ES2163086T3 - Derivados de la 4-hidroxi-piperidina. - Google Patents

Derivados de la 4-hidroxi-piperidina.

Info

Publication number
ES2163086T3
ES2163086T3 ES97121040T ES97121040T ES2163086T3 ES 2163086 T3 ES2163086 T3 ES 2163086T3 ES 97121040 T ES97121040 T ES 97121040T ES 97121040 T ES97121040 T ES 97121040T ES 2163086 T3 ES2163086 T3 ES 2163086T3
Authority
ES
Spain
Prior art keywords
hydroxy
double link
derivatives
hydrogen
present
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97121040T
Other languages
English (en)
Inventor
Alexander Alanine
Bernd Buttelmann
Neidhart Marie-Paule Heitz
Emmanuel Pinard
Rene Wyler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of ES2163086T3 publication Critical patent/ES2163086T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/48—Oxygen atoms attached in position 4 having an acyclic carbon atom attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

LA PRESENTE INVENCION TRATA DE DERIVADOS DE 4 RIDINA DE FORMULA GENERAL (I), EN LA CUAL X DENOTA O ENTRE SI, HIDROGENO, HIDROXI, (ALQUILO INFERIOR) NO, 1 INDEPENDIENTEMENTE ENTRE SI, HIDROGENO, HIDROXI, ALQUILO INFERIOR, HALOGENO, ALCOXI INFERIOR, TRIFLUOROMETILO O TRIFLUOROMETILOXI; A Y B PUEDEN SER UN DOBLE ENLACE, SIEMPRE QUE CUANDO A ES UN DOBLE ENLACE, B NO PUEDE SER UN DOBLE ENLACE; N ES 0 AMENTE ACEPTABLES DE LOS MISMOS. LOS COMPUESTOS DE LA PRESENTE INVENCION SON BLOQUEADORES SELECTIVOS DEL SUBTIPO DEL RECEPTOR DE NMDA (N OCESOS DE MEDIACION QUE SUBYACEN EN EL DESARROLLO DEL SNC, INCLUYENDO EL APRENDIZAJE Y LA FORMACION Y FUNCIONAMIENTO DE LA MEMORIA.
ES97121040T 1996-12-03 1997-12-01 Derivados de la 4-hidroxi-piperidina. Expired - Lifetime ES2163086T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP96119345 1996-12-03

Publications (1)

Publication Number Publication Date
ES2163086T3 true ES2163086T3 (es) 2002-01-16

Family

ID=8223458

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97121040T Expired - Lifetime ES2163086T3 (es) 1996-12-03 1997-12-01 Derivados de la 4-hidroxi-piperidina.

Country Status (30)

Country Link
US (1) US6359138B1 (es)
JP (1) JP3045988B2 (es)
KR (1) KR100257947B1 (es)
CN (2) CN1162425C (es)
AR (1) AR009641A1 (es)
AT (1) ATE205830T1 (es)
AU (1) AU736597B2 (es)
BR (1) BR9705509B1 (es)
CA (1) CA2220649C (es)
CO (1) CO4910155A1 (es)
CZ (1) CZ376997A3 (es)
DE (1) DE69706813T2 (es)
DK (1) DK0846683T3 (es)
ES (1) ES2163086T3 (es)
HK (1) HK1011859A1 (es)
HR (1) HRP970653B1 (es)
ID (1) ID17678A (es)
IL (1) IL122352A0 (es)
MA (1) MA24410A1 (es)
NO (1) NO975541L (es)
NZ (1) NZ329271A (es)
PE (1) PE20499A1 (es)
PL (1) PL323447A1 (es)
PT (1) PT846683E (es)
RU (1) RU2184112C2 (es)
SG (1) SG71062A1 (es)
TR (1) TR199701488A2 (es)
UY (1) UY24797A1 (es)
YU (1) YU46997A (es)
ZA (1) ZA9710653B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20012060A1 (it) * 2001-10-05 2003-04-05 Recordati Chem Pharm Nuovi eterocilcli n-acilati
US7005432B2 (en) * 2002-05-16 2006-02-28 Hoffman-La Roche Inc. Substituted imidazol-pyridazine derivatives
HUP0401522A2 (en) * 2004-07-29 2006-04-28 Richter Gedeon Vegyeszet New 4-benzylidene-piperidine derivatives, pharmaceutical compositions containing the same and process for their preparation
TW200621677A (en) * 2004-09-21 2006-07-01 Astellas Pharma Inc Cyclic amine derivative or salt thereof
KR101233223B1 (ko) * 2004-12-21 2013-02-14 제이엔씨 석유 화학 주식회사 크로만환을 가지는 액정 화합물, 액정 조성물 및 이 액정조성물을 함유하는 액정 표시소자
RU2538982C1 (ru) * 2013-11-19 2015-01-10 Федеральное Государственное Бюджетное Образовательное Учреждение Высшего Профессионального Образования "Нижегородский Государственный Университет Им. Н.И. Лобачевского" Производное n-(1s)-1',2',3'-триметокси-6,7-дигидро-1н-бензо[5',6':5,4]циклогепта-[3,2-f]бензофуран-1-ил)ацетамида и его применение
EP3233077A4 (en) * 2014-12-19 2018-08-08 The Broad Institute Inc. Dopamine d2 receptor ligands

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE546389C (de) 1927-12-30 1932-03-14 Ralph Mayhew Vorrichtung zur Bedienung von Tasteninstrumenten
US3476760A (en) 1967-03-06 1969-11-04 Smithkline Corp Substituted piperidinoalkylthianaphthenes and benzofurans
US3506671A (en) * 1967-11-01 1970-04-14 Smithkline Corp 1-naphthylalkyl-4-phenylpiperidine derivatives
US3557123A (en) * 1967-11-01 1971-01-19 Smith Kline French Lab 1-naphthylalkyl-4-phenylpiperidine derivatives
DE2507782A1 (de) 1975-02-22 1976-09-02 Merck Patent Gmbh Tetralon- und indanon-derivate sowie verfahren zu ihrer herstellung
US4016281A (en) 1975-02-22 1977-04-05 Merck Patent Gesellschaft Mit Beschrankter Haftung Tetralone and indanone compounds
US4039676A (en) 1975-06-23 1977-08-02 Ciba-Geigy Corporation 2-piperidinoalkyl-1,4-benzodioxans
GB8515388D0 (en) 1985-06-18 1985-07-17 Ici Plc Heterocyclic compounds
GB8515389D0 (en) 1985-06-18 1985-07-17 Ici Plc Heterocyclic compounds
DE69132141T2 (de) 1990-05-10 2000-09-21 Pfizer Inc., New York Neuroprotective indolone und verwandte derivate
DE4140542A1 (de) 1991-12-09 1993-06-17 Bayer Ag Piperdylmethyl substituierte chormanderivate
US5436255A (en) 1992-07-23 1995-07-25 Pfizer Inc. Method of treating diseases susceptable to treatment by blocking NMDA-receptors

Also Published As

Publication number Publication date
NO975541D0 (no) 1997-12-02
PE20499A1 (es) 1999-03-05
AU736597B2 (en) 2001-08-02
CN1162425C (zh) 2004-08-18
PT846683E (pt) 2002-02-28
BR9705509A (pt) 2000-03-14
BR9705509B1 (pt) 2009-01-13
UY24797A1 (es) 2000-12-29
PL323447A1 (en) 1998-06-08
ID17678A (id) 1998-01-22
CA2220649A1 (en) 1998-06-03
HRP970653B1 (en) 2001-12-31
JPH10168060A (ja) 1998-06-23
CN1349989A (zh) 2002-05-22
SG71062A1 (en) 2000-03-21
JP3045988B2 (ja) 2000-05-29
KR19980063726A (ko) 1998-10-07
CZ376997A3 (cs) 1998-06-17
HRP970653A2 (en) 1998-10-31
TR199701488A2 (xx) 1998-06-22
AU4684197A (en) 1998-06-04
CN1086702C (zh) 2002-06-26
IL122352A0 (en) 1998-04-05
DK0846683T3 (da) 2001-11-05
MA24410A1 (fr) 1998-07-01
KR100257947B1 (ko) 2000-07-01
ZA9710653B (en) 1998-06-03
HK1011859A1 (en) 1999-07-23
US6359138B1 (en) 2002-03-19
NZ329271A (en) 1998-12-23
RU2184112C2 (ru) 2002-06-27
ATE205830T1 (de) 2001-10-15
NO975541L (no) 1998-06-04
CA2220649C (en) 2007-02-13
DE69706813D1 (de) 2001-10-25
CO4910155A1 (es) 2000-04-24
AR009641A1 (es) 2000-04-26
DE69706813T2 (de) 2002-04-04
YU46997A (sh) 2000-12-28
CN1188111A (zh) 1998-07-22

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