DE69824174D1 - Ein system zur zellbasierten reihenuntersuchung - Google Patents

Ein system zur zellbasierten reihenuntersuchung

Info

Publication number
DE69824174D1
DE69824174D1 DE69824174T DE69824174T DE69824174D1 DE 69824174 D1 DE69824174 D1 DE 69824174D1 DE 69824174 T DE69824174 T DE 69824174T DE 69824174 T DE69824174 T DE 69824174T DE 69824174 D1 DE69824174 D1 DE 69824174D1
Authority
DE
Germany
Prior art keywords
cells
locations
array
reporter molecules
microplate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69824174T
Other languages
English (en)
Other versions
DE69824174T2 (de
Inventor
Terry Dunlay
Lansing Taylor
H Gough
A Giuliano
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cellomics Inc
Original Assignee
Cellomics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27490752&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69824174(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US08/810,983 external-priority patent/US5989835A/en
Priority claimed from PCT/US1997/009564 external-priority patent/WO1997045730A1/en
Priority claimed from US08/865,341 external-priority patent/US6103479A/en
Application filed by Cellomics Inc filed Critical Cellomics Inc
Publication of DE69824174D1 publication Critical patent/DE69824174D1/de
Application granted granted Critical
Publication of DE69824174T2 publication Critical patent/DE69824174T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1429—Signal processing
    • G01N15/1433—Signal processing using image recognition
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584—Control arrangements for automatic analysers
    • G01N35/00722—Communications; Identification
    • G01N35/00871—Communications between instruments or with remote terminals
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
    • B01J2219/00315—Microtiter plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
    • B01J2219/00315—Microtiter plates
    • B01J2219/00317—Microwell devices, i.e. having large numbers of wells
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00702—Processes involving means for analysing and characterising the products
    • B01J2219/00707—Processes involving means for analysing and characterising the products separated from the reactor apparatus
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/0074—Biological products
    • B01J2219/00743—Cells
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N2015/1486—Counting the particles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N2015/1497—Particle shape

Landscapes

  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nanotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Composite Materials (AREA)
  • Dispersion Chemistry (AREA)
  • Medical Informatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Signal Processing (AREA)
  • Materials Engineering (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Image Processing (AREA)
  • Image Analysis (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
DE69824174T 1997-02-27 1998-02-27 Ein system zur zellbasierten reihenuntersuchung Expired - Lifetime DE69824174T2 (de)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US08/810,983 US5989835A (en) 1997-02-27 1997-02-27 System for cell-based screening
PCT/US1997/009564 WO1997045730A1 (en) 1996-05-30 1997-05-29 Miniaturized cell array methods and apparatus for cell-based screening
US08/865,341 US6103479A (en) 1996-05-30 1997-05-29 Miniaturized cell array methods and apparatus for cell-based screening
WOPCT/US97/09564 1997-05-29
US865341 1997-05-29
US6924697P 1997-12-11 1997-12-11
US6932997P 1997-12-11 1997-12-11
US69246 1997-12-11
US69329 1997-12-11
PCT/US1998/003701 WO1998038490A1 (en) 1997-02-27 1998-02-27 A system for cell-based screening
US810983 2001-03-16

Publications (2)

Publication Number Publication Date
DE69824174D1 true DE69824174D1 (de) 2004-07-01
DE69824174T2 DE69824174T2 (de) 2005-07-14

Family

ID=27490752

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69824174T Expired - Lifetime DE69824174T2 (de) 1997-02-27 1998-02-27 Ein system zur zellbasierten reihenuntersuchung
DE69839501T Expired - Lifetime DE69839501D1 (de) 1997-02-27 1998-02-27 System für Screening biologischer Zellen

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69839501T Expired - Lifetime DE69839501D1 (de) 1997-02-27 1998-02-27 System für Screening biologischer Zellen

Country Status (9)

Country Link
US (1) US6671624B1 (de)
EP (1) EP0983498B1 (de)
JP (3) JP3683591B2 (de)
AT (1) ATE268008T1 (de)
AU (1) AU730100B2 (de)
CA (1) CA2282658C (de)
DE (2) DE69824174T2 (de)
DK (1) DK0983498T3 (de)
WO (1) WO1998038490A1 (de)

