DE69812329D1 - Multiplex-zufluss-immunotest mit magnetischen teilchen als festphase - Google Patents

Multiplex-zufluss-immunotest mit magnetischen teilchen als festphase

Info

Publication number
DE69812329D1
DE69812329D1 DE69812329T DE69812329T DE69812329D1 DE 69812329 D1 DE69812329 D1 DE 69812329D1 DE 69812329 T DE69812329 T DE 69812329T DE 69812329 T DE69812329 T DE 69812329T DE 69812329 D1 DE69812329 D1 DE 69812329D1
Authority
DE
Germany
Prior art keywords
immunotest
multiplex
inflow
solid phase
magnetic particles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69812329T
Other languages
English (en)
Other versions
DE69812329T2 (de
Inventor
I Watkins
B Edwards
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bio Rad Laboratories Inc
Original Assignee
Bio Rad Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25519815&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69812329(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bio Rad Laboratories Inc filed Critical Bio Rad Laboratories Inc
Publication of DE69812329D1 publication Critical patent/DE69812329D1/de
Application granted granted Critical
Publication of DE69812329T2 publication Critical patent/DE69812329T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/537—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G01N33/54333—Modification of conditions of immunological binding reaction, e.g. use of more than one type of particle, use of chemical agents to improve binding, choice of incubation time or application of magnetic field during binding reaction
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/544—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic
    • G01N33/545—Synthetic resin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983—Viruses
    • G01N33/56994—Herpetoviridae, e.g. cytomegalovirus, Epstein-Barr virus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/973—Simultaneous determination of more than one analyte
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]
    • Y10T428/2985—Solid-walled microcapsule from synthetic polymer
    • Y10T428/2987—Addition polymer from unsaturated monomers only
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2989—Microcapsule with solid core [includes liposome]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2991—Coated

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analyzing Materials By The Use Of Magnetic Means (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
DE69812329T 1997-11-18 1998-10-27 Multiplex-zufluss-immunotest mit magnetischen teilchen als festphase Expired - Lifetime DE69812329T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US97256397A 1997-11-18 1997-11-18
US972563 1997-11-18
PCT/US1998/022812 WO1999026067A1 (en) 1997-11-18 1998-10-27 Multiplex flow immunoassays with magnetic particles as solid phase

Publications (2)

Publication Number Publication Date
DE69812329D1 true DE69812329D1 (de) 2003-04-24
DE69812329T2 DE69812329T2 (de) 2004-02-12

Family

ID=25519815

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69812329T Expired - Lifetime DE69812329T2 (de) 1997-11-18 1998-10-27 Multiplex-zufluss-immunotest mit magnetischen teilchen als festphase

Country Status (7)

Country Link
US (6) US6280618B2 (de)
EP (2) EP0965044B1 (de)
JP (1) JP2000516345A (de)
AU (1) AU1203199A (de)
CA (1) CA2260991C (de)
DE (1) DE69812329T2 (de)
WO (1) WO1999026067A1 (de)

Families Citing this family (139)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6933106B2 (en) * 1995-03-13 2005-08-23 Mark Hechinger Platelet immunoglobulin bead suspension and flow cytometry
US6951716B2 (en) * 1995-03-13 2005-10-04 Mark Hechinger Anti-platelet immunoglobulin bead positive control
ES2288760T3 (es) 1996-04-25 2008-01-16 Bioarray Solutions Ltd. Ensamblaje electrocinetico controlado por luz de particulas proximas a superficies.
US7271009B1 (en) 1997-11-18 2007-09-18 Bio-Rad Laboratories, Inc. Multi-analyte diagnostic test for thyroid disorders
WO1999026067A1 (en) 1997-11-18 1999-05-27 Bio-Rad Laboratories, Inc. Multiplex flow immunoassays with magnetic particles as solid phase
JP4318859B2 (ja) * 1997-12-04 2009-08-26 ジーイー・ヘルスケア・ユーケイ・リミテッド 複合アッセイ方法
US20070178604A1 (en) * 1999-04-30 2007-08-02 Bio-Rad Laboratories, Inc. Multi-analyte diagnostic test for thyroid disorders
US6613581B1 (en) * 1999-08-26 2003-09-02 Caliper Technologies Corp. Microfluidic analytic detection assays, devices, and integrated systems
DE10006432A1 (de) * 2000-02-14 2001-08-16 Ganzimmun Inst Fuer Ganzheitli Verfahren zum Nachweis von Helicobacter pylori in Stuhl- und Speichelproben
WO2001063284A2 (en) * 2000-02-25 2001-08-30 Luminex Corporation Internal standards and controls for multiplexed assay
AU2001249444A1 (en) * 2000-03-28 2001-10-08 The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services Methods and compositions for the simultaneous detection of multiple analytes
CA2406321C (en) * 2000-04-13 2008-02-26 Bio-Rad Laboratories, Inc. Multi-analyte diagnostic test for thyroid disorders
US9709559B2 (en) * 2000-06-21 2017-07-18 Bioarray Solutions, Ltd. Multianalyte molecular analysis using application-specific random particle arrays
WO2001098765A1 (en) 2000-06-21 2001-12-27 Bioarray Solutions, Ltd. Multianalyte molecular analysis
US20020019004A1 (en) * 2000-08-03 2002-02-14 Albert Orfao Method for isolating molecules, cells and other particles which are specifically bound to a large particle
US6689615B1 (en) 2000-10-04 2004-02-10 James Murto Methods and devices for processing blood samples
CN100451651C (zh) * 2001-03-09 2009-01-14 株式会社三菱化学药得论 测试全血的方法
US7723123B1 (en) * 2001-06-05 2010-05-25 Caliper Life Sciences, Inc. Western blot by incorporating an affinity purification zone
US7262063B2 (en) 2001-06-21 2007-08-28 Bio Array Solutions, Ltd. Directed assembly of functional heterostructures
US20030095897A1 (en) * 2001-08-31 2003-05-22 Grate Jay W. Flow-controlled magnetic particle manipulation
ES2661167T3 (es) 2001-10-15 2018-03-27 Bioarray Solutions Ltd. Análisis multiplexado de loci polimórficos mediante consulta simultánea y detección mediada por enzimas
US20030108453A1 (en) * 2001-12-07 2003-06-12 Bio-Rad Laboratories, Inc. Block for maintenance, calibration and validation of automated multiplex analytical systems
EP1616179A4 (de) * 2001-12-21 2006-07-12 Centocor Inc Neues screening-verfahren für molekulare antagonisten mittels durchflusszytometrie
US6984497B2 (en) * 2002-04-05 2006-01-10 Bio-Rad Laboratories, Inc. Reducing non-specific binding in immunoassays performed on polymeric solid phases
US20040058333A1 (en) * 2002-09-23 2004-03-25 Bell Michael L. Assay products and procedures
US20060211055A1 (en) * 2002-11-12 2006-09-21 Caliper Life Sciences, Inc. Capture and release assay system and method
US7105359B2 (en) * 2002-11-12 2006-09-12 Matsushita Electric Industrial Co., Ltd. Specific coupling reaction measuring method and reagent kit and specific coupling reaction measuring apparatus for use in the same
US7526114B2 (en) 2002-11-15 2009-04-28 Bioarray Solutions Ltd. Analysis, secure access to, and transmission of array images
GB0228914D0 (en) * 2002-12-11 2003-01-15 Dynal Biotech Asa Particles
US7326573B2 (en) * 2003-01-10 2008-02-05 Beckman Coulter, Inc. Assay procedures and apparatus
ITMI20030339A1 (it) * 2003-02-26 2004-08-27 Pranha 50 Ltda Metodo, apparato e dispositivi per il risanamento di condotte mediante introduzione di tubi in materiale plastico.
FR2855613B1 (fr) * 2003-05-26 2005-08-19 Biocytex Procede de detection et de quantification multiplex d'analytes dans un echantillon a l'aide de microspheres
DE10323901A1 (de) * 2003-05-26 2005-01-05 Institut Virion/Serion Gmbh Verfahren und Testmittel zur Untersuchung und/oder zum Nachweis von Biomolekülen und/oder Wirkstoffen in Flüssigkeitsproben
US9063145B2 (en) * 2003-07-23 2015-06-23 Cellular Technology Limited Multivalent opsonophagocytic assay using bead array and imaging
FR2858688A1 (fr) * 2003-08-04 2005-02-11 Gilbert Skorski Methode et dispositif pour mesurer plusieurs parametres biochimiques dans un echantillon
WO2005029705A2 (en) 2003-09-18 2005-03-31 Bioarray Solutions, Ltd. Number coding for identification of subtypes of coded types of solid phase carriers
US7595279B2 (en) 2003-09-22 2009-09-29 Bioarray Solutions Ltd. Surface immobilized polyelectrolyte with multiple functional groups capable of covalently bonding to biomolecules
CA2544041C (en) 2003-10-28 2015-12-08 Bioarray Solutions Ltd. Optimization of gene expression analysis using immobilized capture probes
AU2004287069B2 (en) 2003-10-29 2009-07-16 Bioarray Solutions, Ltd. Multiplexed nucleic acid analysis by fragmentation of double-stranded DNA
DE112004002053T5 (de) * 2003-10-31 2006-10-05 Trial Corp., Hadano Feine magnetische Polyolefin-Partikel mit einer funktionellen Gruppe an der Oberfläche derselben
US7229778B2 (en) * 2004-02-26 2007-06-12 The Procter & Gamble Company Methods for determining the relative benefits and/or evaluating quantitative changes of products on epithelial tissue
WO2005085850A1 (en) * 2004-02-27 2005-09-15 Tianxin Wang Methods for multiplexed analyte detection
CA2558246C (en) * 2004-03-05 2013-07-09 Bio-Rad Laboratories, Inc. Hsv-2 type-specific immunoassays using glycoprotein g2 peptides
ATE473443T1 (de) * 2004-07-16 2010-07-15 Gyros Patent Ab Abstufung von immunantworten
US7848889B2 (en) 2004-08-02 2010-12-07 Bioarray Solutions, Ltd. Automated analysis of multiplexed probe-target interaction patterns: pattern matching and allele identification
US20060115908A1 (en) * 2004-11-30 2006-06-01 Tetracore, Inc. Multiplexed analyses of contaminant-laden gas in a particle impact collector
GB0500888D0 (en) * 2005-01-17 2005-02-23 Dynal Biotech Asa Process
US20060188905A1 (en) 2005-01-17 2006-08-24 Dynal Biotech Asa Process
US8486629B2 (en) 2005-06-01 2013-07-16 Bioarray Solutions, Ltd. Creation of functionalized microparticle libraries by oligonucleotide ligation or elongation
US20070020699A1 (en) * 2005-07-19 2007-01-25 Idexx Laboratories, Inc. Lateral flow assay and device using magnetic particles
US7749722B2 (en) * 2005-12-15 2010-07-06 Mitsubishi Kagaku Istron, Inc. Measuring method using whole blood
EP1969372A4 (de) * 2005-12-23 2009-04-22 Perkinelmer Las Inc Verfahren und zusammensetzungen zum nachweis enzymatischer aktivität
EP1969337A4 (de) * 2005-12-23 2010-01-27 Perkinelmer Las Inc Multiplex-testverfahren unter verwendung magnetischer und nichtmagnetischer partikel
JP5214464B2 (ja) 2005-12-28 2013-06-19 アドバンスド バイオニュートリション コーポレーション 多糖類、糖類およびポリオール類の乾燥マトリックスを含む、ガラス形態の、プロバイオティクス細菌用送達媒体およびその製造方法
GB2436616A (en) * 2006-03-29 2007-10-03 Inverness Medical Switzerland Assay device and method
US9476856B2 (en) 2006-04-13 2016-10-25 Advanced Liquid Logic, Inc. Droplet-based affinity assays
US20140193807A1 (en) 2006-04-18 2014-07-10 Advanced Liquid Logic, Inc. Bead manipulation techniques
US8637317B2 (en) * 2006-04-18 2014-01-28 Advanced Liquid Logic, Inc. Method of washing beads
US8613889B2 (en) * 2006-04-13 2013-12-24 Advanced Liquid Logic, Inc. Droplet-based washing
US10078078B2 (en) 2006-04-18 2018-09-18 Advanced Liquid Logic, Inc. Bead incubation and washing on a droplet actuator
US7439014B2 (en) 2006-04-18 2008-10-21 Advanced Liquid Logic, Inc. Droplet-based surface modification and washing
US8470606B2 (en) * 2006-04-18 2013-06-25 Duke University Manipulation of beads in droplets and methods for splitting droplets
US8637324B2 (en) 2006-04-18 2014-01-28 Advanced Liquid Logic, Inc. Bead incubation and washing on a droplet actuator
US8809068B2 (en) 2006-04-18 2014-08-19 Advanced Liquid Logic, Inc. Manipulation of beads in droplets and methods for manipulating droplets
US9675972B2 (en) 2006-05-09 2017-06-13 Advanced Liquid Logic, Inc. Method of concentrating beads in a droplet
EP3037807B1 (de) 2006-10-27 2021-03-31 Ramot at Tel Aviv University Ltd. Verfahren und system zur erkennung eines targets in einer population von molekülen
EP2111554B1 (de) 2007-02-09 2013-05-08 Advanced Liquid Logic, Inc. Tröpfchenaktuatorvorrichtungen und verfahren mit magnetischen kügelchen
US8003312B2 (en) * 2007-02-16 2011-08-23 The Board Of Trustees Of The Leland Stanford Junior University Multiplex cellular assays using detectable cell barcodes
WO2008106678A1 (en) 2007-03-01 2008-09-04 Advanced Liquid Logic, Inc. Droplet actuator structures
EP2126038B1 (de) 2007-03-22 2015-01-07 Advanced Liquid Logic, Inc. Enzymassays für einen tropfenaktuator
FR2917173B1 (fr) * 2007-06-08 2009-07-31 Bio Rad Pasteur Sa Procede multiplexe de detection d'une infection
FR2917174B1 (fr) * 2007-06-08 2021-02-12 Bio Rad Pasteur Analyse multiple d'echantillons sanguins
US7947465B2 (en) * 2007-08-20 2011-05-24 Bio-Rad Laboratories, Inc. Simultaneous assay for determining drugs
US8053198B2 (en) 2007-09-14 2011-11-08 Meso Scale Technologies, Llc Diagnostic methods
WO2009052354A2 (en) * 2007-10-17 2009-04-23 Advanced Liquid Logic, Inc. Droplet actuator structures
US8620059B2 (en) * 2007-12-13 2013-12-31 Fpinnovations Characterizing wood furnish by edge pixelated imaging
US7842475B2 (en) * 2008-01-08 2010-11-30 Siemens Healthcare Diagnostics Inc. Stabilization of solid support assay reagents
EP2279405B1 (de) 2008-05-13 2013-09-18 Advanced Liquid Logic, Inc. Tropfenaktuatorvorrichtungen, systeme und verfahren
EP2286228B1 (de) 2008-05-16 2019-04-03 Advanced Liquid Logic, Inc. Tröpfchenaktuatorvorrichtungen und verfahren zur manipulation von kügelchen
US20100047819A1 (en) * 2008-08-19 2010-02-25 Bio-Rad Laboratories, Inc. Multiplex assay for rheumatoid arthritis
GB2464183A (en) * 2008-09-19 2010-04-14 Singulex Inc Sandwich assay
WO2010054385A2 (en) * 2008-11-10 2010-05-14 Luminex Corporation Method and system for manufacture and use of macroporous beads in a multiplex assay
US20120046197A1 (en) 2009-05-01 2012-02-23 Meso Scale Technologies, Llc Biomarkers of therapeutic responsiveness
US20120058916A1 (en) 2009-05-13 2012-03-08 Meso Scale Technologies, Llc. Diagnostic methods for liver disorders
AU2010259022B2 (en) 2009-06-08 2016-05-12 Singulex, Inc. Highly sensitive biomarker panels
JP5451236B2 (ja) * 2009-07-31 2014-03-26 富士フイルム株式会社 検出方法、および該検出方法に用いられる磁性体含有誘電体粒子
WO2011022445A2 (en) * 2009-08-19 2011-02-24 Zeus Scientific, Inc. Improved multiplexed, microparticle-based assay for antibodies to antigens
US8603828B2 (en) * 2009-11-18 2013-12-10 Bio-Rad Laboratories, Inc. Multiplex immunoassays for hemoglobin, hemoglobin variants, and glycated forms
US9500644B2 (en) * 2010-02-23 2016-11-22 Luminex Corporation Particle populations and assays having varying amounts of magnetic material and particle concentrations among different subsets of particles and methods for processing assays having such particle populations
EP3072968A1 (de) 2010-02-25 2016-09-28 Advanced Liquid Logic, Inc. Verfahren zur herstellung von nukleinsäure-bibliotheken
WO2011133450A2 (en) 2010-04-19 2011-10-27 Meso Scale Technologies, Llc. Serology assays
US20110301053A1 (en) 2010-05-06 2011-12-08 Singulex, Inc. Methods for Diagnosing, Staging, Predicting Risk for Developing and Identifying Treatment Responders for Rheumatoid Arthritis
CN102375052A (zh) * 2010-08-17 2012-03-14 复旦大学附属华山医院 一种在同一体系中检测IgM抗体和IgG抗体的方法
US20130293246A1 (en) 2010-11-17 2013-11-07 Advanced Liquid Logic Inc. Capacitance Detection in a Droplet Actuator
AU2012250179B2 (en) 2011-04-27 2016-08-18 Becton Dickinson And Company Devices and methods for separating magnetically labeled moieties in a sample
EP2705374A4 (de) 2011-05-02 2014-11-12 Advanced Liquid Logic Inc Molekulare diagnoseplattform
WO2012154745A2 (en) 2011-05-09 2012-11-15 Advanced Liquid Logic, Inc. Microfluidic feedback using impedance detection
US9140635B2 (en) 2011-05-10 2015-09-22 Advanced Liquid Logic, Inc. Assay for measuring enzymatic modification of a substrate by a glycoprotein having enzymatic activity
DE102011077905A1 (de) * 2011-06-21 2012-12-27 Siemens Aktiengesellschaft Hintergrundfreie magnetische Durchflusszytometrie
EP3511717A3 (de) 2011-09-29 2019-09-25 Meso Scale Technologies, LLC. Biodosimetriepaneele und verfahren
US20130164217A1 (en) 2011-12-21 2013-06-27 Meso Scale Technologies, Llc Method of diagnosing, preventing and/or treating dementia & related disorders
CN104471371B (zh) * 2011-12-21 2018-11-09 贝克顿·迪金森公司 用于对磁标记的样品组分进行无菌分离的流式细胞计数系统
US9663818B2 (en) 2012-06-15 2017-05-30 The University Of Chicago Oligonucleotide-mediated quantitative multiplexed immunoassays
CN102830209B (zh) * 2012-09-11 2014-10-08 浙江大学 一种筛选抗糖尿病活性化合物的方法
WO2014066553A1 (en) 2012-10-26 2014-05-01 Becton, Dickinson And Company Devices and methods for manipulating components in a fluid sample
US20140221368A1 (en) 2013-02-01 2014-08-07 Meso Scale Technologies, Llc Biomarkers of therapeutic responsiveness
US20140309263A1 (en) 2013-02-01 2014-10-16 Meso Scale Technologies, Llc Biomarkers of therapeutic responsiveness
US20140221325A1 (en) 2013-02-01 2014-08-07 Meso Scale Technologies, Llc Glomerulonephritis biomarkers
FR3003353B1 (fr) * 2013-03-14 2015-03-06 Horiba Abx Sas Nouvelle methode de dosage en flux d'un objet d'interet
WO2014176535A1 (en) * 2013-04-26 2014-10-30 Bio-Rad Laboratories, Inc. Multiplex hepatitis b assay
US20150038365A1 (en) 2013-08-01 2015-02-05 Meso Scale Technologies, Llc Lung cancer biomarkers
CN111957453B (zh) 2013-08-13 2022-08-19 先进流体逻辑公司 使用作为流体输入的接通致动器储液器来提高液滴计量的准确度和精度的方法
EP3038834B1 (de) 2013-08-30 2018-12-12 Illumina, Inc. Manipulation von tröpfchen auf hydrophilen oder variegiert hydrophilen oberflächen
WO2015042593A1 (en) * 2013-09-23 2015-03-26 Assaypro, Llc Immunoassays using over-labeled fluorescent probes
WO2015168161A2 (en) 2014-04-29 2015-11-05 Illumina, Inc. Multiplexed single cell gene expression analysis using template switch and tagmentation
WO2016025929A1 (en) * 2014-08-14 2016-02-18 Parallume, Inc. Porous medium with encoded regions
EP3256850A4 (de) 2015-02-09 2018-10-10 Slingshot Biosciences, Inc. Hydrogelpartikel mit abstimmbaren optischen eigenschaften und verfahren zur verwendung davon
CN104714028B (zh) * 2015-03-02 2017-01-25 深圳市凯瑞德生物技术有限公司 一种检测IgM抗体的免疫检测方法
WO2016154038A1 (en) 2015-03-20 2016-09-29 Illumina, Inc. Fluidics cartridge for use in the vertical or substantially vertical position
JP6743150B2 (ja) 2015-08-28 2020-08-19 イルミナ インコーポレイテッド 単一細胞の核酸配列分析
US11209431B2 (en) 2015-10-06 2021-12-28 Bio-Rad Laboratories, Inc. Borrelia immunoassays and materials therefor
CN105675877B (zh) * 2016-03-01 2017-08-22 江南大学 一种基于双色时间分辨荧光标记‑磁分离适配体识别同时检测两种致病菌的方法
ES2786974T3 (es) 2016-04-07 2020-10-14 Illumina Inc Métodos y sistemas para la construcción de bibliotecas de ácidos nucleicos normalizadas
KR20180137506A (ko) 2016-04-15 2018-12-27 벡톤 디킨슨 앤드 컴퍼니 밀폐형 액적 분류기 및 이의 사용 방법
CN107782900A (zh) * 2016-08-31 2018-03-09 朱海燕 人生长分化因子‑15的检测试纸组件
EA202091673A1 (ru) 2018-01-29 2021-02-03 Ст. Джуд Чилдрен'С Рисерч Хоспитал, Инк. Способ амплификации нуклеиновых кислот
EP3762729A1 (de) 2018-03-08 2021-01-13 Meso Scale Technologies, LLC Genetische marker- und/oder biomarker für traumatische hirnverletzung und ultraempfindliche tests für biomarker von traumatischen hirnverletzungen
EP3785015B1 (de) 2018-04-27 2024-06-26 Becton, Dickinson and Company Durchflusszytometer mit eingeschlossenen tröpfchensortierern mit gesteuertem aerosolgehalt und verfahren zur verwendung davon
US11275075B2 (en) 2018-04-27 2022-03-15 Becton, Dickinson And Company Collection systems for flow cytometrically sorted samples and methods of using the same
CN110736737A (zh) * 2018-07-18 2020-01-31 博阳生物科技（上海）有限公司 一种用于化学发光检测的微球组合物及其应用
US20210164971A1 (en) * 2018-08-17 2021-06-03 The Brigham And Women's Hospital, Inc. Droplet arrays for detection and quantification of analytes
JP7495400B2 (ja) 2018-10-30 2024-06-04 ベクトン・ディキンソン・アンド・カンパニー アライメント窓を有する粒子選別モジュール、システム、およびその使用方法
CN112415184A (zh) 2019-08-22 2021-02-26 香港科技大学 用于细胞群体和单细胞的单分子分离系统及其方法和用途
CA3160211A1 (en) 2019-11-05 2021-05-14 Meso Scale Technologies, Llc. Methods and kits for quantitating radiation exposure
WO2021108666A2 (en) 2019-11-26 2021-06-03 Meso Scale Technologies, Llc. Methods and kits for detecting autoimmune diseases
BR112022019541A2 (pt) 2020-03-30 2022-11-16 Illumina Inc Métodos e composições para preparação de bibliotecas de ácido nucleico
EP4143576A1 (de) 2020-05-01 2023-03-08 Meso Scale Technologies, LLC Serologische virusassays
WO2022043415A1 (en) 2020-08-27 2022-03-03 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for detecting the presence of pemphigus-specific autoantibodies in a sample
CN116368577A (zh) * 2021-12-08 2023-06-30 豪夫迈·罗氏有限公司 基于测试结果水平的分析

