DE69828276D1 - Neue zyklische diaminverbindungen und heilmittel das diese enthält - Google Patents

Neue zyklische diaminverbindungen und heilmittel das diese enthält

Info

Publication number
DE69828276D1
DE69828276D1 DE69828276T DE69828276T DE69828276D1 DE 69828276 D1 DE69828276 D1 DE 69828276D1 DE 69828276 T DE69828276 T DE 69828276T DE 69828276 T DE69828276 T DE 69828276T DE 69828276 D1 DE69828276 D1 DE 69828276D1
Authority
DE
Germany
Prior art keywords
optionally substituted
lower alkyl
alkyl group
integer
present
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69828276T
Other languages
English (en)
Other versions
DE69828276T2 (de
Inventor
K Shibuya
Katsumi Kawamine
Yukihiro Sato
Toru Miura
Chiyoka Ozaki
Toshiyuki Edano
Mitsuteru Hirata
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kowa Co Ltd
Original Assignee
Kowa Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kowa Co Ltd filed Critical Kowa Co Ltd
Application granted granted Critical
Publication of DE69828276D1 publication Critical patent/DE69828276D1/de
Publication of DE69828276T2 publication Critical patent/DE69828276T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D263/00Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/58Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D235/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/28Sulfur atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62Benzothiazoles
    • C07D277/68Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/70Sulfur atoms
    • C07D277/74Sulfur atoms substituted by carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509Six-membered rings
    • C07F9/650952Six-membered rings having the nitrogen atoms in the positions 1 and 4
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE69828276T 1997-05-26 1998-05-26 Neue cyclische Diaminverbindungen und Heilmittel das diese enthält Expired - Lifetime DE69828276T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP14989297 1997-05-26
JP14989297 1997-05-26
PCT/JP1998/002300 WO1998054153A1 (fr) 1997-05-26 1998-05-26 Nouveaux composes de diamine cycliques et medicament contenant ces composes

Publications (2)

Publication Number Publication Date
DE69828276D1 true DE69828276D1 (de) 2005-01-27
DE69828276T2 DE69828276T2 (de) 2005-12-15

Family

ID=15484915

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69828276T Expired - Lifetime DE69828276T2 (de) 1997-05-26 1998-05-26 Neue cyclische Diaminverbindungen und Heilmittel das diese enthält

Country Status (19)

Country Link
EP (1) EP0987254B1 (de)
JP (1) JP3614865B2 (de)
KR (1) KR100549804B1 (de)
CN (1) CN1118457C (de)
AT (1) ATE285402T1 (de)
AU (1) AU728151B2 (de)
CA (1) CA2290744C (de)
CZ (1) CZ297451B6 (de)
DE (1) DE69828276T2 (de)
ES (1) ES2235328T3 (de)
HU (1) HUP0002294A3 (de)
ID (1) ID23377A (de)
NO (1) NO315045B1 (de)
NZ (1) NZ501156A (de)
PT (1) PT987254E (de)
RU (1) RU2207341C2 (de)
SK (1) SK284891B6 (de)
TW (1) TW589308B (de)
WO (1) WO1998054153A1 (de)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6452008B2 (en) 1998-02-25 2002-09-17 Sumitomo Pharmaceuticals Company, Limited Pyridone derivatives and process for preparing the same
WO1999043659A1 (fr) * 1998-02-25 1999-09-02 Sumitomo Pharmaceuticals Co., Ltd. Derives de pyridone et leur procede de fabrication
DE60007748T2 (de) 1999-06-28 2004-11-25 Fuji Photo Film Co., Ltd., Minami-Ashigara Benzimidazolderivate und sie enthaltende medikamente
AU776803B2 (en) 1999-06-30 2004-09-23 Fuji Photo Film Co., Ltd. Benzimidazole compounds and medicaments comprising the same
WO2001004110A1 (fr) * 1999-07-07 2001-01-18 Fuji Photo Film Co., Ltd. Composes de benzimidazole
JP4242765B2 (ja) * 2001-08-22 2009-03-25 興和株式会社 血管壁選択的なacat阻害剤
US20060165605A1 (en) * 2001-12-28 2006-07-27 Ye-Mon Chen Process to regenerate fcc spent catalyst
PT1566381E (pt) * 2002-11-28 2009-11-19 Kowa Co Processo para produção de 1-[2-(benzimidazol-2-il-tio)- etil]piperazina ou seus sais
ES2287574T3 (es) * 2002-12-05 2007-12-16 Cv Therapeutics, Inc. Compuestos de piperacina sustituidos y su utilizacion como inhibidores de la oxidacion de acidos grasos.
WO2004052861A1 (ja) * 2002-12-12 2004-06-24 Kowa Co., Ltd. ヒドロキシアルキル環状ジアミン化合物
MY140618A (en) * 2003-02-28 2009-12-31 Kowa Co Method for preparing acid addition salts of polyacidic basic compounds
CN1784395A (zh) * 2003-05-07 2006-06-07 埃科特莱茵药品有限公司 哌嗪-烷基-脲基衍生物
JP4806566B2 (ja) * 2003-05-28 2011-11-02 興和株式会社 環状ジアミン誘導体又はその塩の製造法
MY140849A (en) 2003-07-07 2010-01-29 Kowa Co 2, 4-bis (trifluoroethoxy) pyridine compound and drug containing the compound
KR20060111898A (ko) 2003-08-29 2006-10-30 교와 가부시키가이샤 지질-풍부-플라크의 안정화 방법 및 파열 예방방법
AU2004293013B2 (en) 2003-11-19 2011-04-28 Metabasis Therapeutics, Inc. Novel phosphorus-containing thyromimetics
US7163944B2 (en) 2004-01-26 2007-01-16 Kowa Co., Ltd. Cyclic diamine compound and pharmaceutical containing the same
WO2006003974A1 (ja) * 2004-06-30 2006-01-12 Kowa Co., Ltd. 環状ジアミン誘導体の製造法
CA2576170A1 (en) * 2004-08-16 2006-03-02 The Procter & Gamble Company 2-(amino or substituted amino)-5, 6-substituted phenol compounds, dyeing compositions containing them, and use thereof
CA2585623C (en) 2004-10-27 2012-06-05 Daiichi Sankyo Company Limited Ortho-substituted benzene derivatives
TW200619204A (en) * 2004-12-10 2006-06-16 Kowa Co Method for reduction, stabilization and prevention of rupture of lipid rich plaque
FR2920769B1 (fr) * 2007-09-06 2009-10-30 Galderma Res & Dev Nouveaux derives de n-phenyl acetamide, inhibiteurs de l'enzyme soat-1, compositions pharmaceutiques et cosmetiques les contenant
FR2920774B1 (fr) * 2007-09-06 2009-10-30 Galderma Res & Dev Nouveaux derives de n-phenul acatamide, inhibiteurs de l'enzyme soat-1, compositions pharmaceutiques et cosmetiques les contentant
FR2920770B1 (fr) * 2007-09-06 2009-10-30 Galderma Res & Dev Nouveaux derives de phenylurees, inhibiteurs de l'enzyme soat-1, compositions pharmaceutiques et cosmetiques les contenant
JP5291979B2 (ja) 2008-04-24 2013-09-18 株式会社フジクラ 圧力センサ及びその製造方法と、該圧力センサを備えた電子部品
US20120046364A1 (en) 2009-02-10 2012-02-23 Metabasis Therapeutics, Inc. Novel Sulfonic Acid-Containing Thyromimetics, and Methods for Their Use
JPWO2011081118A1 (ja) * 2009-12-29 2013-05-13 興和株式会社 経口投与用医薬組成物
EP2520299A1 (de) 2009-12-29 2012-11-07 Kowa Co., Ltd. Feste pharmazeutische zusammensetzung zur oralen verabreichung
EP2573081B1 (de) * 2010-05-19 2017-07-12 Kowa Company Ltd. Prophylaktisches und/oder therapeutisches mittel für nicht-alkoholische steatohepatitis
US20160052898A1 (en) * 2013-03-20 2016-02-25 Bayer Pharma Aktiengesellschaft Novel compounds
CN105693524A (zh) * 2014-11-28 2016-06-22 浙江省化工研究院有限公司 一种硝基化合物的制备方法
WO2018097149A1 (ja) * 2016-11-24 2018-05-31 帝人ファーマ株式会社 スルフィド化合物の製造方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3629208A (en) * 1969-06-18 1971-12-21 Monsanto Co N-aminoalkyl thiazolesulfenamides as vulcanization accelerators
CA2003283A1 (en) * 1988-12-05 1990-06-05 C. Anne Higley Imidazoles for the treatment of atherosclerosis
WO1992007825A1 (en) * 1990-11-05 1992-05-14 Taisho Pharmaceutical Co., Ltd. Phenol derivative
US5721266A (en) * 1993-05-28 1998-02-24 Warner-Lambert Company Substituted imidazolinyl-imidazolines as antagonists of SH-2 binding and therapeutic uses thereof
US5596001A (en) * 1993-10-25 1997-01-21 Pfizer Inc. 4-aryl-3-(heteroarylureido)quinoline derivatves
JP4191269B2 (ja) * 1996-05-17 2008-12-03 興和株式会社 新規なアニリド化合物及びこれを含有する医薬
ATE297900T1 (de) * 1997-03-25 2005-07-15 Kowa Co Anilidverbindungen und medikamente, die diese enthalten
ES2262248T3 (es) * 1997-11-14 2006-11-16 Kowa Company. Ltd. Nuevos compuestos amida y medicamente que los contienen.

Also Published As

Publication number Publication date
EP0987254A4 (de) 2000-09-13
AU7451298A (en) 1998-12-30
CN1118457C (zh) 2003-08-20
KR100549804B1 (ko) 2006-02-08
WO1998054153A1 (fr) 1998-12-03
ATE285402T1 (de) 2005-01-15
SK284891B6 (sk) 2006-02-02
EP0987254A1 (de) 2000-03-22
DE69828276T2 (de) 2005-12-15
SK158299A3 (en) 2001-02-12
TW589308B (en) 2004-06-01
KR20010012926A (ko) 2001-02-26
CN1258283A (zh) 2000-06-28
HUP0002294A3 (en) 2001-10-29
AU728151B2 (en) 2001-01-04
NO995783D0 (no) 1999-11-25
NO315045B1 (no) 2003-06-30
JP3614865B2 (ja) 2005-01-26
CA2290744C (en) 2009-12-22
CA2290744A1 (en) 1998-12-03
CZ415999A3 (cs) 2000-05-17
ES2235328T3 (es) 2005-07-01
PT987254E (pt) 2005-04-29
NZ501156A (en) 2002-02-01
EP0987254B1 (de) 2004-12-22
CZ297451B6 (cs) 2006-12-13
ID23377A (id) 2000-04-20
HUP0002294A2 (hu) 2001-09-28
NO995783L (no) 2000-01-26
RU2207341C2 (ru) 2003-06-27

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