Families Citing this family (203)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6794127B1 (en) 1997-06-16 2004-09-21 Diversa Corporation Capillary array-based sample screening
US6972183B1 (en) 1997-06-16 2005-12-06 Diversa Corporation Capillary array-based enzyme screening
US5989835A (en) 1997-02-27 1999-11-23 Cellomics, Inc. System for cell-based screening
US6519583B1 (en) * 1997-05-15 2003-02-11 Incyte Pharmaceuticals, Inc. Graphical viewer for biomolecular sequence data
US7117098B1 (en) 1997-02-27 2006-10-03 Cellomics, Inc. Machine-readable storage medium for analyzing distribution of macromolecules between the cell membrane and the cell cytoplasm
US6759206B1 (en) 1997-02-27 2004-07-06 Cellomics, Inc. System for cell-based screening
US6756207B1 (en) 1997-02-27 2004-06-29 Cellomics, Inc. System for cell-based screening
US7853411B2 (en) 1997-02-27 2010-12-14 Cellomics, Inc. System for cell-based screening
US6416959B1 (en) 1997-02-27 2002-07-09 Kenneth Giuliano System for cell-based screening
ATE354089T1 (de) 1997-04-07 2007-03-15 Fisher Bioimage Aps Ein verfahren zum screenen von substanzen hinsichtlich ihres effekts auf camp spiegel basierend auf intrazellulärer translokation von pka
US6171780B1 (en) * 1997-06-02 2001-01-09 Aurora Biosciences Corporation Low fluorescence assay platforms and related methods for drug discovery
US7160687B1 (en) 1997-05-29 2007-01-09 Cellomics, Inc. Miniaturized cell array methods and apparatus for cell-based screening
WO1999039184A1 (en) * 1998-01-29 1999-08-05 Ribozyme Pharmaceuticals, Inc. Image acquisition and image analysis of biological material
US6825042B1 (en) 1998-02-24 2004-11-30 Vertex Pharmaceuticals (San Diego) Llc Microplate lid
US20030036855A1 (en) 1998-03-16 2003-02-20 Praelux Incorporated, A Corporation Of New Jersey Method and apparatus for screening chemical compounds
US6388788B1 (en) 1998-03-16 2002-05-14 Praelux, Inc. Method and apparatus for screening chemical compounds
WO1999067639A1 (en) * 1998-06-25 1999-12-29 Caliper Technologies Corporation High throughput methods, systems and apparatus for performing cell based screening assays
EP1095277B1 (de) * 1998-07-13 2003-01-22 Cellomics, Inc. Auf zellen basiertes screening-system
US7155344B1 (en) * 1998-07-27 2006-12-26 Caliper Life Sciences, Inc. Distributed database for analytical instruments
CA2344567A1 (en) * 1998-09-18 2000-03-30 Cellomics, Inc. A system for cell-based screening
JP2002525600A (ja) * 1998-09-22 2002-08-13 セロミックス インコーポレイテッド 細胞ベースのスクリーニングのための小型化細胞アレイ方法および装置
FR2784188B1 (fr) * 1998-10-05 2000-12-22 Commissariat Energie Atomique Biopuce et dispositif de lecture d'une biopuce comportant une pluralite de zones de reconnaissance moleculaire
FR2784189B3 (fr) 1998-10-05 2000-11-03 Commissariat Energie Atomique Biopuce et dispositif de lecture d'une biopuce comportant une pluralite de zones de reconnaissance moleculaire
FR2785052B1 (fr) 1998-10-27 2000-12-01 Commissariat Energie Atomique Dispositif de determination de la concentration d'une substance melangee a un fluorophore et procede de mise en oeuvre de ce dispositif
EP1145149B1 (de) 1998-11-13 2005-04-06 Cellomics, Inc. Verfahren und system zum effizienten gewinnen und speichern von experimentellen daten
EP1533720A3 (de) * 1998-11-13 2014-04-30 Cellomics, Inc. Verfahren und System zum effizienten Gewinnen und Speichern von experimentellen Daten
DE19854195C2 (de) * 1998-11-24 2001-02-01 Xerion Pharmaceuticals Gmbh Verfahren zur Identifikation der Funktion von biologischen Molekülen und Vorrichtung zur Durchführung des Verfahrens
US6130745A (en) * 1999-01-07 2000-10-10 Biometric Imaging, Inc. Optical autofocus for use with microtiter plates
FR2788602B1 (fr) * 1999-01-20 2002-06-07 Inst Nat Sante Rech Med Procede de criblage utile pour identifier des ligands potentiels pour un recepteur capable de s'internaliser
