BR0110087A - Compostos para modular proliferação celular - Google Patents
Compostos para modular proliferação celularInfo
- Publication number
- BR0110087A BR0110087A BR0110087-4A BR0110087A BR0110087A BR 0110087 A BR0110087 A BR 0110087A BR 0110087 A BR0110087 A BR 0110087A BR 0110087 A BR0110087 A BR 0110087A
- Authority
- BR
- Brazil
- Prior art keywords
- compounds
- cell proliferation
- modulate cell
- modulate
- styrylacrylonitrile
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 230000004663 cell proliferation Effects 0.000 title abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000002062 proliferating effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
- C07C255/42—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being further bound to other hetero atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
- C07C255/41—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by carboxyl groups, other than cyano groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C327/00—Thiocarboxylic acids
- C07C327/38—Amides of thiocarboxylic acids
- C07C327/40—Amides of thiocarboxylic acids having carbon atoms of thiocarboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C327/44—Amides of thiocarboxylic acids having carbon atoms of thiocarboxamide groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of an unsaturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
- C07C45/29—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups
- C07C45/292—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups with chromium derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/582—Recycling of unreacted starting or intermediate materials
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
"COMPOSTOS PARA MODULAR PROLIFERAçãO CELULAR". Compostos de estirilacrilonitrila que são úteis no tratamento de uma variedade de distúrbios proliferativos celulares tais como câncer são divulgados. Os compostos são da Fórmula (I).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US19693600P | 2000-04-13 | 2000-04-13 | |
PCT/CA2001/000516 WO2001079158A2 (en) | 2000-04-13 | 2001-04-12 | Compounds for modulating cell proliferation |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0110087A true BR0110087A (pt) | 2004-02-17 |
Family
ID=22727358
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0110087-4A BR0110087A (pt) | 2000-04-13 | 2001-04-12 | Compostos para modular proliferação celular |
Country Status (18)
Country | Link |
---|---|
US (3) | US7012095B2 (pt) |
EP (1) | EP1272457B9 (pt) |
JP (1) | JP2003531133A (pt) |
CN (1) | CN100413845C (pt) |
AT (1) | ATE337296T1 (pt) |
AU (2) | AU2001248201B2 (pt) |
BR (1) | BR0110087A (pt) |
CA (1) | CA2406160A1 (pt) |
CY (1) | CY1106447T1 (pt) |
DE (1) | DE60122484T2 (pt) |
DK (1) | DK1272457T3 (pt) |
ES (1) | ES2267747T3 (pt) |
GB (1) | GB2378948B (pt) |
HK (1) | HK1052496A1 (pt) |
MX (1) | MXPA02010089A (pt) |
PT (1) | PT1272457E (pt) |
RU (1) | RU2277531C9 (pt) |
WO (1) | WO2001079158A2 (pt) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7012095B2 (en) | 2000-04-13 | 2006-03-14 | Hsc Research And Development Limited | Compounds for modulating cell proliferation |
EP1453500A1 (en) * | 2001-10-11 | 2004-09-08 | The Hospital For Sick Children | Styryl acrylonitrile compounds and their use to promote myelopoiesis |
CN1633411A (zh) * | 2002-01-18 | 2005-06-29 | 儿童医院 | 用于调节细胞增生的化合物 |
AU2003273702A1 (en) * | 2002-10-11 | 2004-05-04 | The Hospital For Sick Children | Styrylacrylonitrile compounds for inhibition of vascular endothelial growth factor |
CH696238A5 (de) * | 2003-06-30 | 2007-02-28 | Lymphosign Inc | Verfahren zur Herstellung von Zimtaldehydverbindungen. |
EP1654220A4 (en) * | 2003-07-30 | 2006-10-25 | Hospital For Sick Children | COMPOUNDS FOR MODULATING CELL PROLIFERATION |
EP1727822A4 (en) * | 2004-03-26 | 2007-05-09 | Hsc Res Dev Lp | NEW COMPOUNDS FOR MODULATING CELL PROLIFERATION |
US7807719B2 (en) * | 2004-09-14 | 2010-10-05 | Chaim Roifman | Compounds useful for modulating abnormal cell proliferation |
US7202383B2 (en) | 2004-09-14 | 2007-04-10 | The Hospital For Sick Children | Compounds useful for modulating abnormal cell proliferation |
US7678778B2 (en) | 2004-10-25 | 2010-03-16 | Dekk-Tec, Inc. | Salts of isophosphoramide mustard and analogs thereof as anti-tumor agents |
WO2007006143A1 (en) * | 2005-07-13 | 2007-01-18 | The Hospital For Sick Children | Compositions and methods for detecting transformed cells |
US7964583B2 (en) | 2006-02-17 | 2011-06-21 | Ziopharm Oncology, Inc. | Salts of isophosphoramide mustard and analogs thereof as anti-tumor agents |
EP2043606A2 (en) * | 2006-06-13 | 2009-04-08 | Elan Pharma International Limited | Nanoparticulate kinase inhibitor formulations |
JP5659010B2 (ja) | 2007-04-06 | 2015-01-28 | ジオファーム オンコロジー, インコーポレイテッドZiopharm Oncology,Inc. | イソホスホルアミドマスタードの塩およびそれらの類似体 |
US8450337B2 (en) * | 2008-09-30 | 2013-05-28 | Moleculin, Llc | Methods of treating skin disorders with caffeic acid analogs |
WO2013027694A1 (ja) * | 2011-08-24 | 2013-02-28 | 国立大学法人京都大学 | コンフォメーション病診断用分子イメージングプローブ |
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US3125597A (en) * | 1964-03-17 | chj oh | ||
US2798881A (en) * | 1954-11-12 | 1957-07-09 | Du Pont | 4-(aminoaryl)-1, 3-butadiene-2-carbonitriles and their preparation |
US3047606A (en) * | 1958-12-01 | 1962-07-31 | Rohm & Haas | Dialkyl 1-cyanovinylphosphonates, their preparation, and polymers and copolymers thereof |
US3852683A (en) | 1971-10-18 | 1974-12-03 | Eastman Kodak Co | Arylidene dye lasers |
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US4554238A (en) | 1984-03-20 | 1985-11-19 | Minnesota Mining And Manufacturing Company | Spectrally-sensitized imaging system |
JPS60244595A (ja) | 1984-05-18 | 1985-12-04 | Ricoh Co Ltd | 感熱記録材料 |
US4632895A (en) * | 1984-08-23 | 1986-12-30 | Minnesota Mining And Manufacturing Company | Diffusion or sublimation transfer imaging system |
US4617373A (en) * | 1985-02-15 | 1986-10-14 | Eastman Kodak Company | Condensation polymers and products therefrom |
CA1275538C (en) | 1985-08-16 | 1990-10-23 | Wayne P. Pruett | Colored unsaturated polyester material containing copolymerized methine dyes, and products therefrom |
US4950467A (en) * | 1986-11-14 | 1990-08-21 | Ici Americas Inc. | Ultraviolet radiation absorbing compositions |
AU632992B2 (en) | 1987-12-24 | 1993-01-21 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Pharmaceutical compositions comprising benzylidene- and cinnamylidene-malononitrile derivatives for the inhibition of proliferative processes in mammalian cells, certain such novel compounds and their preparation |
US5217999A (en) * | 1987-12-24 | 1993-06-08 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Styryl compounds which inhibit EGF receptor protein tyrosine kinase |
US5196147A (en) | 1988-03-28 | 1993-03-23 | Teijin Limited | Organic nonlinear optical substance |
EP0335641B1 (en) * | 1988-03-28 | 1994-01-05 | Teijin Limited | Organic nonlinear optical substance |
JPH02193954A (ja) | 1989-01-23 | 1990-07-31 | Teijin Ltd | 薄膜規則性構造体 |
JP2672363B2 (ja) | 1989-03-29 | 1997-11-05 | 帝人株式会社 | 有機非線形光学材料 |
JPH03230127A (ja) | 1990-02-05 | 1991-10-14 | Teijin Ltd | 芳香族非線形光学材料 |
JPH03259126A (ja) | 1990-03-09 | 1991-11-19 | Teijin Ltd | 新規な芳香族非線形光学材料 |
US5196446A (en) | 1990-04-16 | 1993-03-23 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Certain indole compounds which inhibit EGF receptor tyrosine kinase |
US5418245A (en) * | 1990-04-16 | 1995-05-23 | Rhone-Poulenc Rorer International (Holdings) Inc. | Styryl-substituted monocyclic and bicyclic heteroaryl compounds which inhibit EGF receptor tyrosine kinase |
JPH0436731A (ja) | 1990-06-01 | 1992-02-06 | Teijin Ltd | 新規な芳香族系非線形光学材料 |
JPH0496026A (ja) | 1990-08-13 | 1992-03-27 | Teijin Ltd | 非線形光学材料 |
