ID30349A - Turunan benzo (5,6) siklohepta (1,2-b) piridin untuk menghambat transferase protein farnesil - Google Patents

Turunan benzo (5,6) siklohepta (1,2-b) piridin untuk menghambat transferase protein farnesil

Info

Publication number
ID30349A
ID30349A IDW991624A ID991624A ID30349A ID 30349 A ID30349 A ID 30349A ID W991624 A IDW991624 A ID W991624A ID 991624 A ID991624 A ID 991624A ID 30349 A ID30349 A ID 30349A
Authority
ID
Indonesia
Prior art keywords
cyclohepta
transferase
benzo
pyridine
block
Prior art date
Application number
IDW991624A
Other languages
English (en)
Inventor
Ronald J Doll
Joseph M Kelly
Alan K Mallams
George F Njoroge
Stacy W Remiszewski
Arthur G Taveras
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of ID30349A publication Critical patent/ID30349A/id

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IDW991624A 1997-06-17 1998-06-15 Turunan benzo (5,6) siklohepta (1,2-b) piridin untuk menghambat transferase protein farnesil ID30349A (id)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US87705797A 1997-06-17 1997-06-17

Publications (1)

Publication Number Publication Date
ID30349A true ID30349A (id) 2001-11-22

Family

ID=25369159

Family Applications (1)

Application Number Title Priority Date Filing Date
IDW991624A ID30349A (id) 1997-06-17 1998-06-15 Turunan benzo (5,6) siklohepta (1,2-b) piridin untuk menghambat transferase protein farnesil

Country Status (30)

Country Link
EP (2) EP0988300B1 (id)
JP (1) JP2002504148A (id)
KR (1) KR100588799B1 (id)
CN (1) CN1131228C (id)
AR (1) AR016074A1 (id)
AT (1) ATE222905T1 (id)
AU (1) AU753863B2 (id)
BR (1) BR9811470A (id)
CA (1) CA2294347C (id)
CO (1) CO4940455A1 (id)
CZ (1) CZ297450B6 (id)
DE (1) DE69807477T2 (id)
DK (1) DK0988300T3 (id)
ES (1) ES2178224T3 (id)
HK (1) HK1022908A1 (id)
HU (1) HUP0003046A3 (id)
ID (1) ID30349A (id)
IL (2) IL133449A0 (id)
MY (1) MY117925A (id)
NO (1) NO318938B1 (id)
NZ (1) NZ501618A (id)
PE (1) PE83799A1 (id)
PL (1) PL191866B1 (id)
PT (1) PT988300E (id)
RU (1) RU2220139C2 (id)
SK (1) SK283820B6 (id)
TR (2) TR200003580T2 (id)
TW (1) TW544451B (id)
WO (1) WO1998057959A1 (id)
ZA (1) ZA985210B (id)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9911869A (pt) 1998-07-06 2001-03-27 Janssen Pharmaceutica Nv Inibidores da transferase da proteìna farnesil para o tratamento das artropatias
US7342016B2 (en) 2000-08-30 2008-03-11 Schering Corporation Farnesyl protein transferase inhibitors as antitumor agents
JP2004514717A (ja) * 2000-11-29 2004-05-20 シェーリング コーポレイション 新規ファルネシルプロテイントランスフェラーゼインヒビター

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4826853A (en) * 1986-10-31 1989-05-02 Schering Corporation 6,11-Dihydro-11-(N-substituted-4-piperidylidene)-5H-benzo(5,6)cyclohepta(1,2-B)pyridines and compositions and methods of use
US5089496A (en) * 1986-10-31 1992-02-18 Schering Corporation Benzo[5,6]cycloheptapyridine compounds, compositions and method of treating allergies
IL111235A (en) * 1993-10-15 2001-03-19 Schering Plough Corp Medicinal preparations for inhibiting protein G activity and for the treatment of malignant diseases, containing tricyclic compounds, some such new compounds and a process for the preparation of some of them
US5719148A (en) * 1993-10-15 1998-02-17 Schering Corporation Tricyclic amide and urea compounds useful for inhibition of g-protein function and for treatment of proliferative diseases

Also Published As

Publication number Publication date
HUP0003046A3 (en) 2002-11-28
PL337481A1 (en) 2000-08-28
BR9811470A (pt) 2000-09-19
TR200003580T2 (tr) 2002-10-21
SK182499A3 (en) 2000-09-12
WO1998057959A1 (en) 1998-12-23
CZ297450B6 (cs) 2006-12-13
KR100588799B1 (ko) 2006-06-13
AR016074A1 (es) 2001-06-20
KR20010013948A (ko) 2001-02-26
HUP0003046A2 (hu) 2001-06-28
NO996236D0 (no) 1999-12-16
IL133449A0 (en) 2001-04-30
DE69807477T2 (de) 2003-02-27
DK0988300T3 (da) 2002-11-25
CZ447199A3 (cs) 2000-06-14
CN1267294A (zh) 2000-09-20
JP2002504148A (ja) 2002-02-05
PT988300E (pt) 2002-12-31
IL133449A (en) 2006-12-10
NO996236L (no) 2000-02-01
PE83799A1 (es) 1999-10-23
EP1156046A1 (en) 2001-11-21
CN1131228C (zh) 2003-12-17
MY117925A (en) 2004-08-30
ES2178224T3 (es) 2002-12-16
NZ501618A (en) 2001-10-26
ATE222905T1 (de) 2002-09-15
PL191866B1 (pl) 2006-07-31
DE69807477D1 (de) 2002-10-02
HK1022908A1 (en) 2000-08-25
TR200000114T2 (tr) 2000-08-21
AU753863B2 (en) 2002-10-31
AU8058298A (en) 1999-01-04
EP0988300A1 (en) 2000-03-29
EP0988300B1 (en) 2002-08-28
TW544451B (en) 2003-08-01
RU2220139C2 (ru) 2003-12-27
CA2294347C (en) 2008-01-29
NO318938B1 (no) 2005-05-30
SK283820B6 (sk) 2004-02-03
CO4940455A1 (es) 2000-07-24
CA2294347A1 (en) 1998-12-23
ZA985210B (en) 1999-01-07

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