US8885913B2 (en) 1999-01-25 2014-11-11 Amnis Corporation Detection of circulating tumor cells using imaging flow cytometry
US8406498B2 (en) 1999-01-25 2013-03-26 Amnis Corporation Blood and cell analysis using an imaging flow cytometer
US7450229B2 (en) 1999-01-25 2008-11-11 Amnis Corporation Methods for analyzing inter-cellular phenomena
US8131053B2 (en) 1999-01-25 2012-03-06 Amnis Corporation Detection of circulating tumor cells using imaging flow cytometry
WO2000050872A2 (en) * 1999-02-26 2000-08-31 Cellomics, Inc. A system for cell-based screening
GB2364704B (en) * 1999-04-15 2004-07-14 Virtual Arrays Inc Combinatorial chemical library supports having indicia at coding positions and methods of use
JP2002544523A (ja) * 1999-05-13 2002-12-24 カリパー・テクノロジーズ・コープ． ターゲット非依存アッセイシステム及び方法
US6651008B1 (en) 1999-05-14 2003-11-18 Cytokinetics, Inc. Database system including computer code for predictive cellular bioinformatics
WO2000070528A2 (en) * 1999-05-14 2000-11-23 Cytokinetics, Inc. Method and apparatus for predictive cellular bioinformatics
AU5269900A (en) * 1999-05-14 2000-12-05 Cellomics, Inc. A system for cell-based screening
US6743576B1 (en) 1999-05-14 2004-06-01 Cytokinetics, Inc. Database system for predictive cellular bioinformatics
US20030228565A1 (en) * 2000-04-26 2003-12-11 Cytokinetics, Inc. Method and apparatus for predictive cellular bioinformatics
US7151847B2 (en) 2001-02-20 2006-12-19 Cytokinetics, Inc. Image analysis of the golgi complex
US6673554B1 (en) * 1999-06-14 2004-01-06 Trellie Bioinformatics, Inc. Protein localization assays for toxicity and antidotes thereto
WO2000079241A2 (en) * 1999-06-21 2000-12-28 Cellomics, Inc. A system for cell-based screening
AU6366200A (en) * 1999-07-27 2001-02-13 Cellomics, Inc. Miniaturized cell array methods and apparatus for cell-based screening
WO2001007891A2 (en) * 1999-07-27 2001-02-01 Cellomics, Inc. Miniaturized cell array methods and apparatus for cell-based screening
AU2002238023B2 (en) * 1999-08-04 2008-03-13 Icagen, Inc Pyridine-substituted benzanilides as potassium ion channel openers
US6986993B1 (en) 1999-08-05 2006-01-17 Cellomics, Inc. System for cell-based screening
EP1203214B1 (de) * 1999-08-05 2005-11-09 Cellomics, Inc. Optisches system analyse für zellen
WO2001011341A2 (en) * 1999-08-05 2001-02-15 Cellomics, Inc. A system for cell-based screening
EP1212619B1 (de) * 1999-09-14 2007-05-23 Xenoport, Inc. Substrate und screeningverfahren für transportproteine
AU1075701A (en) 1999-10-08 2001-04-23 Protogene Laboratories, Inc. Method and apparatus for performing large numbers of reactions using array assembly
WO2001035072A2 (en) * 1999-11-09 2001-05-17 Cellomics, Inc. A system for cell-based screening
CA2360750A1 (en) * 1999-11-22 2001-05-31 Diversa Corporation Capillary array-based sample screening
US6365367B1 (en) 1999-12-06 2002-04-02 Cellomics, Inc. Environmental chamber for the analysis of live cells
WO2001042786A2 (en) * 1999-12-09 2001-06-14 Cellomics, Inc. System for cell based screening : cell spreading
US6406840B1 (en) 1999-12-17 2002-06-18 Biomosaic Systems, Inc. Cell arrays and the uses thereof
WO2001055951A2 (en) 2000-01-25 2001-08-02 Cellomics, Inc. Method and system for automated inference of physico-chemical interaction knowl edge
FR2807543B1 (fr) * 2000-04-06 2004-11-05 Imstar S A Appareil d'imagerie associe a une base de donnees images
US6678391B2 (en) * 2000-04-18 2004-01-13 Matsushita Electric Industrial Co., Ltd. Organism-specimen morphological-change detecting apparatus, and organism-specimen morphological-change detecting method
US7420659B1 (en) * 2000-06-02 2008-09-02 Honeywell Interantional Inc. Flow control system of a cartridge
AU2007201501B2 (en) * 2000-06-08 2009-02-19 The Regents Of The University Of California Visual-servoing optical microscopy
US8548745B2 (en) 2000-06-08 2013-10-01 The Regents Of The University Of California Visual-servoing optical microscopy
EP2325294B1 (de) * 2000-06-08 2016-08-24 The Regents of The University of California Visuelle servosteuerung für optische mikroskopie
US7546210B2 (en) 2000-06-08 2009-06-09 The Regents Of The University Of California Visual-servoing optical microscopy
US6656683B1 (en) 2000-07-05 2003-12-02 Board Of Regents, The University Of Texas System Laser scanning cytology with digital image capture
US20020052882A1 (en) * 2000-07-07 2002-05-02 Seth Taylor Method and apparatus for visualizing complex data sets
US6768982B1 (en) 2000-09-06 2004-07-27 Cellomics, Inc. Method and system for creating and using knowledge patterns
US6813615B1 (en) 2000-09-06 2004-11-02 Cellomics, Inc. Method and system for interpreting and validating experimental data with automated reasoning
US7009651B2 (en) * 2000-10-12 2006-03-07 Amnis Corporation System and method for high numeric aperture imaging systems
WO2002037938A2 (en) 2000-10-24 2002-05-16 Oncosis Llc Method and device for selectively targeting cells within a three -dimensional specimen
AT411066B (de) * 2000-10-24 2003-09-25 Steiner Georg E Verfahren und anordnung zur untersuchung von zellen
US20100279341A1 (en) * 2000-10-24 2010-11-04 Tissuegnostics Gmbh Methods and system for analyzing cells
US6864065B2 (en) 2000-11-08 2005-03-08 Surface Logix, Inc. Assays for monitoring cell motility in real-time
US6844184B2 (en) 2000-11-08 2005-01-18 Surface Logix, Inc. Device for arraying biomolecules and for monitoring cell motility in real-time
US7033819B2 (en) 2000-11-08 2006-04-25 Surface Logix, Inc. System for monitoring cell motility in real-time
US6893851B2 (en) 2000-11-08 2005-05-17 Surface Logix, Inc. Method for arraying biomolecules and for monitoring cell motility in real-time
US7033821B2 (en) 2000-11-08 2006-04-25 Surface Logix, Inc. Device for monitoring cell motility in real-time
US6905881B2 (en) 2000-11-30 2005-06-14 Paul Sammak Microbead-based test plates and test methods for fluorescence imaging systems
US7218764B2 (en) 2000-12-04 2007-05-15 Cytokinetics, Inc. Ploidy classification method
WO2002048693A1 (fr) * 2000-12-14 2002-06-20 Olympus Optical Co., Ltd. Analyseur fluorometrique et analyse fluorometrique
US6599694B2 (en) 2000-12-18 2003-07-29 Cytokinetics, Inc. Method of characterizing potential therapeutics by determining cell-cell interactions
AU2002246792A1 (en) 2000-12-22 2002-08-12 Cellomics, Inc. Identification of individual cells during kinetic assays
US8008459B2 (en) 2001-01-25 2011-08-30 Evolva Sa Concatemers of differentially expressed multiple genes
JP2004525624A (ja) 2001-01-25 2004-08-26 エボルバ バイオテック アクティーゼルスカブ 細胞コレクションのライブラリー
JP2004534207A (ja) * 2001-02-14 2004-11-11 テイボテク・ビーブイビーエイ 高スループット選別用の自動情報管理を提供する方法と装置
US6956961B2 (en) 2001-02-20 2005-10-18 Cytokinetics, Inc. Extracting shape information contained in cell images
US7016787B2 (en) 2001-02-20 2006-03-21 Cytokinetics, Inc. Characterizing biological stimuli by response curves
US6999607B2 (en) 2001-02-20 2006-02-14 Cytokinetics, Inc. Method and apparatus for automated cellular bioinformatics
WO2002073200A1 (en) 2001-03-12 2002-09-19 Cellomics, Inc. Methods to increase the capacity of high content cell-based screening assays
EP1243327A1 (de) * 2001-03-19 2002-09-25 BioChip Technologies GmbH Oberfläche mit einem Muster aus Zellen und Verfahren zu deren Herstellung
WO2002077903A2 (en) 2001-03-26 2002-10-03 Cellomics, Inc. Methods for determining the organization of a cellular component of interest
GB0111004D0 (en) * 2001-05-04 2001-06-27 Univ Sheffield Screening method
US6989276B2 (en) 2001-05-10 2006-01-24 Battelle Energy Alliance, Llc Rapid classification of biological components