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2632478A1 (de) * 1975-07-23 1977-02-24 Coulter Electronics Verfahren zur erfassung und trennung von antigenen und antikoerperchen im blut und in anderen proben
GB1575805A (en) * 1976-03-12 1980-10-01 Technicon Instr Automatic diagnostic apparatus
US4115534A (en) * 1976-08-19 1978-09-19 Minnesota Mining And Manufacturing Company In vitro diagnostic test
GB2014162B (en) * 1978-02-13 1982-08-25 Technicon Instr Particulate reagent for use in immunoassays
JPH0665989B2 (ja) 1984-12-03 1994-08-24 オリンパス光学工業株式会社 免疫学的分析方法
CA1304006C (en) * 1985-12-20 1992-06-23 Edwin F. Ullman Particle separation method
JPS6336151A (ja) 1986-07-30 1988-02-16 Showa Denko Kk 微粒子の螢光強度測定による定量方法
US5091206A (en) * 1987-10-26 1992-02-25 Baxter Diagnostics Inc. Process for producing magnetically responsive polymer particles and application thereof
US6013531A (en) * 1987-10-26 2000-01-11 Dade International Inc. Method to use fluorescent magnetic polymer particles as markers in an immunoassay
US5395688A (en) * 1987-10-26 1995-03-07 Baxter Diagnostics Inc. Magnetically responsive fluorescent polymer particles
NO164622C (no) 1988-05-11 1990-10-24 Tore Lindmo Binaer immunometrisk partikkelbasert metode for maaling av spesifikke serum-antigener ved hjelp av vaeskestroemsmikrofotometri og et ferdigpreparert maaloppsett derav.
US5512439A (en) * 1988-11-21 1996-04-30 Dynal As Oligonucleotide-linked magnetic particles and uses thereof
ES2067018T3 (es) * 1988-12-28 1995-03-16 Stefan Miltenyi Procedimiento y materiales para la separacion en alto gradiente magnetico de materiales biologicos.
FR2658200B1 (fr) * 1990-02-14 1992-07-24 Rhone Poulenc Chimie Procede de preparation de dispersions aqueuses de particules de polymere magnetisable de distribution resserree.
US5665582A (en) * 1990-10-29 1997-09-09 Dekalb Genetics Corp. Isolation of biological materials
WO1993002360A1 (en) 1991-07-16 1993-02-04 Transmed Biotech Incorporated Methods and compositions for simultaneous analysis of multiple analytes
JP2683172B2 (ja) 1991-10-01 1997-11-26 キヤノン株式会社 検体測定方法及び検体測定装置
CA2072548A1 (en) * 1992-06-26 1993-12-27 Michael W. Stewart Methods for determining antiphospholipid antibodies
DE4309333A1 (de) * 1993-03-17 1994-09-22 Silica Gel Gmbh Superparamagnetische Teilchen, Verfahren zu ihrer Herstellung und Verwendung derselben
US5648124A (en) * 1993-07-09 1997-07-15 Seradyn, Inc. Process for preparing magnetically responsive microparticles
EP0852004B1 (de) 1995-10-11 2011-01-19 Luminex Corporation Gleichzeitige mehrfachanalyse klinischer proben
US5981180A (en) * 1995-10-11 1999-11-09 Luminex Corporation Multiplexed analysis of clinical specimens apparatus and methods
IL117605A0 (en) 1996-03-21 1996-07-23 Markman Ofer Multi-antigen serological diagnosis
JP2709296B2 (ja) 1996-05-27 1998-02-04 オリンパス光学工業株式会社 免疫学的分析方法
US6449562B1 (en) * 1996-10-10 2002-09-10 Luminex Corporation Multiplexed analysis of clinical specimens apparatus and method
US5858648A (en) * 1996-11-04 1999-01-12 Sienna Biotech, Inc. Assays using reference microparticles
US6023540A (en) 1997-03-14 2000-02-08 Trustees Of Tufts College Fiber optic sensor with encoded microspheres
WO1999026067A1 (en) * 1997-11-18 1999-05-27 Bio-Rad Laboratories, Inc. Multiplex flow immunoassays with magnetic particles as solid phase

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US7569399B2 (en) 2009-08-04
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US20010054580A1 (en) 2001-12-27
US6280618B2 (en) 2001-08-28
EP0965044B1 (de) 2003-03-19
JP2000516345A (ja) 2000-12-05
US20060275820A1 (en) 2006-12-07
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US6872578B2 (en) 2005-03-29
US20060269962A1 (en) 2006-11-30

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