DE69706813T2 - 4-Hydroxypiperidinderivate - Google Patents

4-Hydroxypiperidinderivate

Info

Publication number
DE69706813T2
DE69706813T2 DE69706813T DE69706813T DE69706813T2 DE 69706813 T2 DE69706813 T2 DE 69706813T2 DE 69706813 T DE69706813 T DE 69706813T DE 69706813 T DE69706813 T DE 69706813T DE 69706813 T2 DE69706813 T2 DE 69706813T2
Authority
DE
Germany
Prior art keywords
hydroxypiperidinderivate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69706813T
Other languages
English (en)
Other versions
DE69706813D1 (de
Inventor
Alexander Alanine
Bernd Buettelmann
Neidhart Marie-Paule Heitz
Emmanuel Pinard
Rene Wyler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of DE69706813D1 publication Critical patent/DE69706813D1/de
Publication of DE69706813T2 publication Critical patent/DE69706813T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40Oxygen atoms
    • C07D211/44Oxygen atoms attached in position 4
    • C07D211/48Oxygen atoms attached in position 4 having an acyclic carbon atom attached in position 4
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D221/00Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
DE69706813T 1996-12-03 1997-12-01 4-Hydroxypiperidinderivate Expired - Lifetime DE69706813T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP96119345 1996-12-03

Publications (2)

Publication Number Publication Date
DE69706813D1 DE69706813D1 (de) 2001-10-25
DE69706813T2 true DE69706813T2 (de) 2002-04-04

Family

ID=8223458

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69706813T Expired - Lifetime DE69706813T2 (de) 1996-12-03 1997-12-01 4-Hydroxypiperidinderivate

Country Status (30)

Country Link
US (1) US6359138B1 (de)
JP (1) JP3045988B2 (de)
KR (1) KR100257947B1 (de)
CN (2) CN1086702C (de)
AR (1) AR009641A1 (de)
AT (1) ATE205830T1 (de)
AU (1) AU736597B2 (de)
BR (1) BR9705509B1 (de)
CA (1) CA2220649C (de)
CO (1) CO4910155A1 (de)
CZ (1) CZ376997A3 (de)
DE (1) DE69706813T2 (de)
DK (1) DK0846683T3 (de)
ES (1) ES2163086T3 (de)
HK (1) HK1011859A1 (de)
HR (1) HRP970653B1 (de)
ID (1) ID17678A (de)
IL (1) IL122352A0 (de)
MA (1) MA24410A1 (de)
NO (1) NO975541L (de)
NZ (1) NZ329271A (de)
PE (1) PE20499A1 (de)
PL (1) PL323447A1 (de)
PT (1) PT846683E (de)
RU (1) RU2184112C2 (de)
SG (1) SG71062A1 (de)
TR (1) TR199701488A2 (de)
UY (1) UY24797A1 (de)
YU (1) YU46997A (de)
ZA (1) ZA9710653B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20012060A1 (it) * 2001-10-05 2003-04-05 Recordati Chem Pharm Nuovi eterocilcli n-acilati
US7005432B2 (en) * 2002-05-16 2006-02-28 Hoffman-La Roche Inc. Substituted imidazol-pyridazine derivatives
HUP0401522A2 (en) * 2004-07-29 2006-04-28 Richter Gedeon Vegyeszet New 4-benzylidene-piperidine derivatives, pharmaceutical compositions containing the same and process for their preparation
TW200621677A (en) * 2004-09-21 2006-07-01 Astellas Pharma Inc Cyclic amine derivative or salt thereof
KR101233223B1 (ko) * 2004-12-21 2013-02-14 제이엔씨 석유 화학 주식회사 크로만환을 가지는 액정 화합물, 액정 조성물 및 이 액정조성물을 함유하는 액정 표시소자
RU2538982C1 (ru) * 2013-11-19 2015-01-10 Федеральное Государственное Бюджетное Образовательное Учреждение Высшего Профессионального Образования "Нижегородский Государственный Университет Им. Н.И. Лобачевского" Производное n-(1s)-1',2',3'-триметокси-6,7-дигидро-1н-бензо[5',6':5,4]циклогепта-[3,2-f]бензофуран-1-ил)ацетамида и его применение
WO2016100940A1 (en) * 2014-12-19 2016-06-23 The Broad Institute, Inc. Dopamine d2 receptor ligands