USRE46351E1 (en) 2001-05-10 2017-03-28 Battelle Energy Alliance, Llc Antibody profiling sensitivity through increased reporter antibody layering
USRE44031E1 (en) 2001-05-10 2013-02-26 Battelle Energy Alliance, Llc Antibody profiling sensitivity through increased reporter antibody layering
US7695919B2 (en) 2001-05-10 2010-04-13 Battelle Energy Alliance, Llc Antibody profiling sensitivity through increased reporter antibody layering
JP4846138B2 (ja) * 2001-07-10 2011-12-28 シスメックス株式会社 画像検索システム
DE60234131D1 (de) 2001-08-01 2009-12-03 Cellomics Inc Neue fusionsproteine und molekulare bindungsassays
US8227240B2 (en) 2001-08-14 2012-07-24 The Washington University Systems for screening pharmaceutical chemicals
AU2002323649A1 (en) * 2001-09-06 2003-03-24 Genomic Profiling Systems, Inc. Rapid detection of replicating cells
WO2003077552A1 (en) 2002-02-13 2003-09-18 Reify Corporation Method and apparatus for acquisition, compression, and characterization of spatiotemporal signals
JP4033697B2 (ja) * 2002-04-01 2008-01-16 独立行政法人科学技術振興機構 細胞チップ作製方法と標的蛋白質スクリーニング方法
JP2003294736A (ja) * 2002-04-01 2003-10-15 Japan Science & Technology Corp 蛍光蛋白質融合プローブを用いたスクリーニング方法
EP1527339B1 (de) 2002-06-03 2006-08-16 PamGene B.V. Hoch-durchsatz assay zur messung von zellulären antworten mit hilfe von mikroarrays
GB0229734D0 (en) * 2002-12-23 2003-01-29 Qinetiq Ltd Grading oestrogen and progesterone receptors expression
JP4137682B2 (ja) * 2003-03-31 2008-08-20 オリンパス株式会社 蛍光分光分析装置
WO2004101788A2 (en) * 2003-05-09 2004-11-25 University Of Pittsburgh Of The Commonwealth System Of Higher Education Small interfering rna libraries and methods of synthesis and use
EP1640453A4 (de) * 2003-06-25 2009-09-02 Nat Inst Of Advanced Ind Scien Digitale zelle
JP4146310B2 (ja) * 2003-07-17 2008-09-10 浜松ホトニクス株式会社 組成の均一度の評価方法及び組成の均一度の評価装置
US20050014217A1 (en) 2003-07-18 2005-01-20 Cytokinetics, Inc. Predicting hepatotoxicity using cell based assays
US7235353B2 (en) 2003-07-18 2007-06-26 Cytokinetics, Inc. Predicting hepatotoxicity using cell based assays
GB2423988A (en) 2003-07-18 2006-09-13 Cytokinetics Inc Characterizing biological stimuli by response curves
GB0317679D0 (en) * 2003-07-29 2003-09-03 Amersham Biosciences Uk Ltd Analysing biological entities
JP4507060B2 (ja) * 2003-10-01 2010-07-21 横河電機株式会社 創薬スクリーニング方法および装置
JP4454998B2 (ja) 2003-09-29 2010-04-21 株式会社ニコン 細胞観察装置および細胞観察方法
FR2862069B1 (fr) * 2003-11-07 2006-06-23 Celogos Analyse automatique d'echantillons cellulaires
US20050186554A1 (en) * 2004-01-15 2005-08-25 Vladimir Temov Image analysis and assay system
JP4271054B2 (ja) * 2004-02-12 2009-06-03 オリンパス株式会社 細胞画像解析装置
US8953866B2 (en) 2004-03-16 2015-02-10 Amnis Corporation Method for imaging and differential analysis of cells
CA2598602A1 (en) * 2004-03-16 2005-10-20 Amnis Corporation Image based quantitation of molecular translocation
WO2005090945A1 (en) 2004-03-16 2005-09-29 Amnis Corporation Method for imaging and differential analysis of cells
KR101147147B1 (ko) 2004-04-01 2012-05-25 머크 샤프 앤드 돔 코포레이션 Ｒｎａ 간섭의 오프 타겟 효과 감소를 위한 변형된폴리뉴클레오타이드
JPWO2006001397A1 (ja) * 2004-06-25 2008-04-17 独立行政法人産業技術総合研究所 細胞ネットワーク解析システム
US7323318B2 (en) 2004-07-15 2008-01-29 Cytokinetics, Inc. Assay for distinguishing live and dead cells
US7999929B2 (en) 2004-08-02 2011-08-16 The Furukawa Electric Co., Ltd. Specimen optical information recognizing device and its recognizing method
US20060040338A1 (en) * 2004-08-18 2006-02-23 Odyssey Thera, Inc. Pharmacological profiling of drugs with cell-based assays
JP4509702B2 (ja) * 2004-08-31 2010-07-21 オリンパス株式会社 細胞内の顆粒状構造物の測定方法
JP4577645B2 (ja) * 2004-09-30 2010-11-10 横河電機株式会社 スクリーニング装置
US20060166234A1 (en) 2004-11-22 2006-07-27 Barbara Robertson Apparatus and system having dry control gene silencing compositions
US7923207B2 (en) 2004-11-22 2011-04-12 Dharmacon, Inc. Apparatus and system having dry gene silencing pools
US7935811B2 (en) 2004-11-22 2011-05-03 Dharmacon, Inc. Apparatus and system having dry gene silencing compositions
US7818130B2 (en) * 2004-12-09 2010-10-19 Cellomics, Inc. Automated method and system for setting image analysis parameters to control image analysis operations
GB0427050D0 (en) * 2004-12-10 2005-01-12 Amersham Biosciences Uk Ltd Method of,and apparatus and computer software for,imaging biological objects
JP2006238802A (ja) * 2005-03-03 2006-09-14 Olympus Corp 細胞観察装置、細胞観察方法、顕微鏡システム、及び細胞観察プログラム
CN101151378B (zh) * 2005-03-30 2013-04-03 奥林巴斯株式会社 规定部位发光量测定方法、规定部位发光量测定装置、表达量测定方法及测定装置
US20080219542A1 (en) * 2005-04-18 2008-09-11 Vladimir Temov Systems for characterizing localization in biological cells
US20070021433A1 (en) 2005-06-03 2007-01-25 Jian-Qiang Fan Pharmacological chaperones for treating obesity
JP2006350740A (ja) * 2005-06-16 2006-12-28 Olympus Corp 画像処理装置および画像処理プログラム
US20060291706A1 (en) * 2005-06-23 2006-12-28 Applera Corporation Method of extracting intensity data from digitized image
JP2008052227A (ja) * 2005-09-15 2008-03-06 Olympus Corp 観察装置
US9057046B2 (en) 2005-09-26 2015-06-16 Rapid Micro Biosystems, Inc. Cassette containing growth medium
WO2007067999A2 (en) 2005-12-09 2007-06-14 Amnis Corporation Extended depth of field imaging for high speed object analysis
MX338460B (es) * 2005-12-21 2016-04-15 Meso Scale Technologies Llc Aparatos, metodos y reactivos de ensayo.
US20100227316A1 (en) * 2005-12-27 2010-09-09 Olympus Corporation Luminescense measuring apparatus and luminescense measuring method
JP4757023B2 (ja) * 2005-12-28 2011-08-24 富士通株式会社 インジェクション装置およびインジェクション方法
WO2008018905A2 (en) * 2006-01-17 2008-02-14 Cellumen, Inc. Method for predicting biological systems responses
US8129105B2 (en) 2006-04-13 2012-03-06 Ralph Zuckerman Method and apparatus for the non-invasive measurement of tissue function and metabolism by determination of steady-state fluorescence anisotropy
CN101484806A (zh) 2006-05-17 2009-07-15 协乐民公司 一种对组织进行自动分析的方法
JP4890096B2 (ja) * 2006-05-19 2012-03-07 浜松ホトニクス株式会社 画像取得装置、画像取得方法、及び画像取得プログラム
EP2034349B2 (de) 2006-06-08 2023-07-19 Nikon Corporation Beobachtungsvorrichtung und beobachtungsverfahren
US7706591B2 (en) 2006-07-13 2010-04-27 Cellomics, Inc. Neuronal profiling
JP4885646B2 (ja) * 2006-08-14 2012-02-29 オリンパス株式会社 細胞自動解析装置および細胞自動解析方法
US8809514B2 (en) 2006-09-22 2014-08-19 Ge Healthcare Dharmacon, Inc. Tripartite oligonucleotide complexes and methods for gene silencing by RNA interference
US7769219B2 (en) * 2006-12-11 2010-08-03 Cytyc Corporation Method for assessing image focus quality
US9557217B2 (en) * 2007-02-13 2017-01-31 Bti Holdings, Inc. Universal multidetection system for microplates
US8351674B2 (en) 2007-05-31 2013-01-08 Battelle Energy Alliance, Llc Image portion identification methods, image parsing methods, image parsing systems, and articles of manufacture
EP2554975A1 (de) * 2007-12-17 2013-02-06 Life Technologies Corporation Verfahren und Substrat zum Erfassen von Defekten in anorganisch beschichteten Polymeroberflächen
GB0800938D0 (en) * 2008-01-18 2008-02-27 Ge Healthcare Uk Ltd Multiplex cell signalling assay
JP5259207B2 (ja) * 2008-02-05 2013-08-07 オリンパス株式会社 細胞画像解析装置及びその方法並びにそのソフトウェア
US8188060B2 (en) 2008-02-11 2012-05-29 Dharmacon, Inc. Duplex oligonucleotides with enhanced functionality in gene regulation
EP3567363B1 (de) * 2008-04-11 2022-03-23 Meso Scale Technologies, LLC Vorrichtung mit einem plattenhandhabungssystem zum durchführen von lumineszenz-assays in mehrfachlochplatten
CN102099458A (zh) * 2008-06-05 2011-06-15 威斯康星医学院公司 用于高通量试验的三维组织
US8446463B2 (en) * 2008-08-22 2013-05-21 Genprime, Inc. Apparatus, method and article to perform assays using assay strips
CN102224260B (zh) 2008-09-24 2015-11-25 施特劳斯控股公司 用于检测分析物的试剂盒和装置
US8175369B2 (en) * 2008-12-12 2012-05-08 Molecular Devices, Llc Multi-nucleated cell classification and micronuclei scoring
JP4997255B2 (ja) * 2009-01-05 2012-08-08 オリンパス株式会社 細胞画像解析装置
JP5364430B2 (ja) * 2009-04-22 2013-12-11 オリンパス株式会社 細胞画像取得装置及び細胞画像取得方法
JP5530126B2 (ja) * 2009-07-24 2014-06-25 オリンパス株式会社 三次元細胞画像解析システム及びそれに用いる三次元細胞画像解析装置
JP5525774B2 (ja) * 2009-07-24 2014-06-18 オリンパス株式会社 細胞画像解析装置
JP5439096B2 (ja) * 2009-09-08 2014-03-12 株式会社日立ハイテクノロジーズ 細菌分類装置および細菌検査前処理装置
US8969009B2 (en) 2009-09-17 2015-03-03 Vicki S. Thompson Identification of discriminant proteins through antibody profiling, methods and apparatus for identifying an individual
US9410965B2 (en) 2009-09-17 2016-08-09 Battelle Energy Alliance, Llc Identification of discriminant proteins through antibody profiling, methods and apparatus for identifying an individual
US8451524B2 (en) 2009-09-29 2013-05-28 Amnis Corporation Modifying the output of a laser to achieve a flat top in the laser's Gaussian beam intensity profile
US9001200B2 (en) * 2010-01-12 2015-04-07 Bio-Rad Laboratories, Inc. Cell characterization using multiple focus planes
US8817115B1 (en) 2010-05-05 2014-08-26 Amnis Corporation Spatial alignment of image data from a multichannel detector using a reference image
JP2012118126A (ja) * 2010-11-29 2012-06-21 Olympus Corp 観察装置および観察方法
US10018631B2 (en) 2011-03-17 2018-07-10 Cernostics, Inc. Systems and compositions for diagnosing Barrett's esophagus and methods of using the same
JP6105613B2 (ja) 2011-11-07 2017-03-29 ラピッド マイクロ バイオシステムズ インコーポレイテッド 無菌試験用カセット
JP2013137635A (ja) * 2011-12-28 2013-07-11 Dainippon Screen Mfg Co Ltd 画像表示装置および画像表示方法
DE102012100098B4 (de) * 2012-01-06 2021-09-16 Becker & Hickl Gmbh Verfahren zur Aufzeichnung von zeitlichen Änderungen der Zeitfunktion eines optischen Signals mit räumlicher Auflösung entlang einer Linie im Raum
CN107841461A (zh) 2012-04-16 2018-03-27 快速微型生物系统公司 细胞培养装置
US20140046722A1 (en) * 2012-08-10 2014-02-13 Sample6 Technologies, Inc. System for on-site environment monitoring
WO2014111936A1 (en) 2013-01-17 2014-07-24 Novellusdx Ltd. Methods and systems for identifying patient specific driver mutations
JP5639670B2 (ja) 2013-02-01 2014-12-10 浜松ホトニクス株式会社 画像取得装置及び撮像装置
JP6343874B2 (ja) * 2013-05-10 2018-06-20 株式会社ニコン 観察装置、観察方法、観察システム、そのプログラム、および細胞の製造方法
TWI496112B (zh) * 2013-09-13 2015-08-11 Univ Nat Cheng Kung 細胞影像分割方法以及核質比評估方法
JP2015192636A (ja) * 2014-03-31 2015-11-05 株式会社ニコン 測定装置、スクリーニング装置、測定方法及びスクリーニング方法
JP2014157158A (ja) * 2014-04-17 2014-08-28 Olympus Corp 細胞観察方法、三次元細胞画像解析システム及びそれに用いる三次元細胞画像解析装置
JP6395251B2 (ja) * 2014-05-30 2018-09-26 国立研究開発法人理化学研究所 光学顕微鏡システムおよびスクリーニング装置
EP3822361A1 (de) * 2015-02-20 2021-05-19 Takara Bio USA, Inc. Verfahren zur schnellen präzisen abgabe, visualisierung und analyse von einzelzellen
JP6548965B2 (ja) * 2015-06-15 2019-07-24 オリンパス株式会社 顕微鏡システムおよび顕微鏡観察方法
AU2016341304B2 (en) * 2015-10-23 2022-12-08 Novartis Ag Method of deriving a value for percent biomarker positivity for selected cells present in a field of view
JP6824654B2 (ja) * 2015-10-30 2021-02-03 シスメックス株式会社 細胞情報取得方法および細胞情報取得装置
AU2016359685B2 (en) 2015-11-25 2022-12-22 Cernostics, Inc. Methods of predicting progression of Barrett's esophagus
EP3428261A4 (de) * 2016-03-11 2019-12-04 Nikon Corporation Bildverarbeitungsvorrichtung, beobachtungsvorrichtung und programm
CN109070044B (zh) * 2016-07-21 2021-07-30 宝生物工程（美国)有限公司 使用多孔装置进行的多z平面成像和分配
US10576475B2 (en) 2016-09-15 2020-03-03 Genprime, Inc. Diagnostic assay strip cassette
JP7109130B2 (ja) 2018-04-04 2022-07-29 株式会社エビデント 顕微鏡
CN112740017A (zh) 2018-04-19 2021-04-30 曙光诊断学公司 靶标检测
WO2021061840A1 (en) * 2019-09-23 2021-04-01 Synthego Corporation Genetic variant panels and methods of generation and use thereof
CN111832191B (zh) * 2020-07-29 2023-06-30 南开大学 基于生长域的微管内增量式细胞质速度场评估方法
US11995833B2 (en) 2020-07-31 2024-05-28 The Joan and Irwin Jacobs Technion-Cornell Institute System and method for on-phase microscopy

