B CN 111905188 B CN111905188 B CN 111905188B CN 202010932203 A CN202010932203 A CN 202010932203A CN 111905188 B CN111905188 B CN 111905188B
Authority
CN
China
Prior art keywords
fluid
infusion
fluid reservoir
reservoir
medical device
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN202010932203.XA
Other languages
English (en)
Other versions
CN111905188A (zh
Inventor
K·G·施密德
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Insulet Corp
Original Assignee
Insulet Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Insulet Corp filed Critical Insulet Corp
Publication of CN111905188A publication Critical patent/CN111905188A/zh
Application granted granted Critical
Publication of CN111905188B publication Critical patent/CN111905188B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
    • A61M5/14248—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body of the skin patch type
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/172—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic
    • A61M5/1723—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic using feedback of body parameters, e.g. blood-sugar, pressure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M2005/1401—Functional features
    • A61M2005/1402—Priming
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M2005/14208—Pressure infusion, e.g. using pumps with a programmable infusion control system, characterised by the infusion program
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
    • A61M5/14248—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body of the skin patch type
    • A61M2005/14252—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body of the skin patch type with needle insertion means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/158—Needles for infusions; Accessories therefor, e.g. for inserting infusion needles, or for holding them on the body
    • A61M2005/1585—Needle inserters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/172—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic
    • A61M5/1723—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic using feedback of body parameters, e.g. blood-sugar, pressure
    • A61M2005/1726—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic using feedback of body parameters, e.g. blood-sugar, pressure the body parameters being measured at, or proximate to, the infusion site

Landscapes

  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

本发明涉及流体输送和输注装置及其使用方法。一种医疗装置，包括：输注装置，所述输注装置包括流体储存器和流体地联接到所述流体储存器的经皮接入工具，所述经皮接入工具构造成将治疗流体输送至患者皮下，其中，所述输注装置在所述治疗流体被引入到所述流体储存器之前以待机模式操作，以及在用所述治疗流体将所述流体储存器填充到预定的填充水平期间以所述待机模式操作，其中，所述输注装置能够操作以产生指示所述流体储存器已经被填充的信号，以及在产生指示所述流体储存器已经被填充的所述信号时，所述输注装置利用所述信号来导致在预定的输注延迟时间段之后来自所述流体储存器的所述治疗流体的输注。

Description

流体输送和输注装置及其使用方法
本申请是名称为“流体输送和输注装置及其使用方法”、国际申请日为2016年2月18日、国际申请号为PCT/US2016/018452、国家申请号为201680016631.X的发明专利申请的分案申请。
相关申请的交叉引用
本申请要求于2015年2月18日提交的美国临时申请第62/117,937号的权益，其全部内容通过引用并入本文。
技术领域
本发明涉及医疗装置，例如用于将治疗液体输送到患者的流体输送装置，更具体地，本发明涉及用于将治疗液体输送到患者的输注泵。
背景技术
流体输送装置具有许多用途，例如将液体药物或其它治疗流体输送到患者皮下。在患有糖尿病的患者中，例如，已经使用便携式输注泵将胰岛素输送到患者。这些便携式输注泵具有提供复杂的流体输送特性的能力，包括可变的基础速率和推注要求。仔细控制药物输送的能力可以使得药物和治疗具有更好的疗效，并且对患者的毒性更小。
一些现有的便携式输注泵包括用于容纳液体药物的储存器，并且使用机电泵送或计量技术将液体药物通过管道输送到插入患者皮下的针和/或软套管。这些现有装置允许通过位于装置外壳上的机电按钮或开关进行控制和编程。装置包括通过文本或图形屏幕的视觉反馈，并且可以包括警报或警告灯以及音频或振动信号和报警。这种装置通常被穿戴在线束或口袋中或者绑在患者身上。
已经将一些输注泵设计成相对较小、成本低、重量轻且易于使用。这种泵的一个例子是可从Insulet Corporation获得的
Figure BDA0002670603890000021
胰岛素输注泵。还例如在美国专利号7,128,727；7,018,360；和7,144,384以及美国专利申请公开号2007/0118405、2006/0282290、2005/0238507和2004/0010207中更详细地描述输注泵的示例，这些文献的全部内容通过引用并入本文。这些泵包括插入机构，用于使经皮接入工具(例如，针和/或软套管)插入患者体内。尽管这样的泵是有效的并且提供了优于其它胰岛素输注泵的显著优点，但是可以改进插入机构的设计，例如以减小泵的尺寸和/或提高使用者的舒适度。这些泵还包括流体驱动机构，用于将来自储存器的流体驱动通过经皮接入工具。还可以改进流体驱动机构以便于泵的组装和使用。
发明内容
本公开提供了各种流体输送装置，用于将液体药物或其它治疗流体输送至患者皮下。
在某些实施例中，流体输送装置可以包括向患者施用液体药物或其它治疗流体的便携式输注装置。流体输送装置可以包括用于提供电源的一个或多个电池、用于保持流体的流体储存器、用于将流体驱出储存器的流体驱动机构、用于从储存器接收流体并通过经皮接入工具将流体输送到目的地的流体通道机构、以及用于部署经皮接入工具的经皮接入工具插入机构。
在某些实施例中，输注装置可以包括：用于容纳治疗流体的流体储存器；以及流体地联接到流体储存器的经皮接入工具，经皮接入工具可以将治疗流体输送到皮下并且将监测测试条引入皮下。
在某些实施例中，可以提供治疗患者的方法，方法包括提供具有综合监测的输注装置，其中，输注装置包括：用于容纳治疗流体的流体储存器；以及流体地联接到流体储存器的经皮接入工具，经皮接入工具可以将治疗流体输送到皮下并且将监测测试条引入皮下；用经皮接入工具将治疗流体输送到患者皮下，并且用经皮接入工具将监测测试条引入患者皮下。
在某些实施例中，经皮接入工具包括针/套管针，并且经皮接入工具插入机构构造成在单次不间断运动中插入和缩回针/套管针。以这种方式，患者经历的针/套管针的插入和缩回的疼痛可以降低。
在某些实施例中，流体输送装置可以包括：流体储存器；流体地联接到流体储存器的经皮接入工具，经皮接入工具包括针/套管针；以及用于部署经皮接入工具的经皮接入工具插入机构，其中，插入机构构造成在单次不间断运动中插入和缩回针/套管针。
在某些实施例中，流体输送装置可以包括：流体储存器；流体地联接到流体储存器的经皮接入工具，经皮接入工具包括至少一个针/套管针；以及用于部署经皮接入工具的经皮接入工具插入机构，其中，插入机构构造成当针/套管针沿着插入方向移动时利用增加的插入力插入针/套管针。
在某些实施例中，用于部署包括套管和位于套管内部的针/套管针的经皮接入工具的经皮接入工具插入机构可以包括：构造成沿着插入方向和缩回方向移动针/套管针的第一滑动构件；构造成沿着插入方向移动套管的第二滑动构件；扭簧；以及连杆，连杆联接在扭簧和第一滑动构件之间，使得存储在扭簧中的能量使连杆沿着插入方向和缩回方向移动第一滑动构件。
在某些实施例中，驱动机构可以包括离合机构。如本文所解释的，通过使用离合机构，可以减少灌注泵的流体路径灌注脉冲的数量，并且可以更好地确保在放置在身体上之前流体路径的充分且适当的灌注。离合机构还可以适合于其它药物应用而不需要显著的重新设计，并且比用于输注装置的常规驱动机构更容易检查。
在某些实施例中，流体输送装置可以包括：流体储存器；流体地联接到流体储存器的经皮接入工具；以及用于从储存器驱动流体的驱动机构。驱动机构可以包括：接收在储存器中的柱塞；从柱塞延伸的丝杠；与丝杠螺纹啮合的螺母；驱动轮；以及联接到驱动轮的离合机构，其中，离合机构构造成在分离时允许螺母穿过离合机构，并且构造成在接合时夹紧螺母，使得驱动轮旋转螺母以将丝杠和柱塞推进到储存器中。
在某些实施例中，流体输送装置可以包括：流体储存器；流体地联接到流体储存器的经皮接入工具；以及用于从储存器驱动流体的驱动机构。驱动机构可以包括：接收在储存器中的柱塞；包括第一伸长构件和第二伸长构件的伸长组件；第一伸长构件从柱塞延伸；第二伸长构件联接到第一伸长构件；驱动轮；以及联接到驱动轮的离合机构，其中，离合机构构造成在分离时允许第二伸长构件穿过，并且构造成在接合时夹紧第二伸长构件，使得驱动轮旋转第二伸长构件以将第一伸长构件和柱塞推进到储存器中。
在某些实施例中，操作前述流体输送装置的方法可以包括：提供流体输送装置；将离合机构保持在分离位置；用流体填充流体储存器；使第二伸长构件穿过离合机构，使得柱塞在储存器内缩回；从分离位置释放离合机构；并且使离合机构与第二伸长构件接合。
在某些实施例中，本公开提供了包括输注装置的医疗装置，输注装置包括用于容纳治疗流体的流体储存器和流体地联接到流体储存器的经皮接入工具，经皮接入工具构造成将治疗流体输送到患者皮下；其中，在治疗流体被引入到流体储存器之前输注装置以待机模式操作；其中，在用治疗流体将流体储存器填充到预定的填充水平时输注装置操作以在预定的部署时间段内部署经皮接入工具。
在某些实施例中，预定的部署时间段可以大于或等于30秒，和/或预定的部署时间段可以小于或等于15分钟。在其它实施例中，经皮接入工具引入时间段可以大于或等于1分钟，和/或小于或等于10分钟。在其它实施例中，经皮接入工具引入时间段可以大于或等于2分钟，和/或小于或等于5分钟。
在某些实施例中，输注装置可以包括非暂时性存储器，非暂时性存储器包括存储的指令，当指令被至少一个处理器执行时，指令使得输注装置在预定的部署时间段内部署经皮接入工具。
在某些实施例中，输注装置可以包括至少一个传感器，其中，当流体储存器中的治疗流体达到预定的填充水平时，所述至少一个传感器可以通过向所述至少一个处理器发送输入信号来操作。
在某些实施例中，所述至少一个处理器可以通过检测来自所述至少一个传感器的输入信号来操作，并且在检测到来自所述至少一个传感器的输入信号时，所述至少一个处理器可以操作以执行指令，指令使得输注装置在预定的部署时间段内部署经皮接入工具。
在某些实施例中，输注装置可以操作以在预定的输注延迟时间段之后将流体储存器中的治疗流体输送通过经皮接入工具。输注装置可以操作以在经皮接入工具被部署时开始预定的输注延迟时间段。预定的输注延迟时间段可以是至少1小时、至少8小时、至少16小时或至少20小时。
在某些实施例中，提供了治疗患者的方法，方法包括：将治疗流体引入到输注装置，其中，输注装置包括容纳治疗流体的流体储存器以及流体地联接到流体储存器的经皮接入工具，经皮接入工具用于将治疗流体输送至患者皮下；将输注装置固定到患者；将经皮接入工具引入到患者；用经皮接入工具将治疗流体输送至患者皮下；其中，在将治疗流体引入到输注装置之后在经皮接入工具引入时间段内将经皮接入工具引入到患者，其中，经皮接入工具引入时间段大于或等于30秒，并且小于或等于15分钟。
在某些实施例中，输注装置可以包括非暂时性存储器，非暂时性存储器构造成存储指令，当指令被至少一个处理器执行时，指令使得输注装置在治疗流体被引入到输注装置之后在经皮接入工具引入时间段内将经皮接入工具引入到患者。
在某些实施例中，输注装置可以包括传感器，当容纳在流体储存器中的流体达到预定水平时，传感器发送由所述至少一个处理器检测的输入信号。
在某些实施例中，来自传感器的输入信号可以使得所述至少一个处理器执行指令，指令使得输注装置在治疗流体被引入到输注装置之后在经皮接入工具引入时间段内将经皮接入工具引入到患者。
在某些实施例中，经皮接入工具引入时间段可以大于或等于1分钟，和/或小于或等于10分钟。在某些实施例中，经皮接入工具引入时间段可以大于或等于2分钟，和/或小于或等于5分钟。
在某些实施例中，输注装置可以在经皮接入工具被引入到患者时开始的输注延迟时间段之后用经皮接入工具将治疗流体输送到患者皮下，其中，预定时间段为至少1小时。在某些实施例中，输注延迟时间段可以是至少8小时、至少16小时或至少20小时。
附图说明
通过阅读下面的详细描述以及附图，将更好地理解这些和其它特征和优点，其中：
图1是与本公开一致的流体输送装置的顶部透视图，其中，经皮接入工具插入机构处于部署前位置；
图2是缩回到图1所示的处于部署前位置的流体输送装置中的针和套管的底部透视图；
图3是图1所示的流体输送装置的顶部透视图，其中，插入机构处于中间位置；
图4是从图3所示的处于中间位置的流体输送装置延伸的针和套管的底部透视图；
图5是图1所示的流体输送装置的顶部透视图，其中，插入机构处于部署后位置；
图6是从图5所示的处于部署后位置的流体输送装置延伸的套管的底部透视图；
图7是与本公开一致的处于部署前位置的插入机构的另一实施例的侧透视图；
图8是处于中间位置的图7所示的插入机构的侧透视图；
图9是处于部署后位置的图7所示的插入机构的侧透视图；
图10是锁定在部署前位置和部署后位置的图7所示的插入机构的第二滑动构件的顶部透视图；
图11是图1所示的流体输送装置的流体驱动机构在填充之前的顶部透视图，其中，离合机构处于分离位置；
图12是图11所示的流体驱动机构的侧剖视图；
图13是图11所示的流体驱动机构在填充之后的顶部透视图，其中，离合机构处于分离位置；
图14是图11所示的流体驱动机构的顶部透视图，其中，离合机构被释放到接合位置；以及
图15和16是图11所示的流体驱动机构的顶部透视图，其中，离合机构处于接合位置。
图17-23是在图1-6所示的流体输送装置中使用以经皮地插入监测测试条的双内腔套管的视图；
图24-29是流体输送装置的另一实施例的视图，其包括具有D形内腔的套管，用于经皮地插入监测测试条；
图30-32是在图24-29的流体输送装置中使用的D形内腔套管的视图；
图33和34是与图18-23的流体输送装置中的D形内腔套管一起使用的半圆形套管针的视图；
图35-41是流体输送装置的另一实施例的视图，其包括椭圆形套管针，用于经皮地插入监测测试条；
图42是用于在图35-41所示的流体输送装置中使用的椭圆形套管针的侧视图；
图43是用于在图35-41所示的流体输送装置中使用的第二滑动构件的顶部透视图。
具体实施方式
与本公开的实施例一致的流体输送装置可以用于通过经皮接入工具(例如，针/套管针和/或套管)向患者输送治疗流体(例如，液体药物)。可以使用经皮接入工具插入机构来部署经皮接入工具，例如，通过在单次不间断运动中插入和缩回针/套管针来部署。随着针/套管针沿着插入方向移动，插入机构还可以提供增加的插入力。流体输送装置还可以包括离合机构，以便于填充储存器和接合用于将流体驱出储存器的驱动机构。在某些实施例中，流体输送装置可以包括便携式输注装置。
在其它实施例中，流体输送装置可以用于将治疗流体输送到具有综合监测的患者。在这些实施例中，流体输送装置可以包括经皮接入工具，经皮接入工具构造成例如使用一个或多个针、套管和/或套管针将监测测试条引入穿过患者皮肤。
参考图1-6，示出并描述了流体输送装置100的一个实施例。在示例性实施例中，流体输送装置100用于向人或动物皮下输送诸如液体药物的流体。本领域技术人员将认识到流体输送装置100可以用于输送其它类型的流体。流体输送装置100可以用于以受控的方式(例如，根据实现剂量要求的流体输送特性、连续输注和可变流量输送)输送流体。
根据一个实施例，流体输送装置100可以包括用于提供电源的一个或多个电池110、用于保持流体的流体储存器130、用于将流体驱出储存器130的流体驱动机构150、用于从储存器130接收流体并通过经皮接入工具172将流体输送到目的地的流体通道机构170、以及用于部署经皮接入工具172的经皮接入工具插入机构180。流体输送装置100可以包括具有用于控制装置的控制电路的电路板101和在流体输送装置100的部件之间提供机械和/或电气连接的底盘102。流体输送装置100还可以包括壳体104以包封电路板101、底盘102以及部件110、130、150、170、180。
流体输送装置100还可以包括综合监测。联接到装置100中的监视器(未示出)的监测测试条120可以通过经皮接入工具172引入皮下。流体输送装置100可以构造成从监测测试条接收关于患者的一个或多个生理状况的数据。例如，流体输送装置100可以构造成从监测测试条接收关于患者的葡萄糖水平的数据，并且基于葡萄糖水平确定从储存器的流体(诸如，胰岛素)的输出。监测测试条的一个示例是CGM测试条(例如，可从Nova Biomedical获得的类型)，其可以被理解为构造成测试患者血液中葡萄糖的浓度水平的葡萄糖传感器。
经皮接入工具172包括引入套管针或针174，引入套管针或针至少部分地定位在套管176(例如，软的柔性套管)的内腔175内，套管的内腔能够将流体输送到患者。特别地，引入针/套管针174可以初始地穿透皮肤，使得引入针/套管针174和套管176二者都被引入(插入)到患者，并且引入针/套管针174然后可以缩回到套管内使得套管176保持插入。诸如管道178的流体路径将储存器130流体地联接到经皮接入工具172的套管176的内腔175。经皮接入工具172还可以用于将监测测试条引入患者皮下以用于监测目的，如下面更详细描述的那样。
经皮接入工具插入机构180联接到经皮接入工具172以部署经皮接入工具172，例如，通过将针/套管针174和套管176插入穿过患者皮肤并缩回针/套管针174。在图示的实施例中，插入机构180包括弹簧偏压的连杆机构182和分别联接到针/套管针174和套管176的滑动构件184、186，用于沿着插入方向移动针/套管针174和套管176并且用于沿着缩回方向移动针/套管针174。在单次不间断运动中，弹簧偏压的连杆机构182从部署前位置(图1)移动到中间位置(图3)并且移动到部署后位置(图5)，在部署前位置中，针/套管针174和套管176二者均缩回(图2)，在中间位置中，针/套管针174和套管176二者均插入(图4)，在部署后位置中，针/套管针174缩回并且套管176插入(图6)。
弹簧偏压的连杆机构182的一个实施例包括螺旋扭簧181和联接在扭簧181和第一滑动构件184之间的第一连杆183a和第二连杆183b。储存在扭簧181中的能量向连杆183a、183b施加力，连杆向第一滑动构件184施加力以沿着插入方向和缩回方向移动第一滑动构件184。在部署前的位置(图1)中，扭簧181被加载，并且滑动构件184、186被锁定并阻止移动。当滑动构件184、186被释放时，存储在扭簧181中的能量使得第一连杆183a旋转(例如，如图所示顺时针)，第一连杆通过第二连杆183b向第一滑动构件184施加力，使得带有针/套管针174的第一滑动构件184(与第二滑动构件186一起)沿着插入方向移动。在中间位置(图3)中，连杆183a、183b完全伸展，并且针/套管针174和套管176被插入，第二滑动构件186被锁定，并且存储在扭簧181中的剩余能量使得第一连杆183a继续旋转，第一连杆通过第二连杆183b向第一滑动构件184施加相反的力，使得带有针/套管针174的第一滑动构件184沿着缩回方向移动到部署后位置(图5)。在所示的实施例中，第二滑动构件186被一个或多个锁止部187锁定以阻止缩回。因此，以上述方式，通过扭簧181的能量的第一连杆183a的连续不间断的顺时针旋转向经皮接入工具插入机构180提供在单次不间断运动中插入和缩回针/套管针174的能力。
弹簧偏压的连杆机构182允许单个弹簧和单次运动来实现插入和缩回并且具有相对较小的尺寸。由于连杆183a、183b引导(vector)施加到滑动构件184、186的力的方式，弹簧偏压的连杆机构182还减少了由锁定和阻止(holding back)滑动构件184、186而引起的静态应力，并且提供了更平顺且更舒适的针/套管针插入。当连杆183a、183b完全缩回时，在部署前位置中，滑动构件184、186上的静态力相对较小。当部署开始并且连杆183a、183b开始变得伸展时，因为随着连杆183a、183b伸展，力矢量在插入方向上增加，所以插入力增加，直到在完全伸展的中间位置处达到最大插入力。通过逐渐增加插入力，针/套管针插入和缩回更平顺、更安静且更少疼痛。
在图7-10中更详细地示出了插入机构280的另一实施例。滑动构件284、286可滑动地接收在框架290中，并且由包括扭簧281和连杆283a、283b的弹簧偏压的连杆机构282移动。在该实施例中，抵靠(cam)指部292(例如，从框架290延伸)接合在滑动构件284、286中的一个或两个的下方，以将滑动构件锁定在缩回或部署前位置(图7)。在该部署前的位置中，抵靠指部292通过释放杆296保持抵靠滑动构件284、286，释放杆可以被移动(旋转)以允许抵靠指部292移动并释放滑动构件284、286(图8)。抵靠指部292可以沿向下方向偏压和/或第二滑动构件286可以包括抵靠(cam)表面287，以有助于在致动时在锁定机构293上沿着抵靠指部292移动。
释放杆296包括杆297，用于使释放杆296在抵靠抵靠指部292的接合位置(图7)和释放抵靠指部292的分离位置(图8)之间枢转。释放杆296可以朝向分离位置偏置并且在接合位置中保持抵靠抵靠指部292，直到杆297被释放，从而允许释放杆296移动到分离位置。在所示的实施例中，杆297接合流体驱动机构150的驱动轮256的旋转表面257，使得在部分旋转时杆297被保持在接合位置，并且在旋转期间的某一时刻杆被释放(例如，当旋转表面257的平坦部分允许杆297移动时)。
如图9和10所示，抵靠指部292还可以用于将第二滑动构件286锁定在插入位置。当连杆机构282在中间位置完全伸展并且防止第二滑动构件286缩回而使得套管保持插入时，第二滑动构件286的锁定部分288接合抵靠指部292的锁定部分293。如上所述，第二滑动构件286还可以由从框架290的顶部延伸的一个或多个锁止部(未示出)锁定。
参考图11-16，流体驱动机构150的一个实施例使用离合机构160来促进填充储存器130和接合用于将流体驱出储存器130的流体驱动机构150。流体驱动机构150包括呈伸长轴形式的第一螺纹构件(例如，螺纹驱动杆或丝杠152)，其具有从柱塞136延伸的外螺纹，柱塞接收在储存器130中并且用O形环137相对于储存器130的内表面密封。丝杠152和柱塞136可以是不可分离的插入模制的组件。呈伸长轴形式的第二螺纹构件(例如，具有内螺纹的管螺母154)螺纹啮合丝杠152，并且可以通过离合机构160由驱动轮156驱动。
当储存器130为空时(图11和12)，柱塞136定位在储存器130的一端处，使得柱塞136伸展并且离合机构160分离。在某些实施例中，储存器130可以通过打开通向储存器130的入口端口并在足够的液压压力下泵入流体以使柱塞136在储存器130内缩回来填充流体。之后，入口端口可以关闭。当储存器130被填充并且柱塞136移动到储存器130的相对(缩回)端时(图13)，离合机构160保持分离，以允许管螺母154进入驱动轮156的毂的伸长圆柱形孔(沿着驱动轴线)。然后，离合机构160可以接合(图14-16)，使得驱动轮156的旋转致使离合机构160旋转管螺母154，这导致丝杠152将柱塞推进到储存器130中以从储存器130输送流体。在替代实施例中，可以在柱塞136已经缩回时填充储存器130。
在所示的实施例中，离合机构160包括离合弹簧162(例如，螺旋扭簧)，离合弹簧位于驱动轮156的与储存器130相邻的一端处的沉头孔中。当离合弹簧162被加载时，离合弹簧的内径162大于管螺母154的外径，从而使离合弹簧162与管螺母154分离，并且允许管螺母154穿过弹簧162的中心孔并进入驱动轮156的伸长孔中。替代地，当离合弹簧162卸载时，离合弹簧162的内径小于管螺母154的外径，从而接合或夹紧管螺母154并允许驱动轮156旋转管螺母154。在图示的实施例中，在填充储存器130之前，离合弹簧162通过与驱动轮156接合的弹簧闩164保持在加载的分离位置(图11-13)。在储存器130已经被填充之后，因此可以通过旋转驱动轮156直到弹簧闩164释放离合弹簧162而使离合弹簧162接合(图14)，从而允许离合弹簧162卸载并夹紧管螺母154(图15和16)，此时可以通过驱动轮156的持续旋转从储存器130分配流体。
如图所示，弹簧闩164可以被离合弹簧162偏压，使得随着驱动轮156旋转，弹簧闩164抵靠储存器盖132的表面旋转地移动，直到离合弹簧162将弹簧闩164偏移到储存器盖132中的窗部133中。当弹簧闩164移动到窗部133中时，离合弹簧162的由弹簧闩164保持的端部被释放，从而使离合机构160接合。当离合弹簧162接合时，驱动轮156接触离合弹簧162的端部163，以在离合弹簧162上产生推力，推力致使离合弹簧162旋转管螺母154。流体驱动机构150还可以使用能够允许管螺母154或其它类型的螺母或螺纹构件穿过离合机构然后被激活以接合螺母或螺纹构件的其它离合机构。
在所示的实施例中，驱动轮156包括棘轮157，棘轮由致动器158接合以递增地驱动轮156并将柱塞136推进到储存器130中。该致动机构的示例在美国专利申请公开号2005/0238507中更详细地描述，其全部内容通过引用并入本文。
通过使用离合机构，在组装时发生丝杠和螺母之间的啮合，因此不需要螺母旋转以通过装置的操作来啮合丝杠。这减少了灌注泵的流体通道灌注脉冲的数量，并且确保了在放置在身体上之前流体路径的充分且适当的灌注。离合机构还使得能够改变螺距以用于其它药物应用，而不需要重新设计在其它现有泵中的流体驱动机构中使用的倾斜螺母。离合机构的部件也比倾斜螺母组件更容易检查。
根据一个实施例，如图17-23所示，提供用于输送流体的经皮接入的套管176还可以用于引入监测测试条120。在该实施例中，套管176包括用于接收针/套管针174的第一内腔175和用于接收测试条120的第二内腔177。如图所示，第一内腔175具有圆形(圆柱形)轮廓，第二内腔177具有矩形轮廓。套管176还可以包括一个或多个窗部179a、179b，其提供通向测试条120上的一个或多个传感器122a、122b的通道。如图所示，套管176的所述多个窗部179a、179b可以布置在套管176的侧壁的同一侧上，其中，所布置的第一窗部179a与套管176的远端尖端的距离小于第二窗部179b与套管176的远端尖端的距离。
为了将测试条120插入第二内腔177中，测试条120在套管176的头部178处进入第二内腔177并延伸到窗部179a、179b。因此，至少一个窗部179a、179b暴露监测测试条120的传感器122a、122b。在示例性实施例中，设置有两个窗部179a、179b，其中，最靠近套管176的尖端的窗部179a提供通向主传感器区域的通道，距离尖端最远的窗部179b提供基准。尽管示出了双内腔套管的具体形状和构造，但是也可以使用其它构造的具有第一内腔和第二内腔的套管来输送治疗流体和将测试条引入皮下。
根据另一实施例，如图24-34所示，流体输送装置300可以包括经皮接入工具372，其具有用于输送流体的第一套管376和用于引入测试条320的第二套管377。第一套管376接收第一针/套管针374(示出为圆形针)，以便于插入第一套管376，并且第二套管377接收第二针/套管针375(示出为半圆形套管针)，以便于插入第二套管377。流体输送装置300包括与上述第一实施例类似的插入机构380，但是其中滑动构件384、386联接到针374和套管针375二者以及套管376、377二者。插入机构380以与上述方式相同的方式插入第二套管377和套管针375，然后缩回套管针375。在套管针375缩回之后，测试条320保持插入。因此，第一针/套管针374和第二针/套管针375二者可以同时引入到患者，特别是为了减少顺序插入的疼痛。
与上述实施例类似，第一套管376包括圆形(圆柱形)内腔376a。如图30-32中更详细所示，第二套管377包括半圆形(D形)内腔377a，以允许监测条在套管377内安置得相对平坦。第二套管377还包括一个或多个窗部379a、379b，其提供通向测试条320上的一个或多个传感器320a、320b的通道(参见图27和29)。如图所示，类似于先前的实施例，套管377的所述多个窗部379a、379b可以布置在套管377的侧壁的同一侧上，其中，所布置的第一窗部379a与套管377的远端尖端的距离小于第二窗部379b与套管377的远端尖端的距离。因此，至少一个窗部379a、379b暴露监测测试条320的传感器320a、320b。在示例性实施例中，设置有两个窗部379a、379b，其中，最靠近套管377的尖端的窗部379a提供通向主传感器区域的通道，并且距离尖端最远的窗部379b提供基准。如图33和34中更详细所示，套管针375具有对应于D形内腔377a的形状，以允许套管针375缩回并且保持测试条320插入(参见图29)。如图所示，套管针包括对应于平面测试条320的平面侧表面373，使得当组装时，平面测试条320可以位于第二套管377中的套管针375的平面侧表面373附近。
根据另一实施例，如图35-43所示，流体输送装置400可以包括经皮接入工具472，其具有用于输送流体的套管476和用于引入测试条420的针或套管针475(示出为半圆形套管针)。套管476接收针/套管针474(示出为圆形针)以便于套管476的插入，并且套管针475与测试条420一起插入。流体输送装置400包括类似于上述第一实施例的插入机构480，但是其中滑动构件484、468联接到针474和套管针475二者。插入机构480以与上述针/套管针相同的方式插入套管针475(图37和38)，然后缩回套管针475(图39和40)。在套管针475缩回之后，测试条420保持插入(图41)。与先前的实施例不同，针/套管针475仅将监测测试条420引入皮下(即，不利用套管来引入监测测试条420)。
在图42中更详细地示出了套管针475。在图43中更详细地示出了第二滑动构件486。在该实施例中，第二滑动构件486设计成捕获套管476，并且设计成接收套管针475并允许其穿过。
因此，流体输送装置的各种实施例可以使用经皮接入工具来输送流体和将测试条引入皮下以提供综合监测。
在某些实施例中，本公开的流体输送装置100(或300或400)的操作序列可以基于用流体将流体储存器130填充到预定的填充水平而自动地触发或以其它方式开始。例如，流体储存器130可以包括提供流体填充水平的反馈的流体填充传感器，流体填充水平的反馈可以作为存储在非暂时性存储器中并由计算机处理器运行的计算机指令程序的输入，计算机处理器随着流体输送装置100的电路板101储放和定位。
在流体储存器130被填充流体之前，流体输送装置100(更具体地，计算机处理器)可以处于待机(例如，睡眠)模式。一旦计算机处理器检测到来自流体填充传感器的输入信号(流体储存器130中的流体已经达到预定的填充水平)，则计算机处理器可以执行计算机程序，计算机程序包括指令以在经皮接入工具引入时间段内自动地操作经皮接入工具插入机构180，经皮接入工具引入时间段也可以被理解为预定的部署时间段，即，填充流体储存器130与针/套管针174和套管176穿过患者皮肤之间的时间段。
例如，临床医生可以在诊所处用治疗流体填充流体储存器130，这导致流体填充传感器发送由计算机处理器检测的关于流体储存器130的填充状态的输入信号。在接收到来自流体填充传感器的输入信号时，正由计算机处理器运行的用于流体输送装置100的操作计算机程序可以指示流体输送装置100在经皮接入工具引入时间段内操作经皮接入工具插入机构180。在经皮接入工具引入时间段期间，临床医生可以将流体输送装置100适当地放置和定位在患者上。经皮接入工具引入时间段应该足够长以将流体输送装置100适当地安装在患者上，但不要太长以至于临床医生和患者必须等待相当长的时间以便经皮接入工具插入机构180操作。
在某些实施例中，经皮接入工具引入时间段可以大于或等于30秒，并且小于或等于15分钟。更具体地，经皮接入工具引入时间段可以大于或等于1分钟，并且小于或等于10分钟。更具体地，经皮接入工具引入时间段可以大于或等于2分钟，并且小于或等于5分钟。
还可以期望在将针/套管针174和套管176插入穿过患者皮肤之后对输注的开始延迟输注延迟时间段。例如，如果来自流体储存器130的流体可能与已经存在于患者体内的第一组合物(例如，另一种治疗组合物，其也可以是治疗流体)不利地反应或因其而导致不太有效，则可以期望延迟输注这样的流体。
在这种情况下，可以期望自动地延迟输注来自流体储存器130的流体，直到与第一治疗组合物引入到患者时患者体内的浓度水平相比，患者体内的第一治疗组合物降低至所述浓度水平的小于20％(并且更特别地小于10％，甚至更特别地小于5％)的水平。
假设可能不能准确地预测患者体内的治疗组合物的浓度降低速率，则可以期望对来自流体储存器130的流体的输注延迟预定的输注延迟时间段。
例如，将针/套管针174和套管176插入穿过患者皮肤和输注来自流体储存器的流体之间的输注延迟时间段可以是至少1小时。在其它实施例中，输注延迟时间段可以是至少2小时、至少4小时、至少8小时、至少12小时、至少16小时、至少20小时、至少24小时、至少28小时、至少32小时、至少36小时、至少40小时、至少44小时、至少48小时、至少52小时、至少56小时、至少60小时、至少64小时、至少68小时或至少72小时。
虽然本文已经描述了本发明的原理，但是本领域技术人员应当理解，该描述仅通过示例作出而不是作为对本发明的范围的限制。除了本文所示和描述的示例性实施例之外，还考虑了本发明的范围内的其它实施例。本领域普通技术人员进行的修改和替换被认为是在本发明的范围内，除了所附权利要求之外，范围不受限制。

Claims (12)

1.一种医疗装置，包括：
输注装置，所述输注装置包括流体储存器和流体地联接到所述流体储存器的经皮接入工具，所述经皮接入工具构造成将治疗流体输送至患者皮下，
其中，所述输注装置在所述治疗流体被引入到所述流体储存器之前以待机模式操作，以及在用所述治疗流体将所述流体储存器填充到预定的填充水平期间以所述待机模式操作，
其中，所述输注装置能够操作以产生指示所述流体储存器已经被填充的信号，以及在产生指示所述流体储存器已经被填充的所述信号时，所述输注装置在来自所述流体储存器的所述治疗流体的输注之前等待预定的输注延迟时间段。
2.根据权利要求1所述的医疗装置，其中，所述输注装置包括非暂时性存储器，非暂时性存储器包括存储的指令程序，当被至少一个处理器执行时，所述指令程序使得所述输注装置在所述预定的输注延迟时间段之后从所述流 体储存器输注所述治疗流体。
3.根据权利要求2所述的医疗装置，其中，所述输注装置包括至少一个传感器，其中，所述至少一个传感器通过响应于所述流体储存器被填充到预定的填充水平的发生而向所述至少一个处理器发送输入信号来操作。
4.根据权利要求3所述的医疗装置，其中，所述至少一个处理器通过检测来自所述至少一个传感器的所述输入信号来操作，以及在检测到来自所述至少一个传感器的所述输入信号时，所述至少一个处理器操作以执行所述存储的指令程序 ，所述指令程序 使得所述输注装置等待直到所述预定的输注延迟时间段之后以从所述流 体储存器输注所述治疗流体。
5.根据权利要求1所述的医疗装置，其中，所述预定的输注延迟时间段大于或等于60分钟。
6.根据权利要求1所述的医疗装置，其中，所述预定的输注延迟时间段大于或等于2小时。
7.根据权利要求1所述的医疗装置，其中，所述预定的输注延迟时间段为至少8小时。
8.根据权利要求1所述的医疗装置，其中，所述预定的输注延迟时间段为至少24小时。
9.根据权利要求1所述的医疗装置，其中，所述预定的输注延迟时间段是足以使得已经在患者体内的第一治疗组合物从当所述第一治疗组合物引入到患者时患者体内的第一浓度水平降低到患者体内的第二浓度水平的时间。
10.根据权利要求9所述的医疗装置，其中，所述第二浓度水平小于所述第一浓度水平的20％。
11.根据权利要求9所述的医疗装置，其中，所述第二浓度水平小于所述第一浓度水平的10％。
12.根据权利要求9所述的医疗装置，其中，所述第二浓度水平小于所述第一浓度水平的5％。
CN202010932203.XA 2015-02-18 2016-02-18 流体输送和输注装置及其使用方法 Active CN111905188B (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201562117937P 2015-02-18 2015-02-18
US62/117,937 2015-02-18
PCT/US2016/018452 WO2016134137A1 (en) 2015-02-18 2016-02-18 Fluid delivery and infusion devices, and methods of use thereof
CN201680016631.XA CN107405446B (zh) 2015-02-18 2016-02-18 流体输送和输注装置及其使用方法

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201680016631.XA Division CN107405446B (zh) 2015-02-18 2016-02-18 流体输送和输注装置及其使用方法

Publications (2)

Publication Number Publication Date
CN111905188A CN111905188A (zh) 2020-11-10
CN111905188B true CN111905188B (zh) 2022-07-22

Family

ID=56620628

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201680016631.XA Active CN107405446B (zh) 2015-02-18 2016-02-18 流体输送和输注装置及其使用方法
CN202010932203.XA Active CN111905188B (zh) 2015-02-18 2016-02-18 流体输送和输注装置及其使用方法

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CN201680016631.XA Active CN107405446B (zh) 2015-02-18 2016-02-18 流体输送和输注装置及其使用方法

Country Status (7)

Country Link
US (3) US10737024B2 (zh)
EP (2) EP3258991B1 (zh)
JP (1) JP2018505756A (zh)
CN (2) CN107405446B (zh)
AU (2) AU2016219961B2 (zh)
CA (1) CA2977053C (zh)
WO (1) WO2016134137A1 (zh)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1762259B1 (en) 2005-09-12 2010-09-08 Unomedical A/S Inserter for an infusion set with a first and second spring units
US7959598B2 (en) 2008-08-20 2011-06-14 Asante Solutions, Inc. Infusion pump systems and methods
MX2012011085A (es) 2010-03-30 2012-10-10 Unomedical As Dispositivo medico.
WO2012123274A1 (en) 2011-03-14 2012-09-20 Unomedical A/S Inserter system with transport protection
EP2583715A1 (en) 2011-10-19 2013-04-24 Unomedical A/S Infusion tube system and method for manufacture
AU2016219961B2 (en) * 2015-02-18 2020-07-02 Insulet Corporation Fluid delivery and infusion devices, and methods of use thereof
WO2017087888A1 (en) 2015-11-18 2017-05-26 President And Fellows Of Harvard College Systems and methods for monitoring, managing, and treating asthma and anaphylaxis
WO2017123525A1 (en) 2016-01-13 2017-07-20 Bigfoot Biomedical, Inc. User interface for diabetes management system
AU2017207484B2 (en) 2016-01-14 2021-05-13 Bigfoot Biomedical, Inc. Adjusting insulin delivery rates
EP3405230A1 (en) 2016-01-19 2018-11-28 Unomedical A/S Cannula and infusion devices
EP3509667B2 (en) * 2016-09-07 2023-04-26 Fresenius Vial SAS Infusion device having a clutching device
US10765807B2 (en) 2016-09-23 2020-09-08 Insulet Corporation Fluid delivery device with sensor
US11278665B2 (en) 2016-11-22 2022-03-22 Eitan Medical Ltd. Method for delivering a therapeutic substance
US11033682B2 (en) 2017-01-13 2021-06-15 Bigfoot Biomedical, Inc. Insulin delivery methods, systems and devices
EP3710082A1 (en) * 2017-11-14 2020-09-23 Sanofi Wireless electronics assembly for injection devices
USD928199S1 (en) 2018-04-02 2021-08-17 Bigfoot Biomedical, Inc. Medication delivery device with icons
JP7124120B2 (ja) 2018-05-04 2022-08-23 インスレット コーポレイション 制御アルゴリズムベースの薬物送達システムのための安全制約
EP3856285A1 (en) 2018-09-28 2021-08-04 Insulet Corporation Activity mode for artificial pancreas system
US11357909B2 (en) 2018-10-05 2022-06-14 Eitan Medical Ltd. Triggering sequence
WO2020077223A1 (en) 2018-10-11 2020-04-16 Insulet Corporation Event detection for drug delivery system
USD920343S1 (en) 2019-01-09 2021-05-25 Bigfoot Biomedical, Inc. Display screen or portion thereof with graphical user interface associated with insulin delivery
JP2020110485A (ja) * 2019-01-16 2020-07-27 キヤノンメディカルシステムズ株式会社 薬液投与装置
CN113950341B (zh) 2019-05-20 2024-03-19 优诺医疗有限公司 可旋转的输注装置及其方法
US11801344B2 (en) 2019-09-13 2023-10-31 Insulet Corporation Blood glucose rate of change modulation of meal and correction insulin bolus quantity
US11935637B2 (en) 2019-09-27 2024-03-19 Insulet Corporation Onboarding and total daily insulin adaptivity
WO2021066566A2 (ko) * 2019-10-04 2021-04-08 이오플로우(주) 약액 주입 장치
US11957875B2 (en) 2019-12-06 2024-04-16 Insulet Corporation Techniques and devices providing adaptivity and personalization in diabetes treatment
US11833329B2 (en) 2019-12-20 2023-12-05 Insulet Corporation Techniques for improved automatic drug delivery performance using delivery tendencies from past delivery history and use patterns
US11551802B2 (en) 2020-02-11 2023-01-10 Insulet Corporation Early meal detection and calorie intake detection
US11547800B2 (en) 2020-02-12 2023-01-10 Insulet Corporation User parameter dependent cost function for personalized reduction of hypoglycemia and/or hyperglycemia in a closed loop artificial pancreas system
US11986630B2 (en) 2020-02-12 2024-05-21 Insulet Corporation Dual hormone delivery system for reducing impending hypoglycemia and/or hyperglycemia risk
US11607493B2 (en) 2020-04-06 2023-03-21 Insulet Corporation Initial total daily insulin setting for user onboarding
US11684716B2 (en) 2020-07-31 2023-06-27 Insulet Corporation Techniques to reduce risk of occlusions in drug delivery systems
WO2022147985A1 (en) * 2021-01-05 2022-07-14 Medtrum Technologies Inc. A skin patch drug infusion device
US11904140B2 (en) 2021-03-10 2024-02-20 Insulet Corporation Adaptable asymmetric medicament cost component in a control system for medicament delivery
WO2023049900A1 (en) 2021-09-27 2023-03-30 Insulet Corporation Techniques enabling adaptation of parameters in aid systems by user input

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101489603A (zh) * 2006-06-30 2009-07-22 诺沃-诺迪斯克有限公司 在佩戴时间期间具有医疗输注补偿的灌注装置
WO2010147659A2 (en) * 2009-06-17 2010-12-23 Medtronic Minimed, Inc. Closed-loop glucose and/or insulin control system