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE546389C (de) 1927-12-30 1932-03-14 Ralph Mayhew Vorrichtung zur Bedienung von Tasteninstrumenten
US3476760A (en) * 1967-03-06 1969-11-04 Smithkline Corp Substituted piperidinoalkylthianaphthenes and benzofurans
US3557123A (en) * 1967-11-01 1971-01-19 Smith Kline French Lab 1-naphthylalkyl-4-phenylpiperidine derivatives
US3506671A (en) * 1967-11-01 1970-04-14 Smithkline Corp 1-naphthylalkyl-4-phenylpiperidine derivatives
DE2507782A1 (de) 1975-02-22 1976-09-02 Merck Patent Gmbh Tetralon- und indanon-derivate sowie verfahren zu ihrer herstellung
US4016281A (en) 1975-02-22 1977-04-05 Merck Patent Gesellschaft Mit Beschrankter Haftung Tetralone and indanone compounds
US4039676A (en) 1975-06-23 1977-08-02 Ciba-Geigy Corporation 2-piperidinoalkyl-1,4-benzodioxans
GB8515389D0 (en) 1985-06-18 1985-07-17 Ici Plc Heterocyclic compounds
GB8515388D0 (en) 1985-06-18 1985-07-17 Ici Plc Heterocyclic compounds
ATE192149T1 (de) 1990-05-10 2000-05-15 Pfizer Neuroprotective indolone und verwandte derivate
DE4140542A1 (de) 1991-12-09 1993-06-17 Bayer Ag Piperdylmethyl substituierte chormanderivate
US5436255A (en) 1992-07-23 1995-07-25 Pfizer Inc. Method of treating diseases susceptable to treatment by blocking NMDA-receptors

Also Published As

Publication number Publication date
KR19980063726A (ko) 1998-10-07
CZ376997A3 (cs) 1998-06-17
NZ329271A (en) 1998-12-23
US6359138B1 (en) 2002-03-19
ES2163086T3 (es) 2002-01-16
CN1162425C (zh) 2004-08-18
YU46997A (sh) 2000-12-28
CO4910155A1 (es) 2000-04-24
BR9705509A (pt) 2000-03-14
BR9705509B1 (pt) 2009-01-13
ATE205830T1 (de) 2001-10-15
PT846683E (pt) 2002-02-28
HK1011859A1 (en) 1999-07-23
HRP970653A2 (en) 1998-10-31
UY24797A1 (es) 2000-12-29
CN1086702C (zh) 2002-06-26
MA24410A1 (fr) 1998-07-01
SG71062A1 (en) 2000-03-21
CN1349989A (zh) 2002-05-22
RU2184112C2 (ru) 2002-06-27
DK0846683T3 (da) 2001-11-05
CA2220649C (en) 2007-02-13
AU4684197A (en) 1998-06-04
AU736597B2 (en) 2001-08-02
JPH10168060A (ja) 1998-06-23
NO975541D0 (no) 1997-12-02
ID17678A (id) 1998-01-22
JP3045988B2 (ja) 2000-05-29
IL122352A0 (en) 1998-04-05
TR199701488A2 (xx) 1998-06-22
PE20499A1 (es) 1999-03-05
PL323447A1 (en) 1998-06-08
KR100257947B1 (ko) 2000-07-01
NO975541L (no) 1998-06-04
CA2220649A1 (en) 1998-06-03
ZA9710653B (en) 1998-06-03
AR009641A1 (es) 2000-04-26
HRP970653B1 (en) 2001-12-31
DE69706813D1 (de) 2001-10-25
CN1188111A (zh) 1998-07-22

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Legal Events

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