Family Cites Families (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3851972A (en) * 1973-10-18 1974-12-03 Coulter Electronics Automatic method and system for analysis and review of a plurality of stored slides
JPS5698635A (en) * 1980-01-11 1981-08-08 Omron Tateisi Electronics Co Cell analyzing device
US4344816A (en) 1980-12-19 1982-08-17 Bell Telephone Laboratories, Incorporated Selectively etched bodies
US4647531A (en) 1984-02-06 1987-03-03 Ortho Diagnostic Systems, Inc. Generalized cytometry instrument and methods of use
JPS6131282A (ja) 1984-07-24 1986-02-13 Fuji Xerox Co Ltd シリアルカラ−感熱転写プリンタ
US5096807A (en) 1985-03-06 1992-03-17 Murex Corporation Imaging immunoassay detection system with background compensation and its use
US4673988A (en) 1985-04-22 1987-06-16 E.I. Du Pont De Nemours And Company Electronic mosaic imaging process
US4998284A (en) 1987-11-17 1991-03-05 Cell Analysis Systems, Inc. Dual color camera microscope and methodology for cell staining and analysis
US5016283A (en) 1985-11-04 1991-05-14 Cell Analysis Systems, Inc. Methods and apparatus for immunoploidy analysis
US4741043B1 (en) * 1985-11-04 1994-08-09 Cell Analysis Systems Inc Method of and apparatus for image analyses of biological specimens
US4762701A (en) 1986-10-31 1988-08-09 Smithkline Beckman Corporation In vivo cellular tracking
US4783401A (en) 1986-10-31 1988-11-08 Smithkline Beckman Corporation Viable cell labelling
US4859584A (en) 1986-10-31 1989-08-22 Smithkline Beckman Corporation Cell growth rate determination by measurement of changes in cyanine dye levels in plasma membranes
US5079600A (en) 1987-03-06 1992-01-07 Schnur Joel M High resolution patterning on solid substrates
SE462408B (sv) 1988-11-10 1990-06-18 Pharmacia Ab Optiskt biosensorsystem utnyttjande ytplasmonresonans foer detektering av en specific biomolekyl, saett att kalibrera sensoranordningen samt saett att korrigera foer baslinjedrift i systemet
US5031797A (en) 1988-11-18 1991-07-16 Beckman Instruments, Inc. Reagent storage and delivery system
US4982739A (en) 1989-02-06 1991-01-08 Board Of Regents For The Univeristy Of Oklahoma Biosample aspirator
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5107422A (en) 1989-10-02 1992-04-21 Kamentsky Louis A Method and apparatus for measuring multiple optical properties of biological specimens
US5072382A (en) 1989-10-02 1991-12-10 Kamentsky Louis A Methods and apparatus for measuring multiple optical properties of biological specimens
JPH0469776A (ja) 1990-07-11 1992-03-04 Omron Corp 赤血球小核細胞の自動分類方法及び赤血球小核細胞の自動分類装置及び赤血球小核細胞標本作成方法
US5401629A (en) 1990-08-07 1995-03-28 The Salk Institute Biotechnology/Industrial Associates, Inc. Assay methods and compositions useful for measuring the transduction of an intracellular signal
US5233369A (en) 1990-12-27 1993-08-03 Xerox Corporation Method and apparatus for supplying ink to an ink jet printer
US5548661A (en) * 1991-07-12 1996-08-20 Price; Jeffrey H. Operator independent image cytometer
US5790710A (en) 1991-07-12 1998-08-04 Jeffrey H. Price Autofocus system for scanning microscopy
IL102486A (en) 1991-10-04 1997-11-20 Orgenics Ltd Method and apparatus for detection of nucleic acid sequences with a nucleic acid probe
US5326691A (en) 1991-11-21 1994-07-05 John Hozier Micro-libraries and methods of making and manipulating them methods for generating and analyzing micro-libraries
US5384261A (en) 1991-11-22 1995-01-24 Affymax Technologies N.V. Very large scale immobilized polymer synthesis using mechanically directed flow paths
US5670113A (en) 1991-12-20 1997-09-23 Sibia Neurosciences, Inc. Automated analysis equipment and assay method for detecting cell surface protein and/or cytoplasmic receptor function using same
US5355215A (en) * 1992-09-30 1994-10-11 Environmental Research Institute Of Michigan Method and apparatus for quantitative fluorescence measurements
GB9223259D0 (en) * 1992-11-06 1992-12-23 Quatro Biosystems Ltd Method and apparatus for image analysis
DE69435112D1 (de) 1993-09-10 2008-08-21 Univ Columbia Verwendung von grünem fluoreszenzprotein
US5491084A (en) 1993-09-10 1996-02-13 The Trustees Of Columbia University In The City Of New York Uses of green-fluorescent protein
WO1995021191A1 (en) 1994-02-04 1995-08-10 William Ward Bioluminescent indicator based upon the expression of a gene for a modified green-fluorescent protein
US5581487A (en) 1994-02-23 1996-12-03 Science Applications International Corporation Method and apparatus for microscopic screening of cytological samples
US5502467A (en) 1994-03-07 1996-03-26 Spectra, Inc. Ink jet printhead with ink viscosity control
US5627908A (en) * 1994-09-20 1997-05-06 Neopath, Inc. Method for cytological system dynamic normalization
WO1996009598A1 (en) 1994-09-20 1996-03-28 Neopath, Inc. Cytological slide scoring apparatus
US5500071A (en) 1994-10-19 1996-03-19 Hewlett-Packard Company Miniaturized planar columns in novel support media for liquid phase analysis
US5571410A (en) 1994-10-19 1996-11-05 Hewlett Packard Company Fully integrated miniaturized planar liquid sample handling and analysis device
US5556752A (en) 1994-10-24 1996-09-17 Affymetrix, Inc. Surface-bound, unimolecular, double-stranded DNA
US5585069A (en) 1994-11-10 1996-12-17 David Sarnoff Research Center, Inc. Partitioned microelectronic and fluidic device array for clinical diagnostics and chemical synthesis
WO1996023898A1 (en) 1995-01-31 1996-08-08 Novo Nordisk A/S A method of detecting biologically active substances
GB9504446D0 (en) 1995-03-06 1995-04-26 Medical Res Council Improvements in or relating to gene expression
US5732150A (en) 1995-09-19 1998-03-24 Ihc Health Services, Inc. Method and system for multiple wavelength microscopy image analysis
US5567294A (en) 1996-01-30 1996-10-22 Board Of Governors, University Of Alberta Multiple capillary biochemical analyzer with barrier member
US5989835A (en) 1997-02-27 1999-11-23 Cellomics, Inc. System for cell-based screening
US6103479A (en) 1996-05-30 2000-08-15 Cellomics, Inc. Miniaturized cell array methods and apparatus for cell-based screening
US5804436A (en) 1996-08-02 1998-09-08 Axiom Biotechnologies, Inc. Apparatus and method for real-time measurement of cellular response
US5885840A (en) 1997-02-10 1999-03-23 Compucyte Corp. Multiple assays of cell specimens

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