HUP0002121A2 - Eljárás flurbiprofen gyógypasztillák előállítására - Google Patents

Eljárás flurbiprofen gyógypasztillák előállítására

Info

Publication number
HUP0002121A2
HUP0002121A2 HU0002121A HUP0002121A HUP0002121A2 HU P0002121 A2 HUP0002121 A2 HU P0002121A2 HU 0002121 A HU0002121 A HU 0002121A HU P0002121 A HUP0002121 A HU P0002121A HU P0002121 A2 HUP0002121 A2 HU P0002121A2
Authority
HU
Hungary
Prior art keywords
medicinal
flurbiprofen
lozenges
lozenge
preparation
Prior art date
Application number
HU0002121A
Other languages
English (en)
Inventor
Andrew Day
Huw Lyn Jones
Carl Simon Smith
Original Assignee
The Boots Company Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Boots Company Plc filed Critical The Boots Company Plc
Publication of HUP0002121A2 publication Critical patent/HUP0002121A2/hu
Publication of HUP0002121A3 publication Critical patent/HUP0002121A3/hu
Publication of HU224954B1 publication Critical patent/HU224954B1/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/04—Drugs for disorders of the respiratory system for throat disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Physiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Pulmonology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nutrition Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Otolaryngology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A találmány tárgyát hatóanyagként flurbiprofent tartalmazógyógypasztillák előállítására szolgáló eljárás képezi, amely eljárás akövetkező lépésekből áll: 1) flurbiprofen és egy tömegnövelő szerkeverékének egy kötőanyag poláros oldószeres oldatával valógranulálása; 2) egy gyógypasztillaképző készítmény megolvasztása; 3) agranulátum összekeverése a gyógypasztillaképző készítménnyel; 4) azígy kapott keveréknek olyan gyógypasztillává való formázása, aholminden egyes gyógypasztilla a flurbiprofen terápiásan hatásosmennyiségét tartalmazza. Ó
HU0002121A 1997-05-22 1998-05-20 Process for making flurbiprofen lozenges HU224954B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9710521.7A GB9710521D0 (en) 1997-05-22 1997-05-22 Process
PCT/EP1998/003167 WO1998052539A1 (en) 1997-05-22 1998-05-20 Process for making flurbiprofen lozenges

Publications (3)

Publication Number Publication Date
HUP0002121A2 true HUP0002121A2 (hu) 2000-12-28
HUP0002121A3 HUP0002121A3 (en) 2001-04-28
HU224954B1 HU224954B1 (en) 2006-04-28

Family

ID=10812840

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0002121A HU224954B1 (en) 1997-05-22 1998-05-20 Process for making flurbiprofen lozenges

Country Status (31)

Country Link
US (1) US6194003B1 (hu)
EP (1) EP0983059B1 (hu)
JP (1) JP2001527567A (hu)
KR (1) KR20010012739A (hu)
CN (1) CN1154480C (hu)
AR (1) AR015812A1 (hu)
AT (1) ATE245021T1 (hu)
AU (1) AU725760B2 (hu)
BG (1) BG103881A (hu)
BR (1) BR9809651A (hu)
CA (1) CA2290830C (hu)
CZ (1) CZ290816B6 (hu)
DE (1) DE69816440T2 (hu)
DK (1) DK0983059T3 (hu)
ES (1) ES2202871T3 (hu)
GB (1) GB9710521D0 (hu)
HU (1) HU224954B1 (hu)
ID (1) ID22949A (hu)
IL (1) IL132999A0 (hu)
IN (1) IN187837B (hu)
MY (1) MY118410A (hu)
NO (1) NO995681D0 (hu)
NZ (1) NZ500664A (hu)
PL (1) PL190947B1 (hu)
PT (1) PT983059E (hu)
RU (1) RU2203046C2 (hu)
SK (1) SK283701B6 (hu)
TR (1) TR199902725T2 (hu)
UA (1) UA53714C2 (hu)
WO (1) WO1998052539A1 (hu)
ZA (1) ZA984260B (hu)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1235558B1 (en) 1999-12-09 2006-05-03 The Boots Company PLC Compressed tablet composition comprising a nsaid
AU5702201A (en) * 2000-04-13 2001-10-30 Mayo Foundation Abeta<sub>42</sub> lowering agents
JP4886107B2 (ja) * 2000-10-13 2012-02-29 サンスター株式会社 歯周病予防用口腔内溶解錠
WO2004071431A2 (en) * 2003-02-05 2004-08-26 Myriad Genetics, Inc. Method and composition for treating neurodegenerative disorders
JP2007528857A (ja) * 2003-07-11 2007-10-18 ミリアド ジェネティクス， インコーポレイテッド アルツハイマー病の処置のための薬学的方法、投与レジメンおよび投薬形態
FR2865648B1 (fr) 2004-02-03 2006-06-30 Philippe Perovitch Procede de diffusion de molecules insolubles en milieu aqueux et composition mettant en oeuvre ce procede
US20070293538A1 (en) * 2004-04-13 2007-12-20 Myriad Genetics, Incorporated Pharmaceutical Composition And Methods For Treating Neurodegenerative Disorders
MXPA06012165A (es) * 2004-04-29 2007-01-17 Keystone Retaining Wall System Chapas para muros, muros de contencion y similares.
WO2006020852A2 (en) * 2004-08-11 2006-02-23 Myriad Genetics, Inc. Pharmaceutical composition and method for treating neurodegenerative disorders
WO2006020853A2 (en) * 2004-08-11 2006-02-23 Myriad Genetics, Inc. Pharmaceutical composition and method for treating neurodegenerative disorders
WO2006020850A2 (en) * 2004-08-11 2006-02-23 Myriad Genetics, Inc. Pharmaceutical composition and method for treating neurodegenerative disorders
AU2006211023B2 (en) 2005-02-03 2012-05-24 Takeda Nycomed As Fast wet-massing method for the preparation of calcium-containing compositions
GB2423710A (en) 2005-03-01 2006-09-06 Boots Healthcare Int Ltd Lozenge production process
KR20080039876A (ko) * 2005-07-22 2008-05-07 미리어드 제네틱스, 인크. 높은 약물 충진 제형 및 투여형
EP1942877A4 (en) * 2005-11-02 2011-09-14 Teikoku Pharma Usa Inc ORGANOLEPTICALLY ACCEPTABLE ORAL DOSAGE FORMS OF IBUPROFEN, MANUFACTURING METHOD AND APPLICATION
US20080033045A1 (en) * 2006-07-07 2008-02-07 Myriad Genetics, Incorporated Treatment of psychiatric disorders
EA200901188A1 (ru) * 2007-07-23 2010-04-30 ТЕЙКОКУ ФАРМА ЮЭсЭй, ИНК. Органолептически приемлемые дозированные лекарственные формы индольных агонистов серотониновых рецепторов для перорального применения и способы их применения
US8569375B2 (en) * 2008-08-22 2013-10-29 Reckitt Benckiser Healthcare (Uk) Limited Compositions
IT1397132B1 (it) 2009-12-01 2013-01-04 Alfa Wassermann Spa Composizioni comprendenti antiinfiammatori non steroidei.
IT1406107B1 (it) * 2010-12-13 2014-02-14 Alfa Wassermann Spa Composizioni solide comprendenti antiinfiammatori non steroidei, processi per la loro preparazione e loro uso.
DK2701681T3 (en) 2011-04-29 2017-01-09 Moberg Pharma Ab PHARMACEUTICAL COMPOSITIONS COMPRISING A LOCAL ANESTHETICS as bupivacaine for local administration to the mouth or throat
EP2609911A1 (en) * 2011-12-29 2013-07-03 Sanovel Ilac Sanayi ve Ticaret A.S. A novel process for preparing orally disintegrating flurbiprofen formulations
FR2997856B1 (fr) * 2012-11-14 2015-04-24 Pf Medicament Pastille medicamenteuse a base d'ibuprofene sodique dihydrate
WO2017029710A1 (ja) * 2015-08-18 2017-02-23 合同会社Ｐｈａｒｍａ Ｓｅｅｄｓ Ｃｒｅａｔｅ ＮＳＡＩＤｓまたはヘパリン類含有口腔用組成物
WO2020013781A2 (en) * 2018-03-27 2020-01-16 Pisak Mehmet Nevzat Synergistic effect of flurbiprofen and a gastro protective agent for the treatment of pain and inflammation

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4389393A (en) 1982-03-26 1983-06-21 Forest Laboratories, Inc. Sustained release therapeutic compositions based on high molecular weight hydroxypropylmethylcellulose
US4666716A (en) * 1984-09-04 1987-05-19 Richardson-Vicks Inc. Antidiarrheal compositions and use thereof
IT1243342B (it) 1990-07-13 1994-06-10 Farcon Ag Composizioni farmaceutiche orali liquide ad attivita' antiinfiammatoria
US5302394A (en) 1992-07-14 1994-04-12 Mcneil-Ppc, Inc. Dextromethorphan continuous lozenge manufacturing process
US5458879A (en) * 1994-03-03 1995-10-17 The Procter & Gamble Company Oral vehicle compositions
TW442287B (en) * 1995-06-13 2001-06-23 American Home Produits Corp Organoleptically acceptable oral pharmaceutical composition comprising the S(+)1,8-diethyl-1-1,3,4,9-tetrahydropyrano[3,4-b] indole-1-acetic acid (Etodolac)
US5614207A (en) * 1995-06-30 1997-03-25 Mcneil-Ppc, Inc. Dry mouth lozenge
GB9523833D0 (en) * 1995-11-22 1996-01-24 Boots Co Plc Medical treatment

Also Published As

Publication number Publication date
KR20010012739A (ko) 2001-02-26
JP2001527567A (ja) 2001-12-25
ES2202871T3 (es) 2004-04-01
PL190947B1 (pl) 2006-02-28
SK158899A3 (en) 2000-05-16
GB9710521D0 (en) 1997-07-16
AU7916598A (en) 1998-12-11
SK283701B6 (sk) 2003-12-02
MY118410A (en) 2004-10-30
ZA984260B (en) 1999-02-20
DK0983059T3 (da) 2003-11-03
EP0983059B1 (en) 2003-07-16
WO1998052539A1 (en) 1998-11-26
HU224954B1 (en) 2006-04-28
TR199902725T2 (xx) 2000-02-21
AR015812A1 (es) 2001-05-30
UA53714C2 (uk) 2003-02-17
DE69816440T2 (de) 2004-05-13
RU2203046C2 (ru) 2003-04-27
CN1154480C (zh) 2004-06-23
EP0983059A1 (en) 2000-03-08
NO995681L (no) 1999-11-19
NZ500664A (en) 2001-01-26
BG103881A (en) 2000-05-31
ID22949A (id) 1999-12-16
BR9809651A (pt) 2000-07-11
IN187837B (hu) 2002-06-29
IL132999A0 (en) 2001-03-19
ATE245021T1 (de) 2003-08-15
CZ290816B6 (cs) 2002-10-16
CN1255848A (zh) 2000-06-07
CA2290830C (en) 2006-07-11
PL336624A1 (en) 2000-07-03
CZ412099A3 (cs) 2000-02-16
DE69816440D1 (de) 2003-08-21
AU725760B2 (en) 2000-10-19
HUP0002121A3 (en) 2001-04-28
NO995681D0 (no) 1999-11-19
US6194003B1 (en) 2001-02-27
CA2290830A1 (en) 1998-11-26
PT983059E (pt) 2003-11-28

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Legal Events

Date Code Title Description
NF4A Restoration of patent protection
GB9A Succession in title

Owner name: RECKITT BENCKISER HEALTHCARE INTERNATIONAL LIM, GB

Free format text: FORMER OWNER(S): THE BOOTS COMPANY PLC, GB

Owner name: RECKITT BENCKISER HEALTHCARE (UK) LIMITED, GB

Free format text: FORMER OWNER(S): THE BOOTS COMPANY PLC, GB

MM4A Lapse of definitive patent protection due to non-payment of fees