Family Cites Families (577)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5935099A (en) 1992-09-09 1999-08-10 Sims Deltec, Inc. Drug pump systems and methods
US5338157B1 (en) 1992-09-09 1999-11-02 Sims Deltec Inc Systems and methods for communicating with ambulat
US2797149A (en) 1953-01-08 1957-06-25 Technicon International Ltd Methods of and apparatus for analyzing liquids containing crystalloid and non-crystalloid constituents
US3631847A (en) 1966-03-04 1972-01-04 James C Hobbs Method and apparatus for injecting fluid into the vascular system
US3634039A (en) 1969-12-22 1972-01-11 Thomas L Brondy Blood testing machine
US3841328A (en) 1972-08-04 1974-10-15 J Jensen Airplane hijacking injector
US3812843A (en) 1973-03-12 1974-05-28 Lear Siegler Inc Method and apparatus for injecting contrast media into the vascular system
US4146029A (en) 1974-04-23 1979-03-27 Ellinwood Jr Everett H Self-powered implanted programmable medication system and method
US3963380A (en) 1975-01-06 1976-06-15 Thomas Jr Lyell J Micro pump powered by piezoelectric disk benders
US4245634A (en) 1975-01-22 1981-01-20 Hospital For Sick Children Artificial beta cell
CA1040271A (en) 1975-01-22 1978-10-10 Anthony M. Albisser Artificial beta cell
US4055175A (en) 1976-05-07 1977-10-25 Miles Laboratories, Inc. Blood glucose control apparatus
US4151845A (en) 1977-11-25 1979-05-01 Miles Laboratories, Inc. Blood glucose control apparatus
US4559037A (en) 1977-12-28 1985-12-17 Siemens Aktiengesellschaft Device for the pre-programmable infusion of liquids
US4373527B1 (en) 1979-04-27 1995-06-27 Univ Johns Hopkins Implantable programmable medication infusion system
DE3023211A1 (de) 1979-06-28 1981-01-22 Ti Fords Ltd Verfahren und vorrichtung zur ermittlung einer waesserigen fluessigkeit in flaschen und behaeltern
US4403984A (en) 1979-12-28 1983-09-13 Biotek, Inc. System for demand-based adminstration of insulin
AU546785B2 (en) 1980-07-23 1985-09-19 Commonwealth Of Australia, The Open-loop controlled infusion of diabetics
US4559033A (en) 1980-10-27 1985-12-17 University Of Utah Research Foundation Apparatus and methods for minimizing peritoneal injection catheter obstruction
JPS57211361A (en) 1981-06-23 1982-12-25 Terumo Corp Liquid injecting apparatus
IT1142930B (it) 1981-11-04 1986-10-15 Luigi Bernardi Apparecchio portatile che infonde insulina sulla base dei rilevamenti glicemici
US4529401A (en) 1982-01-11 1985-07-16 Cardiac Pacemakers, Inc. Ambulatory infusion pump having programmable parameters
US4464170A (en) 1982-09-29 1984-08-07 Miles Laboratories, Inc. Blood glucose control apparatus and method
US4526568A (en) 1982-09-29 1985-07-02 Miles Laboratories, Inc. Diagnostic method and apparatus for clamping blood glucose concentration
US4624661A (en) 1982-11-16 1986-11-25 Surgidev Corp. Drug dispensing system
IT1170375B (it) 1983-04-19 1987-06-03 Giuseppe Bombardieri Apparecchio che infonde insulina o glucosio nel soggetto diabetico sulla base di determinazioni di concentrazioni di glucosio ottenute senza bisogno di prelievi del sangue del paziente
US4573968A (en) 1983-08-16 1986-03-04 Ivac Corporation Infusion and blood chemistry monitoring system
US4781693A (en) 1983-09-02 1988-11-01 Minntech Corporation Insulin dispenser for peritoneal cavity
US4743243A (en) 1984-01-03 1988-05-10 Vaillancourt Vincent L Needle with vent filter assembly
US4685903A (en) 1984-01-06 1987-08-11 Pacesetter Infusion, Ltd. External infusion pump apparatus
JPH0657250B2 (ja) 1984-06-29 1994-08-03 バクスター・インターナショナル・インコーポレーテッド 血液抽出及び再注輸の血流制御装置
US4755173A (en) 1986-02-25 1988-07-05 Pacesetter Infusion, Ltd. Soft cannula subcutaneous injection set
US5349852A (en) 1986-03-04 1994-09-27 Deka Products Limited Partnership Pump controller using acoustic spectral analysis
US4778451A (en) 1986-03-04 1988-10-18 Kamen Dean L Flow control system using boyle's law
AT384737B (de) 1986-04-04 1987-12-28 Thoma Dipl Ing Dr Techn Herwig Vorrichtung zur stroemungskonstanten abgabe fluessiger arzneimittel
US4731726A (en) 1986-05-19 1988-03-15 Healthware Corporation Patient-operated glucose monitor and diabetes management system
US4981140A (en) 1986-09-12 1991-01-01 Philip Wyatt Method and apparatus for arterial and venous blood sampling
CA1283827C (en) 1986-12-18 1991-05-07 Giorgio Cirelli Appliance for injection of liquid formulations
US4976720A (en) 1987-01-06 1990-12-11 Advanced Cardiovascular Systems, Inc. Vascular catheters
AT391998B (de) 1987-02-02 1990-12-27 Falko Dr Skrabal Vorrichtung zur bestimmung der konzentration zumindest einer medizinischen substanz in lebenden organismen
GB8710610D0 (en) 1987-05-05 1987-06-10 British Res Agricult Eng Rotor assemblies
US4940527A (en) 1987-06-01 1990-07-10 Abbott Laboratories Two-part test cartridge for centrifuge
US5207642A (en) 1987-08-07 1993-05-04 Baxter International Inc. Closed multi-fluid delivery system and method
US4925444A (en) 1987-08-07 1990-05-15 Baxter Travenol Laboratories, Inc. Closed multi-fluid delivery system and method
US4919596A (en) 1987-12-04 1990-04-24 Pacesetter Infusion, Ltd. Fluid delivery control and monitoring apparatus for a medication infusion system
US4994047A (en) 1988-05-06 1991-02-19 Menlo Care, Inc. Multi-layer cannula structure
JP2755654B2 (ja) 1988-07-07 1998-05-20 住友ベークライト株式会社 ブドウ糖濃度応答インスリン放出装置
US4854170A (en) 1988-10-12 1989-08-08 Separation Technology, Inc. Apparatus and method for using ultrasound to determine hematocrit
US5153827A (en) 1989-01-30 1992-10-06 Omni-Flow, Inc. An infusion management and pumping system having an alarm handling system
US6262798B1 (en) 1992-09-29 2001-07-17 Board Of Regents, The University Of Texas System Method and apparatus for direct spectrophotometric measurements in unaltered whole blood
IE66526B1 (en) 1989-03-17 1996-01-24 Baxter Int A pre-slit injection site usable with a blunt cannula
US5134079A (en) 1989-03-27 1992-07-28 International Technidyne Corp. Fluid sample collection and delivery system and methods particularly adapted for body fluid sampling
CA1328359C (en) 1989-03-27 1994-04-12 Michael D. Mintz Fluid sample collection and delivery system and methods particularly adapted for body fluid sampling
US5102406A (en) 1989-06-02 1992-04-07 Arnold Victor A Device and method for avoiding contamination of multi-dose medicament vials
US5716343A (en) 1989-06-16 1998-02-10 Science Incorporated Fluid delivery apparatus
US4975581A (en) 1989-06-21 1990-12-04 University Of New Mexico Method of and apparatus for determining the similarity of a biological analyte from a model constructed from known biological fluids
US5007286A (en) 1989-08-03 1991-04-16 Malcolm Robert G Solid-state transducer based dynamic fluid flow sensing system
US5109850A (en) 1990-02-09 1992-05-05 Massachusetts Institute Of Technology Automatic blood monitoring for medication delivery method and apparatus
JPH0451966A (ja) 1990-06-19 1992-02-20 Toichi Ishikawa 薬液連続注入器
US5125415A (en) 1990-06-19 1992-06-30 Smiths Industries Medical Systems, Inc. Syringe tip cap with self-sealing filter
US5176662A (en) 1990-08-23 1993-01-05 Minimed Technologies, Ltd. Subcutaneous injection set with improved cannula mounting arrangement
US5165406A (en) 1990-09-13 1992-11-24 Via Medical Corporation Electrochemical sensor apparatus and method
US5468727A (en) 1990-12-13 1995-11-21 Board Of Regents, The University Of Texas System Methods of normalizing metabolic parameters in diabetics
TW279133B (zh) 1990-12-13 1996-06-21 Elan Med Tech
US5061424A (en) 1991-01-22 1991-10-29 Becton, Dickinson And Company Method for applying a lubricious coating to an article
US5273517A (en) 1991-07-09 1993-12-28 Haemonetics Corporation Blood processing method and apparatus with disposable cassette
EP0535700B1 (en) 1991-10-04 1997-03-26 The Perkin-Elmer Corporation Method and apparatus for comparing spectra
US5244463A (en) 1991-12-06 1993-09-14 Block Medical, Inc. Programmable infusion pump
DE4141944C2 (de) 1991-12-19 1995-06-08 Hansa Metallwerke Ag Einrichtung zur berührungslosen Steuerung einer Sanitärarmatur
EP0549341A1 (en) 1991-12-24 1993-06-30 W.R. Grace & Co.-Conn. Hollow fiber plasma sampler
US5421812A (en) 1992-03-04 1995-06-06 Cobe Laboratories, Inc. Method and apparatus for controlling concentrations in tubing system
US5377674A (en) 1992-05-08 1995-01-03 Kuestner; J. Todd Method for non-invasive and in-vitro hemoglobin concentration measurement
US5385539A (en) 1992-06-30 1995-01-31 Advanced Haemotechnologies Apparatus for monitoring hematocrit levels of blood
US5342298A (en) 1992-07-31 1994-08-30 Advanced Cardiovascular Systems, Inc. Automated fluid pressure control system
US5330634A (en) 1992-08-28 1994-07-19 Via Medical Corporation Calibration solutions useful for analyses of biological fluids and methods employing same
US5232439A (en) 1992-11-02 1993-08-03 Infusion Technologies Corporation Method for pumping fluid from a flexible, variable geometry reservoir
US5956501A (en) 1997-01-10 1999-09-21 Health Hero Network, Inc. Disease simulation system and method
DE4336336A1 (de) 1992-11-23 1994-05-26 Lang Volker Kasetteninfusionssystem
US5299571A (en) 1993-01-22 1994-04-05 Eli Lilly And Company Apparatus and method for implantation of sensors
US5257980A (en) 1993-04-05 1993-11-02 Minimed Technologies, Ltd. Subcutaneous injection set with crimp-free soft cannula
EP0631137B1 (en) 1993-06-25 2002-03-20 Edward W. Stark Glucose related measurement method and apparatus
DK88893D0 (da) 1993-07-30 1993-07-30 Radiometer As A method and an apparatus for determining the content of a constituent of blood of an individual
US5389078A (en) 1993-10-06 1995-02-14 Sims Deltec, Inc. Programmable infusion pump for administering medication to patients
US5582184A (en) 1993-10-13 1996-12-10 Integ Incorporated Interstitial fluid collection and constituent measurement
US5885211A (en) 1993-11-15 1999-03-23 Spectrix, Inc. Microporation of human skin for monitoring the concentration of an analyte
US5458140A (en) 1993-11-15 1995-10-17 Non-Invasive Monitoring Company (Nimco) Enhancement of transdermal monitoring applications with ultrasound and chemical enhancers
US5997501A (en) 1993-11-18 1999-12-07 Elan Corporation, Plc Intradermal drug delivery device
US5411889A (en) 1994-02-14 1995-05-02 Nalco Chemical Company Regulating water treatment agent dosage based on operational system stresses
EP0672427A1 (en) 1994-03-17 1995-09-20 Siemens-Elema AB System for infusion of medicine into the body of a patient
US5569186A (en) 1994-04-25 1996-10-29 Minimed Inc. Closed loop infusion pump system with removable glucose sensor
DE4415896A1 (de) 1994-05-05 1995-11-09 Boehringer Mannheim Gmbh Analysesystem zur Überwachung der Konzentration eines Analyten im Blut eines Patienten
US5685859A (en) 1994-06-02 1997-11-11 Nikomed Aps Device for fixating a drainage tube and a drainage tube assembly
US5700695A (en) 1994-06-30 1997-12-23 Zia Yassinzadeh Sample collection and manipulation method
US5505709A (en) 1994-09-15 1996-04-09 Minimed, Inc., A Delaware Corporation Mated infusion pump and syringe
CA2159052C (en) 1994-10-28 2007-03-06 Rainer Alex Injection device
IE72524B1 (en) 1994-11-04 1997-04-23 Elan Med Tech Analyte-controlled liquid delivery device and analyte monitor
US5685844A (en) 1995-01-06 1997-11-11 Abbott Laboratories Medicinal fluid pump having multiple stored protocols
DE19500529C5 (de) 1995-01-11 2007-11-22 Dräger Medical AG & Co. KG Bedieneinheit für ein Beatmungsgerät
JPH11500029A (ja) 1995-02-07 1999-01-06 ジェンシア・インコーポレイテッド フィードバック制御される薬剤デリバリーシステム
US5697899A (en) 1995-02-07 1997-12-16 Gensia Feedback controlled drug delivery system
US5741228A (en) 1995-02-17 1998-04-21 Strato/Infusaid Implantable access device
US5665065A (en) 1995-05-26 1997-09-09 Minimed Inc. Medication infusion device with blood glucose data input
US5584813A (en) 1995-06-07 1996-12-17 Minimed Inc. Subcutaneous injection set
US5655530A (en) 1995-08-09 1997-08-12 Rio Grande Medical Technologies, Inc. Method for non-invasive blood analyte measurement with improved optical interface
US6240306B1 (en) 1995-08-09 2001-05-29 Rio Grande Medical Technologies, Inc. Method and apparatus for non-invasive blood analyte measurement with fluid compartment equilibration
US7016713B2 (en) 1995-08-09 2006-03-21 Inlight Solutions, Inc. Non-invasive determination of direction and rate of change of an analyte
AU7015096A (en) 1995-09-08 1997-04-09 Integ, Inc. Body fluid sampler
US5693018A (en) 1995-10-11 1997-12-02 Science Incorporated Subdermal delivery device
US6072180A (en) 1995-10-17 2000-06-06 Optiscan Biomedical Corporation Non-invasive infrared absorption spectrometer for the generation and capture of thermal gradient spectra from living tissue
US6058934A (en) 1995-11-02 2000-05-09 Chiron Diagnostics Corporation Planar hematocrit sensor incorporating a seven-electrode conductivity measurement cell
US5800405A (en) 1995-12-01 1998-09-01 I-Flow Corporation Syringe actuation device
DE69637553D1 (de) 1995-12-19 2008-07-10 Abbott Lab Vorrichtung zum Detektieren eines Analyten und zur Verabreichung einer therapeutischen Substanz
US6040578A (en) 1996-02-02 2000-03-21 Instrumentation Metrics, Inc. Method and apparatus for multi-spectral analysis of organic blood analytes in noninvasive infrared spectroscopy
FI118509B (fi) 1996-02-12 2007-12-14 Nokia Oyj Menetelmä ja laitteisto potilaan veren glukoosipitoisuuden ennustamiseksi
US5703364A (en) 1996-02-15 1997-12-30 Futrex, Inc. Method and apparatus for near-infrared quantitative analysis
US5801057A (en) 1996-03-22 1998-09-01 Smart; Wilson H. Microsampling device and method of construction
US5865806A (en) 1996-04-04 1999-02-02 Becton Dickinson And Company One step catheter advancement automatic needle retraction system
SE9602298D0 (sv) 1996-06-11 1996-06-11 Siemens Elema Ab Arrangement for analysing body fluids
US6183434B1 (en) 1996-07-03 2001-02-06 Spectrx, Inc. Multiple mechanical microporation of skin or mucosa
JP2000515778A (ja) 1996-07-08 2000-11-28 アニマス コーポレーシヨン 体液成分レベルの生体内測定および制御のための埋込可能センサーおよびシステム
US5758643A (en) 1996-07-29 1998-06-02 Via Medical Corporation Method and apparatus for monitoring blood chemistry
US5755682A (en) 1996-08-13 1998-05-26 Heartstent Corporation Method and apparatus for performing coronary artery bypass surgery
US5804048A (en) 1996-08-15 1998-09-08 Via Medical Corporation Electrode assembly for assaying glucose
US5932175A (en) 1996-09-25 1999-08-03 Via Medical Corporation Sensor apparatus for use in measuring a parameter of a fluid sample
US5714123A (en) 1996-09-30 1998-02-03 Lifescan, Inc. Protective shield for a blood glucose strip
CA2272304C (en) 1996-11-22 2007-01-23 Therakos, Inc. Integrated cassette for valving, pumping and controlling movement of fluids
US6093156A (en) 1996-12-06 2000-07-25 Abbott Laboratories Method and apparatus for obtaining blood for diagnostic tests
US5947911A (en) 1997-01-09 1999-09-07 Via Medical Corporation Method and apparatus for reducing purge volume in a blood chemistry monitoring system
EP0958499B1 (en) 1997-01-17 2002-08-07 Metracor Technologies Inc Method for calibrating sensors used in diagnostic testing
US5851197A (en) 1997-02-05 1998-12-22 Minimed Inc. Injector for a subcutaneous infusion set
JP3394262B2 (ja) 1997-02-06 2003-04-07 セラセンス、インク． 小体積インビトロ被検体センサー
US6979309B2 (en) 1997-02-14 2005-12-27 Nxstage Medical Inc. Systems and methods for performing blood processing and/or fluid exchange procedures
WO1998037801A1 (en) 1997-02-27 1998-09-03 Minnesota Mining And Manufacturing Company Cassette for measuring parameters of blood
US6741877B1 (en) 1997-03-04 2004-05-25 Dexcom, Inc. Device and method for determining analyte levels
US6161028A (en) 1999-03-10 2000-12-12 Optiscan Biomedical Corporation Method for determining analyte concentration using periodic temperature modulation and phase detection
US6270455B1 (en) 1997-03-28 2001-08-07 Health Hero Network, Inc. Networked system for interactive communications and remote monitoring of drug delivery
US5871470A (en) 1997-04-18 1999-02-16 Becton Dickinson And Company Combined spinal epidural needle set
US6285448B1 (en) 1997-05-05 2001-09-04 J. Todd Kuenstner Clinical analyte determination by infrared spectroscopy
US6050978A (en) 1997-05-09 2000-04-18 Becton Dickinson And Company Needleless valve connector
US7267665B2 (en) 1999-06-03 2007-09-11 Medtronic Minimed, Inc. Closed loop system for controlling insulin infusion
US6558351B1 (en) 1999-06-03 2003-05-06 Medtronic Minimed, Inc. Closed loop system for controlling insulin infusion
US5954643A (en) 1997-06-09 1999-09-21 Minimid Inc. Insertion set for a transcutaneous sensor
US6500150B1 (en) 1997-06-16 2002-12-31 Elan Pharma International Limited Pre-filled drug-delivery device and method of manufacture and assembly of same
US5948695A (en) 1997-06-17 1999-09-07 Mercury Diagnostics, Inc. Device for determination of an analyte in a body fluid
US6071292A (en) 1997-06-28 2000-06-06 Transvascular, Inc. Transluminal methods and devices for closing, forming attachments to, and/or forming anastomotic junctions in, luminal anatomical structures
US7010336B2 (en) 1997-08-14 2006-03-07 Sensys Medical, Inc. Measurement site dependent data preprocessing method for robust calibration and prediction
US6115673A (en) 1997-08-14 2000-09-05 Instrumentation Metrics, Inc. Method and apparatus for generating basis sets for use in spectroscopic analysis
