DE69517864D1 - Verfahren und Vorrichtung zur Zählung und Klassifizierung von Zellen - Google Patents

Verfahren und Vorrichtung zur Zählung und Klassifizierung von Zellen

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Publication number
DE69517864D1
DE69517864D1 DE69517864T DE69517864T DE69517864D1 DE 69517864 D1 DE69517864 D1 DE 69517864D1 DE 69517864 T DE69517864 T DE 69517864T DE 69517864 T DE69517864 T DE 69517864T DE 69517864 D1 DE69517864 D1 DE 69517864D1
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DE
Germany
Prior art keywords
container
cells
scanned images
data
neighborhood
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69517864T
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English (en)
Other versions
DE69517864T2 (de
Inventor
Ning L Sizto
Louis J Dietz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biometric Imaging Inc
Original Assignee
Biometric Imaging Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biometric Imaging Inc filed Critical Biometric Imaging Inc
Application granted granted Critical
Publication of DE69517864D1 publication Critical patent/DE69517864D1/de
Publication of DE69517864T2 publication Critical patent/DE69517864T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06VIMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V20/00Scenes; Scene-specific elements
    • G06V20/60Type of objects
    • G06V20/69Microscopic objects, e.g. biological cells or cellular parts
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N15/14Electro-optical investigation, e.g. flow cytometers
    • G01N15/1468Electro-optical investigation, e.g. flow cytometers with spatial resolution of the texture or inner structure of the particle
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00Chemistry: molecular biology and microbiology
    • Y10S435/968High energy substrates, e.g. fluorescent, chemiluminescent, radioactive
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00Chemistry: molecular biology and microbiology
    • Y10S435/973Simultaneous determination of more than one analyte
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00Chemistry: analytical and immunological testing
    • Y10S436/805Optical property
DE69517864T 1994-05-02 1995-05-02 Verfahren und Vorrichtung zur Zählung und Klassifizierung von Zellen Expired - Fee Related DE69517864T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/236,645 US5556764A (en) 1993-02-17 1994-05-02 Method and apparatus for cell counting and cell classification

Publications (2)

Publication Number Publication Date
DE69517864D1 true DE69517864D1 (de) 2000-08-17
DE69517864T2 DE69517864T2 (de) 2001-03-15

Family

ID=22890377

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69517864T Expired - Fee Related DE69517864T2 (de) 1994-05-02 1995-05-02 Verfahren und Vorrichtung zur Zählung und Klassifizierung von Zellen

Country Status (6)

Country Link
US (2) US5556764A (de)
EP (2) EP0987535A3 (de)
JP (1) JP3591911B2 (de)
AT (1) ATE194710T1 (de)
CA (1) CA2148204A1 (de)
DE (1) DE69517864T2 (de)

Families Citing this family (128)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5556764A (en) * 1993-02-17 1996-09-17 Biometric Imaging, Inc. Method and apparatus for cell counting and cell classification
WO1996007888A1 (en) * 1994-09-02 1996-03-14 Biometric Imaging, Inc. Calibration method and apparatus for optical scanner
USRE43097E1 (en) 1994-10-13 2012-01-10 Illumina, Inc. Massively parallel signature sequencing by ligation of encoded adaptors
DE19621312A1 (de) 1996-05-28 1997-12-04 Bayer Ag Maskierung der Hintergrundfluoreszenz und Signalverstärkung bei der optischen Analyse biologisch medizinischer Assays
WO1998028623A1 (en) * 1996-12-20 1998-07-02 Gamera Bioscience Corporation An affinity binding-based system for detecting particulates in a fluid
EP1017987B1 (de) 1997-01-31 2005-06-15 The Horticulture And Food Research Institute Of New Zealand Limited Optische vorrichtung und methode
EP1947442A3 (de) * 1997-05-05 2008-07-30 ChemoMetec A/S Verfahren und Vorrichtung zur Bestimmung von biologischen Teilchen in einer flüssigen Probe
JP4294740B2 (ja) * 1997-05-23 2009-07-15 ソレクサ・インコーポレイテッド 分析物の系列的プロセシングのためのシステムおよび装置
US5876946A (en) * 1997-06-03 1999-03-02 Pharmacopeia, Inc. High-throughput assay
US6710871B1 (en) 1997-06-09 2004-03-23 Guava Technologies, Inc. Method and apparatus for detecting microparticles in fluid samples
US5834203A (en) * 1997-08-25 1998-11-10 Applied Spectral Imaging Method for classification of pixels into groups according to their spectra using a plurality of wide band filters and hardwire therefore
US6316215B1 (en) 1999-12-27 2001-11-13 Edwin L. Adair Methods of cancer screening utilizing fluorescence detection techniques and selectable imager charge integration periods
US6149867A (en) 1997-12-31 2000-11-21 Xy, Inc. Sheath fluids and collection systems for sex-specific cytometer sorting of sperm
US20030036855A1 (en) * 1998-03-16 2003-02-20 Praelux Incorporated, A Corporation Of New Jersey Method and apparatus for screening chemical compounds
US6388788B1 (en) 1998-03-16 2002-05-14 Praelux, Inc. Method and apparatus for screening chemical compounds
US20030153023A1 (en) * 1999-05-13 2003-08-14 Starzl Timothy W. Enumeration method of analyte detection
CA2328408C (en) * 1998-05-14 2005-02-15 Luminex Corporation Zero dead time architecture and method for flow cytometer
ATE423314T1 (de) 1998-06-24 2009-03-15 Illumina Inc Dekodierung von matrixartig-angeordneten sensoren durch mikropartikel
US6873719B1 (en) * 1998-08-19 2005-03-29 Oxoid Limited Image acquisition apparatus
CA2341359A1 (en) 1998-08-21 2000-03-02 Ian Walton Novel optical architectures for microvolume laser-scanning cytometers
US6423505B1 (en) * 1998-12-03 2002-07-23 Becton Dickinson And Company Methods and reagents for quantitation of HLA-DR and CD11b expression on peripheral blood cells
US6200766B1 (en) 1998-12-03 2001-03-13 Becton Dickinson And Company Methods and reagents for quantitation of HLA-DR expression on peripheral blood cells
US6130745A (en) 1999-01-07 2000-10-10 Biometric Imaging, Inc. Optical autofocus for use with microtiter plates
US6355934B1 (en) 1999-02-26 2002-03-12 Packard Biochip Technologies Imaging system for an optical scanner
