ATE294172T1 - Substituierte benzocycloheptapyridine derivate verwendbar als farnesyl-protein transferase inhibitoren - Google Patents
Substituierte benzocycloheptapyridine derivate verwendbar als farnesyl-protein transferase inhibitorenInfo
- Publication number
- ATE294172T1 ATE294172T1 AT97941476T AT97941476T ATE294172T1 AT E294172 T1 ATE294172 T1 AT E294172T1 AT 97941476 T AT97941476 T AT 97941476T AT 97941476 T AT97941476 T AT 97941476T AT E294172 T1 ATE294172 T1 AT E294172T1
- Authority
- AT
- Austria
- Prior art keywords
- protein transferase
- farnesyl
- transferase inhibitors
- cells
- independently selected
- Prior art date
Links
- XYNHQVIVVBWVAG-UHFFFAOYSA-N 4h-cyclohepta[f]quinoline Chemical class C1=CC=CC=C2C3=CC=CNC3=CC=C21 XYNHQVIVVBWVAG-UHFFFAOYSA-N 0.000 title 1
- 239000003528 protein farnesyltransferase inhibitor Substances 0.000 title 1
- 230000002159 abnormal effect Effects 0.000 abstract 2
- 230000010261 cell growth Effects 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 230000002401 inhibitory effect Effects 0.000 abstract 2
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 102000004357 Transferases Human genes 0.000 abstract 1
- 108090000992 Transferases Proteins 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000004030 farnesyl group Chemical group [H]C([*])([H])C([H])=C(C([H])([H])[H])C([H])([H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 125000004404 heteroalkyl group Chemical group 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000004446 heteroarylalkyl group Chemical group 0.000 abstract 1
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 1
- 125000005885 heterocycloalkylalkyl group Chemical group 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Furan Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US71370596A | 1996-09-13 | 1996-09-13 | |
| PCT/US1997/015902 WO1998011097A1 (en) | 1996-09-13 | 1997-09-11 | Substituted benzocycloheptapyridine useful as inhibitors of farnesyl-protein transferase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE294172T1 true ATE294172T1 (de) | 2005-05-15 |
Family
ID=24867191
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97941476T ATE294172T1 (de) | 1996-09-13 | 1997-09-11 | Substituierte benzocycloheptapyridine derivate verwendbar als farnesyl-protein transferase inhibitoren |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP0931077B1 (https=) |
| JP (1) | JP2001500506A (https=) |
| KR (1) | KR20000036102A (https=) |
| CN (1) | CN1104428C (https=) |
| AT (1) | ATE294172T1 (https=) |
| AU (1) | AU4337597A (https=) |
| CA (1) | CA2264666A1 (https=) |
| DE (1) | DE69733142T2 (https=) |
| ES (1) | ES2242232T3 (https=) |
| HU (1) | HUP0000073A3 (https=) |
| IL (1) | IL128926A0 (https=) |
| NZ (1) | NZ334341A (https=) |
| WO (1) | WO1998011097A1 (https=) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR9910144A (pt) | 1998-01-21 | 2002-04-02 | Millennium Pharm Inc | Antagonistas de receptores de quimiocinas e seu uso |
| US6509346B2 (en) | 1998-01-21 | 2003-01-21 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
| US6613905B1 (en) | 1998-01-21 | 2003-09-02 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
| US6433165B1 (en) | 1998-01-21 | 2002-08-13 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
| US7271176B2 (en) | 1998-09-04 | 2007-09-18 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use thereof |
| US6288083B1 (en) | 1998-09-04 | 2001-09-11 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
| US6503926B2 (en) | 1998-09-04 | 2003-01-07 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
| US7541365B2 (en) | 2001-11-21 | 2009-06-02 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
| TWI291467B (en) | 2002-11-13 | 2007-12-21 | Millennium Pharm Inc | CCR1 antagonists and methods of use therefor |
| WO2005017160A2 (en) | 2003-08-13 | 2005-02-24 | Children's Hospital Medical Center | Mobilization of hematopoietic cells |
| RU2408584C2 (ru) | 2005-06-23 | 2011-01-10 | Мерк Шарп Энд Домэ Корп. | Ингибиторы тирозинкиназы |
| TW200813021A (en) | 2006-07-10 | 2008-03-16 | Merck & Co Inc | Tyrosine kinase inhibitors |
| EP2081905B1 (en) | 2006-07-28 | 2012-09-12 | Boehringer Ingelheim International GmbH | Sulfonyl compounds which modulate the cb2 receptor |
| JP5492092B2 (ja) | 2007-11-07 | 2014-05-14 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｃｂ２受容体を調節する化合物 |
| EP2326629B1 (en) | 2008-07-10 | 2013-10-02 | Boehringer Ingelheim International GmbH | Sulfone compounds which modulate the cb2 receptor |
| WO2010036630A2 (en) | 2008-09-25 | 2010-04-01 | Boehringer Ingelheim International Gmbh | Compounds which selectively modulate the cb2 receptor |
| WO2010096371A2 (en) | 2009-02-18 | 2010-08-26 | Boehringer Ingelheim International Gmbh | Heterocyclic compounds which modulate the cb2 receptor |
| US8299103B2 (en) | 2009-06-15 | 2012-10-30 | Boehringer Ingelheim International Gmbh | Compounds which selectively modulate the CB2 receptor |
| JP5756800B2 (ja) * | 2009-06-16 | 2015-07-29 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｃｂ２受容体を調節するアゼチジン２−カルボキサミド誘導体 |
| JP2013505295A (ja) | 2009-09-22 | 2013-02-14 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｃｂ２受容体を選択的に調節する化合物 |
| US9315454B2 (en) | 2010-01-15 | 2016-04-19 | Boehringer Ingelheim International Gmbh | Compounds which modulate the CB2 receptor |
| EP2542539B1 (en) | 2010-03-05 | 2014-02-26 | Boehringer Ingelheim International GmbH | Tetrazole compounds which selectively modulate the cb2 receptor |
| JP5746764B2 (ja) | 2010-07-22 | 2015-07-08 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｃｂ２受容体を調節する化合物 |
| EP2803668A1 (en) | 2013-05-17 | 2014-11-19 | Boehringer Ingelheim International Gmbh | Novel (cyano-dimethyl-methyl)-isoxazoles and -[1,3,4]thiadiazoles |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1593417A (en) * | 1976-12-22 | 1981-07-15 | Squibb & Sons Inc | Carbocyclic-fused pyrazolopyridine derivatives |
| US5089496A (en) * | 1986-10-31 | 1992-02-18 | Schering Corporation | Benzo[5,6]cycloheptapyridine compounds, compositions and method of treating allergies |
| IE68935B1 (en) * | 1990-06-22 | 1996-07-24 | Schering Corp | Bis-benzo or benzopyrido cyclohepta piperidene piperidylidene and piperazine compounds compositions and methods of use |
| SG48750A1 (en) * | 1993-10-15 | 1998-05-18 | Schering Corp | Tricyclic carbonate compounds useful for inhabition of g-protein function for treatment of proliferative diseases |
| IL111235A (en) * | 1993-10-15 | 2001-03-19 | Schering Plough Corp | Medicinal preparations for inhibiting protein G activity and for the treatment of malignant diseases, containing tricyclic compounds, some such new compounds and a process for the preparation of some of them |
-
1997
- 1997-09-11 CA CA002264666A patent/CA2264666A1/en not_active Abandoned
- 1997-09-11 KR KR1019997002121A patent/KR20000036102A/ko not_active Withdrawn
- 1997-09-11 DE DE69733142T patent/DE69733142T2/de not_active Expired - Fee Related
- 1997-09-11 JP JP10513761A patent/JP2001500506A/ja not_active Ceased
- 1997-09-11 IL IL12892697A patent/IL128926A0/xx unknown
- 1997-09-11 AT AT97941476T patent/ATE294172T1/de not_active IP Right Cessation
- 1997-09-11 AU AU43375/97A patent/AU4337597A/en not_active Abandoned
- 1997-09-11 NZ NZ334341A patent/NZ334341A/xx unknown
- 1997-09-11 CN CN97199528A patent/CN1104428C/zh not_active Expired - Fee Related
- 1997-09-11 WO PCT/US1997/015902 patent/WO1998011097A1/en not_active Ceased
- 1997-09-11 ES ES97941476T patent/ES2242232T3/es not_active Expired - Lifetime
- 1997-09-11 EP EP97941476A patent/EP0931077B1/en not_active Expired - Lifetime
- 1997-09-11 HU HU0000073A patent/HUP0000073A3/hu unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2001500506A (ja) | 2001-01-16 |
| IL128926A0 (en) | 2000-02-17 |
| CN1236365A (zh) | 1999-11-24 |
| DE69733142D1 (de) | 2005-06-02 |
| EP0931077B1 (en) | 2005-04-27 |
| CA2264666A1 (en) | 1998-03-19 |
| EP0931077A1 (en) | 1999-07-28 |
| NZ334341A (en) | 2001-01-26 |
| DE69733142T2 (de) | 2006-03-16 |
| HUP0000073A2 (hu) | 2001-10-28 |
| CN1104428C (zh) | 2003-04-02 |
| ES2242232T3 (es) | 2005-11-01 |
| WO1998011097A1 (en) | 1998-03-19 |
| KR20000036102A (ko) | 2000-06-26 |
| HUP0000073A3 (en) | 2002-02-28 |
| AU4337597A (en) | 1998-04-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE294172T1 (de) | Substituierte benzocycloheptapyridine derivate verwendbar als farnesyl-protein transferase inhibitoren | |
| ATE345338T1 (de) | Tricyclische piperdinyl derivate verwendbar als farnesyl-protein transferase inhibitoren | |
| ATE242231T1 (de) | Carbonyl-piperaznyl und piperidinyl derivate zur hemmung farnesyl protein transferase | |
| ATE259365T1 (de) | Chinolinderivate verwendbar zur hemmung der farnesyl-protein transferase | |
| MY117290A (en) | Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses, and methods and intermediates useful for their preparation | |
| ATE286046T1 (de) | Trizyklische inhibitoren der farnesyl protein transferase | |
| SE8303824L (sv) | N-imidazolylderivat av bicykliska foreningar och forfarande for deras framstellning | |
| DK0715623T3 (da) | Blodpladeaggregationsinhibitorer | |
| NO991230D0 (no) | Trisykliske forbindelser for inhibering av G-proteinfunksjon og for behandling av proliferative sykdommer | |
| ATE356816T1 (de) | Trizyklische keto amid derivative als farnesyl protein transferase inhibitoren | |
| DE69709774D1 (de) | Substituierte benzocycloheptapyridine derivate verwendbar als farnesyl-protein transferase inhibitoren | |
| NO991235L (no) | Forbindelser anvendelige for inhibering av farnesylproteintransferase | |
| ATE299140T1 (de) | Farnesyl-protein transferase inhibitoren | |
| EA200001248A1 (ru) | Новые линейные и циклические производные мочевины, способ их получения и их содержащие фармацевтические композиции | |
| ES2192671T3 (es) | Compuestos triciclicos que tienen actividad como inhibidores de ras-fpt. | |
| ATE218137T1 (de) | Benzo(5,6)cyclohepta(1,2-b)pyridin derivate als farnesyl protein transferase inhibitoren | |
| US5712261A (en) | Method for preventing or treating hypertriglyceridemia | |
| DE69014337D1 (de) | Verwendung von 5-Alkylpyridazin-Derivaten als Medikamente zur Beeinflussung des cholinergen Systems. | |
| DK614989D0 (da) | Indolderivater, fremgangsmaade til deres fremstilling og farmaceutiske midler indeholdende dem | |
| ID19401A (id) | N-sianoimina trisiklik baru yang berguna sebagai inhibitor farnesil-protein transferase | |
| EA199800470A1 (ru) | Производные фосфоновой кислоты, обладающие ингибирующей активностью в отношении металлопептидаз | |
| ATE236149T1 (de) | Tricyclische aminooxyamide derivate als farnesyl protein transferase inhibitoren | |
| ATE248831T1 (de) | Benzo(5,6)cyclohepta(1,2b)pyridine derivate anwendbar als farnesyl protein transferase inhibitoren | |
| NO991232D0 (no) | Substituerte benzosykloheptapyridinderivater anvendelige for inhibering av farnesylproteintransferase | |
| BR9712035A (pt) | Compostos Úteis para inibi-Æo de transferase de prote¡na farnesila |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |