ES2160106T3 - Derivados de la quinazolina. - Google Patents

Derivados de la quinazolina.

Info

Publication number
ES2160106T3
ES2160106T3 ES93924207T ES93924207T ES2160106T3 ES 2160106 T3 ES2160106 T3 ES 2160106T3 ES 93924207 T ES93924207 T ES 93924207T ES 93924207 T ES93924207 T ES 93924207T ES 2160106 T3 ES2160106 T3 ES 2160106T3
Authority
ES
Spain
Prior art keywords
hydrogen
group
quinazoline
alcoxi
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93924207T
Other languages
English (en)
Inventor
Jong Wook Lee
Jeong Seok Chae
Chang Seop Kim
Jae Kyu Kim
Dae Sung Lim
Jeong Won Lee
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yuhan Corp
Original Assignee
Yuhan Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yuhan Corp filed Critical Yuhan Corp
Application granted granted Critical
Publication of ES2160106T3 publication Critical patent/ES2160106T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

EL PRESENTE INVENTO ESTA REFERIDO A UN COMPUESTO DE LA QUINAZOLINA REPRESENTADO POR LA FORMULA (I) Y SUS SALES FARMACEUTICAMENTE ACEPTADAS, DONDE R1 Y R2 SON, INDEPENDIENTES UNO DEL OTRO, HIDROGENO O UN GRUPO ALQUILO C1-C4; R3 ES HIDROGENO O HALOGENO; R4, R5, R6, R7, R8 Y R9 PUEDEN SER IGUALES O DIFERENTES, SON HIDROGENO O UN GRUPO ALQUILO C1-C4, CICLOPROPOIL, O R5 Y R6 PUEDEN FORMAR UN CICLOPENTIL O CICLOHEXIL ANILLADOS, R10 ES HIDROGENO, UN ALQUILO C1-C4, UN ALCOXI C1-C4, UN HIDROXI C1-C4 ALCOXI, O UN GRUPO METITIOMETILOXI.
ES93924207T 1992-12-29 1993-10-29 Derivados de la quinazolina. Expired - Lifetime ES2160106T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR920026290 1992-12-29

Publications (1)

Publication Number Publication Date
ES2160106T3 true ES2160106T3 (es) 2001-11-01

Family

ID=19347436

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93924207T Expired - Lifetime ES2160106T3 (es) 1992-12-29 1993-10-29 Derivados de la quinazolina.

Country Status (7)

Country Link
US (1) US5686458A (es)
EP (1) EP0677049B1 (es)
JP (1) JP2654585B2 (es)
KR (1) KR0144833B1 (es)
DE (1) DE69330497T2 (es)
ES (1) ES2160106T3 (es)
WO (1) WO1994014795A1 (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2197298C (en) * 1994-08-13 1999-10-19 Jong Wook Lee Novel pyrimidine derivatives and processes for the preparation thereof
AU7692896A (en) * 1995-12-01 1997-06-27 Novartis Ag Quinazolin-2,4-diazirines as NPY receptor antagonist
US6252076B1 (en) 1996-05-04 2001-06-26 Yuhan Corporation Process for preparation of pyrimidine derivatives
CN1190427C (zh) * 1996-05-04 2005-02-23 株式会社柳韩洋行 制备嘧啶衍生物的方法
HU226752B1 (en) * 1996-10-29 2009-09-28 Yuhan Corp Process for preparation of pyrimidine derivatives
IN188411B (es) * 1997-03-27 2002-09-21 Yuhan Corp
US6706721B1 (en) 1998-04-29 2004-03-16 Osi Pharmaceuticals, Inc. N-(3-ethynylphenylamino)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine mesylate anhydrate and monohydrate
KR100272471B1 (ko) 1998-11-17 2000-11-15 김선진 신규의 피리미딘 유도체 및 그의 제조방법
US6852739B1 (en) * 1999-02-26 2005-02-08 Nitromed Inc. Methods using proton pump inhibitors and nitric oxide donors
US7087613B2 (en) * 1999-11-11 2006-08-08 Osi Pharmaceuticals, Inc. Treating abnormal cell growth with a stable polymorph of N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine hydrochloride
UA74803C2 (uk) 1999-11-11 2006-02-15 Осі Фармасьютікалз, Інк. Стійкий поліморф гідрохлориду n-(3-етинілфеніл)-6,7-біс(2-метоксіетокси)-4-хіназолінаміну, спосіб його одержання (варіанти) та фармацевтичне застосування
US6900226B2 (en) * 2000-09-06 2005-05-31 Hoffman-La Roche Inc. Neuropeptide Y antagonists
UA80393C2 (uk) 2000-12-07 2007-09-25 Алтана Фарма Аг Фармацевтична композиція, яка містить інгібітор фде 4, диспергований в матриці
MY140561A (en) 2002-02-20 2009-12-31 Nycomed Gmbh Dosage form containing pde 4 inhibitor as active ingredient
US7211590B2 (en) * 2002-08-01 2007-05-01 Nitromed, Inc. Nitrosated proton pump inhibitors, compositions and methods of use
ME00524B (me) 2003-03-10 2011-10-10 Astrazeneca Ab Novi postupak za dobijanje roflumilasta
EP1974730A1 (en) 2003-11-03 2008-10-01 AstraZeneca AB Imidazo[1,2-a]pyridine derivatives for use in the treatment of sleep disturbance due to silent gastro-esophageal reflux
US20070237315A1 (en) * 2004-02-24 2007-10-11 First Data Corporation System for maintaining type and/or status information for a party - communication point relationship
AU2005290360B2 (en) 2004-09-03 2011-06-30 Yuhan Corporation Pyrrolo(3,2-b)pyridine derivatives and processes for the preparation thereof
CA2601250C (en) 2005-03-16 2014-10-28 Nycomed Gmbh Taste masked dosage form containing roflumilast
KR101657616B1 (ko) * 2013-05-24 2016-09-19 주식회사유한양행 피리미딘 고리를 포함하는 바이사이클릭 유도체 및 그의 제조방법
EP3055301B1 (en) 2013-10-07 2019-11-20 Kadmon Corporation, LLC (2-(5-isoindolin-2-yl)pyrimidin-4-yl)-amine derivatives as rho kinase inhibitors for treating autoimmune diseases

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4044136A (en) * 1972-09-09 1977-08-23 Pfizer Inc. Aminoquinazoline therapeutic agents
GB1383409A (en) * 1972-09-09 1974-02-12 Pfizer Ltd Derivatives of 2-amino- and 4-amino-quinazoline and pharmaceutical compositions containing them
US3956495A (en) * 1973-10-30 1976-05-11 Eli Lilly And Company 2,4-Diaminoquinazolines as antithrombotic agents
IL88507A (en) * 1987-12-03 1993-02-21 Smithkline Beckman Intercredit 2,4-diaminoquinazolines, process for their preparation and pharmaceutical compositions comprising them
GB8910722D0 (en) * 1989-05-10 1989-06-28 Smithkline Beckman Intercredit Compounds
CA2015981A1 (en) * 1989-05-10 1990-11-10 Thomas H. Brown Compounds
KR930702292A (ko) * 1990-11-06 1993-09-08 알렌 제이. 스피겔 종양 치료 활성을 증대시키기 위한 퀴나졸린 유도체

Also Published As

Publication number Publication date
WO1994014795A1 (en) 1994-07-07
DE69330497D1 (de) 2001-08-30
KR0144833B1 (ko) 1998-07-15
JPH08500841A (ja) 1996-01-30
DE69330497T2 (de) 2002-05-29
KR940014385A (ko) 1994-07-18
US5686458A (en) 1997-11-11
EP0677049B1 (en) 2001-07-25
JP2654585B2 (ja) 1997-09-17
EP0677049A1 (en) 1995-10-18

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