BR0110087A - Compostos para modular proliferação celular - Google Patents
Compostos para modular proliferação celularInfo
- Publication number
- BR0110087A BR0110087A BR0110087-4A BR0110087A BR0110087A BR 0110087 A BR0110087 A BR 0110087A BR 0110087 A BR0110087 A BR 0110087A BR 0110087 A BR0110087 A BR 0110087A
- Authority
- BR
- Brazil
- Prior art keywords
- compounds
- cell proliferation
- modulate cell
- modulate
- styrylacrylonitrile
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 230000004663 cell proliferation Effects 0.000 title abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000002062 proliferating effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
- C07C255/42—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being further bound to other hetero atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
- C07C255/41—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by carboxyl groups, other than cyano groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C327/00—Thiocarboxylic acids
- C07C327/38—Amides of thiocarboxylic acids
- C07C327/40—Amides of thiocarboxylic acids having carbon atoms of thiocarboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C327/44—Amides of thiocarboxylic acids having carbon atoms of thiocarboxamide groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of an unsaturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
- C07C45/29—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups
- C07C45/292—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups with chromium derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/582—Recycling of unreacted starting or intermediate materials
Abstract
"COMPOSTOS PARA MODULAR PROLIFERAçãO CELULAR". Compostos de estirilacrilonitrila que são úteis no tratamento de uma variedade de distúrbios proliferativos celulares tais como câncer são divulgados. Os compostos são da Fórmula (I).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US19693600P | 2000-04-13 | 2000-04-13 | |
PCT/CA2001/000516 WO2001079158A2 (en) | 2000-04-13 | 2001-04-12 | Compounds for modulating cell proliferation |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0110087A true BR0110087A (pt) | 2004-02-17 |
Family
ID=22727358
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0110087-4A BR0110087A (pt) | 2000-04-13 | 2001-04-12 | Compostos para modular proliferação celular |
Country Status (18)
Country | Link |
---|---|
US (3) | US6800659B2 (pt) |
EP (1) | EP1272457B9 (pt) |
JP (1) | JP2003531133A (pt) |
CN (1) | CN100413845C (pt) |
AT (1) | ATE337296T1 (pt) |
AU (2) | AU4820101A (pt) |
BR (1) | BR0110087A (pt) |
CA (1) | CA2406160A1 (pt) |
CY (1) | CY1106447T1 (pt) |
DE (1) | DE60122484T2 (pt) |
DK (1) | DK1272457T3 (pt) |
ES (1) | ES2267747T3 (pt) |
GB (1) | GB2378948B (pt) |
HK (1) | HK1052496A1 (pt) |
MX (1) | MXPA02010089A (pt) |
PT (1) | PT1272457E (pt) |
RU (1) | RU2277531C9 (pt) |
WO (1) | WO2001079158A2 (pt) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2378948B (en) | 2000-04-13 | 2004-11-10 | Hsc Res Dev Lp | Novel compounds for modulating cell proliferation |
EP1453500A1 (en) * | 2001-10-11 | 2004-09-08 | The Hospital For Sick Children | Styryl acrylonitrile compounds and their use to promote myelopoiesis |
JP4383885B2 (ja) | 2002-01-18 | 2009-12-16 | ザ・ホスピタル・フォー・シック・チルドレン | 細胞増殖を調節する化合物 |
EP1551381A2 (en) * | 2002-10-11 | 2005-07-13 | The Hospital for Sick Children | Styrylacrylonitrile compounds for inhibition of vascular endothelial growth factor |
CH696238A5 (de) * | 2003-06-30 | 2007-02-28 | Lymphosign Inc | Verfahren zur Herstellung von Zimtaldehydverbindungen. |
EP1654220A4 (en) * | 2003-07-30 | 2006-10-25 | Hospital For Sick Children | COMPOUNDS FOR MODULATING CELL PROLIFERATION |
JP2007530455A (ja) * | 2004-03-26 | 2007-11-01 | エイチエスシー リサーチ アンド ディベロップメント リミテッド パートナーシップ | 細胞増殖を調節する化合物 |
US7807719B2 (en) * | 2004-09-14 | 2010-10-05 | Chaim Roifman | Compounds useful for modulating abnormal cell proliferation |
US7202383B2 (en) | 2004-09-14 | 2007-04-10 | The Hospital For Sick Children | Compounds useful for modulating abnormal cell proliferation |
KR101292026B1 (ko) | 2004-10-25 | 2013-08-01 | 데크-테크 인코포레이티드 | 종양 치료제로서의 이소포스포르아미드 머스타드 및 이의동족체의 염 |
WO2007006143A1 (en) * | 2005-07-13 | 2007-01-18 | The Hospital For Sick Children | Compositions and methods for detecting transformed cells |
US7964583B2 (en) | 2006-02-17 | 2011-06-21 | Ziopharm Oncology, Inc. | Salts of isophosphoramide mustard and analogs thereof as anti-tumor agents |
WO2007146943A2 (en) * | 2006-06-13 | 2007-12-21 | Elan Pharma International Ltd. | Nanoparticulate kinase inhibitor formulations |
DK2155682T3 (en) | 2007-04-06 | 2015-09-21 | Ziopharm Oncology Inc | SALTS OF isophosphoramide mustard and analogs thereof |
US8450337B2 (en) * | 2008-09-30 | 2013-05-28 | Moleculin, Llc | Methods of treating skin disorders with caffeic acid analogs |
JPWO2013027694A1 (ja) * | 2011-08-24 | 2015-03-19 | 国立大学法人京都大学 | コンフォメーション病診断用分子イメージングプローブ |
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GB2378948B (en) | 2000-04-13 | 2004-11-10 | Hsc Res Dev Lp | Novel compounds for modulating cell proliferation |
-
2001
- 2001-04-12 GB GB0226316A patent/GB2378948B/en not_active Expired - Fee Related
- 2001-04-12 CN CNB018089364A patent/CN100413845C/zh not_active Expired - Fee Related
- 2001-04-12 ES ES01921087T patent/ES2267747T3/es not_active Expired - Lifetime
- 2001-04-12 CA CA002406160A patent/CA2406160A1/en not_active Abandoned
- 2001-04-12 EP EP01921087A patent/EP1272457B9/en not_active Expired - Lifetime
- 2001-04-12 JP JP2001576760A patent/JP2003531133A/ja active Pending
- 2001-04-12 MX MXPA02010089A patent/MXPA02010089A/es active IP Right Grant
- 2001-04-12 US US09/834,728 patent/US6800659B2/en not_active Expired - Lifetime
- 2001-04-12 BR BR0110087-4A patent/BR0110087A/pt not_active Application Discontinuation
- 2001-04-12 DE DE60122484T patent/DE60122484T2/de not_active Expired - Lifetime
- 2001-04-12 DK DK01921087T patent/DK1272457T3/da active
- 2001-04-12 RU RU2002127415/04A patent/RU2277531C9/ru not_active IP Right Cessation
- 2001-04-12 WO PCT/CA2001/000516 patent/WO2001079158A2/en active IP Right Grant
- 2001-04-12 AU AU4820101A patent/AU4820101A/xx active Pending
- 2001-04-12 US US10/240,740 patent/US7012095B2/en not_active Expired - Fee Related
- 2001-04-12 PT PT01921087T patent/PT1272457E/pt unknown
- 2001-04-12 AU AU2001248201A patent/AU2001248201B2/en not_active Ceased
- 2001-04-12 AT AT01921087T patent/ATE337296T1/de not_active IP Right Cessation
-
2003
- 2003-07-07 HK HK03104797A patent/HK1052496A1/xx not_active IP Right Cessation
-
2004
- 2004-03-17 US US10/803,607 patent/US20040209845A1/en not_active Abandoned
-
2006
- 2006-11-15 CY CY20061101659T patent/CY1106447T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
HK1052496A1 (en) | 2003-09-19 |
WO2001079158A2 (en) | 2001-10-25 |
AU4820101A (en) | 2001-10-30 |
GB0226316D0 (en) | 2002-12-18 |
RU2002127415A (ru) | 2004-02-27 |
PT1272457E (pt) | 2007-01-31 |
RU2277531C2 (ru) | 2006-06-10 |
GB2378948A (en) | 2003-02-26 |
EP1272457B9 (en) | 2006-12-20 |
AU2001248201B2 (en) | 2006-12-14 |
US20030109502A1 (en) | 2003-06-12 |
US7012095B2 (en) | 2006-03-14 |
CY1106447T1 (el) | 2011-10-12 |
DE60122484T2 (de) | 2006-12-21 |
EP1272457A2 (en) | 2003-01-08 |
DK1272457T3 (da) | 2007-01-08 |
CN100413845C (zh) | 2008-08-27 |
US6800659B2 (en) | 2004-10-05 |
DE60122484D1 (de) | 2006-10-05 |
ES2267747T3 (es) | 2007-03-16 |
US20040072803A1 (en) | 2004-04-15 |
MXPA02010089A (es) | 2004-08-19 |
CN1429202A (zh) | 2003-07-09 |
RU2277531C9 (ru) | 2006-11-20 |
JP2003531133A (ja) | 2003-10-21 |
GB2378948B (en) | 2004-11-10 |
CA2406160A1 (en) | 2001-10-25 |
WO2001079158A3 (en) | 2002-01-31 |
US20040209845A1 (en) | 2004-10-21 |
ATE337296T1 (de) | 2006-09-15 |
EP1272457B1 (en) | 2006-08-23 |
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B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] |
Free format text: DE ACORDO COM ART. 34 " II " DA LPI ( LEI 9279, DE 14/05/96 ) , O EXAME FICA SUSPENSO PARA QUE O REQUERENTE APRESENTE DOCUMENTOS NECESSARIOS A REGULARIZACAO DO PROCESSO E EXAME DO PEDIDO. |
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B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B09B | Patent application refused [chapter 9.2 patent gazette] | ||
B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL. |