FR2788602B1 - Procede de criblage utile pour identifier des ligands potentiels pour un recepteur capable de s'internaliser - Google Patents
Procede de criblage utile pour identifier des ligands potentiels pour un recepteur capable de s'internaliserInfo
- Publication number
- FR2788602B1 FR2788602B1 FR9900588A FR9900588A FR2788602B1 FR 2788602 B1 FR2788602 B1 FR 2788602B1 FR 9900588 A FR9900588 A FR 9900588A FR 9900588 A FR9900588 A FR 9900588A FR 2788602 B1 FR2788602 B1 FR 2788602B1
- Authority
- FR
- France
- Prior art keywords
- internalizing
- screening method
- receiver capable
- method useful
- identifying potential
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
- G01N33/5035—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects on sub-cellular localization
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/715—Assays involving receptors, cell surface antigens or cell surface determinants for cytokines; for lymphokines; for interferons
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
- G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/91—Transferases (2.)
- G01N2333/912—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- G01N2333/91205—Phosphotransferases in general
- G01N2333/9121—Phosphotransferases in general with an alcohol group as acceptor (2.7.1), e.g. general tyrosine, serine or threonine kinases
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Pathology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9900588A FR2788602B1 (fr) | 1999-01-20 | 1999-01-20 | Procede de criblage utile pour identifier des ligands potentiels pour un recepteur capable de s'internaliser |
CA002359213A CA2359213A1 (fr) | 1999-01-20 | 2000-01-19 | Identification des ligands d'un recepteur capable de s'internaliser |
EP00900617A EP1145003A1 (fr) | 1999-01-20 | 2000-01-19 | Identification des ligands d'un recepteur capable de s'internaliser |
PCT/FR2000/000113 WO2000043779A1 (fr) | 1999-01-20 | 2000-01-19 | Identification des ligands d'un recepteur capable de s'internaliser |
JP2000595149A JP2002535654A (ja) | 1999-01-20 | 2000-01-19 | インターナリゼーションによって細胞内に取込まれ得る受容体リガンドの同定方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9900588A FR2788602B1 (fr) | 1999-01-20 | 1999-01-20 | Procede de criblage utile pour identifier des ligands potentiels pour un recepteur capable de s'internaliser |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2788602A1 FR2788602A1 (fr) | 2000-07-21 |
FR2788602B1 true FR2788602B1 (fr) | 2002-06-07 |
Family
ID=9541041
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR9900588A Expired - Fee Related FR2788602B1 (fr) | 1999-01-20 | 1999-01-20 | Procede de criblage utile pour identifier des ligands potentiels pour un recepteur capable de s'internaliser |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1145003A1 (fr) |
JP (1) | JP2002535654A (fr) |
CA (1) | CA2359213A1 (fr) |
FR (1) | FR2788602B1 (fr) |
WO (1) | WO2000043779A1 (fr) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE0004781D0 (sv) * | 2000-12-22 | 2000-12-22 | Active Biotech Ab | A screening assay for antagonists of human leukocyte receptors |
ATE419274T1 (de) * | 2002-10-25 | 2009-01-15 | Mds Analytical Technologies Us | Verfahren zur identifizierung von transmembranrezeptoragonisten mit reduzierter internalisierung |
DE102005003687A1 (de) * | 2005-01-26 | 2006-07-27 | Sphingo Tec Gmbh | Immunoassay zur Bestimmung der Freisetzung von Neurotensin in die Zirkulation |
GB2439377A (en) * | 2006-06-09 | 2007-12-27 | Pasteur Institut Korea | Methods of identifying modulators of and modulating GPCR cellular distribution and medical uses thereof |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5135848A (en) * | 1989-10-23 | 1992-08-04 | Lehigh University And Northeast Benjamin Franklin Technology Center Of Pa | Methods for evaluating cholesterol metabolism and reagents therefor |
US5760188A (en) * | 1992-12-31 | 1998-06-02 | Martin R&F Inc. | Marker for neurotensin receptor |
US6455300B1 (en) * | 1995-12-08 | 2002-09-24 | Han Htun | Method and compositions for monitoring DNA binding molecules in living cells |
US5776700A (en) * | 1996-09-05 | 1998-07-07 | Trustees Of The University Of Pennsylvania | Thrombine receptor activation assay for use in identifying thrombin receptor antagonists |
DE69839501D1 (de) * | 1997-02-27 | 2008-06-26 | Cellomics Inc | System für Screening biologischer Zellen |
AU4992599A (en) * | 1998-07-13 | 2000-02-01 | Cellomics, Inc. | A system for cell-based screening |
-
1999
- 1999-01-20 FR FR9900588A patent/FR2788602B1/fr not_active Expired - Fee Related
-
2000
- 2000-01-19 EP EP00900617A patent/EP1145003A1/fr not_active Withdrawn
- 2000-01-19 JP JP2000595149A patent/JP2002535654A/ja not_active Withdrawn
- 2000-01-19 CA CA002359213A patent/CA2359213A1/fr not_active Abandoned
- 2000-01-19 WO PCT/FR2000/000113 patent/WO2000043779A1/fr not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
EP1145003A1 (fr) | 2001-10-17 |
WO2000043779A1 (fr) | 2000-07-27 |
JP2002535654A (ja) | 2002-10-22 |
FR2788602A1 (fr) | 2000-07-21 |
CA2359213A1 (fr) | 2000-07-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
TQ | Partial transmission of property | ||
ST | Notification of lapse |