DE69825758T3 - Annäherungs-szintillationstest - Google Patents
Annäherungs-szintillationstest Download PDFInfo
- Publication number
- DE69825758T3 DE69825758T3 DE69825758T DE69825758T DE69825758T3 DE 69825758 T3 DE69825758 T3 DE 69825758T3 DE 69825758 T DE69825758 T DE 69825758T DE 69825758 T DE69825758 T DE 69825758T DE 69825758 T3 DE69825758 T3 DE 69825758T3
- Authority
- DE
- Germany
- Prior art keywords
- phosphor
- spa
- assay
- beads
- quenching
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
- G01N33/54346—Nanoparticles
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
- G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54306—Solid-phase reaction mechanisms
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/585—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
- G01N33/587—Nanoparticles
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/60—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances involving radioactive labelled substances
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Nanotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Stereophonic System (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Conversion Of X-Rays Into Visible Images (AREA)
- Apparatus For Radiation Diagnosis (AREA)
- Luminescent Compositions (AREA)
- Nuclear Medicine (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP97306264 | 1997-08-18 | ||
| EP97306264 | 1997-08-18 | ||
| PCT/GB1998/002459 WO1999009415A1 (en) | 1997-08-18 | 1998-08-17 | Scintillation proximity test |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DE69825758D1 DE69825758D1 (de) | 2004-09-23 |
| DE69825758T2 DE69825758T2 (de) | 2005-09-01 |
| DE69825758T3 true DE69825758T3 (de) | 2011-01-13 |
Family
ID=8229469
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69825758T Expired - Lifetime DE69825758T3 (de) | 1997-08-18 | 1998-08-17 | Annäherungs-szintillationstest |
Country Status (9)
| Country | Link |
|---|---|
| US (4) | US6524786B1 (enExample) |
| EP (1) | EP1007971B2 (enExample) |
| JP (1) | JP3719932B2 (enExample) |
| AT (1) | ATE274189T1 (enExample) |
| AU (1) | AU756423B2 (enExample) |
| DE (1) | DE69825758T3 (enExample) |
| DK (1) | DK1007971T3 (enExample) |
| ES (1) | ES2227869T3 (enExample) |
| WO (1) | WO1999009415A1 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2227869T3 (es) * | 1997-08-18 | 2005-04-01 | Amersham Plc | Ensayo de proximidad por escintilacion. |
| GB2342350A (en) * | 1998-10-05 | 2000-04-12 | Univ Nottingham Trent | Solid supports containing oxazole scintillants |
| JP4282251B2 (ja) * | 2000-08-02 | 2009-06-17 | 富士フイルム株式会社 | 生化学解析用ユニットおよびそれを用いた生化学解析方法 |
| GB0027516D0 (en) * | 2000-11-10 | 2000-12-27 | Amersham Pharm Biotech Uk Ltd | Support and method for cell based assays |
| GB0107563D0 (en) | 2001-03-27 | 2001-05-16 | Amersham Pharm Biotech Uk Ltd | NO synthase assay particles and method |
| US7011814B2 (en) * | 2001-04-23 | 2006-03-14 | Sicel Technologies, Inc. | Systems, methods and devices for in vivo monitoring of a localized response via a radiolabeled analyte in a subject |
| KR100483314B1 (ko) * | 2002-03-23 | 2005-04-15 | 학교법인 인제학원 | 디지털 엑스레이 이미지 디텍터 |
| US7072628B2 (en) * | 2002-04-05 | 2006-07-04 | Qualcomm, Incorporated | Method and apparatus for determining receive diversity in mobile station |
| US7454006B2 (en) * | 2003-01-31 | 2008-11-18 | Qwest Communications International Inc. | Systems, methods and apparatus for providing a plurality of telecommunication services |
| GB0403913D0 (en) * | 2004-02-21 | 2004-03-24 | Amersham Biosciences Uk Ltd | P-glycoprotein assay |
| CN1280623C (zh) * | 2004-07-16 | 2006-10-18 | 北京博奥生物芯片有限责任公司 | 一种用于荧光仪器校准测量的校准基片及其制备方法 |
| CA2618715C (en) * | 2005-08-11 | 2015-05-19 | Perkinelmer Las, Inc. | Assay particles and methods of use |
| EP1994407A4 (en) | 2005-12-30 | 2009-05-20 | Turun Yliopisto | METHOD FOR DETERMINING THE CONCENTRATION, LOAD OR SIZE UNIT OF A SUBSTANCE |
| DE102006031563A1 (de) * | 2006-06-27 | 2008-01-03 | Dieter Ebert | Lumineszenzstoff-Zusammensetzung |
| CA2938498A1 (en) * | 2014-02-18 | 2015-08-27 | Shire Human Genetic Therapies, Inc. | Substrate clearance assays for lysosomal enzymes |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4415808A (en) * | 1980-12-24 | 1983-11-15 | General Electric Company | Scintillation detector array employing zig-zag plates |
| GB8513538D0 (en) | 1985-05-29 | 1985-07-03 | Mackay C D | Electrophoresis |
| JPS6247555A (ja) * | 1985-08-23 | 1987-03-02 | エフ．ホフマン ― ラ ロシュ アーゲー | シンチレ−シヨン近接定量法 |
| US4922092A (en) * | 1986-11-26 | 1990-05-01 | Image Research Limited | High sensitivity optical imaging apparatus |
| WO1991008489A1 (en) * | 1989-12-01 | 1991-06-13 | Packard Instrument Company, Inc. | Scintillation proximity radioimmunoassay using solid scintillator support body |
| EP0510753B1 (en) * | 1991-04-26 | 1996-10-23 | Agfa-Gevaert N.V. | Luminescent article with protective coating and manufacture |
| EP0556005B1 (en) * | 1992-02-14 | 1996-04-17 | AMERSHAM INTERNATIONAL plc | Fluorescent compounds |
| ATE136925T1 (de) * | 1992-02-14 | 1996-05-15 | Amersham Int Plc | Fluoreszente verbindungen |
| JPH0627023A (ja) * | 1992-07-07 | 1994-02-04 | Toto Ltd | 光バイオセンサー |
| US5698397A (en) * | 1995-06-07 | 1997-12-16 | Sri International | Up-converting reporters for biological and other assays using laser excitation techniques |
| FI925064A7 (fi) * | 1992-11-09 | 1994-05-10 | Erkki Juhani Soini | Menetelmä ja laitteisto bioaffiniteettimäärityksiä varten |
| CA2139409C (en) * | 1993-05-17 | 2005-01-04 | Neil David Cook | Devices and methods for the measurement of cellular biochemical processes |
| JPH072955U (ja) * | 1993-06-17 | 1995-01-17 | アロカ株式会社 | マイクロプレート |
| US6319530B1 (en) * | 1993-07-07 | 2001-11-20 | Jack Guttman, Inc. | Method of photocopying an image onto an edible web for decorating iced baked goods |
| JPH07270426A (ja) * | 1994-03-31 | 1995-10-20 | Suzuki Motor Corp | 血液等の凝集データ収集装置 |
| US5961923A (en) * | 1995-04-25 | 1999-10-05 | Irori | Matrices with memories and uses thereof |
| DE69510921T2 (de) * | 1995-05-25 | 1999-12-30 | Nycomed Amersham Plc, Little Chalfont | Fluoreszente Verbindungen |
| JP3518940B2 (ja) * | 1996-01-09 | 2004-04-12 | オリンパス株式会社 | 免疫反応検査装置の性能管理方法および免疫反応検査装置用性能管理プレート |
| ES2227869T3 (es) * | 1997-08-18 | 2005-04-01 | Amersham Plc | Ensayo de proximidad por escintilacion. |
| US6198577B1 (en) * | 1998-03-10 | 2001-03-06 | Glaxo Wellcome, Inc. | Doubly telecentric lens and imaging system for multiwell plates |
| US20020131990A1 (en) * | 2000-11-30 | 2002-09-19 | Barkalow David G. | Pullulan free edible film compositions and methods of making the same |
-
1998
- 1998-08-17 ES ES98938832T patent/ES2227869T3/es not_active Expired - Lifetime
- 1998-08-17 DK DK98938832T patent/DK1007971T3/da active
- 1998-08-17 WO PCT/GB1998/002459 patent/WO1999009415A1/en not_active Ceased
- 1998-08-17 AU AU87429/98A patent/AU756423B2/en not_active Expired
- 1998-08-17 AT AT98938832T patent/ATE274189T1/de not_active IP Right Cessation
- 1998-08-17 DE DE69825758T patent/DE69825758T3/de not_active Expired - Lifetime
- 1998-08-17 EP EP98938832A patent/EP1007971B2/en not_active Expired - Lifetime
- 1998-08-17 US US09/485,954 patent/US6524786B1/en not_active Expired - Lifetime
- 1998-08-17 JP JP2000510028A patent/JP3719932B2/ja not_active Expired - Lifetime
-
2002
- 2002-12-13 US US10/319,305 patent/US7081365B2/en not_active Expired - Lifetime
-
2006
- 2006-02-17 US US11/356,688 patent/US7214539B2/en not_active Expired - Lifetime
-
2007
- 2007-05-07 US US11/744,938 patent/US20070207547A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1007971A1 (en) | 2000-06-14 |
| US20030152978A1 (en) | 2003-08-14 |
| US7081365B2 (en) | 2006-07-25 |
| US6524786B1 (en) | 2003-02-25 |
| JP2001516028A (ja) | 2001-09-25 |
| US20060141536A1 (en) | 2006-06-29 |
| ATE274189T1 (de) | 2004-09-15 |
| US7214539B2 (en) | 2007-05-08 |
| DK1007971T3 (da) | 2004-12-06 |
| AU756423B2 (en) | 2003-01-09 |
| EP1007971B2 (en) | 2009-07-22 |
| EP1007971B1 (en) | 2004-08-18 |
| AU8742998A (en) | 1999-03-08 |
| JP3719932B2 (ja) | 2005-11-24 |
| US20070207547A1 (en) | 2007-09-06 |
| DE69825758T2 (de) | 2005-09-01 |
| WO1999009415A1 (en) | 1999-02-25 |
| ES2227869T3 (es) | 2005-04-01 |
| DE69825758D1 (de) | 2004-09-23 |
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