CN1104428C - 用作法呢基－蛋白转移酶抑制剂的取代的苯并芳庚并吡啶 - Google Patents

用作法呢基－蛋白转移酶抑制剂的取代的苯并芳庚并吡啶 Download PDF

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Publication number
CN1104428C
CN1104428C CN97199528A CN97199528A CN1104428C CN 1104428 C CN1104428 C CN 1104428C CN 97199528 A CN97199528 A CN 97199528A CN 97199528 A CN97199528 A CN 97199528A CN 1104428 C CN1104428 C CN 1104428C
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China
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alkyl
compound
aryl
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group
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CN97199528A
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English (en)
Chinese (zh)
Other versions
CN1236365A (zh
Inventor
D·F·拉恩
A·B·库珀
A·K·马拉姆斯
R·J·多尔
F·G·尼奥罗格
A·G·塔韦拉斯
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Merck Sharp and Dohme LLC
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Schering Corp
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Publication of CN1236365A publication Critical patent/CN1236365A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
CN97199528A 1996-09-13 1997-09-11 用作法呢基－蛋白转移酶抑制剂的取代的苯并芳庚并吡啶 Expired - Fee Related CN1104428C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US71370596A 1996-09-13 1996-09-13
US08/713,705 1996-09-13

Publications (2)

Publication Number Publication Date
CN1236365A CN1236365A (zh) 1999-11-24
CN1104428C true CN1104428C (zh) 2003-04-02

Family

ID=24867191

Family Applications (1)

Application Number Title Priority Date Filing Date
CN97199528A Expired - Fee Related CN1104428C (zh) 1996-09-13 1997-09-11 用作法呢基－蛋白转移酶抑制剂的取代的苯并芳庚并吡啶

Country Status (13)

Country Link
EP (1) EP0931077B1 (https=)
JP (1) JP2001500506A (https=)
KR (1) KR20000036102A (https=)
CN (1) CN1104428C (https=)
AT (1) ATE294172T1 (https=)
AU (1) AU4337597A (https=)
CA (1) CA2264666A1 (https=)
DE (1) DE69733142T2 (https=)
ES (1) ES2242232T3 (https=)
HU (1) HUP0000073A3 (https=)
IL (1) IL128926A0 (https=)
NZ (1) NZ334341A (https=)
WO (1) WO1998011097A1 (https=)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9910144A (pt) 1998-01-21 2002-04-02 Millennium Pharm Inc Antagonistas de receptores de quimiocinas e seu uso
US6509346B2 (en) 1998-01-21 2003-01-21 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
US6613905B1 (en) 1998-01-21 2003-09-02 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
US6433165B1 (en) 1998-01-21 2002-08-13 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
US7271176B2 (en) 1998-09-04 2007-09-18 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use thereof
US6288083B1 (en) 1998-09-04 2001-09-11 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
US6503926B2 (en) 1998-09-04 2003-01-07 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
US7541365B2 (en) 2001-11-21 2009-06-02 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
TWI291467B (en) 2002-11-13 2007-12-21 Millennium Pharm Inc CCR1 antagonists and methods of use therefor
WO2005017160A2 (en) 2003-08-13 2005-02-24 Children's Hospital Medical Center Mobilization of hematopoietic cells
RU2408584C2 (ru) 2005-06-23 2011-01-10 Мерк Шарп Энд Домэ Корп. Ингибиторы тирозинкиназы
TW200813021A (en) 2006-07-10 2008-03-16 Merck & Co Inc Tyrosine kinase inhibitors
EP2081905B1 (en) 2006-07-28 2012-09-12 Boehringer Ingelheim International GmbH Sulfonyl compounds which modulate the cb2 receptor
JP5492092B2 (ja) 2007-11-07 2014-05-14 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｃｂ２受容体を調節する化合物
EP2326629B1 (en) 2008-07-10 2013-10-02 Boehringer Ingelheim International GmbH Sulfone compounds which modulate the cb2 receptor
WO2010036630A2 (en) 2008-09-25 2010-04-01 Boehringer Ingelheim International Gmbh Compounds which selectively modulate the cb2 receptor
WO2010096371A2 (en) 2009-02-18 2010-08-26 Boehringer Ingelheim International Gmbh Heterocyclic compounds which modulate the cb2 receptor
US8299103B2 (en) 2009-06-15 2012-10-30 Boehringer Ingelheim International Gmbh Compounds which selectively modulate the CB2 receptor
JP5756800B2 (ja) * 2009-06-16 2015-07-29 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｃｂ２受容体を調節するアゼチジン２−カルボキサミド誘導体
JP2013505295A (ja) 2009-09-22 2013-02-14 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｃｂ２受容体を選択的に調節する化合物
US9315454B2 (en) 2010-01-15 2016-04-19 Boehringer Ingelheim International Gmbh Compounds which modulate the CB2 receptor
EP2542539B1 (en) 2010-03-05 2014-02-26 Boehringer Ingelheim International GmbH Tetrazole compounds which selectively modulate the cb2 receptor
JP5746764B2 (ja) 2010-07-22 2015-07-08 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｃｂ２受容体を調節する化合物
EP2803668A1 (en) 2013-05-17 2014-11-19 Boehringer Ingelheim International Gmbh Novel (cyano-dimethyl-methyl)-isoxazoles and -[1,3,4]thiadiazoles

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0396083A1 (en) * 1989-05-01 1990-11-07 Schering Corporation Heterocyclic N-oxide derivatives of substituted benzo[5,6]cycloheptapyridines, compositions and methods of use
WO1992000293A1 (en) * 1990-06-22 1992-01-09 Schering Corporation Bis-benzo or benzopyrido cyclo hepta piperidene, piperidylidene and piperazine compounds and compositions

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1593417A (en) * 1976-12-22 1981-07-15 Squibb & Sons Inc Carbocyclic-fused pyrazolopyridine derivatives
SG48750A1 (en) * 1993-10-15 1998-05-18 Schering Corp Tricyclic carbonate compounds useful for inhabition of g-protein function for treatment of proliferative diseases
IL111235A (en) * 1993-10-15 2001-03-19 Schering Plough Corp Medicinal preparations for inhibiting protein G activity and for the treatment of malignant diseases, containing tricyclic compounds, some such new compounds and a process for the preparation of some of them

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0396083A1 (en) * 1989-05-01 1990-11-07 Schering Corporation Heterocyclic N-oxide derivatives of substituted benzo[5,6]cycloheptapyridines, compositions and methods of use
WO1992000293A1 (en) * 1990-06-22 1992-01-09 Schering Corporation Bis-benzo or benzopyrido cyclo hepta piperidene, piperidylidene and piperazine compounds and compositions

Also Published As

Publication number Publication date
JP2001500506A (ja) 2001-01-16
IL128926A0 (en) 2000-02-17
CN1236365A (zh) 1999-11-24
DE69733142D1 (de) 2005-06-02
EP0931077B1 (en) 2005-04-27
ATE294172T1 (de) 2005-05-15
CA2264666A1 (en) 1998-03-19
EP0931077A1 (en) 1999-07-28
NZ334341A (en) 2001-01-26
DE69733142T2 (de) 2006-03-16
HUP0000073A2 (hu) 2001-10-28
ES2242232T3 (es) 2005-11-01
WO1998011097A1 (en) 1998-03-19
KR20000036102A (ko) 2000-06-26
HUP0000073A3 (en) 2002-02-28
AU4337597A (en) 1998-04-02

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