US5858005A (en) 1997-08-27 1999-01-12 Science Incorporated Subcutaneous infusion set with dynamic needle
US6200287B1 (en) 1997-09-05 2001-03-13 Gambro, Inc. Extracorporeal blood processing methods and apparatus
US6102872A (en) 1997-11-03 2000-08-15 Pacific Biometrics, Inc. Glucose detector and method
US5964718A (en) 1997-11-21 1999-10-12 Mercury Diagnostics, Inc. Body fluid sampling device
US6036924A (en) 1997-12-04 2000-03-14 Hewlett-Packard Company Cassette of lancet cartridges for sampling blood
US5971941A (en) 1997-12-04 1999-10-26 Hewlett-Packard Company Integrated system and method for sampling blood and analysis
US6159192A (en) 1997-12-04 2000-12-12 Fowles; Thomas A. Sliding reconstitution device with seal
US6579690B1 (en) 1997-12-05 2003-06-17 Therasense, Inc. Blood analyte monitoring through subcutaneous measurement
DE19756872B4 (de) 1997-12-19 2005-06-02 Siemens Ag Vorrichtung zur Verabreichung einer Infusion und/oder Perfusion an einen Patienten
WO1999032883A2 (en) 1997-12-19 1999-07-01 Amira Medical Embossed test strip system
US6244776B1 (en) 1998-01-05 2001-06-12 Lien J. Wiley Applicators for health and beauty products
SE523080C2 (sv) 1998-01-08 2004-03-23 Electrolux Ab Dockningssystem för självgående arbetsredskap
EP1563866B1 (en) 1998-02-05 2007-10-03 Biosense Webster, Inc. Intracardiac drug delivery
US6721582B2 (en) 1999-04-06 2004-04-13 Argose, Inc. Non-invasive tissue glucose level monitoring
US6728560B2 (en) 1998-04-06 2004-04-27 The General Hospital Corporation Non-invasive tissue glucose level monitoring
US6126637A (en) 1998-04-15 2000-10-03 Science Incorporated Fluid delivery device with collapsible needle cover
US6283944B1 (en) 1998-04-30 2001-09-04 Medtronic, Inc. Infusion systems with patient-controlled dosage features
US6175752B1 (en) 1998-04-30 2001-01-16 Therasense, Inc. Analyte monitoring device and methods of use
ATE246356T1 (de) 1998-05-13 2003-08-15 Cygnus Therapeutic Systems Vorrichtung zum vorhersagen von physiologischen messwerten
US6662030B2 (en) 1998-05-18 2003-12-09 Abbott Laboratories Non-invasive sensor having controllable temperature feature
US6312888B1 (en) 1998-06-10 2001-11-06 Abbott Laboratories Diagnostic assay for a sample of biological fluid
US6226082B1 (en) 1998-06-25 2001-05-01 Amira Medical Method and apparatus for the quantitative analysis of a liquid sample with surface enhanced spectroscopy
US6214629B1 (en) 1998-08-06 2001-04-10 Spectral Diagnostics, Inc. Analytical test device and method for use in medical diagnoses
US6554798B1 (en) 1998-08-18 2003-04-29 Medtronic Minimed, Inc. External infusion device with remote programming, bolus estimator and/or vibration alarm capabilities
US5993423A (en) 1998-08-18 1999-11-30 Choi; Soo Bong Portable automatic syringe device and injection needle unit thereof
US6949081B1 (en) 1998-08-26 2005-09-27 Non-Invasive Technology, Inc. Sensing and interactive drug delivery
US6087182A (en) 1998-08-27 2000-07-11 Abbott Laboratories Reagentless analysis of biological samples
DE19840965A1 (de) 1998-09-08 2000-03-09 Disetronic Licensing Ag Vorrichtung zur Selbstverabreichung eines Produktfluids
DE69908602T2 (de) 1998-09-30 2004-06-03 Cygnus, Inc., Redwood City Verfahren und vorrichtung zum vorhersagen von physiologischen messwerten
US6402689B1 (en) 1998-09-30 2002-06-11 Sicel Technologies, Inc. Methods, systems, and associated implantable devices for dynamic monitoring of physiological and biological properties of tumors
US6157041A (en) 1998-10-13 2000-12-05 Rio Grande Medical Technologies, Inc. Methods and apparatus for tailoring spectroscopic calibration models
DE69918324T2 (de) 1998-11-20 2005-08-04 Novo Nordisk A/S Injektionsnadel
DK1144028T3 (da) 1998-11-30 2004-10-18 Novo Nordisk As System til at hjælpe en bruger under medicinsk selvbehandling, hvor nævnte selvbehandling omfatter en flerhed af handlinger
US6540672B1 (en) 1998-12-09 2003-04-01 Novo Nordisk A/S Medical system and a method of controlling the system for use by a patient for medical self treatment
US6077055A (en) 1998-12-03 2000-06-20 Sims Deltec, Inc. Pump system including cassette sensor and occlusion sensor
US6128519A (en) 1998-12-16 2000-10-03 Pepex Biomedical, Llc System and method for measuring a bioanalyte such as lactate
US6200338B1 (en) 1998-12-31 2001-03-13 Ethicon, Inc. Enhanced radiopacity of peripheral and central catheter tubing
US6280381B1 (en) 1999-07-22 2001-08-28 Instrumentation Metrics, Inc. Intelligent system for noninvasive blood analyte prediction
US6531095B2 (en) 1999-02-11 2003-03-11 Careside, Inc. Cartridge-based analytical instrument with optical detector
JP2002536103A (ja) 1999-02-12 2002-10-29 シグナス， インコーポレイテッド 生物学的系に存在する分析物の頻繁な測定のためのデバイスおよび方法
US20010034023A1 (en) 1999-04-26 2001-10-25 Stanton Vincent P. Gene sequence variations with utility in determining the treatment of disease, in genes relating to drug processing
JP3594534B2 (ja) 1999-04-30 2004-12-02 ヘルマン ファウ、リリエンフェルトアル 物質を検出する装置
US6669663B1 (en) 1999-04-30 2003-12-30 Medtronic, Inc. Closed loop medicament pump
US6334851B1 (en) 1999-05-10 2002-01-01 Microfab Technologies, Inc. Method for collecting interstitial fluid from the skin
US6835553B2 (en) 1999-05-11 2004-12-28 M-Biotech, Inc. Photometric glucose measurement system using glucose-sensitive hydrogel
US6546268B1 (en) 1999-06-02 2003-04-08 Ball Semiconductor, Inc. Glucose sensor
US7806886B2 (en) 1999-06-03 2010-10-05 Medtronic Minimed, Inc. Apparatus and method for controlling insulin infusion with state variable feedback
WO2001003572A1 (de) 1999-07-08 2001-01-18 Steffen Leonhardt Vorrichtung zur messung des menschlichen blutzuckerspiegels
US6697654B2 (en) 1999-07-22 2004-02-24 Sensys Medical, Inc. Targeted interference subtraction applied to near-infrared measurement of analytes
US6512937B2 (en) 1999-07-22 2003-01-28 Sensys Medical, Inc. Multi-tier method of developing localized calibration models for non-invasive blood analyte prediction
US6196046B1 (en) 1999-08-25 2001-03-06 Optiscan Biomedical Corporation Devices and methods for calibration of a thermal gradient spectrometer
US6261065B1 (en) 1999-09-03 2001-07-17 Baxter International Inc. System and methods for control of pumps employing electrical field sensing
EP1103796B1 (de) * 1999-11-19 2003-10-08 ESEC Trading S.A. Sensor zur Detektion eines vorbestimmten Füllgrades eines Behälters
US6470279B1 (en) 1999-11-23 2002-10-22 James Samsoondar Method for calibrating spectrophotometric apparatus with synthetic fluids to measure plasma and serum analytes
DE60018796T2 (de) 1999-12-16 2006-04-13 Alza Corp., Mountain View Vorrichtung zur erhöhung des transdermalen flusses von probenwirkstoffen
US6477901B1 (en) 1999-12-21 2002-11-12 Integrated Sensing Systems, Inc. Micromachined fluidic apparatus
US6811534B2 (en) 2000-01-21 2004-11-02 Medtronic Minimed, Inc. Ambulatory medical apparatus and method using a telemetry system with predefined reception listening periods
US6895263B2 (en) 2000-02-23 2005-05-17 Medtronic Minimed, Inc. Real time self-adjusting calibration algorithm
US6751490B2 (en) 2000-03-01 2004-06-15 The Board Of Regents Of The University Of Texas System Continuous optoacoustic monitoring of hemoglobin concentration and hematocrit
US6375627B1 (en) 2000-03-02 2002-04-23 Agilent Technologies, Inc. Physiological fluid extraction with rapid analysis
US6572542B1 (en) 2000-03-03 2003-06-03 Medtronic, Inc. System and method for monitoring and controlling the glycemic state of a patient
CA2401388C (en) 2000-03-28 2009-09-08 Elan Pharma International Limited Device for measuring a volume of drug
US6485465B2 (en) 2000-03-29 2002-11-26 Medtronic Minimed, Inc. Methods, apparatuses, and uses for infusion pump fluid pressure and force detection
IT1314759B1 (it) 2000-05-08 2003-01-03 Menarini Farma Ind Strumentazione per la misura ed il controllo del contenuto di glucosiolattato o altri metaboliti in fluidi biologici
AU2001261618A1 (en) 2000-05-18 2001-11-26 Argose, Inc. Pre-and post-processing of spectral data for calibration using multivariate analysis techniques
US6699221B2 (en) 2000-06-15 2004-03-02 Vincent L. Vaillancourt Bloodless catheter
US6475196B1 (en) 2000-08-18 2002-11-05 Minimed Inc. Subcutaneous infusion cannula
WO2002017210A2 (en) 2000-08-18 2002-02-28 Cygnus, Inc. Formulation and manipulation of databases of analyte and associated values
IL138073A0 (en) 2000-08-24 2001-10-31 Glucon Inc Photoacoustic assay and imaging system
WO2002020073A2 (en) 2000-09-08 2002-03-14 Insulet Corporation Devices, systems and methods for patient infusion
WO2002024065A1 (en) 2000-09-22 2002-03-28 Knobbe, Lim & Buckingham Method and apparatus for real-time estimation and control of pysiological parameters
US6553841B1 (en) 2000-09-26 2003-04-29 Helix Technology Corporation Pressure transducer assembly
WO2002027659A2 (en) 2000-09-26 2002-04-04 Advantage 3D Llc Method and system for generation, storage and distribution of omni-directional object views
AU2001296588B2 (en) * 2000-10-04 2006-06-08 Insulet Corporation Data collection assembly for patient infusion system
US8715177B2 (en) 2000-10-06 2014-05-06 Ip Holdings, Inc. Intelligent drug delivery appliance
DK1341569T3 (da) 2000-11-09 2007-05-29 Insulet Corp Transkutant uddelingsmiddel
US20020076354A1 (en) 2000-12-01 2002-06-20 Cohen David Samuel Apparatus and methods for separating components of particulate suspension
US6645142B2 (en) 2000-12-01 2003-11-11 Optiscan Biomedical Corporation Glucose monitoring instrument having network connectivity
US6560471B1 (en) 2001-01-02 2003-05-06 Therasense, Inc. Analyte monitoring device and methods of use
JP4996015B2 (ja) 2001-03-12 2012-08-08 メディキット株式会社 留置用カテーテル
US7139598B2 (en) 2002-04-04 2006-11-21 Veralight, Inc. Determination of a measure of a glycation end-product or disease state using tissue fluorescence
US7043288B2 (en) 2002-04-04 2006-05-09 Inlight Solutions, Inc. Apparatus and method for spectroscopic analysis of tissue to detect diabetes in an individual
US6574490B2 (en) 2001-04-11 2003-06-03 Rio Grande Medical Technologies, Inc. System for non-invasive measurement of glucose in humans
US6865408B1 (en) 2001-04-11 2005-03-08 Inlight Solutions, Inc. System for non-invasive measurement of glucose in humans
US7756558B2 (en) 2004-05-24 2010-07-13 Trutouch Technologies, Inc. Apparatus and methods for mitigating the effects of foreign interferents on analyte measurements in spectroscopy
US6748250B1 (en) 2001-04-27 2004-06-08 Medoptix, Inc. Method and system of monitoring a patient
US6837988B2 (en) 2001-06-12 2005-01-04 Lifescan, Inc. Biological fluid sampling and analyte measurement devices and methods
US6890291B2 (en) 2001-06-25 2005-05-10 Mission Medical, Inc. Integrated automatic blood collection and processing unit
US20030208113A1 (en) 2001-07-18 2003-11-06 Mault James R Closed loop glycemic index system
US6544212B2 (en) 2001-07-31 2003-04-08 Roche Diagnostics Corporation Diabetes management system
US6687620B1 (en) 2001-08-01 2004-02-03 Sandia Corporation Augmented classical least squares multivariate spectral analysis
US6788965B2 (en) 2001-08-03 2004-09-07 Sensys Medical, Inc. Intelligent system for detecting errors and determining failure modes in noninvasive measurement of blood and tissue analytes
US20040147034A1 (en) 2001-08-14 2004-07-29 Gore Jay Prabhakar Method and apparatus for measuring a substance in a biological sample
WO2003016882A1 (en) 2001-08-14 2003-02-27 Purdue Research Foundation Measuring a substance in a biological sample
US6678542B2 (en) 2001-08-16 2004-01-13 Optiscan Biomedical Corp. Calibrator configured for use with noninvasive analyte-concentration monitor and employing traditional measurements
US8152789B2 (en) 2001-10-23 2012-04-10 Medtronic Minimed, Inc. System and method for providing closed loop infusion formulation delivery
WO2003023356A2 (en) 2001-09-07 2003-03-20 Argose, Inc. Portable non-invasive glucose monitor
US6827702B2 (en) 2001-09-07 2004-12-07 Medtronic Minimed, Inc. Safety limits for closed-loop infusion pump control
US6740072B2 (en) 2001-09-07 2004-05-25 Medtronic Minimed, Inc. System and method for providing closed loop infusion formulation delivery
FI20011918A0 (fi) 2001-10-01 2001-10-01 Mirhava Ltd Automaattinen verisuoni yhteyden hallintalaite
AU2002341372A1 (en) 2001-10-09 2003-04-22 Glucon Inc. Method and apparatus for determining absorption of electromagnetic radiation by a material
US7050157B2 (en) 2001-11-08 2006-05-23 Optiscan Biomedical Corp. Reagent-less whole-blood glucose meter
US7061593B2 (en) 2001-11-08 2006-06-13 Optiscan Biomedical Corp. Device and method for in vitro determination of analyte concentrations within body fluids
US6958809B2 (en) 2001-11-08 2005-10-25 Optiscan Biomedical Corporation Reagent-less whole-blood glucose meter
US6989891B2 (en) 2001-11-08 2006-01-24 Optiscan Biomedical Corporation Device and method for in vitro determination of analyte concentrations within body fluids
AU2002346484A1 (en) 2001-11-21 2003-06-10 Optiscan Biomedical Corporation Method and apparatus for improving the accuracy of alternative site analyte concentration measurements
US7009180B2 (en) 2001-12-14 2006-03-07 Optiscan Biomedical Corp. Pathlength-independent methods for optically determining material composition
US6862534B2 (en) 2001-12-14 2005-03-01 Optiscan Biomedical Corporation Method of determining an analyte concentration in a sample from an absorption spectrum
US7139593B2 (en) 2001-12-14 2006-11-21 Samsung Electronics Co., Ltd. System and method for improving performance of an adaptive antenna array in a vehicular environment
US7204823B2 (en) 2001-12-19 2007-04-17 Medtronic Minimed, Inc. Medication delivery system and monitor
US6985870B2 (en) 2002-01-11 2006-01-10 Baxter International Inc. Medication delivery system
CA2418399A1 (en) 2002-02-11 2003-08-11 Bayer Healthcare, Llc Non-invasive system for the determination of analytes in body fluids
US20030212379A1 (en) 2002-02-26 2003-11-13 Bylund Adam David Systems and methods for remotely controlling medication infusion and analyte monitoring
US20080172026A1 (en) 2006-10-17 2008-07-17 Blomquist Michael L Insulin pump having a suspension bolus
US6878136B2 (en) 2002-02-28 2005-04-12 Medical Product Specialists Huber needle with anti-rebound safety mechanism
US7500949B2 (en) 2002-03-01 2009-03-10 Medtronic Minimed, Inc. Multilumen catheter
GB0206792D0 (en) 2002-03-22 2002-05-01 Leuven K U Res & Dev Normoglycemia
US7027848B2 (en) 2002-04-04 2006-04-11 Inlight Solutions, Inc. Apparatus and method for non-invasive spectroscopic measurement of analytes in tissue using a matched reference analyte
US6960192B1 (en) 2002-04-23 2005-11-01 Insulet Corporation Transcutaneous fluid delivery system
US20050238507A1 (en) 2002-04-23 2005-10-27 Insulet Corporation Fluid delivery device
US6758835B2 (en) 2002-05-01 2004-07-06 Medtg, Llc Disposable needle assembly having sensors formed therein permitting the simultaneous drawing and administering of fluids and method of forming the same
US7175606B2 (en) 2002-05-24 2007-02-13 Baxter International Inc. Disposable medical fluid unit having rigid frame
US20040010207A1 (en) 2002-07-15 2004-01-15 Flaherty J. Christopher Self-contained, automatic transcutaneous physiologic sensing system
US7018360B2 (en) 2002-07-16 2006-03-28 Insulet Corporation Flow restriction system and method for patient infusion device
US7278983B2 (en) 2002-07-24 2007-10-09 Medtronic Minimed, Inc. Physiological monitoring device for controlling a medication infusion device
US8512276B2 (en) 2002-07-24 2013-08-20 Medtronic Minimed, Inc. System for providing blood glucose measurements to an infusion device
US7404796B2 (en) 2004-03-01 2008-07-29 Becton Dickinson And Company System for determining insulin dose using carbohydrate to insulin ratio and insulin sensitivity factor
WO2004024211A2 (en) 2002-09-12 2004-03-25 Children's Hospital Medical Center Method and device for painless injection of medication
US20040051368A1 (en) 2002-09-17 2004-03-18 Jimmy Caputo Systems and methods for programming pumps
US7144384B2 (en) 2002-09-30 2006-12-05 Insulet Corporation Dispenser components and methods for patient infusion device
US7128727B2 (en) 2002-09-30 2006-10-31 Flaherty J Christopher Components and methods for patient infusion device
US7025744B2 (en) 2002-10-04 2006-04-11 Dsu Medical Corporation Injection site for male luer or other tubular connector
EP1575656B1 (en) 2002-10-11 2009-06-17 Becton, Dickinson and Company Insulin delivery system with sensor
US7029443B2 (en) 2002-10-21 2006-04-18 Pacesetter, Inc. System and method for monitoring blood glucose levels using an implantable medical device
US7248912B2 (en) 2002-10-31 2007-07-24 The Regents Of The University Of California Tissue implantable sensors for measurement of blood solutes
US6931328B2 (en) 2002-11-08 2005-08-16 Optiscan Biomedical Corp. Analyte detection system with software download capabilities
US20040133166A1 (en) 2002-11-22 2004-07-08 Minimed Inc. Methods, apparatuses, and uses for infusion pump fluid pressure and force detection
US7142814B2 (en) 2002-12-11 2006-11-28 Shary Nassimi Automatic Bluetooth inquiry mode headset
US20040122353A1 (en) 2002-12-19 2004-06-24 Medtronic Minimed, Inc. Relay device for transferring information between a sensor system and a fluid delivery system
AU2003303597A1 (en) 2002-12-31 2004-07-29 Therasense, Inc. Continuous glucose monitoring system and methods of use
US8771183B2 (en) 2004-02-17 2014-07-08 Abbott Diabetes Care Inc. Method and system for providing data communication in continuous glucose monitoring and management system
KR100521855B1 (ko) 2003-01-30 2005-10-14 최수봉 무선교신이 가능한 인슐린펌프 제어방법
US8016798B2 (en) 2003-02-24 2011-09-13 Integrated Sensing Systems, Inc. Fluid delivery system and sensing unit therefor
US7354429B2 (en) 2003-05-27 2008-04-08 Integrated Sensing Systems, Inc. Device and method for detecting and treating chemical and biological agents
US9872890B2 (en) 2003-03-19 2018-01-23 Paul C. Davidson Determining insulin dosing schedules and carbohydrate-to-insulin ratios in diabetic patients
JP4091865B2 (ja) * 2003-03-24 2008-05-28 日機装株式会社 薬剤注入装置
US20040204868A1 (en) 2003-04-09 2004-10-14 Maynard John D. Reduction of errors in non-invasive tissue sampling
CA2522282A1 (en) 2003-04-15 2004-10-28 Optiscan Biomedical Corporation Sample element for use in material analysis
US7271912B2 (en) 2003-04-15 2007-09-18 Optiscan Biomedical Corporation Method of determining analyte concentration in a sample using infrared transmission data
US20050022274A1 (en) 2003-04-18 2005-01-27 Robert Campbell User interface for infusion pump remote controller and method of using the same
US20050215982A1 (en) * 2003-04-30 2005-09-29 Luis Malave RF medical device
US20040241736A1 (en) 2003-05-21 2004-12-02 Hendee Shonn P. Analyte determinations
US7258673B2 (en) 2003-06-06 2007-08-21 Lifescan, Inc Devices, systems and methods for extracting bodily fluid and monitoring an analyte therein
JP2007511252A (ja) 2003-06-09 2007-05-10 ニプロ ダイアビティーズ システムズ，インコーポレイテッド 注入ポンプにおけるカップリングシステム
US8066639B2 (en) 2003-06-10 2011-11-29 Abbott Diabetes Care Inc. Glucose measuring device for use in personal area network
WO2005007223A2 (en) 2003-07-16 2005-01-27 Sasha John Programmable medical drug delivery systems and methods for delivery of multiple fluids and concentrations
US7519408B2 (en) 2003-11-19 2009-04-14 Dexcom, Inc. Integrated receiver for continuous analyte sensor
US7591801B2 (en) 2004-02-26 2009-09-22 Dexcom, Inc. Integrated delivery device for continuous glucose sensor
PL1662987T3 (pl) 2003-09-11 2012-04-30 Theranos Inc Urządzenie medyczne do monitorowania analitu oraz podawania leku
DE10346167A1 (de) 2003-10-01 2005-05-25 Merck Patent Gmbh Glänzende schwarze Interferenzpigmente
US7320676B2 (en) 2003-10-02 2008-01-22 Medtronic, Inc. Pressure sensing in implantable medical devices
KR100567837B1 (ko) 2003-10-24 2006-04-05 케이제이헬스케어 주식회사 혈당측정이 가능한 이동통신단말기와 결합되는 인슐린펌프와, 인슐린 펌프의 제어정보 전송을 위한 네트워크시스템
WO2006053007A2 (en) 2004-11-09 2006-05-18 Angiotech Biocoatings Corp. Antimicrobial needle coating for extended infusion
EP2316331B1 (en) 2003-12-09 2016-06-29 Dexcom, Inc. Signal processing for continuous analyte sensor
US20050137573A1 (en) 2003-12-19 2005-06-23 Animas Corporation System, method, and communication hub for controlling external infusion device
NZ585119A (en) 2004-03-08 2011-08-26 Ichor Medical Systems Inc Medical injector with surrounding electrical field generating penetrating electrodes
WO2005093629A2 (en) 2004-03-26 2005-10-06 Novo Nordisk A/S Device for displaying data relevant for a diabetic patient
US20060009727A1 (en) 2004-04-08 2006-01-12 Chf Solutions Inc. Method and apparatus for an extracorporeal control of blood glucose
US20080051764A1 (en) 2004-04-19 2008-02-28 Board Of Regents, The University Of Texas System Physiological Monitoring With Continuous Treatment
WO2005110601A1 (en) 2004-05-07 2005-11-24 Optiscan Biomedical Corporation Sample element with separator
US7651845B2 (en) 2004-05-13 2010-01-26 The Regents Of The University Of California Method and apparatus for glucose control and insulin dosing for diabetics
US20050261660A1 (en) 2004-05-24 2005-11-24 Choi Soo B Method for controlling insulin pump using Bluetooth protocol
US8535016B2 (en) 2004-07-13 2013-09-17 Waters Technologies Corporation High pressure pump control
US7291107B2 (en) 2004-08-26 2007-11-06 Roche Diagnostics Operations, Inc. Insulin bolus recommendation system
US7608042B2 (en) 2004-09-29 2009-10-27 Intellidx, Inc. Blood monitoring system
US20060229531A1 (en) 2005-02-01 2006-10-12 Daniel Goldberger Blood monitoring system
US20070191716A1 (en) 2004-09-29 2007-08-16 Daniel Goldberger Blood monitoring system
EP1805499A4 (en) 2004-10-21 2010-07-21 Optiscan Biomedical Corp METHOD AND DEVICE FOR DETERMINING AN ANALYZ CONCENTRATION IN A SAMPLE OF INTERFERING SUBSTANCE
CN100541234C (zh) 2004-12-21 2009-09-16 纳幕尔杜邦公司 用于在基材上形成图案化氟聚合物膜的方法
US20060167350A1 (en) 2005-01-27 2006-07-27 Monfre Stephen L Multi-tier method of developing localized calibration models for non-invasive blood analyte prediction
US7547281B2 (en) * 2005-02-01 2009-06-16 Medtronic Minimed, Inc. Algorithm sensor augmented bolus estimator for semi-closed loop infusion system
US20070083160A1 (en) 2005-10-06 2007-04-12 Hall W D System and method for assessing measurements made by a body fluid analyzing device
US20060189926A1 (en) 2005-02-14 2006-08-24 Hall W D Apparatus and methods for analyzing body fluid samples
US7785258B2 (en) 2005-10-06 2010-08-31 Optiscan Biomedical Corporation System and method for determining a treatment dose for a patient
US8251907B2 (en) 2005-02-14 2012-08-28 Optiscan Biomedical Corporation System and method for determining a treatment dose for a patient
US20060200070A1 (en) 2005-02-14 2006-09-07 Callicoat David N Method and apparatus for calibrating an analyte detection system with a calibration sample
US20060189925A1 (en) 2005-02-14 2006-08-24 Gable Jennifer H Methods and apparatus for extracting and analyzing a component of a bodily fluid
US20060204535A1 (en) 2005-02-25 2006-09-14 Johnson Johnnie M Cell-friendly cannula and needle
US20090054753A1 (en) 2007-08-21 2009-02-26 Mark Ries Robinson Variable Sampling Interval for Blood Analyte Determinations
JP5001934B2 (ja) 2005-04-15 2012-08-15 バイエル・ヘルスケア・エルエルシー 体内グルコースを測定する非侵襲的システム及び方法
US20060253085A1 (en) 2005-05-06 2006-11-09 Medtronic Minimed, Inc. Dual insertion set
US7806854B2 (en) 2005-05-13 2010-10-05 Trustees Of Boston University Fully automated control system for type 1 diabetes
US7509156B2 (en) 2005-05-18 2009-03-24 Clarian Health Partners, Inc. System for managing glucose levels in patients with diabetes or hyperglycemia
DE602006011000D1 (de) 2005-05-26 2010-01-21 Infusion Systems Llc Implantierbare infusionsvorrichtung mit mehreren kontrollierbaren flüssigkeitsausgängen
EP1728468A1 (de) 2005-06-04 2006-12-06 Roche Diagnostics GmbH Bewertung von Werten der Blutglucosekonzentration zur Einstellung der Insulindosierung
US20060276771A1 (en) 2005-06-06 2006-12-07 Galley Paul J System and method providing for user intervention in a diabetes control arrangement
US20070060869A1 (en) 2005-08-16 2007-03-15 Tolle Mike C V Controller device for an infusion pump
US7766829B2 (en) 2005-11-04 2010-08-03 Abbott Diabetes Care Inc. Method and system for providing basal profile modification in analyte monitoring and management systems
CA2630094A1 (en) 2005-11-15 2007-05-24 Luminous Medical, Inc. Blood analyte determinations
US7704457B2 (en) 2005-11-18 2010-04-27 Patton Charles J Automatic, field portable analyzer using discrete sample aliquots
US20080200838A1 (en) 2005-11-28 2008-08-21 Daniel Goldberger Wearable, programmable automated blood testing system
US20070129690A1 (en) 2005-12-02 2007-06-07 Joel Rosenblatt Catheter with polymeric coating
US8666760B2 (en) 2005-12-30 2014-03-04 Carefusion 303, Inc. Medication order processing and reconciliation
US20070173974A1 (en) 2006-01-25 2007-07-26 Chyi-Yeu Lin Device and method for interacting with autonomous robot
BRPI0708063A2 (pt) 2006-02-17 2011-05-17 Alan L Buchman dispositivos de limpeza de cateter
US20070197163A1 (en) 2006-02-23 2007-08-23 Research In Motion Limited Combination modes for network connection management
US8478557B2 (en) 2009-07-31 2013-07-02 Abbott Diabetes Care Inc. Method and apparatus for providing analyte monitoring system calibration accuracy
WO2007124448A2 (en) 2006-04-20 2007-11-01 Rosero Spencer Z Method and apparatus for the management of diabetes
CA2679733C (en) 2006-05-09 2017-06-20 Axela Inc. Automated analyzer using light diffraction
US20070282269A1 (en) 2006-05-31 2007-12-06 Seattle Medical Technologies Cannula delivery apparatus and method for a disposable infusion device
US7920907B2 (en) 2006-06-07 2011-04-05 Abbott Diabetes Care Inc. Analyte monitoring system and method
US7736338B2 (en) 2006-08-23 2010-06-15 Medtronic Minimed, Inc. Infusion medium delivery system, device and method with needle inserter and needle inserter device and method
US9056165B2 (en) 2006-09-06 2015-06-16 Medtronic Minimed, Inc. Intelligent therapy recommendation algorithm and method of using the same
EP2063762A1 (en) 2006-09-06 2009-06-03 Medingo Ltd. Fluid delivery system with optical sensing of analyte concentration levels
US8561614B2 (en) 2006-09-28 2013-10-22 Covidien Lp Multi-layer cuffs for medical devices
GB2443261B (en) 2006-10-26 2009-04-22 Starbridge Systems Ltd Wax micro actuator
GB2443260C (en) 2006-10-26 2017-11-29 Cellnovo Ltd Micro-valve
US8377040B2 (en) 2006-11-06 2013-02-19 Becton, Dickinson And Company Extravascular system venting
US20080214919A1 (en) 2006-12-26 2008-09-04 Lifescan, Inc. System and method for implementation of glycemic control protocols
US7946985B2 (en) 2006-12-29 2011-05-24 Medtronic Minimed, Inc. Method and system for providing sensor redundancy
US7734323B2 (en) 2007-01-24 2010-06-08 Smiths Medical Asd, Inc. Correction factor testing using frequent blood glucose input
US20080228056A1 (en) 2007-03-13 2008-09-18 Michael Blomquist Basal rate testing using frequent blood glucose input
US20080249386A1 (en) 2007-04-04 2008-10-09 Pronia Medical Systems, Llc Systems, Methods, and Computer Program Product for Improved Management of Medical Procedures for Patients on Medical Protocols
US20080269714A1 (en) 2007-04-25 2008-10-30 Medtronic Minimed, Inc. Closed loop/semi-closed loop therapy modification system
US20080269723A1 (en) 2007-04-25 2008-10-30 Medtronic Minimed, Inc. Closed loop/semi-closed loop therapy modification system
CA2685808C (en) 2007-04-30 2013-06-11 Medtronic Minimed, Inc. Needle inserting and fluid flow connection for infusion medium delivery system
US8417311B2 (en) 2008-09-12 2013-04-09 Optiscan Biomedical Corporation Fluid component analysis system and method for glucose monitoring and control
US8221345B2 (en) 2007-05-30 2012-07-17 Smiths Medical Asd, Inc. Insulin pump based expert system
US8454510B2 (en) 2007-06-20 2013-06-04 Medingo Ltd. Method and device for assessing carbohydrate-to-insulin ratio
JP2010530279A (ja) 2007-06-21 2010-09-09 メディンゴ・リミテッド 低血糖を防止するための装置および方法
US8078787B2 (en) 2007-06-22 2011-12-13 Apple Inc. Communication between a host device and an accessory via an intermediate device
ES2845400T3 (es) 2007-06-27 2021-07-26 Hoffmann La Roche Sistema para determinar una administración de insulina y comunicar una dosis en un programa informático de páncreas automatizado
US20090036753A1 (en) 2007-07-31 2009-02-05 King Allen B Continuous glucose monitoring-directed adjustments in basal insulin rate and insulin bolus dosing formulas
US7717903B2 (en) 2007-09-06 2010-05-18 M2 Group Holdings, Inc. Operating an infusion pump system
US7935076B2 (en) 2007-09-07 2011-05-03 Asante Solutions, Inc. Activity sensing techniques for an infusion pump system
EP2197350A2 (en) 2007-09-11 2010-06-23 Baxter International Inc. Infusion therapy sensor system
MX2010002936A (es) 2007-09-17 2010-08-09 Satish Sundar Controlador de bomba de infusion de alta precision.
CN102155387A (zh) 2007-10-02 2011-08-17 艾默生环境优化技术有限公司 具有改进的阀板的压缩机
WO2009049252A1 (en) 2007-10-10 2009-04-16 Optiscan Biomedical Corporation Fluid component analysis system and method for glucose monitoring and control
DE102007049446A1 (de) 2007-10-16 2009-04-23 Cequr Aps Katheter-Einführeinrichtung
US7695434B2 (en) 2007-10-19 2010-04-13 Lifescan Scotland, Ltd. Medical device for predicting a user's future glycemic state
US20100262117A1 (en) 2007-11-02 2010-10-14 University Of Virginia Patent Foundation Predictive control based system and method for control of insulin delivery in diabetes using glucose sensing
US8615281B2 (en) 2007-11-21 2013-12-24 Medingo Ltd. Hypodermic optical monitoring of bodily analyte
WO2009066288A1 (en) 2007-11-21 2009-05-28 Medingo Ltd. Analyte monitoring and fluid dispensing system
US7918825B2 (en) 2007-11-29 2011-04-05 Insulet Corporation Interfacing a prefilled syringe with an infusion pump to fill the infusion pump
US20100262434A1 (en) 2007-12-13 2010-10-14 Shaya Steven A Method and apparatus to calculate diabetic sensitivity factors affecting blood glucose
US9839395B2 (en) 2007-12-17 2017-12-12 Dexcom, Inc. Systems and methods for processing sensor data
DE112009000224T5 (de) 2008-01-31 2011-01-05 Fisher-Rosemount Systems, Inc., Austin Robuster andaptiver modellprädiktiver Regler mit Abstimmung zum Ausgleich einer Modellfehlanpassung
US20110004188A1 (en) 2008-02-04 2011-01-06 Avraham Shekalim Drug delivery system with wireless monitor
US20090221890A1 (en) 2008-02-28 2009-09-03 Daniel Saffer Diabetes Management System
DK2252956T3 (en) * 2008-03-03 2019-03-25 Hoffmann La Roche INSULIN PUMP WITH REPLACEMENT OPPORTUNITIES
KR20110042026A (ko) 2008-03-12 2011-04-22 유니버시티 오브 마이애미 저혈당증의 치료 및 검출을 위한 분석 및 방법
JP5506780B2 (ja) * 2008-04-09 2014-05-28 エフ．ホフマン−ラ ロシュ アーゲー 流体を送り出すためのシステム、装置および方法
TWI394580B (zh) 2008-04-28 2013-05-01 Halozyme Inc 超快起作用胰島素組成物
US8140275B2 (en) 2008-07-18 2012-03-20 Insulet Corporation Calculating insulin on board for extended bolus being delivered by an insulin delivery device
US8734422B2 (en) 2008-08-31 2014-05-27 Abbott Diabetes Care Inc. Closed loop control with improved alarm functions
US8622988B2 (en) 2008-08-31 2014-01-07 Abbott Diabetes Care Inc. Variable rate closed loop control and methods
EP2323720A4 (en) 2008-09-09 2013-04-10 Pulmonx Corp SYSTEMS AND METHODS FOR INHIBITING PENETRATION OF A SECRETION FLOW IN A FUNCTIONAL EVALUATION CATHETER
GB2464114B (en) 2008-10-02 2012-06-13 Cellnovo Ltd Linear capacitive displacement sensor
US9409052B2 (en) 2008-10-03 2016-08-09 Adidas Ag Program products, methods, and systems for providing location-aware fitness monitoring services
US8632497B2 (en) 2008-10-09 2014-01-21 Roche Diagnostics Operations Inc. Skin securable drug delivery device with a shock absorbing protective shield
US20100174228A1 (en) 2008-10-24 2010-07-08 Bruce Buckingham Hypoglycemia prediction and control
US8613719B2 (en) 2008-11-03 2013-12-24 Calibra Medical, Inc. Dosage sensing unit with tactile feedback
WO2010053702A1 (en) 2008-11-07 2010-05-14 Delphi Technologies, Inc. Method of automatically programming an infusion pump
US9370621B2 (en) 2008-12-16 2016-06-21 Medtronic Minimed, Inc. Needle insertion systems and methods
US9375529B2 (en) 2009-09-02 2016-06-28 Becton, Dickinson And Company Extended use medical device
DK2400882T3 (en) 2009-02-26 2017-09-18 Dreamed Diabetes Ltd METHOD AND SYSTEM FOR AUTOMATIC MONITORING OF DIABETES-RELATED TREATMENTS
GR1007310B (el) 2009-03-09 2011-06-10 Αχιλλεας Τσουκαλης Εμφυτευσιμος βιοαισθητηρας με αυτοματη βαθμονομηση
US8172798B2 (en) 2009-05-12 2012-05-08 Sigma International General Medical Apparatus LLC System and method for managing infusion therapies
WO2010135638A2 (en) 2009-05-22 2010-11-25 Abbott Diabetes Care Inc. Methods for reducing false hypoglycemia alarm occurrence
EP2433235A2 (en) 2009-05-22 2012-03-28 Abbott Diabetes Care, Inc. Safety features for integrated insulin delivery system
US8597274B2 (en) 2009-05-22 2013-12-03 Abbott Diabetes Care Inc. Usability features for integrated insulin delivery system
CN102576375B (zh) 2009-05-29 2016-05-18 弗吉尼亚大学专利基金会 用于糖尿病的开环和闭环控制的系统协调器和模块化体系结构
US20110152770A1 (en) 2009-07-30 2011-06-23 Tandem Diabetes Care, Inc. Infusion pump system with disposable cartridge having pressure venting and pressure feedback
US8547239B2 (en) 2009-08-18 2013-10-01 Cequr Sa Methods for detecting failure states in a medicine delivery device
US8900190B2 (en) 2009-09-02 2014-12-02 Medtronic Minimed, Inc. Insertion device systems and methods
ES2730101T3 (es) 2009-09-08 2019-11-08 Hoffmann La Roche Dispositivos, sistemas y procedimientos para ajustar los parámetros de administración de líquido
US20110099507A1 (en) 2009-10-28 2011-04-28 Google Inc. Displaying a collection of interactive elements that trigger actions directed to an item
US9858386B2 (en) 2009-11-02 2018-01-02 Universita Degli Studi Di Padova Method to recalibrate continuous glucose monitoring data on-line
US9149454B2 (en) 2009-11-12 2015-10-06 Acacia Pharma Limited Use of bethanechol for treatment of xerostomia
US20110124996A1 (en) 2009-11-20 2011-05-26 Roche Diagnostics Operations, Inc. Diabetes health management systems and methods
WO2011082272A2 (en) 2009-12-31 2011-07-07 Deka Products Limited Partnership Infusion pump assembley
US8348898B2 (en) * 2010-01-19 2013-01-08 Medimop Medical Projects Ltd. Automatic needle for drug pump
US9457145B2 (en) 2010-01-20 2016-10-04 Roche Diabetes Care, Inc. Method and device for improving glycemic control
US10911515B2 (en) 2012-05-24 2021-02-02 Deka Products Limited Partnership System, method, and apparatus for electronic patient care
CN102753222B (zh) 2010-02-05 2015-01-07 赛诺菲-安万特德国有限公司 具有定时锁的载药模块
US9662438B2 (en) 2010-02-05 2017-05-30 Deka Products Limited Partnership Devices, methods and systems for wireless control of medical devices
IL211800A (en) 2010-03-21 2014-03-31 Isaac Zukier Liquid or clot injection device
US8810394B2 (en) 2010-04-16 2014-08-19 Medtronic, Inc. Reservoir monitoring for implantable fluid delivery devices
ES2545411T5 (es) 2010-06-07 2024-04-05 Amgen Inc Dispositivo de administración de fármaco
EP2397181B1 (en) 2010-06-18 2014-01-15 F. Hoffmann-La Roche AG Insertion device having a permanently locking rotating needle cover
US20110313680A1 (en) 2010-06-22 2011-12-22 Doyle Iii Francis J Health Monitoring System
EP2605813B1 (en) * 2010-08-17 2018-08-01 University of Florida Research Foundation, Inc. Intelligent drug delivery system to optimizing medical treatment or therapy.
US9132233B2 (en) * 2010-08-26 2015-09-15 B. Braun Melsungen Ag Infusion control device
US9498573B2 (en) 2010-09-24 2016-11-22 Perqflo, Llc Infusion pumps
EP2436412A1 (en) 2010-10-04 2012-04-04 Unomedical A/S A sprinkler cannula
WO2012051344A2 (en) 2010-10-12 2012-04-19 Regents Of The University Of California, The Maintaining multiple defined physiological zones using model predictive control
US9211378B2 (en) 2010-10-22 2015-12-15 Cequr Sa Methods and systems for dosing a medicament
US8852152B2 (en) 2011-02-09 2014-10-07 Asante Solutions, Inc. Infusion pump systems and methods
CN203609736U (zh) 2011-02-09 2014-05-28 贝克顿·迪金森公司 具有自动插入和引导器针缩回功能的注入器械
EP3421065B1 (en) 2011-02-09 2020-07-08 Becton, Dickinson and Company Insulin infusion set
CN203724531U (zh) 2011-02-09 2014-07-23 贝克顿·迪金森公司 输液器具
US10136845B2 (en) 2011-02-28 2018-11-27 Abbott Diabetes Care Inc. Devices, systems, and methods associated with analyte monitoring devices and devices incorporating the same
ES2927800T3 (es) 2011-03-01 2022-11-11 Nutrition 21 Llc Composición de insulina y cromo para el tratamiento y la prevención de diabetes, hipoglicemia y trastornos relacionados
WO2012122520A1 (en) 2011-03-10 2012-09-13 Abbott Diabetes Care Inc. Multi-function analyte monitor device and methods of use
EP3536241B1 (en) 2011-04-08 2023-03-29 Dexcom, Inc. Systems and methods for processing and transmitting sensor data
US20120271655A1 (en) 2011-04-19 2012-10-25 Yishai Knobel Methods and Systems for Enabling Applications on a Mobile Computing Device to Access Data Associated with a Peripheral Medical Device
US8308680B1 (en) 2011-04-26 2012-11-13 Medtronic Minimed, Inc. Selective alarms for an infusion device
JP2014523499A (ja) 2011-05-05 2014-09-11 エクシジェント テクノロジーズ， エルエルシー 往復動界面動電ポンプの差動圧力制御のシステムおよび方法
US9075900B2 (en) 2011-05-18 2015-07-07 Exco Intouch Systems, methods and computer program products for providing compliant delivery of content, applications and/or solutions
JP2014524791A (ja) 2011-06-23 2014-09-25 ユニバーシティ オブ ヴァージニア パテント ファウンデーション 糖尿病患者の血糖値の監視と制御のための統合プラットフォーム
ES2864552T3 (es) 2011-11-22 2021-10-14 Becton Dickinson Co Sistema de administración de medicamentos con un mecanismo de retardo
EP2902054B1 (en) 2011-12-07 2018-02-07 Becton, Dickinson and Company Needle shielding assemblies and infusion devices for use therewith
US20130178791A1 (en) 2012-01-09 2013-07-11 Jonathan C. Javitt Method and system for detecting and treating biological and chemical warfare agents
US10987505B2 (en) 2012-03-07 2021-04-27 Deka Products Limited Partnership Infusion pump assembly
US9463280B2 (en) * 2012-03-26 2016-10-11 Medimop Medical Projects Ltd. Motion activated septum puncturing drug delivery device
EP3549524B1 (en) 2012-03-30 2023-01-25 Insulet Corporation Fluid delivery device with transcutaneous access tool, insertion mechanism and blood glucose monitoring for use therewith
WO2013177565A1 (en) 2012-05-25 2013-11-28 Amylin Pharmaceuticals, Llc Insulin-pramlintide compositions and methods for making and using them
WO2013182321A1 (en) 2012-06-09 2013-12-12 Roche Diagnostics Gmbh Disposable inserter for use with a medical device
US20130338576A1 (en) 2012-06-15 2013-12-19 Wayne C. Jaeschke, Jr. Portable infusion pump with pressure and temperature compensation
WO2013189918A1 (de) 2012-06-18 2013-12-27 Fresenius Kabi Deutschland Gmbh Portkanülensystem zum punktieren von portkathetern
US9757510B2 (en) 2012-06-29 2017-09-12 Animas Corporation Method and system to handle manual boluses or meal events for closed-loop controllers
US10130767B2 (en) 2012-08-30 2018-11-20 Medtronic Minimed, Inc. Sensor model supervisor for a closed-loop insulin infusion system
US9878096B2 (en) 2012-08-30 2018-01-30 Medtronic Minimed, Inc. Generation of target glucose values for a closed-loop operating mode of an insulin infusion system
WO2014035672A2 (en) 2012-08-30 2014-03-06 Medtronic Minimed, Inc. Safeguarding techniques for a closed-loop insulin infusion system
AU2015200834B2 (en) 2012-08-30 2016-07-14 Medtronic Minimed, Inc. Safeguarding techniques for a closed-loop insulin infusion system
US9171343B1 (en) 2012-09-11 2015-10-27 Aseko, Inc. Means and method for improved glycemic control for diabetic patients
US20150213217A1 (en) 2012-09-13 2015-07-30 Parkland Center For Clinical Innovation Holistic hospital patient care and management system and method for telemedicine
CN109963271B (zh) 2012-11-12 2022-06-03 埃姆皮公司 用于电刺激的无线配对和通信的系统及方法
US9253433B2 (en) 2012-11-27 2016-02-02 International Business Machines Corporation Method and apparatus for tagging media with identity of creator or scene
TWM452390U (zh) 2012-12-11 2013-05-01 Dongguan Masstop Liquid Crystal Display Co Ltd 主動式電容觸控筆
US20140276536A1 (en) 2013-03-14 2014-09-18 Asante Solutions, Inc. Infusion Pump System and Methods
US9907909B2 (en) 2012-12-20 2018-03-06 Animas Corporation Method and system for a hybrid control-to-target and control-to-range model predictive control of an artificial pancreas
WO2014109898A1 (en) 2013-01-14 2014-07-17 The Regents Of University Of California Model-based personalization scheme of an artificial pancreas for type i diabetes applications
CN105050539B (zh) 2013-01-14 2018-05-18 加利福尼亚大学董事会 用于1型糖尿病应用的人造胰腺的模型预测控制问题中的每日周期性目标区间调节
US10573413B2 (en) 2013-03-14 2020-02-25 Roche Diabetes Care, Inc. Method for the detection and handling of hypoglycemia
US9795737B2 (en) 2013-03-15 2017-10-24 Animas Corporation Method and system for closed-loop control of an artificial pancreas
US10016561B2 (en) 2013-03-15 2018-07-10 Tandem Diabetes Care, Inc. Clinical variable determination
CN105142695B (zh) 2013-03-15 2020-06-02 安进公司 身体轮廓可调适的自动注射器装置
ES2671001T3 (es) 2013-03-15 2018-06-04 Animas Corporation Modelo de tiempo-acción de insulina
EP2986215B1 (en) 2013-04-16 2020-08-19 Bigfoot Biomedical, Inc. Discretionary insulin delivery systems and methods
US10003545B2 (en) 2013-04-26 2018-06-19 Roche Diabetes Care, Inc. Mobile phone application for diabetes care with medical feature activation
CN105228675B (zh) 2013-05-31 2018-04-27 瓦莱里塔斯公司 具有可插入式预填充筒的流体输送装置
EP3011487B1 (en) 2013-06-21 2023-09-27 Fresenius Vial SAS Method and control device for controlling the administration of insulin to a patient
CA2918332C (en) 2013-07-18 2023-08-08 Parkland Center For Clinical Innovation Patient care surveillance system and method
AU2014290745A1 (en) 2013-07-19 2015-12-17 Dexcom, Inc. Time averaged basal rate optimizer
WO2015056259A1 (en) 2013-10-14 2015-04-23 Dreamed-Diabetes Ltd. System and method for improved artificial pancreas management
EP2862586B1 (en) 2013-10-21 2021-09-01 F. Hoffmann-La Roche AG Control unit for infusion pump units, including a controlled intervention unit
US9940846B2 (en) 2013-10-31 2018-04-10 Dexcom, Inc. Adaptive interface for continuous monitoring devices
US10311972B2 (en) 2013-11-11 2019-06-04 Icu Medical, Inc. Medical device system performance index
JP6643558B2 (ja) 2013-11-14 2020-02-12 リージェンツ オブ ザ ユニバーシティー オブ カリフォルニア グルコース率増加検出器及びそれを含む人工膵臓、差し迫った有害事象のリアルタイム予測のためのヘルスモニタリングシステム並びにヘルスモニタリングシステム用の食事検出モジュール
ES2721974T3 (es) 2013-12-01 2019-08-06 Becton Dickinson Co Dispositivo para medicamento
US9849240B2 (en) 2013-12-12 2017-12-26 Medtronic Minimed, Inc. Data modification for predictive operations and devices incorporating same
US20150173674A1 (en) 2013-12-20 2015-06-25 Diabetes Sentry Products Inc. Detecting and communicating health conditions
JP6137338B2 (ja) 2013-12-25 2017-05-31 富士通株式会社 ペアリング処理装置、ペアリング処理方法及びペアリング処理プログラム
EP3087548A4 (en) 2013-12-26 2017-09-13 Tandem Diabetes Care, Inc. Safety processor for wireless control of a drug delivery device
WO2015103543A1 (en) 2014-01-03 2015-07-09 University Of Virginia Patent Foundation Central data exchange node for system monitoring and control of blood glucose levels in diabetic patients
US9486580B2 (en) 2014-01-31 2016-11-08 Aseko, Inc. Insulin management
US9898585B2 (en) 2014-01-31 2018-02-20 Aseko, Inc. Method and system for insulin management
US9399096B2 (en) 2014-02-06 2016-07-26 Medtronic Minimed, Inc. Automatic closed-loop control adjustments and infusion systems incorporating same
US10773032B2 (en) 2014-03-14 2020-09-15 Shl Medical Ag Monitoring device
US9610402B2 (en) * 2014-03-24 2017-04-04 Medtronic Minimed, Inc. Transcutaneous conduit insertion mechanism with a living hinge for use with a fluid infusion patch pump device
US10238323B2 (en) 2014-06-06 2019-03-26 Dexcom, Inc. Fault discrimination and responsive processing based on data and context
WO2015196174A1 (en) 2014-06-20 2015-12-23 Greene Howard E Infusion delivery devices and methods
US20150379237A1 (en) 2014-06-30 2015-12-31 Gary Mills Infusion pump error display
ES2921199T3 (es) 2014-08-01 2022-08-19 Becton Dickinson Co Dispositivo de inyección con monitorización continua de glucosa
CA2957432C (en) 2014-08-06 2017-07-25 Regents Of The University Of California Moving-horizon state-initializer for control applications
US9717845B2 (en) 2014-08-19 2017-08-01 Medtronic Minimed, Inc. Geofencing for medical devices
CN107106769A (zh) 2014-08-28 2017-08-29 尤尼特拉克特注射器控股有限公司 用于药物递送装置的皮肤传感器
JP6734262B2 (ja) 2014-09-15 2020-08-05 サノフイＳａｎｏｆｉ 接触センサを含む、皮膚装着型の薬剤送達デバイス
US20160082187A1 (en) 2014-09-23 2016-03-24 Animas Corporation Decisions support for patients with diabetes
US10529454B2 (en) 2014-10-17 2020-01-07 Bradley E. Kahlbaugh Human metabolic condition management
US9943645B2 (en) 2014-12-04 2018-04-17 Medtronic Minimed, Inc. Methods for operating mode transitions and related infusion devices and systems
US9636453B2 (en) 2014-12-04 2017-05-02 Medtronic Minimed, Inc. Advance diagnosis of infusion device operating mode viability
US10307535B2 (en) 2014-12-19 2019-06-04 Medtronic Minimed, Inc. Infusion devices and related methods and systems for preemptive alerting
WO2016115372A1 (en) 2015-01-16 2016-07-21 Becton, Dickinson And Company Smart module for autoinjection devices
AU2016219961B2 (en) * 2015-02-18 2020-07-02 Insulet Corporation Fluid delivery and infusion devices, and methods of use thereof
EP3834863A1 (en) 2015-03-02 2021-06-16 Amgen, Inc Device and method for making aseptic connections
US10617363B2 (en) 2015-04-02 2020-04-14 Roche Diabetes Care, Inc. Methods and systems for analyzing glucose data measured from a person having diabetes
US10646650B2 (en) 2015-06-02 2020-05-12 Illinois Institute Of Technology Multivariable artificial pancreas method and system
EP3314548B1 (en) 2015-06-28 2021-10-06 The Regents of The University of California Velocity-weighting model predictive control of an artificial pancreas for type 1 diabetes applications
US10463297B2 (en) 2015-08-21 2019-11-05 Medtronic Minimed, Inc. Personalized event detection methods and related devices and systems
JP6976259B2 (ja) 2015-11-04 2021-12-08 バイエル・ヘルスケア・エルエルシーBayer HealthCare LLC バーコードデータベースおよびソフトウェア更新システム
EP3380061A4 (en) 2015-11-24 2019-07-24 Insulet Corporation AUTOMATED WEARABLE DRUG DELIVERY SYSTEM
US10413665B2 (en) 2015-11-25 2019-09-17 Insulet Corporation Wearable medication delivery device
US10248839B2 (en) 2015-11-30 2019-04-02 Intel Corporation Locating objects within depth images
EP3389491B1 (en) 2015-12-18 2024-05-22 Dexcom, Inc. Data backfilling for continuous glucose monitoring
US10987468B2 (en) 2016-01-05 2021-04-27 Bigfoot Biomedical, Inc. Operating multi-modal medicine delivery systems
US9980140B1 (en) 2016-02-11 2018-05-22 Bigfoot Biomedical, Inc. Secure communication architecture for medical devices
US10792423B2 (en) 2016-04-13 2020-10-06 The Trustees Of The University Of Pennsylvania Methods, systems, and computer readable media for physiology parameter-invariant meal detection
US20200268968A1 (en) 2016-04-22 2020-08-27 Children`S Medical Center Corporation Methods and systems for managing diabetes
US9974903B1 (en) 2016-05-02 2018-05-22 Dexcom, Inc. System and method for providing alerts optimized for a user
WO2017205819A1 (en) 2016-05-26 2017-11-30 Insulet Corporation Multi-dose drug delivery device
US10332632B2 (en) 2016-06-01 2019-06-25 Roche Diabetes Care, Inc. Control-to-range failsafes
WO2018009614A1 (en) 2016-07-06 2018-01-11 President And Fellows Of Harvard College Event-triggered model predictive control for embedded artificial pancreas systems
US10052441B2 (en) 2016-08-02 2018-08-21 Becton, Dickinson And Company System and method for measuring delivered dose
US11202579B2 (en) 2016-08-08 2021-12-21 Zoll Medical Corporation Wrist-worn device for coordinating patient care
CA3029272A1 (en) 2016-09-09 2018-03-15 Dexcom, Inc. Systems and methods for cgm-based bolus calculator for display and for provision to medicament delivery devices
US10987032B2 (en) 2016-10-05 2021-04-27 Cláudio Afonso Ambrósio Method, system, and apparatus for remotely controlling and monitoring an electronic device
US10561788B2 (en) 2016-10-06 2020-02-18 Medtronic Minimed, Inc. Infusion systems and methods for automated exercise mitigation
US11097051B2 (en) 2016-11-04 2021-08-24 Medtronic Minimed, Inc. Methods and apparatus for detecting and reacting to insufficient hypoglycemia response
US10854322B2 (en) 2016-12-21 2020-12-01 Medtronic Minimed, Inc. Infusion systems and methods for patient activity adjustments
WO2018120104A1 (en) 2016-12-30 2018-07-05 Medtrum Technologies Inc. System and method for closed loop control in artificial pancreas
US11033682B2 (en) 2017-01-13 2021-06-15 Bigfoot Biomedical, Inc. Insulin delivery methods, systems and devices
US10881793B2 (en) 2017-01-13 2021-01-05 Bigfoot Biomedical, Inc. System and method for adjusting insulin delivery
US10583250B2 (en) 2017-01-13 2020-03-10 Bigfoot Biomedical, Inc. System and method for adjusting insulin delivery
CA3046354A1 (en) 2017-01-17 2018-07-26 Kaleo, Inc. Medicament delivery devices with wireless connectivity and event detection
US11197949B2 (en) 2017-01-19 2021-12-14 Medtronic Minimed, Inc. Medication infusion components and systems
US20200046268A1 (en) 2017-02-15 2020-02-13 University Of Virginia Patent Foundation System, method, and computer readable medium for a basal rate profile adaptation algorithm for closed-loop artificial pancreas systems
JP6929673B2 (ja) 2017-03-21 2021-09-01 テルモ株式会社 算出装置、送液装置、及びインスリン投与システム
US10729849B2 (en) 2017-04-07 2020-08-04 LifeSpan IP Holdings, LLC Insulin-on-board accounting in an artificial pancreas system
US11147920B2 (en) 2017-04-18 2021-10-19 Lifescan Ip Holdings, Llc Diabetes management system with automatic basal and manual bolus insulin control
EP3618713B1 (en) 2017-05-05 2021-12-15 Eli Lilly and Company Closed loop control of physiological glucose
WO2019005686A1 (en) 2017-06-26 2019-01-03 Abbott Diabetes Care Inc. INTEGRATED CGM ARCHITECTURES AND DESIGNS FOR ARTIFICIAL PANCREAS
US20210193285A1 (en) 2017-10-19 2021-06-24 Dreamed Diabetes Ltd. A system and method for use in disease treatment management
WO2019094440A1 (en) 2017-11-08 2019-05-16 General Vibration Corporation Coherent phase switching and modulation of a linear actuator array
US11197964B2 (en) 2017-12-12 2021-12-14 Bigfoot Biomedical, Inc. Pen cap for medication injection pen having temperature sensor
WO2019125932A1 (en) 2017-12-21 2019-06-27 Eli Lilly And Company Closed loop control of physiological glucose
JP7124120B2 (ja) 2018-05-04 2022-08-23 インスレット コーポレイション 制御アルゴリズムベースの薬物送達システムのための安全制約
EP3811373A1 (en) 2018-06-22 2021-04-28 Eli Lilly and Company Insulin and pramlintide delivery systems, methods, and devices
US10335464B1 (en) 2018-06-26 2019-07-02 Novo Nordisk A/S Device for titrating basal insulin
AU2018264051B2 (en) 2018-08-09 2020-03-26 Final Bell Brand Co. A vaporization device, method of using the device, a charging case, a kit, and a vibration assembly
EP3856285A1 (en) 2018-09-28 2021-08-04 Insulet Corporation Activity mode for artificial pancreas system
US11097052B2 (en) 2018-09-28 2021-08-24 Medtronic Minimed, Inc. Insulin infusion device with configurable target blood glucose value for automatic basal insulin delivery operation
US10894126B2 (en) 2018-09-28 2021-01-19 Medtronic Minimed, Inc. Fluid infusion system that automatically determines and delivers a correction bolus
WO2020081393A1 (en) 2018-10-15 2020-04-23 President And Fellows Of Harvard College Control model for artificial pancreas
JP2022541491A (ja) 2019-07-16 2022-09-26 ベータ バイオニクス，インコーポレイテッド 血糖制御システム
CA3147267A1 (en) 2019-08-02 2021-02-11 Abbott Diabetes Care Inc. Systems, devices, and methods relating to medication dose guidance
US11935637B2 (en) 2019-09-27 2024-03-19 Insulet Corporation Onboarding and total daily insulin adaptivity
EP4185348A1 (en) 2020-07-22 2023-05-31 Insulet Corporation Open-loop insulin delivery basal parameters based on insulin delivery records

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101489603A (zh) * 2006-06-30 2009-07-22 诺沃-诺迪斯克有限公司 在佩戴时间期间具有医疗输注补偿的灌注装置
WO2010147659A2 (en) * 2009-06-17 2010-12-23 Medtronic Minimed, Inc. Closed-loop glucose and/or insulin control system

Also Published As

Publication number Publication date
AU2020217447B2 (en) 2022-03-31
EP3258991B1 (en) 2020-10-21
AU2016219961B2 (en) 2020-07-02
EP3733227A1 (en) 2020-11-04
CN111905188A (zh) 2020-11-10
US10737024B2 (en) 2020-08-11
US11596740B2 (en) 2023-03-07
AU2016219961A1 (en) 2017-09-14
EP3258991A4 (en) 2018-09-12
JP2018505756A (ja) 2018-03-01
WO2016134137A1 (en) 2016-08-25
AU2020217447A1 (en) 2020-09-03
EP3733227B1 (en) 2024-05-01
US20200306448A1 (en) 2020-10-01
CA2977053A1 (en) 2016-08-25
CN107405446A (zh) 2017-11-28
CN107405446B (zh) 2020-09-29
CA2977053C (en) 2023-08-01
EP3258991A1 (en) 2017-12-27
US20160235908A1 (en) 2016-08-18
US20230218823A1 (en) 2023-07-13

Similar Documents

Publication Publication Date Title
CN111905188B (zh) 流体输送和输注装置及其使用方法
US11229741B2 (en) Fluid delivery device, transcutaneous access tool and fluid drive mechanism for use therewith
US11383034B2 (en) Monitoring a physiological parameter associated with tissue of a host to confirm delivery of medication

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant