DE69824332T2 - N-Aryl-piperidinderivate und ihre Verwendung als 5-HT1B-Rezeptorliganden - Google Patents

N-Aryl-piperidinderivate und ihre Verwendung als 5-HT1B-Rezeptorliganden Download PDF

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Publication number
DE69824332T2
DE69824332T2 DE69824332T DE69824332T DE69824332T2 DE 69824332 T2 DE69824332 T2 DE 69824332T2 DE 69824332 T DE69824332 T DE 69824332T DE 69824332 T DE69824332 T DE 69824332T DE 69824332 T2 DE69824332 T2 DE 69824332T2
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DE
Germany
Prior art keywords
dihydro
piperid
benzodioxin
fumarate
amine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69824332T
Other languages
German (de)
English (en)
Other versions
DE69824332D1 (de
Inventor
Jean-Louis Peglion
Bertrand Goument
Mark Millan
Alain Gobert
Valerie Audinot
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Les Laboratoires Servier SAS
Original Assignee
Les Laboratoires Servier SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Les Laboratoires Servier SAS filed Critical Les Laboratoires Servier SAS
Publication of DE69824332D1 publication Critical patent/DE69824332D1/de
Application granted granted Critical
Publication of DE69824332T2 publication Critical patent/DE69824332T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D411/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D411/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Psychiatry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE69824332T 1997-03-27 1998-03-26 N-Aryl-piperidinderivate und ihre Verwendung als 5-HT1B-Rezeptorliganden Expired - Fee Related DE69824332T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9703760A FR2761358B1 (fr) 1997-03-27 1997-03-27 Nouveaux composes de n-aryl piperidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR9703760 1997-03-27

Publications (2)

Publication Number Publication Date
DE69824332D1 DE69824332D1 (de) 2004-07-15
DE69824332T2 true DE69824332T2 (de) 2005-06-16

Family

ID=9505236

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69824332T Expired - Fee Related DE69824332T2 (de) 1997-03-27 1998-03-26 N-Aryl-piperidinderivate und ihre Verwendung als 5-HT1B-Rezeptorliganden

Country Status (17)

Country Link
US (1) US5965575A (https=)
EP (1) EP0867436B1 (https=)
JP (1) JPH10279578A (https=)
CN (1) CN1090628C (https=)
AT (1) ATE268767T1 (https=)
AU (1) AU731018B2 (https=)
BR (1) BR9803295A (https=)
CA (1) CA2232116C (https=)
DE (1) DE69824332T2 (https=)
DK (1) DK0867436T3 (https=)
ES (1) ES2223110T3 (https=)
FR (1) FR2761358B1 (https=)
NO (1) NO314628B1 (https=)
NZ (1) NZ330041A (https=)
PL (1) PL194118B1 (https=)
PT (1) PT867436E (https=)
ZA (1) ZA982607B (https=)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2782515B1 (fr) * 1998-08-21 2000-09-22 Adir NOUVEAUX DERIVES DE L'INDANE-1-Ol, LEUR PROCEDE DE PREPARATION ET LES COMPOSITIONS PHARMACEUTIQUES QUI LES CONTIENNENT
JP2002535365A (ja) * 1999-01-28 2002-10-22 ブリストル−マイヤーズ スクイブ カンパニー 抗うつ性複素環化合物
EP1189900B1 (en) * 1999-06-30 2004-01-14 Bristol-Myers Squibb Company Heterocyclic aminopyrrolidine derivatives as melatonergic agents
GB0013737D0 (en) 2000-06-07 2000-07-26 Astrazeneca Ab Novel compounds
SE0103650D0 (sv) * 2001-11-01 2001-11-01 Astrazeneca Ab Therapeutic heterocyclic compounds
SE0103646D0 (sv) * 2001-11-01 2001-11-01 Astrazeneca Ab Therapeutic chroman compounds
NZ526699A (en) * 2001-01-16 2005-03-24 Astrazeneca Ab 8-amino derivatives and their use in treating migraine
NZ535574A (en) * 2001-01-16 2006-07-28 Astrazeneca Ab Therapeutic heterocyclic compounds
WO2002069973A1 (en) * 2001-03-02 2002-09-12 Sepracor, Inc. Piperidine-piperazine ligand for neurotransmitter receptors
SE0103836D0 (sv) * 2001-11-16 2001-11-16 Astrazeneca Ab Novel compounds
JP2005343790A (ja) * 2002-05-31 2005-12-15 Ajinomoto Co Inc カルシウムチャネル拮抗薬を含有する医薬組成物
SE0300480D0 (sv) 2003-02-21 2003-02-21 Astrazeneca Ab Novel compounds
GB0312609D0 (en) 2003-06-02 2003-07-09 Astrazeneca Ab Novel compounds
ES2331519T3 (es) * 2003-06-30 2010-01-07 Nycomed Gmbh Derivados de pirrolo-dihidroisoquinolina como inhibidores de pde10.
RS20050945A (sr) * 2003-06-30 2008-06-05 Altana Pharma Ag., Novi pirolodihidroizohinolini koji se mogu upotrebiti u tretmanu kancera
EP1661894A4 (en) * 2003-07-14 2007-02-28 Ube Industries METHOD FOR PRODUCING 4-AMINOTETRAHYDROPYRANES AND THEIR SALTS WITH ACIDS, INTERMEDIATE PRODUCTS FOR THE METHOD AND METHOD FOR THE PRODUCTION THEREOF
AR045258A1 (es) * 2003-08-21 2005-10-19 Altana Pharma Ag Un producto farmaceutico para inyeccion
US20060085924A1 (en) * 2004-10-13 2006-04-27 Gaelle Brun Coloring composition comprising at least one pigment and at least one electrophilic cyanoacrylate monomer
AU2006218054A1 (en) * 2005-01-12 2006-08-31 Nycomed Gmbh Novel pyrrolodihydroisoquinolines as PDE10 inhibitors
WO2006075012A2 (en) * 2005-01-12 2006-07-20 Nycomed Gmbh Pyrrolodihydroisoquinolines as antiproliferative agents
US8599822B2 (en) * 2005-03-23 2013-12-03 Cisco Technology, Inc. Slot-based transmission synchronization mechanism in wireless mesh networks
FR2884251B1 (fr) * 2005-04-08 2007-07-13 Servier Lab Derives de piperazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
UY29892A1 (es) * 2005-11-04 2007-06-29 Astrazeneca Ab Nuevos derivados de cromano, composiciones farmaceuticas conteniendolos, procesos de preparacion y aplicaciones
MX2008014450A (es) 2006-05-18 2009-03-09 Mannkind Corp Inhibidores de cinasa intracelular.
BRPI0809106A2 (pt) 2007-03-22 2014-08-26 Astrazeneca Ab Derivados de quinolina para o tratamento de doenças inflamatórias
US8106073B2 (en) 2007-11-30 2012-01-31 Astrazeneca Ab Quinoline derivatives 057
TW200944523A (en) * 2008-02-08 2009-11-01 Organon Nv (Dihydro)pyrrolo[2,1-a]isoquinolines
WO2020183011A1 (en) 2019-03-14 2020-09-17 Institut Curie Htr1d inhibitors and uses thereof in the treatment of cancer

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2692264B1 (fr) * 1992-06-12 1994-08-05 Adir Nouvelles piperazines 1,4-disubstituees, leur procede de preparation et les compositions pharmaceutiques les contenant.
GB9318431D0 (en) * 1993-09-06 1993-10-20 Boots Co Plc Therapeutic agents
FR2734819B1 (fr) * 1995-05-31 1997-07-04 Adir Nouveaux composes de la piperazine, de la piperidine et de la 1,2,5,6-tetrahydropyridine, leur procede de preparation et les compositions pharmaceutiques les contenant

Also Published As

Publication number Publication date
ATE268767T1 (de) 2004-06-15
BR9803295A (pt) 2000-03-21
EP0867436A1 (fr) 1998-09-30
EP0867436B1 (fr) 2004-06-09
FR2761358A1 (fr) 1998-10-02
DE69824332D1 (de) 2004-07-15
FR2761358B1 (fr) 1999-05-07
ES2223110T3 (es) 2005-02-16
PL325575A1 (en) 1998-09-28
CA2232116C (fr) 2003-09-16
CN1197072A (zh) 1998-10-28
PL194118B1 (pl) 2007-04-30
JPH10279578A (ja) 1998-10-20
AU731018B2 (en) 2001-03-22
DK0867436T3 (da) 2004-10-04
HK1014954A1 (en) 1999-10-08
US5965575A (en) 1999-10-12
CA2232116A1 (fr) 1998-09-27
NO981415L (no) 1998-09-28
PT867436E (pt) 2004-09-30
NO314628B1 (no) 2003-04-22
AU5967798A (en) 1998-10-01
CN1090628C (zh) 2002-09-11
NO981415D0 (no) 1998-03-27
ZA982607B (en) 1998-09-30
NZ330041A (en) 1999-01-28

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8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee