TR200000114T2 - Farnesil protein transferazı'nın önlenmesine mahsus benzo(5,6)siklohepta(1,2-B)piridin türevleri. - Google Patents

Farnesil protein transferazı'nın önlenmesine mahsus benzo(5,6)siklohepta(1,2-B)piridin türevleri.

Info

Publication number
TR200000114T2
TR200000114T2 TR2000/00114T TR200000114T TR200000114T2 TR 200000114 T2 TR200000114 T2 TR 200000114T2 TR 2000/00114 T TR2000/00114 T TR 2000/00114T TR 200000114 T TR200000114 T TR 200000114T TR 200000114 T2 TR200000114 T2 TR 200000114T2
Authority
TR
Turkey
Prior art keywords
prevention
formula
cyclohepta
benzo
protein transferase
Prior art date
Application number
TR2000/00114T
Other languages
English (en)
Inventor
J. Doll Ronald
M. Kelly Joseph
K. Mallams Alan
George Njoroge F.
W. Remiszewski Stacy
G. Taveras Arthur
Original Assignee
Schering Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corporation filed Critical Schering Corporation
Publication of TR200000114T2 publication Critical patent/TR200000114T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

(Formül(I), (Formül(II), Formül(III), Formül(IV), Formül(V), Formül(VI)); Formüller, (I), (II), (III), (IV), (V) ve (VI) gibi, yeni bilesikler açiklanmaktadir. Ayni zamanda açiklanan, hücrelerin anormal büyümesinin önlenmesine mahsus, farnesil protein transferazi'nin önlenmesine mahsus ve yeni bilesiklerin kullanilmasi ile kanser hastaliklarinin tedavi edilmesine mahsus yöntemlerdir.
TR2000/00114T 1997-06-17 1998-06-15 Farnesil protein transferazı'nın önlenmesine mahsus benzo(5,6)siklohepta(1,2-B)piridin türevleri. TR200000114T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US87705797A 1997-06-17 1997-06-17

Publications (1)

Publication Number Publication Date
TR200000114T2 true TR200000114T2 (tr) 2000-08-21

Family

ID=25369159

Family Applications (2)

Application Number Title Priority Date Filing Date
TR2000/03580T TR200003580T2 (tr) 1997-06-17 1998-06-15 Farnesil protein transferazı'nın önlenmesine mahsus benzo(5,6)siklohepta(1,2-B)piridin türevleri
TR2000/00114T TR200000114T2 (tr) 1997-06-17 1998-06-15 Farnesil protein transferazı'nın önlenmesine mahsus benzo(5,6)siklohepta(1,2-B)piridin türevleri.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
TR2000/03580T TR200003580T2 (tr) 1997-06-17 1998-06-15 Farnesil protein transferazı'nın önlenmesine mahsus benzo(5,6)siklohepta(1,2-B)piridin türevleri

Country Status (30)

Country Link
EP (2) EP1156046A1 (tr)
JP (1) JP2002504148A (tr)
KR (1) KR100588799B1 (tr)
CN (1) CN1131228C (tr)
AR (1) AR016074A1 (tr)
AT (1) ATE222905T1 (tr)
AU (1) AU753863B2 (tr)
BR (1) BR9811470A (tr)
CA (1) CA2294347C (tr)
CO (1) CO4940455A1 (tr)
CZ (1) CZ297450B6 (tr)
DE (1) DE69807477T2 (tr)
DK (1) DK0988300T3 (tr)
ES (1) ES2178224T3 (tr)
HK (1) HK1022908A1 (tr)
HU (1) HUP0003046A3 (tr)
ID (1) ID30349A (tr)
IL (2) IL133449A0 (tr)
MY (1) MY117925A (tr)
NO (1) NO318938B1 (tr)
NZ (1) NZ501618A (tr)
PE (1) PE83799A1 (tr)
PL (1) PL191866B1 (tr)
PT (1) PT988300E (tr)
RU (1) RU2220139C2 (tr)
SK (1) SK283820B6 (tr)
TR (2) TR200003580T2 (tr)
TW (1) TW544451B (tr)
WO (1) WO1998057959A1 (tr)
ZA (1) ZA985210B (tr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9911869A (pt) 1998-07-06 2001-03-27 Janssen Pharmaceutica Nv Inibidores da transferase da proteìna farnesil para o tratamento das artropatias
US7342016B2 (en) 2000-08-30 2008-03-11 Schering Corporation Farnesyl protein transferase inhibitors as antitumor agents
AU3514302A (en) * 2000-11-29 2002-06-11 Schering Corp 0ovel farnesyl protein transferase inhibitors

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5089496A (en) * 1986-10-31 1992-02-18 Schering Corporation Benzo[5,6]cycloheptapyridine compounds, compositions and method of treating allergies
US4826853A (en) * 1986-10-31 1989-05-02 Schering Corporation 6,11-Dihydro-11-(N-substituted-4-piperidylidene)-5H-benzo(5,6)cyclohepta(1,2-B)pyridines and compositions and methods of use
US5719148A (en) * 1993-10-15 1998-02-17 Schering Corporation Tricyclic amide and urea compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
IL111235A (en) * 1993-10-15 2001-03-19 Schering Plough Corp Medicinal preparations for inhibiting protein G activity and for the treatment of malignant diseases, containing tricyclic compounds, some such new compounds and a process for the preparation of some of them

Also Published As

Publication number Publication date
NO318938B1 (no) 2005-05-30
WO1998057959A1 (en) 1998-12-23
KR100588799B1 (ko) 2006-06-13
PT988300E (pt) 2002-12-31
PE83799A1 (es) 1999-10-23
DE69807477D1 (de) 2002-10-02
MY117925A (en) 2004-08-30
EP0988300B1 (en) 2002-08-28
CA2294347A1 (en) 1998-12-23
AU753863B2 (en) 2002-10-31
ES2178224T3 (es) 2002-12-16
TR200003580T2 (tr) 2002-10-21
EP1156046A1 (en) 2001-11-21
IL133449A0 (en) 2001-04-30
BR9811470A (pt) 2000-09-19
HUP0003046A3 (en) 2002-11-28
RU2220139C2 (ru) 2003-12-27
CA2294347C (en) 2008-01-29
CN1131228C (zh) 2003-12-17
NO996236L (no) 2000-02-01
CN1267294A (zh) 2000-09-20
JP2002504148A (ja) 2002-02-05
HK1022908A1 (en) 2000-08-25
TW544451B (en) 2003-08-01
IL133449A (en) 2006-12-10
NZ501618A (en) 2001-10-26
PL191866B1 (pl) 2006-07-31
CZ297450B6 (cs) 2006-12-13
PL337481A1 (en) 2000-08-28
DK0988300T3 (da) 2002-11-25
CO4940455A1 (es) 2000-07-24
AR016074A1 (es) 2001-06-20
ZA985210B (en) 1999-01-07
EP0988300A1 (en) 2000-03-29
SK283820B6 (sk) 2004-02-03
NO996236D0 (no) 1999-12-16
AU8058298A (en) 1999-01-04
SK182499A3 (en) 2000-09-12
DE69807477T2 (de) 2003-02-27
HUP0003046A2 (hu) 2001-06-28
ID30349A (id) 2001-11-22
ATE222905T1 (de) 2002-09-15
CZ447199A3 (cs) 2000-06-14
KR20010013948A (ko) 2001-02-26

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