CO4940455A1 - Compuestos para la inhibicion de la transferasa de proteina de farnesilo - Google Patents

Compuestos para la inhibicion de la transferasa de proteina de farnesilo

Info

Publication number
CO4940455A1
CO4940455A1 CO98034141A CO98034141A CO4940455A1 CO 4940455 A1 CO4940455 A1 CO 4940455A1 CO 98034141 A CO98034141 A CO 98034141A CO 98034141 A CO98034141 A CO 98034141A CO 4940455 A1 CO4940455 A1 CO 4940455A1
Authority
CO
Colombia
Prior art keywords
compounds
farnesilo
inhibition
protein transfer
inhibiting
Prior art date
Application number
CO98034141A
Other languages
English (en)
Inventor
Arthur G Taveras
Ronald J Doll
Joseph M Kelly
Alan K Mallams
George F Njoroge
W Remiszewski Stacy
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of CO4940455A1 publication Critical patent/CO4940455A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Un compuesto seleccionado de:También se describen los métodos para inhibir el crecimiento anormal de células, para inhibir la transferasa de proteína de farnesilo y para tratar cánceres usando los nuevos compuestos.
CO98034141A 1997-06-17 1998-06-16 Compuestos para la inhibicion de la transferasa de proteina de farnesilo CO4940455A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US87705797A 1997-06-17 1997-06-17

Publications (1)

Publication Number Publication Date
CO4940455A1 true CO4940455A1 (es) 2000-07-24

Family

ID=25369159

Family Applications (1)

Application Number Title Priority Date Filing Date
CO98034141A CO4940455A1 (es) 1997-06-17 1998-06-16 Compuestos para la inhibicion de la transferasa de proteina de farnesilo

Country Status (30)

Country Link
EP (2) EP0988300B1 (es)
JP (1) JP2002504148A (es)
KR (1) KR100588799B1 (es)
CN (1) CN1131228C (es)
AR (1) AR016074A1 (es)
AT (1) ATE222905T1 (es)
AU (1) AU753863B2 (es)
BR (1) BR9811470A (es)
CA (1) CA2294347C (es)
CO (1) CO4940455A1 (es)
CZ (1) CZ297450B6 (es)
DE (1) DE69807477T2 (es)
DK (1) DK0988300T3 (es)
ES (1) ES2178224T3 (es)
HK (1) HK1022908A1 (es)
HU (1) HUP0003046A3 (es)
ID (1) ID30349A (es)
IL (2) IL133449A0 (es)
MY (1) MY117925A (es)
NO (1) NO318938B1 (es)
NZ (1) NZ501618A (es)
PE (1) PE83799A1 (es)
PL (1) PL191866B1 (es)
PT (1) PT988300E (es)
RU (1) RU2220139C2 (es)
SK (1) SK283820B6 (es)
TR (2) TR200003580T2 (es)
TW (1) TW544451B (es)
WO (1) WO1998057959A1 (es)
ZA (1) ZA985210B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9911869A (pt) 1998-07-06 2001-03-27 Janssen Pharmaceutica Nv Inibidores da transferase da proteìna farnesil para o tratamento das artropatias
US7342016B2 (en) 2000-08-30 2008-03-11 Schering Corporation Farnesyl protein transferase inhibitors as antitumor agents
JP2004514717A (ja) * 2000-11-29 2004-05-20 シェーリング　コーポレイション 新規ファルネシルプロテイントランスフェラーゼインヒビター

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4826853A (en) * 1986-10-31 1989-05-02 Schering Corporation 6,11-Dihydro-11-(N-substituted-4-piperidylidene)-5H-benzo(5,6)cyclohepta(1,2-B)pyridines and compositions and methods of use
US5089496A (en) * 1986-10-31 1992-02-18 Schering Corporation Benzo[5,6]cycloheptapyridine compounds, compositions and method of treating allergies
IL111235A (en) * 1993-10-15 2001-03-19 Schering Plough Corp Medicinal preparations for inhibiting protein G activity and for the treatment of malignant diseases, containing tricyclic compounds, some such new compounds and a process for the preparation of some of them
US5719148A (en) * 1993-10-15 1998-02-17 Schering Corporation Tricyclic amide and urea compounds useful for inhibition of g-protein function and for treatment of proliferative diseases

Also Published As

Publication number Publication date
HUP0003046A3 (en) 2002-11-28
PL337481A1 (en) 2000-08-28
BR9811470A (pt) 2000-09-19
TR200003580T2 (tr) 2002-10-21
SK182499A3 (en) 2000-09-12
WO1998057959A1 (en) 1998-12-23
CZ297450B6 (cs) 2006-12-13
KR100588799B1 (ko) 2006-06-13
AR016074A1 (es) 2001-06-20
KR20010013948A (ko) 2001-02-26
HUP0003046A2 (hu) 2001-06-28
NO996236D0 (no) 1999-12-16
IL133449A0 (en) 2001-04-30
DE69807477T2 (de) 2003-02-27
DK0988300T3 (da) 2002-11-25
CZ447199A3 (cs) 2000-06-14
CN1267294A (zh) 2000-09-20
JP2002504148A (ja) 2002-02-05
PT988300E (pt) 2002-12-31
IL133449A (en) 2006-12-10
NO996236L (no) 2000-02-01
PE83799A1 (es) 1999-10-23
EP1156046A1 (en) 2001-11-21
CN1131228C (zh) 2003-12-17
MY117925A (en) 2004-08-30
ES2178224T3 (es) 2002-12-16
NZ501618A (en) 2001-10-26
ID30349A (id) 2001-11-22
ATE222905T1 (de) 2002-09-15
PL191866B1 (pl) 2006-07-31
DE69807477D1 (de) 2002-10-02
HK1022908A1 (en) 2000-08-25
TR200000114T2 (tr) 2000-08-21
AU753863B2 (en) 2002-10-31
AU8058298A (en) 1999-01-04
EP0988300A1 (en) 2000-03-29
EP0988300B1 (en) 2002-08-28
TW544451B (en) 2003-08-01
RU2220139C2 (ru) 2003-12-27
CA2294347C (en) 2008-01-29
NO318938B1 (no) 2005-05-30
SK283820B6 (sk) 2004-02-03
CA2294347A1 (en) 1998-12-23
ZA985210B (en) 1999-01-07

Similar Documents

Publication Publication Date Title
ATE286046T1 (de) Trizyklische inhibitoren der farnesyl protein transferase
PT904274E (pt) Inibidores da farnesil transferase
IL128931A0 (en) Tricylic antitumor compounds being farnesyl protein transferase inhibitors
ATE181737T1 (de) Cck oder gastrin modulierende 5-heterocyclicyl- 1,5-benzodiazepine
BR9712980A (pt) Compostos úteis para inibição de transferase de proteina de farnesila
BR9711477A (pt) Derivado de benzocicloheptapiridina substituida Úteis para inibi-Æo de transferase de farnesila
CO4940455A1 (es) Compuestos para la inhibicion de la transferasa de proteina de farnesilo
ZA985211B (en) Benzo (5,6) cycloheptapyridine compounds useful as farnesyl protein transferase inhibitors
IL189502A0 (en) Methods and compositions for inhibiting neoplastic cell growth
ECSP982537A (es) Compuestos para la inhibicion de la transferasa de proteina de farnesilo (case in0747k)
MX9705893A (es) NUEVO INHIBIDORES DE LA beta-GLUCURONIDASA.
SE9602416D0 (sv) New forms of an organic salt of N'N-diacetylcystine
NO991231D0 (no) Forbindelser for inhibering av farnesylproteintransferase
ATE247106T1 (de) Substituierte benzocycloheptapyridine derivate verwendbar als farnesyl protein transferase inhibitoren
ES1035685Y (es) Inserto para el sellado de lingoteras.