DE69733142T2 - Substituierte benzocycloheptapyridine derivate verwendbar als farnesyl-protein transferase inhibitoren - Google Patents

Substituierte benzocycloheptapyridine derivate verwendbar als farnesyl-protein transferase inhibitoren Download PDF

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Publication number
DE69733142T2
DE69733142T2 DE69733142T DE69733142T DE69733142T2 DE 69733142 T2 DE69733142 T2 DE 69733142T2 DE 69733142 T DE69733142 T DE 69733142T DE 69733142 T DE69733142 T DE 69733142T DE 69733142 T2 DE69733142 T2 DE 69733142T2
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DE
Germany
Prior art keywords
aryl
substituted
optionally
alkyl
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69733142T
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German (de)
English (en)
Other versions
DE69733142D1 (de
Inventor
F. Dinanath RANE
B. Alan COOPER
K. Alan MALLAMS
J. Ronald DOLL
George F. Njoroge
G. Arthur TAVERAS
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Schering Corp
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Publication date
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Publication of DE69733142D1 publication Critical patent/DE69733142D1/de
Application granted granted Critical
Publication of DE69733142T2 publication Critical patent/DE69733142T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
DE69733142T 1996-09-13 1997-09-11 Substituierte benzocycloheptapyridine derivate verwendbar als farnesyl-protein transferase inhibitoren Expired - Fee Related DE69733142T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US71370596A 1996-09-13 1996-09-13
US713705 1996-09-13
PCT/US1997/015902 WO1998011097A1 (en) 1996-09-13 1997-09-11 Substituted benzocycloheptapyridine useful as inhibitors of farnesyl-protein transferase

Publications (2)

Publication Number Publication Date
DE69733142D1 DE69733142D1 (de) 2005-06-02
DE69733142T2 true DE69733142T2 (de) 2006-03-16

Family

ID=24867191

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69733142T Expired - Fee Related DE69733142T2 (de) 1996-09-13 1997-09-11 Substituierte benzocycloheptapyridine derivate verwendbar als farnesyl-protein transferase inhibitoren

Country Status (13)

Country Link
EP (1) EP0931077B1 (https=)
JP (1) JP2001500506A (https=)
KR (1) KR20000036102A (https=)
CN (1) CN1104428C (https=)
AT (1) ATE294172T1 (https=)
AU (1) AU4337597A (https=)
CA (1) CA2264666A1 (https=)
DE (1) DE69733142T2 (https=)
ES (1) ES2242232T3 (https=)
HU (1) HUP0000073A3 (https=)
IL (1) IL128926A0 (https=)
NZ (1) NZ334341A (https=)
WO (1) WO1998011097A1 (https=)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9910144A (pt) 1998-01-21 2002-04-02 Millennium Pharm Inc Antagonistas de receptores de quimiocinas e seu uso
US6509346B2 (en) 1998-01-21 2003-01-21 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
US6613905B1 (en) 1998-01-21 2003-09-02 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
US6433165B1 (en) 1998-01-21 2002-08-13 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
US7271176B2 (en) 1998-09-04 2007-09-18 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use thereof
US6288083B1 (en) 1998-09-04 2001-09-11 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
US6503926B2 (en) 1998-09-04 2003-01-07 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
US7541365B2 (en) 2001-11-21 2009-06-02 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
TWI291467B (en) 2002-11-13 2007-12-21 Millennium Pharm Inc CCR1 antagonists and methods of use therefor
WO2005017160A2 (en) 2003-08-13 2005-02-24 Children's Hospital Medical Center Mobilization of hematopoietic cells
RU2408584C2 (ru) 2005-06-23 2011-01-10 Мерк Шарп Энд Домэ Корп. Ингибиторы тирозинкиназы
TW200813021A (en) 2006-07-10 2008-03-16 Merck & Co Inc Tyrosine kinase inhibitors
EP2081905B1 (en) 2006-07-28 2012-09-12 Boehringer Ingelheim International GmbH Sulfonyl compounds which modulate the cb2 receptor
JP5492092B2 (ja) 2007-11-07 2014-05-14 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｃｂ２受容体を調節する化合物
EP2326629B1 (en) 2008-07-10 2013-10-02 Boehringer Ingelheim International GmbH Sulfone compounds which modulate the cb2 receptor
WO2010036630A2 (en) 2008-09-25 2010-04-01 Boehringer Ingelheim International Gmbh Compounds which selectively modulate the cb2 receptor
WO2010096371A2 (en) 2009-02-18 2010-08-26 Boehringer Ingelheim International Gmbh Heterocyclic compounds which modulate the cb2 receptor
US8299103B2 (en) 2009-06-15 2012-10-30 Boehringer Ingelheim International Gmbh Compounds which selectively modulate the CB2 receptor
JP5756800B2 (ja) * 2009-06-16 2015-07-29 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｃｂ２受容体を調節するアゼチジン２−カルボキサミド誘導体
JP2013505295A (ja) 2009-09-22 2013-02-14 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｃｂ２受容体を選択的に調節する化合物
US9315454B2 (en) 2010-01-15 2016-04-19 Boehringer Ingelheim International Gmbh Compounds which modulate the CB2 receptor
EP2542539B1 (en) 2010-03-05 2014-02-26 Boehringer Ingelheim International GmbH Tetrazole compounds which selectively modulate the cb2 receptor
JP5746764B2 (ja) 2010-07-22 2015-07-08 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｃｂ２受容体を調節する化合物
EP2803668A1 (en) 2013-05-17 2014-11-19 Boehringer Ingelheim International Gmbh Novel (cyano-dimethyl-methyl)-isoxazoles and -[1,3,4]thiadiazoles

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1593417A (en) * 1976-12-22 1981-07-15 Squibb & Sons Inc Carbocyclic-fused pyrazolopyridine derivatives
US5089496A (en) * 1986-10-31 1992-02-18 Schering Corporation Benzo[5,6]cycloheptapyridine compounds, compositions and method of treating allergies
IE68935B1 (en) * 1990-06-22 1996-07-24 Schering Corp Bis-benzo or benzopyrido cyclohepta piperidene piperidylidene and piperazine compounds compositions and methods of use
SG48750A1 (en) * 1993-10-15 1998-05-18 Schering Corp Tricyclic carbonate compounds useful for inhabition of g-protein function for treatment of proliferative diseases
IL111235A (en) * 1993-10-15 2001-03-19 Schering Plough Corp Medicinal preparations for inhibiting protein G activity and for the treatment of malignant diseases, containing tricyclic compounds, some such new compounds and a process for the preparation of some of them

Also Published As

Publication number Publication date
JP2001500506A (ja) 2001-01-16
IL128926A0 (en) 2000-02-17
CN1236365A (zh) 1999-11-24
DE69733142D1 (de) 2005-06-02
EP0931077B1 (en) 2005-04-27
ATE294172T1 (de) 2005-05-15
CA2264666A1 (en) 1998-03-19
EP0931077A1 (en) 1999-07-28
NZ334341A (en) 2001-01-26
HUP0000073A2 (hu) 2001-10-28
CN1104428C (zh) 2003-04-02
ES2242232T3 (es) 2005-11-01
WO1998011097A1 (en) 1998-03-19
KR20000036102A (ko) 2000-06-26
HUP0000073A3 (en) 2002-02-28
AU4337597A (en) 1998-04-02

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Legal Events

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8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee