FR2761358B1 - Nouveaux composes de n-aryl piperidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent - Google Patents

Nouveaux composes de n-aryl piperidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Info

Publication number
FR2761358B1
FR2761358B1 FR9703760A FR9703760A FR2761358B1 FR 2761358 B1 FR2761358 B1 FR 2761358B1 FR 9703760 A FR9703760 A FR 9703760A FR 9703760 A FR9703760 A FR 9703760A FR 2761358 B1 FR2761358 B1 FR 2761358B1
Authority
FR
France
Prior art keywords
novel
preparation
pharmaceutical compositions
aryl
compositions containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR9703760A
Other languages
English (en)
French (fr)
Other versions
FR2761358A1 (fr
Inventor
Jean Louis Peglion
Bertrand Goument
Mark Millan
Alain Gobert
Valerie Audinot
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ADIR SARL
Original Assignee
ADIR SARL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ADIR SARL filed Critical ADIR SARL
Priority to FR9703760A priority Critical patent/FR2761358B1/fr
Priority to CA002232116A priority patent/CA2232116C/fr
Priority to DK98400711T priority patent/DK0867436T3/da
Priority to CN98109437A priority patent/CN1090628C/zh
Priority to AT98400711T priority patent/ATE268767T1/de
Priority to PL325575A priority patent/PL194118B1/pl
Priority to PT98400711T priority patent/PT867436E/pt
Priority to EP98400711A priority patent/EP0867436B1/fr
Priority to NZ330041A priority patent/NZ330041A/xx
Priority to DE69824332T priority patent/DE69824332T2/de
Priority to ES98400711T priority patent/ES2223110T3/es
Priority to AU59677/98A priority patent/AU731018B2/en
Priority to ZA982607A priority patent/ZA982607B/xx
Priority to NO19981415A priority patent/NO314628B1/no
Priority to BR9803295A priority patent/BR9803295A/pt
Priority to US09/049,233 priority patent/US5965575A/en
Priority to JP10081710A priority patent/JPH10279578A/ja
Publication of FR2761358A1 publication Critical patent/FR2761358A1/fr
Priority to HK99100194.6A priority patent/HK1014954B/xx
Application granted granted Critical
Publication of FR2761358B1 publication Critical patent/FR2761358B1/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D411/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D411/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Psychiatry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
FR9703760A 1997-03-27 1997-03-27 Nouveaux composes de n-aryl piperidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent Expired - Fee Related FR2761358B1 (fr)

Priority Applications (18)

Application Number Priority Date Filing Date Title
FR9703760A FR2761358B1 (fr) 1997-03-27 1997-03-27 Nouveaux composes de n-aryl piperidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
CA002232116A CA2232116C (fr) 1997-03-27 1998-03-12 Nouveaux composes de n-aryl piperidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
CN98109437A CN1090628C (zh) 1997-03-27 1998-03-26 新的n－芳基哌啶化合物,其制备方法和含有它们的药物组合物
AT98400711T ATE268767T1 (de) 1997-03-27 1998-03-26 N-aryl-piperidinderivate und ihre verwendung als 5-ht1b-rezeptorliganden
PL325575A PL194118B1 (pl) 1997-03-27 1998-03-26 Związki N-arylopiperydyny, sposób wytwarzania związków N-arylopiperydyny, oraz kompozycje farmaceutyczne zawierające te związki
PT98400711T PT867436E (pt) 1997-03-27 1998-03-26 Derivados de n-aril-piperidina e sua utilizacao como ligandos do receptor 5-ht1b
EP98400711A EP0867436B1 (fr) 1997-03-27 1998-03-26 Dérivés de N-aryl pipéridine et leur utilisation comme ligands du récepteur 5-HT1B
NZ330041A NZ330041A (en) 1997-03-27 1998-03-26 1-(benzo fused oxygen and/or sulphur containing heterocyclic ring)-piperidine derivatives and medicaments
DE69824332T DE69824332T2 (de) 1997-03-27 1998-03-26 N-Aryl-piperidinderivate und ihre Verwendung als 5-HT1B-Rezeptorliganden
ES98400711T ES2223110T3 (es) 1997-03-27 1998-03-26 Derivados de n-arilpiperidina y su empleo como ligandos del receptor 5-ht1b.
DK98400711T DK0867436T3 (da) 1997-03-27 1998-03-26 N-arylpiperidinderivater og deres anvendelse som 5-HT1B-receptorligander
ZA982607A ZA982607B (en) 1997-03-27 1998-03-27 N-arylpiperidine compounds a process for their preparation and pharmaceutical compositions containing them
AU59677/98A AU731018B2 (en) 1997-03-27 1998-03-27 New N-aryl piperidine compounds, a process for their preparation and pharmaceutical compositions containing them
NO19981415A NO314628B1 (no) 1997-03-27 1998-03-27 Nye N-arylpiperidin-forbindelser, en fremgangsmåte ved fremstilling derav og farmasöytiske preparater som inneholder slike
BR9803295A BR9803295A (pt) 1997-03-27 1998-03-27 preparos e composições farmacêuticas contendo os mesmos.
US09/049,233 US5965575A (en) 1997-03-27 1998-03-27 N-aryl piperidine compounds as 5HT1B antagonists
JP10081710A JPH10279578A (ja) 1997-03-27 1998-03-27 新規なアリールピペリジン化合物、その製造法、及びそれらを含む医薬組成物
HK99100194.6A HK1014954B (en) 1997-03-27 1999-01-14 New n-arylpiperidine compounds, a process for their preparation and pharmaceutical compositions containing them

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9703760A FR2761358B1 (fr) 1997-03-27 1997-03-27 Nouveaux composes de n-aryl piperidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (2)

Publication Number Publication Date
FR2761358A1 FR2761358A1 (fr) 1998-10-02
FR2761358B1 true FR2761358B1 (fr) 1999-05-07

Family

ID=9505236

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9703760A Expired - Fee Related FR2761358B1 (fr) 1997-03-27 1997-03-27 Nouveaux composes de n-aryl piperidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Country Status (17)

Country Link
US (1) US5965575A (https=)
EP (1) EP0867436B1 (https=)
JP (1) JPH10279578A (https=)
CN (1) CN1090628C (https=)
AT (1) ATE268767T1 (https=)
AU (1) AU731018B2 (https=)
BR (1) BR9803295A (https=)
CA (1) CA2232116C (https=)
DE (1) DE69824332T2 (https=)
DK (1) DK0867436T3 (https=)
ES (1) ES2223110T3 (https=)
FR (1) FR2761358B1 (https=)
NO (1) NO314628B1 (https=)
NZ (1) NZ330041A (https=)
PL (1) PL194118B1 (https=)
PT (1) PT867436E (https=)
ZA (1) ZA982607B (https=)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2782515B1 (fr) * 1998-08-21 2000-09-22 Adir NOUVEAUX DERIVES DE L'INDANE-1-Ol, LEUR PROCEDE DE PREPARATION ET LES COMPOSITIONS PHARMACEUTIQUES QUI LES CONTIENNENT
JP2002535365A (ja) * 1999-01-28 2002-10-22 ブリストル−マイヤーズ スクイブ カンパニー 抗うつ性複素環化合物
EP1189900B1 (en) * 1999-06-30 2004-01-14 Bristol-Myers Squibb Company Heterocyclic aminopyrrolidine derivatives as melatonergic agents
GB0013737D0 (en) 2000-06-07 2000-07-26 Astrazeneca Ab Novel compounds
SE0103650D0 (sv) * 2001-11-01 2001-11-01 Astrazeneca Ab Therapeutic heterocyclic compounds
SE0103646D0 (sv) * 2001-11-01 2001-11-01 Astrazeneca Ab Therapeutic chroman compounds
NZ526699A (en) * 2001-01-16 2005-03-24 Astrazeneca Ab 8-amino derivatives and their use in treating migraine
NZ535574A (en) * 2001-01-16 2006-07-28 Astrazeneca Ab Therapeutic heterocyclic compounds
WO2002069973A1 (en) * 2001-03-02 2002-09-12 Sepracor, Inc. Piperidine-piperazine ligand for neurotransmitter receptors
SE0103836D0 (sv) * 2001-11-16 2001-11-16 Astrazeneca Ab Novel compounds
JP2005343790A (ja) * 2002-05-31 2005-12-15 Ajinomoto Co Inc カルシウムチャネル拮抗薬を含有する医薬組成物
SE0300480D0 (sv) 2003-02-21 2003-02-21 Astrazeneca Ab Novel compounds
GB0312609D0 (en) 2003-06-02 2003-07-09 Astrazeneca Ab Novel compounds
ES2331519T3 (es) * 2003-06-30 2010-01-07 Nycomed Gmbh Derivados de pirrolo-dihidroisoquinolina como inhibidores de pde10.
RS20050945A (sr) * 2003-06-30 2008-06-05 Altana Pharma Ag., Novi pirolodihidroizohinolini koji se mogu upotrebiti u tretmanu kancera
EP1661894A4 (en) * 2003-07-14 2007-02-28 Ube Industries METHOD FOR PRODUCING 4-AMINOTETRAHYDROPYRANES AND THEIR SALTS WITH ACIDS, INTERMEDIATE PRODUCTS FOR THE METHOD AND METHOD FOR THE PRODUCTION THEREOF
AR045258A1 (es) * 2003-08-21 2005-10-19 Altana Pharma Ag Un producto farmaceutico para inyeccion
US20060085924A1 (en) * 2004-10-13 2006-04-27 Gaelle Brun Coloring composition comprising at least one pigment and at least one electrophilic cyanoacrylate monomer
AU2006218054A1 (en) * 2005-01-12 2006-08-31 Nycomed Gmbh Novel pyrrolodihydroisoquinolines as PDE10 inhibitors
WO2006075012A2 (en) * 2005-01-12 2006-07-20 Nycomed Gmbh Pyrrolodihydroisoquinolines as antiproliferative agents
US8599822B2 (en) * 2005-03-23 2013-12-03 Cisco Technology, Inc. Slot-based transmission synchronization mechanism in wireless mesh networks
FR2884251B1 (fr) * 2005-04-08 2007-07-13 Servier Lab Derives de piperazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
UY29892A1 (es) * 2005-11-04 2007-06-29 Astrazeneca Ab Nuevos derivados de cromano, composiciones farmaceuticas conteniendolos, procesos de preparacion y aplicaciones
MX2008014450A (es) 2006-05-18 2009-03-09 Mannkind Corp Inhibidores de cinasa intracelular.
BRPI0809106A2 (pt) 2007-03-22 2014-08-26 Astrazeneca Ab Derivados de quinolina para o tratamento de doenças inflamatórias
US8106073B2 (en) 2007-11-30 2012-01-31 Astrazeneca Ab Quinoline derivatives 057
TW200944523A (en) * 2008-02-08 2009-11-01 Organon Nv (Dihydro)pyrrolo[2,1-a]isoquinolines
WO2020183011A1 (en) 2019-03-14 2020-09-17 Institut Curie Htr1d inhibitors and uses thereof in the treatment of cancer

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2692264B1 (fr) * 1992-06-12 1994-08-05 Adir Nouvelles piperazines 1,4-disubstituees, leur procede de preparation et les compositions pharmaceutiques les contenant.
GB9318431D0 (en) * 1993-09-06 1993-10-20 Boots Co Plc Therapeutic agents
FR2734819B1 (fr) * 1995-05-31 1997-07-04 Adir Nouveaux composes de la piperazine, de la piperidine et de la 1,2,5,6-tetrahydropyridine, leur procede de preparation et les compositions pharmaceutiques les contenant

Also Published As

Publication number Publication date
ATE268767T1 (de) 2004-06-15
BR9803295A (pt) 2000-03-21
EP0867436A1 (fr) 1998-09-30
EP0867436B1 (fr) 2004-06-09
FR2761358A1 (fr) 1998-10-02
DE69824332D1 (de) 2004-07-15
ES2223110T3 (es) 2005-02-16
PL325575A1 (en) 1998-09-28
CA2232116C (fr) 2003-09-16
CN1197072A (zh) 1998-10-28
DE69824332T2 (de) 2005-06-16
PL194118B1 (pl) 2007-04-30
JPH10279578A (ja) 1998-10-20
AU731018B2 (en) 2001-03-22
DK0867436T3 (da) 2004-10-04
HK1014954A1 (en) 1999-10-08
US5965575A (en) 1999-10-12
CA2232116A1 (fr) 1998-09-27
NO981415L (no) 1998-09-28
PT867436E (pt) 2004-09-30
NO314628B1 (no) 2003-04-22
AU5967798A (en) 1998-10-01
CN1090628C (zh) 2002-09-11
NO981415D0 (no) 1998-03-27
ZA982607B (en) 1998-09-30
NZ330041A (en) 1999-01-28

Similar Documents

Publication Publication Date Title
FR2761358B1 (fr) Nouveaux composes de n-aryl piperidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
MA21800A1 (fr) Procede de preparation de produits nouveaux.
EP0801067A4 (en) NEW CHINUCLIDINE DERIVATIVES AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM
ES2044836T3 (es) Derivado de la piperidina, su utilizacion y compuesto farmaceutico que lo contiene.
FR2662162B1 (fr) Nouveaux derives de l'amino piperidine, de l'amino pyrrolidine et de l'amino perhydroazepine, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
DE69624437D1 (de) 4,6-diarylpyrimidin-derivate und deren salze
FR2695387B1 (fr) Nouveaux composés benzopyraniques, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
PT98362A (pt) Processo para a preparacao de derivados de tioalquiltio-cefalosporina e de composicoes farmaceuticas que os contem
HUT59139A (en) Process for producing tricyclic compounds and antimicrobial pharmaceutical compositions comprising same
EP0648779A3 (de) Neue 11-Benzaldoxim-17beta methoxy-17alpha-methoxymethyl-estradien-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel.
ES2147749T3 (es) Procedimiento para la preparacion de derivados de ciano-metoxiiminometilo.
ATE141606T1 (de) Cephemverbindungen und verfahren zu ihrer herstellung
DE3882438D1 (de) Alkansulfonanilid-derivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzung.
PT87277A (pt) Process for the preparation of new bicyclic compounds and pharmaceutical compositions comprising same
FR2756826B1 (fr) Nouveaux derives tetrahydropyridiniques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2735129B1 (fr) Nouveaux derives de l'indole, de l'indazole et du benzisoxazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2760014B1 (fr) Nouveaux composes de 2-amino indane, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
DE69105786D1 (de) Harnstoffderivate, deren Herstellung sowie diese enthaltende pharmazeutische Zusammensetzungen.
FR2669030B1 (fr) Nouveaux derives d'imidazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
HUP9800687A1 (hu) N-aril-piperidin-származékok, eljárás előállításukra, és e vegyületeket tartalmazó gyógyszerkészítmények
FR2692262B1 (fr) Nouveaux nicotinates de diacylglycerols, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
DK32789A (da) Derivat af antibiotikum a 42867
FR2674246B1 (fr) Nouveaux derives de l'acide alpha-methylene 5-thiazolacetique, leur procede de preparation et les intermediaires de ce procede, leur application a titre de fongicides et les compositions les renfermant.
FR2777888B1 (fr) Nouveaux derives de l'acide (3,4,7,8,9,10-hexahydro-6,10- dioxo-6h-pyridazino[1,2-a][1,2]diazepine-1-carboxylique, leur procede de preparation et leur application a la preparation de medicaments
AU657423B2 (en) Novel piperidine derivatives and process for preparation thereof

Legal Events

Date Code Title Description
TP Transmission of property
ST Notification of lapse

Effective date: 20061130