DE69816440T2 - Verfahren zur herstellung von flurbiprofen-lutschtabletten - Google Patents

Verfahren zur herstellung von flurbiprofen-lutschtabletten Download PDF

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Publication number
DE69816440T2
DE69816440T2 DE69816440T DE69816440T DE69816440T2 DE 69816440 T2 DE69816440 T2 DE 69816440T2 DE 69816440 T DE69816440 T DE 69816440T DE 69816440 T DE69816440 T DE 69816440T DE 69816440 T2 DE69816440 T2 DE 69816440T2
Authority
DE
Germany
Prior art keywords
flurbiprofen
forming composition
mixture
lozenge
pastilles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69816440T
Other languages
German (de)
English (en)
Other versions
DE69816440D1 (de
Inventor
Andrew Day
Lyn Huw JONES
Simon Carl SMITH
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Reckitt Benckiser Healthcare UK Ltd
Original Assignee
Boots Co PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boots Co PLC filed Critical Boots Co PLC
Application granted granted Critical
Publication of DE69816440D1 publication Critical patent/DE69816440D1/de
Publication of DE69816440T2 publication Critical patent/DE69816440T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/04—Drugs for disorders of the respiratory system for throat disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nutrition Science (AREA)
  • Pulmonology (AREA)
  • Zoology (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Otolaryngology (AREA)
  • Rheumatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69816440T 1997-05-22 1998-05-20 Verfahren zur herstellung von flurbiprofen-lutschtabletten Expired - Lifetime DE69816440T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9710521 1997-05-22
GBGB9710521.7A GB9710521D0 (en) 1997-05-22 1997-05-22 Process
PCT/EP1998/003167 WO1998052539A1 (en) 1997-05-22 1998-05-20 Process for making flurbiprofen lozenges

Publications (2)

Publication Number Publication Date
DE69816440D1 DE69816440D1 (de) 2003-08-21
DE69816440T2 true DE69816440T2 (de) 2004-05-13

Family

ID=10812840

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69816440T Expired - Lifetime DE69816440T2 (de) 1997-05-22 1998-05-20 Verfahren zur herstellung von flurbiprofen-lutschtabletten

Country Status (31)

Country Link
US (1) US6194003B1 (enExample)
EP (1) EP0983059B1 (enExample)
JP (1) JP2001527567A (enExample)
KR (1) KR20010012739A (enExample)
CN (1) CN1154480C (enExample)
AR (1) AR015812A1 (enExample)
AT (1) ATE245021T1 (enExample)
AU (1) AU725760B2 (enExample)
BG (1) BG103881A (enExample)
BR (1) BR9809651A (enExample)
CA (1) CA2290830C (enExample)
CZ (1) CZ290816B6 (enExample)
DE (1) DE69816440T2 (enExample)
DK (1) DK0983059T3 (enExample)
ES (1) ES2202871T3 (enExample)
GB (1) GB9710521D0 (enExample)
HU (1) HU224954B1 (enExample)
ID (1) ID22949A (enExample)
IL (1) IL132999A0 (enExample)
IN (1) IN187837B (enExample)
MY (1) MY118410A (enExample)
NO (1) NO995681L (enExample)
NZ (1) NZ500664A (enExample)
PL (1) PL190947B1 (enExample)
PT (1) PT983059E (enExample)
RU (1) RU2203046C2 (enExample)
SK (1) SK283701B6 (enExample)
TR (1) TR199902725T2 (enExample)
UA (1) UA53714C2 (enExample)
WO (1) WO1998052539A1 (enExample)
ZA (1) ZA984260B (enExample)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4040878B2 (ja) 1999-12-09 2008-01-30 レキット ベンキーザー ヘルスケア （ユーケイ） リミテッド 治療薬
CA2406383A1 (en) * 2000-04-13 2001-10-25 Mayo Foundation For Medical Education And Research A.beta.42 lowering agents
JP4886107B2 (ja) * 2000-10-13 2012-02-29 サンスター株式会社 歯周病予防用口腔内溶解錠
EP1603548A4 (en) * 2003-02-05 2007-10-10 Myriad Genetics Inc METHOD AND COMPOSITION FOR THE TREATMENT OF NEURODEEGENERATIVE DISEASES
WO2005065069A2 (en) * 2003-07-11 2005-07-21 Myriad Genetics, Inc. Pharmaceutical methods, dosing regimes and dosage forms for the treatment of alzheimer's disease
FR2865648B1 (fr) * 2004-02-03 2006-06-30 Philippe Perovitch Procede de diffusion de molecules insolubles en milieu aqueux et composition mettant en oeuvre ce procede
WO2006001877A2 (en) * 2004-04-13 2006-01-05 Myriad Genetics, Inc. Combination treatment for neurodegenerative disorders comprising r-flurbiprofen
KR20070004036A (ko) * 2004-04-29 2007-01-05 키스톤 리테이닝 월 시스템스, 아이엔씨 벽, 옹벽 및 그 외 유사한 것을 위한 베니어
WO2006020850A2 (en) * 2004-08-11 2006-02-23 Myriad Genetics, Inc. Pharmaceutical composition and method for treating neurodegenerative disorders
WO2006020852A2 (en) * 2004-08-11 2006-02-23 Myriad Genetics, Inc. Pharmaceutical composition and method for treating neurodegenerative disorders
CA2618985A1 (en) * 2004-08-11 2006-02-23 Myriad Genetics, Inc. Pharmaceutical composition and method for treating neurodegenerative disorders
CN103479582A (zh) 2005-02-03 2014-01-01 武田奈科明有限公司 制备含钙组合物的快速湿聚结方法
GB2423710A (en) 2005-03-01 2006-09-06 Boots Healthcare Int Ltd Lozenge production process
CA2615063A1 (en) * 2005-07-22 2007-02-01 Myriad Genetics, Inc. High drug load formulations and dosage forms
CN103622926A (zh) * 2005-11-02 2014-03-12 帝国制药美国公司 感官上可接受的布洛芬口服给药制剂、制备和使用它的方法
EP2046119A2 (en) * 2006-07-07 2009-04-15 Myriad Genetics, Inc. Treatment of psychiatric disorders
EA200901188A1 (ru) * 2007-07-23 2010-04-30 ТЕЙКОКУ ФАРМА ЮЭсЭй, ИНК. Органолептически приемлемые дозированные лекарственные формы индольных агонистов серотониновых рецепторов для перорального применения и способы их применения
CN102131496B (zh) * 2008-08-22 2013-10-23 雷克特本克斯尔保健(英国)有限公司 组合物的改进或与组合物有关的改进
IT1397132B1 (it) 2009-12-01 2013-01-04 Alfa Wassermann Spa Composizioni comprendenti antiinfiammatori non steroidei.
IT1406107B1 (it) * 2010-12-13 2014-02-14 Alfa Wassermann Spa Composizioni solide comprendenti antiinfiammatori non steroidei, processi per la loro preparazione e loro uso.
SMT202100228T1 (it) 2011-04-29 2021-05-07 Moberg Pharma Ab Composizioni farmaceutiche comprendenti un anestetico locale come bupivacaina per somministrazione locale alla bocca o alla gola
EP2609911A1 (en) * 2011-12-29 2013-07-03 Sanovel Ilac Sanayi ve Ticaret A.S. A novel process for preparing orally disintegrating flurbiprofen formulations
FR2997856B1 (fr) * 2012-11-14 2015-04-24 Pf Medicament Pastille medicamenteuse a base d'ibuprofene sodique dihydrate
US20180228832A1 (en) * 2015-08-18 2018-08-16 Pharma Seeds Create, Llc Stomatological composition containing nsaid or heparin compound
WO2020013781A2 (en) * 2018-03-27 2020-01-16 Pisak Mehmet Nevzat Synergistic effect of flurbiprofen and a gastro protective agent for the treatment of pain and inflammation