US6937330B2 (en) 1999-04-23 2005-08-30 Ppd Biomarker Discovery Sciences, Llc Disposable optical cuvette cartridge with low fluorescence material
WO2000071991A1 (en) * 1999-05-25 2000-11-30 Biometric Imaging, Inc. Apparatus and method for optical detection in a limited depth of field
JP2003505707A (ja) * 1999-07-21 2003-02-12 サーロメッド・インコーポレーテッド 微小体積レーザ・スキャニング・サイトメトリのためのシステム
US6687395B1 (en) * 1999-07-21 2004-02-03 Surromed, Inc. System for microvolume laser scanning cytometry
US7045049B1 (en) * 1999-10-01 2006-05-16 Nanoplex Technologies, Inc. Method of manufacture of colloidal rod particles as nanobar codes
US20040178076A1 (en) * 1999-10-01 2004-09-16 Stonas Walter J. Method of manufacture of colloidal rod particles as nanobarcodes
US20040209376A1 (en) * 1999-10-01 2004-10-21 Surromed, Inc. Assemblies of differentiable segmented particles
US7208265B1 (en) 1999-11-24 2007-04-24 Xy, Inc. Method of cryopreserving selected sperm cells
US6190877B1 (en) 1999-12-27 2001-02-20 Edwin L. Adair Method of cancer screening primarily utilizing non-invasive cell collection and fluorescence detection techniques
US6750037B2 (en) * 1999-12-27 2004-06-15 Edwin L. Adair Method of cancer screening primarily utilizing non-invasive cell collection, fluorescence detection techniques, and radio tracing detection techniques
US6984498B2 (en) * 1999-12-27 2006-01-10 Adair Edwin L Method of cancer screening primarily utilizing non-invasive cell collection, fluorescence detection techniques, and radio tracing detection techniques
AU2001292894A1 (en) * 2000-09-20 2002-04-02 Surromed, Inc. Method for monitoring resting and activated platelets in unfixed blood samples
WO2002044695A1 (en) * 2000-11-16 2002-06-06 Burstein Technologies, Inc. Methods and apparatus for detecting and quantifying lymphocytes with optical biodiscs
US6787761B2 (en) * 2000-11-27 2004-09-07 Surromed, Inc. Median filter for liquid chromatography-mass spectrometry data
US20020095260A1 (en) * 2000-11-28 2002-07-18 Surromed, Inc. Methods for efficiently mining broad data sets for biological markers
US7713687B2 (en) 2000-11-29 2010-05-11 Xy, Inc. System to separate frozen-thawed spermatozoa into x-chromosome bearing and y-chromosome bearing populations
AU2002237689B2 (en) 2000-11-29 2008-01-10 Xy, Llc. System to separate frozen-thawed spermatozoa into X-chromosome bearing and Y-chromosome bearing populations
US20020146745A1 (en) * 2001-04-03 2002-10-10 Surromed, Inc. Methods and reagents for multiplexed analyte capture, surface array self-assembly, and analysis of complex biological samples
US7016087B2 (en) * 2001-08-08 2006-03-21 Becton Dickinson And Company Photon efficient scanner
US6873915B2 (en) * 2001-08-24 2005-03-29 Surromed, Inc. Peak selection in multidimensional data
US6750457B2 (en) * 2001-08-29 2004-06-15 Becton Dickinson And Company System for high throughput analysis
US20030143637A1 (en) * 2001-08-31 2003-07-31 Selvan Gowri Pyapali Capture layer assemblies for cellular assays including related optical analysis discs and methods
JP2005502872A (ja) * 2001-09-07 2005-01-27 バースタイン テクノロジーズ,インコーポレイティド 光バイオディスクシステムを使用した、核の形態に基づく白血球の型の識別および定量
US20030078739A1 (en) * 2001-10-05 2003-04-24 Surromed, Inc. Feature list extraction from data sets such as spectra
JP2005509882A (ja) * 2001-11-20 2005-04-14 バースタイン テクノロジーズ,インコーポレイティド 細胞分析のための光バイオディスクおよび流体回路ならびにそれに関連する方法
US7764821B2 (en) * 2002-02-14 2010-07-27 Veridex, Llc Methods and algorithms for cell enumeration in a low-cost cytometer
JP4568499B2 (ja) * 2002-02-14 2010-10-27 ベリデックス・リミテッド・ライアビリティ・カンパニー 低コストで細胞計数するための方法およびアルゴリズム
US6846311B2 (en) * 2002-04-02 2005-01-25 Acueity, Inc. Method and apparatus for in VIVO treatment of mammary ducts by light induced fluorescence
US6989100B2 (en) * 2002-05-09 2006-01-24 Ppd Biomarker Discovery Sciences, Llc Methods for time-alignment of liquid chromatography-mass spectrometry data
US20060073470A1 (en) * 2002-05-30 2006-04-06 Naohiro Noda Method of counting microorganisms or cells
DE60307545T2 (de) * 2002-06-21 2007-10-04 Adair, Edwin L., Castle Pines Village Anwendung von Metalloporphyrinen zur Behandlung von Arteriosklerose
EP1545203B1 (de) 2002-08-01 2016-10-19 Xy, Llc Mit niederdruck arbeitendes spermazellentrennsystem
US8486618B2 (en) 2002-08-01 2013-07-16 Xy, Llc Heterogeneous inseminate system
BRPI0313476B1 (pt) 2002-08-15 2015-06-23 Xy Llc Citômetro de fluxo de alta resolução
US7169548B2 (en) 2002-09-13 2007-01-30 Xy, Inc. Sperm cell processing and preservation systems
US7326573B2 (en) * 2003-01-10 2008-02-05 Beckman Coulter, Inc. Assay procedures and apparatus
EP2306174B1 (de) 2003-03-28 2016-05-11 Inguran, LLC Durchflusszytometriedüse zur Orientierung von Partikeln und entsprechendes Verfahren
NZ544103A (en) 2003-05-15 2010-10-29 Xy Llc Efficient haploid cell sorting for flow cytometer systems
US20050019556A1 (en) * 2003-06-17 2005-01-27 Surromed, Inc. Labeling and authentication of metal objects
DE10327839A1 (de) * 2003-06-20 2005-01-05 Arvinmeritor Gmbh Fahrzeugdachmodul
US20050048546A1 (en) * 2003-07-11 2005-03-03 Sharron Penn Multiplexed molecular beacon assay for detection of human pathogens
US7341841B2 (en) * 2003-07-12 2008-03-11 Accelr8 Technology Corporation Rapid microbial detection and antimicrobial susceptibility testing
WO2005027714A2 (en) * 2003-07-12 2005-03-31 Accelr8 Technology Corporation Sensitive and rapid biodetection
US20120077206A1 (en) 2003-07-12 2012-03-29 Accelr8 Technology Corporation Rapid Microbial Detection and Antimicrobial Susceptibility Testing
WO2005095590A2 (en) 2004-03-29 2005-10-13 Monsanto Technology Llc Sperm suspensions for sorting into x or y chromosome-bearing enriched populations
JP4598426B2 (ja) * 2004-03-30 2010-12-15 富士通株式会社 境界抽出方法、プログラムおよびこれを用いた装置
US7248360B2 (en) 2004-04-02 2007-07-24 Ppd Biomarker Discovery Sciences, Llc Polychronic laser scanning system and method of use
JP2006003653A (ja) * 2004-06-17 2006-01-05 Olympus Corp 生体試料観察システム
DE602005023305D1 (de) * 2004-06-17 2010-10-14 Koninkl Philips Electronics Nv Autofocus-mechanismus für ein spektroskopisches system
US7833147B2 (en) 2004-07-22 2010-11-16 Inguran, LLC. Process for enriching a population of sperm cells
US8189899B2 (en) * 2004-07-30 2012-05-29 Veridex, Llc Methods and algorithms for cell enumeration in a low-cost cytometer
CA2588126C (en) * 2004-11-24 2014-01-07 Battelle Memorial Institute Optical system for cell imaging
US7423751B2 (en) * 2005-02-08 2008-09-09 Northrop Grumman Corporation Systems and methods for use in detecting harmful aerosol particles
US7995202B2 (en) * 2006-02-13 2011-08-09 Pacific Biosciences Of California, Inc. Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources
US7804594B2 (en) 2006-12-29 2010-09-28 Abbott Laboratories, Inc. Method and apparatus for rapidly counting and identifying biological particles in a flow stream
US11313785B2 (en) * 2007-05-07 2022-04-26 Global Life Sciences Solutions Usa Llc System and method for the automated analysis of cellular assays and tissues
US8159670B2 (en) 2007-11-05 2012-04-17 Abbott Laboratories Method and apparatus for rapidly counting and identifying biological particles in a flow stream
US9658222B2 (en) 2009-03-02 2017-05-23 Mbio Diagnostics, Inc. Planar waveguide based cartridges and associated methods for detecting target analyte
US8331751B2 (en) * 2009-03-02 2012-12-11 mBio Diagnositcs, Inc. Planar optical waveguide with core of low-index-of-refraction interrogation medium
US9212995B2 (en) 2009-03-02 2015-12-15 Mbio Diagnostics, Inc. System and method for detecting multiple molecules in one assay
NL1038359C2 (en) 2010-03-31 2012-06-27 Aquamarijn Res B V Device and method for separation of circulating tumor cells.
WO2012009617A2 (en) 2010-07-16 2012-01-19 Luminex Corporation Methods, storage mediums, and systems for analyzing particle quantity and distribution within an imaging region of an assay analysis system and for evaluating the performance of a focusing routing performed on an assay analysis system
US8891850B2 (en) * 2010-09-16 2014-11-18 The University Of Kansas System and methods for digital evaluation of cellblock preparations
US10114020B2 (en) 2010-10-11 2018-10-30 Mbio Diagnostics, Inc. System and device for analyzing a fluidic sample
EP2635895A1 (de) 2010-11-03 2013-09-11 Reametrix Inc. Messsystem zur fluoreszenzdetekion und verfahren dafür
US10254204B2 (en) 2011-03-07 2019-04-09 Accelerate Diagnostics, Inc. Membrane-assisted purification
EP2683831B1 (de) 2011-03-07 2015-09-23 Accelerate Diagnostics, Inc. Schnelle zellreinigungssysteme
ES2767133T3 (es) 2011-06-24 2020-06-16 Becton Dickinson Co Citometría de flujo de exploración de espectro de absorción
US9523682B2 (en) 2011-11-16 2016-12-20 Becton, Dickinson And Company Methods and systems for detecting an analyte in a sample
WO2014070235A1 (en) 2012-10-29 2014-05-08 Mbio Diagnostics, Inc. Biological particle identification system, cartridge and associated methods
EP2943788B1 (de) 2013-01-11 2018-08-08 Becton Dickinson and Company Kostengünstige testvorrichtung am versorgungsort
US9677109B2 (en) 2013-03-15 2017-06-13 Accelerate Diagnostics, Inc. Rapid determination of microbial growth and antimicrobial susceptibility
US9595092B2 (en) * 2013-05-10 2017-03-14 The Boeing Company Methods and systems for inspection of composite irregularities
US10088407B2 (en) 2013-05-17 2018-10-02 Becton, Dickinson And Company Systems and methods for efficient contours and gating in flow cytometry
US9545471B2 (en) 2013-08-06 2017-01-17 Viatar LLC Extracorporeal fluidic device for collecting circulating tumor cells and method of use thereof
KR101463005B1 (ko) * 2013-10-15 2014-11-18 (주)한국해양기상기술 특정 파장에 대한 형광 특성을 갖는 미생물 검사방법
JP6632525B2 (ja) 2013-11-06 2020-01-22 ベクトン・ディキンソン・アンド・カンパニーBecton, Dickinson And Company マイクロ流体デバイスならびにその製造方法および使用方法
JP6518245B2 (ja) 2013-11-13 2019-05-22 ベクトン・ディキンソン・アンド・カンパニーBecton, Dickinson And Company 光学撮像システム及びそれを用いた方法
WO2015160420A1 (en) 2014-04-14 2015-10-22 Becton, Dickinson And Company Reagent calibration system and method
CA2960313C (en) 2014-10-14 2019-07-23 Becton, Dickinson And Company Blood sample management using open cell foam
US11298061B2 (en) 2014-10-14 2022-04-12 Becton, Dickinson And Company Blood sample management using open cell foam
US10616219B2 (en) 2014-12-11 2020-04-07 FlowJo, LLC Single cell data management and analysis systems and methods
EP3381559B1 (de) 2015-03-10 2024-02-28 Becton, Dickinson and Company Vorrichtung zur bearbeitung biologischer flüssigproben
WO2016154366A1 (en) * 2015-03-23 2016-09-29 Arris Enterprises, Inc. System and method for selectively compressing images
US10253355B2 (en) 2015-03-30 2019-04-09 Accelerate Diagnostics, Inc. Instrument and system for rapid microorganism identification and antimicrobial agent susceptibility testing
US10023895B2 (en) 2015-03-30 2018-07-17 Accelerate Diagnostics, Inc. Instrument and system for rapid microogranism identification and antimicrobial agent susceptibility testing
US10876953B2 (en) 2015-07-15 2020-12-29 Becton, Dickinson And Company System and method for label selection
WO2017040650A1 (en) 2015-09-01 2017-03-09 Becton, Dickinson And Company Depth filtration device for separating specimen phases
US9830720B2 (en) 2015-09-02 2017-11-28 Becton, Dickinson And Company Graphics control during flow cytometry event gating
EP3469338A4 (de) * 2016-06-10 2020-01-15 The Regents of the University of California Systeme und verfahren zur bildbasierten zellensortierung
US11573182B2 (en) 2017-05-25 2023-02-07 FlowJo, LLC Visualization, comparative analysis, and automated difference detection for large multi-parameter data sets
US11029242B2 (en) 2017-06-12 2021-06-08 Becton, Dickinson And Company Index sorting systems and methods
WO2019018129A1 (en) 2017-07-18 2019-01-24 Becton, Dickinson And Company DYNAMIC INTERACTIVE DISPLAY OF QUANTITATIVE BIOLOGICAL DATA WITH MULTIPLE PARAMETERS
US10593082B2 (en) 2017-07-18 2020-03-17 Becton, Dickinson And Company Dynamic display of multi-parameter quantitative biological data
WO2019018128A1 (en) 2017-07-18 2019-01-24 Becton, Dickinson And Company INTERACTIVE DYNAMIC DISPLAY OF MULTI-PARAMETER QUANTITATIVE BIOLOGICAL DATA
US10883912B2 (en) 2018-06-04 2021-01-05 Becton, Dickinson And Company Biexponential transformation for graphics display
JP2022522263A (ja) 2019-01-11 2022-04-15 ベクトン・ディキンソン・アンド・カンパニー 最適化されたソーティングゲート
WO2020197785A1 (en) * 2019-03-27 2020-10-01 Becton, Dickinson And Company Systems for cell sorting based on frequency-encoded images and methods of use thereof
WO2020205089A1 (en) 2019-04-02 2020-10-08 Becton, Dickinson And Company Compensation editor
US20200333330A1 (en) 2019-04-21 2020-10-22 Becton, Dickinson And Company Cytometric bead array analysis
US20210230583A1 (en) 2020-01-29 2021-07-29 Becton, Dickinson And Company Barcoded wells for spatial mapping of single cells through sequencing
CN115176139A (zh) 2020-01-31 2022-10-11 贝克顿·迪金森公司 用于调整训练门以适应流式细胞仪数据的方法和系统
CN111507956B (zh) * 2020-04-15 2023-04-07 广西科技大学 一种纳米线数量统计方法及系统
CN113029919B (zh) * 2021-03-13 2024-04-02 长春长光辰英生物科学仪器有限公司 一种细胞富集与荧光计数的检测装置以及检测、计数方法

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4060713A (en) * 1971-06-23 1977-11-29 The Perkin-Elmer Corporation Analysis of images
US3999047A (en) * 1972-09-05 1976-12-21 Green James E Method and apparatus utilizing color algebra for analyzing scene regions
US3918812A (en) * 1973-05-07 1975-11-11 Us Energy Diagnoses of disease states by fluorescent measurements utilizing scanning laser beams
US3900265A (en) * 1974-03-08 1975-08-19 Intec Corp Laser scanner flaw detection system
US4045772A (en) * 1974-04-29 1977-08-30 Geometric Data Corporation Automatic focusing system
US4122518A (en) * 1976-05-17 1978-10-24 The United States Of America As Represented By The Administrator Of The National Aeronautics & Space Administration Automated clinical system for chromosome analysis
JPS594058B2 (ja) * 1976-07-23 1984-01-27 株式会社日立製作所 白血球像処理方法
US4129854A (en) * 1976-10-25 1978-12-12 Hitachi, Ltd. Cell classification method
US4199748A (en) * 1976-11-01 1980-04-22 Rush-Presbyterian-St. Luke's Medical Center Automated method and apparatus for classification of cells with application to the diagnosis of anemia
US4097845A (en) * 1976-11-01 1978-06-27 Rush-Presbyterian-St. Luke's Medical Center Method of and an apparatus for automatic classification of red blood cells
US4191940A (en) * 1978-01-09 1980-03-04 Environmental Research Institute Of Michigan Method and apparatus for analyzing microscopic specimens and the like
US4282412A (en) * 1978-08-21 1981-08-04 Florin Robert E Mercury switch for monitoring position of patient
US4229797A (en) * 1978-09-06 1980-10-21 National Biomedical Research Foundation Method and system for whole picture image processing
DE2903855A1 (de) * 1979-02-01 1980-08-14 Bloss Werner H Prof Dr Ing Verfahren zum automatischen markieren von zellen und bestimmung der merkmale von zellen aus zytologischen abstrichpraeparaten
US4318886A (en) * 1979-11-19 1982-03-09 Nippon Kogaku K.K. Automatic HLA typing apparatus
JPS58154064A (ja) * 1982-03-08 1983-09-13 Mitsubishi Rayon Co Ltd リンパ球t細胞百分率測定方法
US4513438A (en) * 1982-04-15 1985-04-23 Coulter Electronics, Inc. Automated microscopy system and method for locating and re-locating objects in an image
US4647531A (en) * 1984-02-06 1987-03-03 Ortho Diagnostic Systems, Inc. Generalized cytometry instrument and methods of use
US4665553A (en) * 1984-05-01 1987-05-12 Ortho Diagnostics Systems Inc. Methods and apparatus for analysis of particles and cells
US4700298A (en) * 1984-09-14 1987-10-13 Branko Palcic Dynamic microscope image processing scanner
US4672559A (en) * 1984-12-26 1987-06-09 E. I. Du Pont De Nemours And Company Method for operating a microscopical mapping system
US4727020A (en) * 1985-02-25 1988-02-23 Becton, Dickinson And Company Method for analysis of subpopulations of blood cells
US4741043B1 (en) * 1985-11-04 1994-08-09 Cell Analysis Systems Inc Method of and apparatus for image analyses of biological specimens
US5121436A (en) * 1987-08-14 1992-06-09 International Remote Imaging Systems, Inc. Method and apparatus for generating a plurality of parameters of an object in a field of view
US4845552A (en) * 1987-08-20 1989-07-04 Bruno Jaggi Quantitative light microscope using a solid state detector in the primary image plane
US5068909A (en) * 1989-05-18 1991-11-26 Applied Imaging Corporation Method and apparatus for generating quantifiable video displays
US5107422A (en) * 1989-10-02 1992-04-21 Kamentsky Louis A Method and apparatus for measuring multiple optical properties of biological specimens
US5072382A (en) * 1989-10-02 1991-12-10 Kamentsky Louis A Methods and apparatus for measuring multiple optical properties of biological specimens
US5556764A (en) * 1993-02-17 1996-09-17 Biometric Imaging, Inc. Method and apparatus for cell counting and cell classification
USD366938S (en) 1994-09-02 1996-02-06 Biometric Imaging, Inc. Cartridge for processing laboratory samples

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CA2148204A1 (en) 1995-11-03
DE69517864T2 (de) 2001-03-15
JP3591911B2 (ja) 2004-11-24
EP0681177A1 (de) 1995-11-08
ATE194710T1 (de) 2000-07-15
JPH0854333A (ja) 1996-02-27
EP0987535A3 (de) 2001-03-21
EP0681177B1 (de) 2000-07-12
US5556764A (en) 1996-09-17
US5962238A (en) 1999-10-05
EP0987535A2 (de) 2000-03-22

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