ES2178224T3 - Derivados de benzo (5,6)ciclohepta(1,2-b)piridina para la inhibicion de la farnesil proteina transferasa. - Google Patents

Derivados de benzo (5,6)ciclohepta(1,2-b)piridina para la inhibicion de la farnesil proteina transferasa.

Info

Publication number
ES2178224T3
ES2178224T3 ES98928888T ES98928888T ES2178224T3 ES 2178224 T3 ES2178224 T3 ES 2178224T3 ES 98928888 T ES98928888 T ES 98928888T ES 98928888 T ES98928888 T ES 98928888T ES 2178224 T3 ES2178224 T3 ES 2178224T3
Authority
ES
Spain
Prior art keywords
protein transferase
ciclohepta
piridine
inhibition
benzo derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES98928888T
Other languages
English (en)
Inventor
Ronald J Doll
Joseph M Kelly
Alan K Mallams
F George Njoroge
Stacy W Remiszewski
Arthur G Taveras
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme Corp
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Application granted granted Critical
Publication of ES2178224T3 publication Critical patent/ES2178224T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

La invención se refiere a los nuevos compuestos, tales como los de la fórmula (I), (II), (III), (IV), (V) y (VI). También se refiere a procedimientos para inhibir el anormal crecimiento de células para inhibir la farnesil protein transferasa y para el tratamiento de cánceres empleando los nuevos compuestos.
ES98928888T 1997-06-17 1998-06-15 Derivados de benzo (5,6)ciclohepta(1,2-b)piridina para la inhibicion de la farnesil proteina transferasa. Expired - Lifetime ES2178224T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US87705797A 1997-06-17 1997-06-17

Publications (1)

Publication Number Publication Date
ES2178224T3 true ES2178224T3 (es) 2002-12-16

Family

ID=25369159

Family Applications (1)

Application Number Title Priority Date Filing Date
ES98928888T Expired - Lifetime ES2178224T3 (es) 1997-06-17 1998-06-15 Derivados de benzo (5,6)ciclohepta(1,2-b)piridina para la inhibicion de la farnesil proteina transferasa.

Country Status (30)

Country Link
EP (2) EP1156046A1 (es)
JP (1) JP2002504148A (es)
KR (1) KR100588799B1 (es)
CN (1) CN1131228C (es)
AR (1) AR016074A1 (es)
AT (1) ATE222905T1 (es)
AU (1) AU753863B2 (es)
BR (1) BR9811470A (es)
CA (1) CA2294347C (es)
CO (1) CO4940455A1 (es)
CZ (1) CZ297450B6 (es)
DE (1) DE69807477T2 (es)
DK (1) DK0988300T3 (es)
ES (1) ES2178224T3 (es)
HK (1) HK1022908A1 (es)
HU (1) HUP0003046A3 (es)
ID (1) ID30349A (es)
IL (2) IL133449A0 (es)
MY (1) MY117925A (es)
NO (1) NO318938B1 (es)
NZ (1) NZ501618A (es)
PE (1) PE83799A1 (es)
PL (1) PL191866B1 (es)
PT (1) PT988300E (es)
RU (1) RU2220139C2 (es)
SK (1) SK283820B6 (es)
TR (2) TR200003580T2 (es)
TW (1) TW544451B (es)
WO (1) WO1998057959A1 (es)
ZA (1) ZA985210B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9911869A (pt) 1998-07-06 2001-03-27 Janssen Pharmaceutica Nv Inibidores da transferase da proteìna farnesil para o tratamento das artropatias
US7342016B2 (en) 2000-08-30 2008-03-11 Schering Corporation Farnesyl protein transferase inhibitors as antitumor agents
AU3514302A (en) * 2000-11-29 2002-06-11 Schering Corp 0ovel farnesyl protein transferase inhibitors

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5089496A (en) * 1986-10-31 1992-02-18 Schering Corporation Benzo[5,6]cycloheptapyridine compounds, compositions and method of treating allergies
US4826853A (en) * 1986-10-31 1989-05-02 Schering Corporation 6,11-Dihydro-11-(N-substituted-4-piperidylidene)-5H-benzo(5,6)cyclohepta(1,2-B)pyridines and compositions and methods of use
US5719148A (en) * 1993-10-15 1998-02-17 Schering Corporation Tricyclic amide and urea compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
IL111235A (en) * 1993-10-15 2001-03-19 Schering Plough Corp Medicinal preparations for inhibiting protein G activity and for the treatment of malignant diseases, containing tricyclic compounds, some such new compounds and a process for the preparation of some of them

Also Published As

Publication number Publication date
NO318938B1 (no) 2005-05-30
WO1998057959A1 (en) 1998-12-23
KR100588799B1 (ko) 2006-06-13
PT988300E (pt) 2002-12-31
PE83799A1 (es) 1999-10-23
DE69807477D1 (de) 2002-10-02
MY117925A (en) 2004-08-30
EP0988300B1 (en) 2002-08-28
CA2294347A1 (en) 1998-12-23
TR200000114T2 (tr) 2000-08-21
AU753863B2 (en) 2002-10-31
TR200003580T2 (tr) 2002-10-21
EP1156046A1 (en) 2001-11-21
IL133449A0 (en) 2001-04-30
BR9811470A (pt) 2000-09-19
HUP0003046A3 (en) 2002-11-28
RU2220139C2 (ru) 2003-12-27
CA2294347C (en) 2008-01-29
CN1131228C (zh) 2003-12-17
NO996236L (no) 2000-02-01
CN1267294A (zh) 2000-09-20
JP2002504148A (ja) 2002-02-05
HK1022908A1 (en) 2000-08-25
TW544451B (en) 2003-08-01
IL133449A (en) 2006-12-10
NZ501618A (en) 2001-10-26
PL191866B1 (pl) 2006-07-31
CZ297450B6 (cs) 2006-12-13
PL337481A1 (en) 2000-08-28
DK0988300T3 (da) 2002-11-25
CO4940455A1 (es) 2000-07-24
AR016074A1 (es) 2001-06-20
ZA985210B (en) 1999-01-07
EP0988300A1 (en) 2000-03-29
SK283820B6 (sk) 2004-02-03
NO996236D0 (no) 1999-12-16
AU8058298A (en) 1999-01-04
SK182499A3 (en) 2000-09-12
DE69807477T2 (de) 2003-02-27
HUP0003046A2 (hu) 2001-06-28
ID30349A (id) 2001-11-22
ATE222905T1 (de) 2002-09-15
CZ447199A3 (cs) 2000-06-14
KR20010013948A (ko) 2001-02-26

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