ATE248831T1 - Benzo(5,6)cyclohepta(1,2b)pyridine derivate anwendbar als farnesyl protein transferase inhibitoren - Google Patents

Benzo(5,6)cyclohepta(1,2b)pyridine derivate anwendbar als farnesyl protein transferase inhibitoren

Info

Publication number
ATE248831T1
ATE248831T1 AT98926277T AT98926277T ATE248831T1 AT E248831 T1 ATE248831 T1 AT E248831T1 AT 98926277 T AT98926277 T AT 98926277T AT 98926277 T AT98926277 T AT 98926277T AT E248831 T1 ATE248831 T1 AT E248831T1
Authority
AT
Austria
Prior art keywords
protein transferase
cyclohepta
farnesyl protein
benzo
pyridine derivatives
Prior art date
Application number
AT98926277T
Other languages
English (en)
Inventor
Alan B Cooper
Ronald J Doll
Anil K Saksena
Viyyoor M Girijavallabhan
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Application granted granted Critical
Publication of ATE248831T1 publication Critical patent/ATE248831T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT98926277T 1997-06-17 1998-06-15 Benzo(5,6)cyclohepta(1,2b)pyridine derivate anwendbar als farnesyl protein transferase inhibitoren ATE248831T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US87745797A 1997-06-17 1997-06-17
PCT/US1998/011497 WO1998057944A1 (en) 1997-06-17 1998-06-15 Benzo(5,6)cyclohepta(1,2b)pyridine derivatives useful for inhibition of farnesyl protein transferase

Publications (1)

Publication Number Publication Date
ATE248831T1 true ATE248831T1 (de) 2003-09-15

Family

ID=25370002

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98926277T ATE248831T1 (de) 1997-06-17 1998-06-15 Benzo(5,6)cyclohepta(1,2b)pyridine derivate anwendbar als farnesyl protein transferase inhibitoren

Country Status (14)

Country Link
EP (1) EP0993454B1 (de)
JP (1) JP2002504146A (de)
KR (1) KR20010013882A (de)
CN (1) CN1267293A (de)
AT (1) ATE248831T1 (de)
AU (1) AU754066B2 (de)
CA (1) CA2293373C (de)
DE (1) DE69817826T2 (de)
ES (1) ES2205501T3 (de)
HK (1) HK1028239A1 (de)
HU (1) HUP0002863A3 (de)
IL (1) IL133391A0 (de)
NZ (1) NZ501614A (de)
WO (1) WO1998057944A1 (de)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993020080A1 (en) * 1992-03-27 1993-10-14 Schering Corporation Bridged bis-aryl carbinol derivatives, compositions and methods of use
IL111258A0 (en) * 1993-10-15 1994-12-29 Schering Corp Tricyclic carbamate compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
US5719148A (en) * 1993-10-15 1998-02-17 Schering Corporation Tricyclic amide and urea compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
US5700806A (en) * 1995-03-24 1997-12-23 Schering Corporation Tricyclic amide and urea compounds useful for inhibition of G-protein function and for treatment of proliferative diseases

Also Published As

Publication number Publication date
HUP0002863A3 (en) 2001-04-28
IL133391A0 (en) 2001-04-30
AU7815298A (en) 1999-01-04
CN1267293A (zh) 2000-09-20
DE69817826T2 (de) 2004-07-15
AU754066B2 (en) 2002-11-07
KR20010013882A (ko) 2001-02-26
DE69817826D1 (de) 2003-10-09
HK1028239A1 (en) 2001-02-09
ES2205501T3 (es) 2004-05-01
JP2002504146A (ja) 2002-02-05
CA2293373A1 (en) 1998-12-23
HUP0002863A2 (hu) 2001-01-29
NZ501614A (en) 2001-10-26
EP0993454A1 (de) 2000-04-19
EP0993454B1 (de) 2003-09-03
WO1998057944A1 (en) 1998-12-23
CA2293373C (en) 2008-09-23

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Legal Events

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