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US5656655A (en) * | 1994-03-17 | 1997-08-12 | Rhone-Poulenc Rorer Pharmaceuticals, Inc. | Styryl-substituted heteroaryl compounds which inhibit EGF receptor tyrosine kinase |
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JP3230127B2 (ja) | 1994-06-09 | 2001-11-19 | 三菱マテリアル株式会社 | チップ材が高い接合強度を有する内燃機関タペット部材 |
US5789448A (en) * | 1994-07-27 | 1998-08-04 | Mitsubishi Chemical Corporation | Benzoylethylene derivative |
JPH09230585A (ja) | 1995-02-01 | 1997-09-05 | Toray Ind Inc | 水なし平版印刷版原版 |
WO1996040629A1 (en) | 1995-06-07 | 1996-12-19 | Sugen, Inc. | Tyrphostin-like compounds for the treatment of cell proliferative disorders or cell differentiation disorders |
JP3259126B2 (ja) | 1995-09-26 | 2002-02-25 | 富士通株式会社 | リング伝送システム及び該システムのスケルチ方法 |
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US5990193A (en) * | 1995-12-12 | 1999-11-23 | University Of Pittsburgh | Polymers for reversible photoinduced sol gel transitions |
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CA2319836C (en) * | 1998-02-06 | 2010-11-23 | De Montfort University | Hydroxylation activated prodrugs |
US7012095B2 (en) | 2000-04-13 | 2006-03-14 | Hsc Research And Development Limited | Compounds for modulating cell proliferation |
-
2001
- 2001-04-12 US US10/240,740 patent/US7012095B2/en not_active Expired - Fee Related
- 2001-04-12 EP EP01921087A patent/EP1272457B9/en not_active Expired - Lifetime
- 2001-04-12 PT PT01921087T patent/PT1272457E/pt unknown
- 2001-04-12 BR BR0110087-4A patent/BR0110087A/pt not_active Application Discontinuation
- 2001-04-12 RU RU2002127415/04A patent/RU2277531C9/ru not_active IP Right Cessation
- 2001-04-12 ES ES01921087T patent/ES2267747T3/es not_active Expired - Lifetime
- 2001-04-12 WO PCT/CA2001/000516 patent/WO2001079158A2/en active IP Right Grant
- 2001-04-12 CA CA002406160A patent/CA2406160A1/en not_active Abandoned
- 2001-04-12 AU AU2001248201A patent/AU2001248201B2/en not_active Ceased
- 2001-04-12 GB GB0226316A patent/GB2378948B/en not_active Expired - Fee Related
- 2001-04-12 DK DK01921087T patent/DK1272457T3/da active
- 2001-04-12 US US09/834,728 patent/US6800659B2/en not_active Expired - Lifetime
- 2001-04-12 DE DE60122484T patent/DE60122484T2/de not_active Expired - Lifetime
- 2001-04-12 JP JP2001576760A patent/JP2003531133A/ja active Pending
- 2001-04-12 AU AU4820101A patent/AU4820101A/xx active Pending
- 2001-04-12 CN CNB018089364A patent/CN100413845C/zh not_active Expired - Fee Related
- 2001-04-12 AT AT01921087T patent/ATE337296T1/de not_active IP Right Cessation
- 2001-04-12 MX MXPA02010089A patent/MXPA02010089A/es active IP Right Grant
-
2003
- 2003-07-07 HK HK03104797A patent/HK1052496A1/xx not_active IP Right Cessation
-
2004
- 2004-03-17 US US10/803,607 patent/US20040209845A1/en not_active Abandoned
-
2006
- 2006-11-15 CY CY20061101659T patent/CY1106447T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
US20040209845A1 (en) | 2004-10-21 |
HK1052496A1 (en) | 2003-09-19 |
DK1272457T3 (da) | 2007-01-08 |
RU2277531C9 (ru) | 2006-11-20 |
US20040072803A1 (en) | 2004-04-15 |
EP1272457B9 (en) | 2006-12-20 |
WO2001079158A2 (en) | 2001-10-25 |
ATE337296T1 (de) | 2006-09-15 |
PT1272457E (pt) | 2007-01-31 |
RU2277531C2 (ru) | 2006-06-10 |
GB2378948A (en) | 2003-02-26 |
CN1429202A (zh) | 2003-07-09 |
WO2001079158A3 (en) | 2002-01-31 |
EP1272457A2 (en) | 2003-01-08 |
DE60122484D1 (de) | 2006-10-05 |
ES2267747T3 (es) | 2007-03-16 |
CN100413845C (zh) | 2008-08-27 |
CY1106447T1 (el) | 2011-10-12 |
US7012095B2 (en) | 2006-03-14 |
DE60122484T2 (de) | 2006-12-21 |
EP1272457B1 (en) | 2006-08-23 |
US20030109502A1 (en) | 2003-06-12 |
MXPA02010089A (es) | 2004-08-19 |
CA2406160A1 (en) | 2001-10-25 |
RU2002127415A (ru) | 2004-02-27 |
GB2378948B (en) | 2004-11-10 |
US6800659B2 (en) | 2004-10-05 |
AU2001248201B2 (en) | 2006-12-14 |
JP2003531133A (ja) | 2003-10-21 |
GB0226316D0 (en) | 2002-12-18 |
AU4820101A (en) | 2001-10-30 |
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