MX9705893A - NUEVO INHIBIDORES DE LA beta-GLUCURONIDASA. - Google Patents

NUEVO INHIBIDORES DE LA beta-GLUCURONIDASA.

Info

Publication number
MX9705893A
MX9705893A MX9705893A MX9705893A MX9705893A MX 9705893 A MX9705893 A MX 9705893A MX 9705893 A MX9705893 A MX 9705893A MX 9705893 A MX9705893 A MX 9705893A MX 9705893 A MX9705893 A MX 9705893A
Authority
MX
Mexico
Prior art keywords
glucoronidase
inhibitors
new beta
tumors
beta
Prior art date
Application number
MX9705893A
Other languages
English (en)
Inventor
Klaus Bosslet
Jorg Czech
Andreas Vasella
Roland Hoos
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of MX9705893A publication Critical patent/MX9705893A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D211/78—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/02—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/59—Hydrogenated pyridine rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/6552—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a six-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrane Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

Los compuestos de las formulas I y II, se adecuan para la represion del crecimiento de tumores así como de la metastatizacion de tumores.
MX9705893A 1996-08-02 1997-08-01 NUEVO INHIBIDORES DE LA beta-GLUCURONIDASA. MX9705893A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19631288A DE19631288A1 (de) 1996-08-02 1996-08-02 Neue Inhibitoren der ß-Glucuronidase

Publications (1)

Publication Number Publication Date
MX9705893A true MX9705893A (es) 1998-02-28

Family

ID=7801634

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9705893A MX9705893A (es) 1996-08-02 1997-08-01 NUEVO INHIBIDORES DE LA beta-GLUCURONIDASA.

Country Status (11)

Country Link
US (1) US5817800A (es)
EP (1) EP0822192B1 (es)
JP (1) JP4203133B2 (es)
AT (1) ATE207067T1 (es)
AU (1) AU717219B2 (es)
CA (1) CA2212200C (es)
DE (2) DE19631288A1 (es)
DK (1) DK0822192T3 (es)
ES (1) ES2166031T3 (es)
MX (1) MX9705893A (es)
PT (1) PT822192E (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19925810A1 (de) * 1999-06-07 2000-12-14 Paz Arzneimittelentwicklung Anwendung von Verapamil und Verapamilderivaten zur Herstellung von Arzneimitteln mit Glucuronidase hemmender Wirkung
EP2544535B1 (en) 2010-03-10 2017-04-19 North Carolina Central University Phenoxy thiophene sulfonamides and their use as inhibitors of glucuronidase
CN103613619B (zh) * 2013-12-13 2016-02-17 沈阳药科大学 N-4-苯磺酰胺基-N’-1-脱氧-β-D-吡喃葡萄糖醛酸基-硫脲化合物的制备方法及医药用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3903289A (en) * 1971-10-06 1975-09-02 Diamond Shamrock Corp 4-Methyl-3-methylcarbamyloximinotetra-hydrothiapyran used to control insects and acarids
US5231185A (en) * 1985-11-19 1993-07-27 Cornell Research Foundation, Inc. Monosaccharide analog-based glycosidase inhibitors
ATE89563T1 (de) * 1986-08-13 1993-06-15 Hoechst Ag Oxiran-pseudooligosaccharide, verfahren zu deren herstellung, deren verwendung und pharmazeutische praeparate.
CA2037767A1 (en) * 1990-03-23 1991-09-24 Mark D. Wittman Conversion of amines to hydroxylamines
EP0647450A1 (en) * 1993-09-09 1995-04-12 BEHRINGWERKE Aktiengesellschaft Improved prodrugs for enzyme mediated activation

Also Published As

Publication number Publication date
PT822192E (pt) 2002-03-28
JPH1077279A (ja) 1998-03-24
ES2166031T3 (es) 2002-04-01
US5817800A (en) 1998-10-06
DK0822192T3 (da) 2002-02-11
CA2212200A1 (en) 1998-02-02
EP0822192A3 (en) 1998-03-18
EP0822192B1 (de) 2001-10-17
EP0822192A2 (de) 1998-02-04
AU717219B2 (en) 2000-03-23
ATE207067T1 (de) 2001-11-15
DE19631288A1 (de) 1998-02-05
JP4203133B2 (ja) 2008-12-24
CA2212200C (en) 2007-05-22
AU3241997A (en) 1998-02-12
DE59704940D1 (de) 2001-11-22

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