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4389393A (en) * 1982-03-26 1983-06-21 Forest Laboratories, Inc. Sustained release therapeutic compositions based on high molecular weight hydroxypropylmethylcellulose
US4666716A (en) * 1984-09-04 1987-05-19 Richardson-Vicks Inc. Antidiarrheal compositions and use thereof
RU2026670C1 (ru) * 1988-10-05 1995-01-20 Дзе Апджон Компани Способ получения тонкодисперсного твердого фармацевтического вещества
IT1243342B (it) 1990-07-13 1994-06-10 Farcon Ag Composizioni farmaceutiche orali liquide ad attivita' antiinfiammatoria
IT1244698B (it) * 1991-02-01 1994-08-08 Gentili Ist Spa Acidi aril-o arilalchil-acil ammino-alchil-idrossidifosfonici, procedimento per la loro preparazione e loro uso in terapia osteo-articolare e dei tessuti connettori in generale
US5302394A (en) * 1992-07-14 1994-04-12 Mcneil-Ppc, Inc. Dextromethorphan continuous lozenge manufacturing process
US5458879A (en) * 1994-03-03 1995-10-17 The Procter & Gamble Company Oral vehicle compositions
TW442287B (en) * 1995-06-13 2001-06-23 American Home Produits Corp Organoleptically acceptable oral pharmaceutical composition comprising the S(+)1,8-diethyl-1-1,3,4,9-tetrahydropyrano[3,4-b] indole-1-acetic acid (Etodolac)
US5614207A (en) * 1995-06-30 1997-03-25 Mcneil-Ppc, Inc. Dry mouth lozenge
GB9523833D0 (en) * 1995-11-22 1996-01-24 Boots Co Plc Medical treatment

Also Published As

Publication number Publication date
CZ412099A3 (cs) 2000-02-16
PL336624A1 (en) 2000-07-03
ZA984260B (en) 1999-02-20
ATE245021T1 (de) 2003-08-15
CZ290816B6 (cs) 2002-10-16
BR9809651A (pt) 2000-07-11
ID22949A (id) 1999-12-16
AU725760B2 (en) 2000-10-19
SK283701B6 (sk) 2003-12-02
ES2202871T3 (es) 2004-04-01
PT983059E (pt) 2003-11-28
WO1998052539A1 (en) 1998-11-26
GB9710521D0 (en) 1997-07-16
EP0983059B1 (en) 2003-07-16
EP0983059A1 (en) 2000-03-08
DE69816440D1 (de) 2003-08-21
IL132999A0 (en) 2001-03-19
HUP0002121A3 (en) 2001-04-28
US6194003B1 (en) 2001-02-27
BG103881A (bg) 2000-05-31
SK158899A3 (en) 2000-05-16
NO995681D0 (no) 1999-11-19
CA2290830C (en) 2006-07-11
MY118410A (en) 2004-10-30
NZ500664A (en) 2001-01-26
KR20010012739A (ko) 2001-02-26
AR015812A1 (es) 2001-05-30
NO995681L (no) 1999-11-19
PL190947B1 (pl) 2006-02-28
JP2001527567A (ja) 2001-12-25
CN1154480C (zh) 2004-06-23
IN187837B (enExample) 2002-06-29
DK0983059T3 (da) 2003-11-03
HU224954B1 (en) 2006-04-28
RU2203046C2 (ru) 2003-04-27
HUP0002121A2 (hu) 2000-12-28
CA2290830A1 (en) 1998-11-26
AU7916598A (en) 1998-12-11
UA53714C2 (uk) 2003-02-17
CN1255848A (zh) 2000-06-07
TR199902725T2 (xx) 2000-02-21

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: RECKITT BENCKISER HEALTHCARE INTERNATIONAL LTD, GB

8327 Change in the person/name/address of the patent owner

Owner name: RECKITT BENCKISER HEALTHCARE (UK) LTD., SLOUGH, GB