ES2163195T3 - Derivados sustituidos de benzocicloheptapiridina utiles para inhibir la farnesil protein transferasa. - Google Patents
Derivados sustituidos de benzocicloheptapiridina utiles para inhibir la farnesil protein transferasa.Info
- Publication number
- ES2163195T3 ES2163195T3 ES97941478T ES97941478T ES2163195T3 ES 2163195 T3 ES2163195 T3 ES 2163195T3 ES 97941478 T ES97941478 T ES 97941478T ES 97941478 T ES97941478 T ES 97941478T ES 2163195 T3 ES2163195 T3 ES 2163195T3
- Authority
- ES
- Spain
- Prior art keywords
- transferasa
- benzocicloheptapiridina
- inhibit
- useful
- farnesil
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 229950008696 farnesil Drugs 0.000 title abstract 2
- 102000004169 proteins and genes Human genes 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- NVKAWKQGWWIWPM-ABEVXSGRSA-N 17-β-hydroxy-5-α-Androstan-3-one Chemical compound C1C(=O)CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CC[C@H]21 NVKAWKQGWWIWPM-ABEVXSGRSA-N 0.000 abstract 1
- 230000002159 abnormal effect Effects 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 210000004881 tumor cell Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Enzymes And Modification Thereof (AREA)
- Cosmetics (AREA)
- Confectionery (AREA)
- Indole Compounds (AREA)
Abstract
LA INVENCION SE REFIERE A NUEVOS COMPUESTOS DE FORMULA (1.0). DICHOS COMPUESTOS SE REPRESENTAN MEDIANTE LAS FORMULAS (1.4) O (1.5), EN LAS QUE R 1 , R 3 Y R 4 SE SELEC CIONAN CADA UNO INDEPENDIENTEMENTE A PARTIR DE LOS ELEMENTOS HALOGENOS. W REPRESENTA UN GRUPO SELECCIONADO A PARTIR DE (A), (B), (C) O (D). ASIMISMO, SE DESCRIBEN PROCEDIMIENTOS DE INHIBICION DE LA FARNESIL PROTEINA TRANSFERASA Y DEL CRECIMIENTO DE CELULAS ANORMALES, COMO CELULAS TUMORALES.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US71192596A | 1996-09-13 | 1996-09-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2163195T3 true ES2163195T3 (es) | 2002-01-16 |
Family
ID=24860067
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES97941478T Expired - Lifetime ES2163195T3 (es) | 1996-09-13 | 1997-09-11 | Derivados sustituidos de benzocicloheptapiridina utiles para inhibir la farnesil protein transferasa. |
Country Status (21)
| Country | Link |
|---|---|
| EP (1) | EP0931079B1 (es) |
| JP (1) | JP2001500508A (es) |
| KR (1) | KR20000036103A (es) |
| CN (1) | CN1122031C (es) |
| AT (1) | ATE209201T1 (es) |
| AU (1) | AU4337797A (es) |
| BR (1) | BR9711477A (es) |
| CA (1) | CA2264513C (es) |
| CZ (1) | CZ87499A3 (es) |
| DE (1) | DE69709774T2 (es) |
| ES (1) | ES2163195T3 (es) |
| HK (1) | HK1018443A1 (es) |
| HU (1) | HUP9904056A3 (es) |
| ID (1) | ID22156A (es) |
| IL (1) | IL128929A0 (es) |
| NO (1) | NO991229L (es) |
| NZ (1) | NZ334437A (es) |
| PL (1) | PL332253A1 (es) |
| SK (1) | SK33599A3 (es) |
| TR (1) | TR199901205T2 (es) |
| WO (1) | WO1998011099A1 (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6358968B1 (en) | 1997-06-17 | 2002-03-19 | Schering Corporation | N-substituted urea inhibitors of farnesyl-protein transferase |
| WO1998057948A1 (en) * | 1997-06-17 | 1998-12-23 | Schering Corporation | Novel n-substituted urea inhibitors of farnesyl-protein transferase |
| CA2319077A1 (en) | 1998-01-21 | 1999-07-29 | Yoshisuke Nakasato | Chemokine receptor antagonists and methods of use therefor |
| US6509346B2 (en) | 1998-01-21 | 2003-01-21 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
| US6613905B1 (en) | 1998-01-21 | 2003-09-02 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
| US6433165B1 (en) | 1998-01-21 | 2002-08-13 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
| US6288083B1 (en) | 1998-09-04 | 2001-09-11 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
| US6503926B2 (en) | 1998-09-04 | 2003-01-07 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
| US7271176B2 (en) | 1998-09-04 | 2007-09-18 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use thereof |
| US7541365B2 (en) | 2001-11-21 | 2009-06-02 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
| TWI291467B (en) | 2002-11-13 | 2007-12-21 | Millennium Pharm Inc | CCR1 antagonists and methods of use therefor |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5719148A (en) * | 1993-10-15 | 1998-02-17 | Schering Corporation | Tricyclic amide and urea compounds useful for inhibition of g-protein function and for treatment of proliferative diseases |
| IL111235A (en) * | 1993-10-15 | 2001-03-19 | Schering Plough Corp | Medicinal preparations for inhibiting protein G activity and for the treatment of malignant diseases, containing tricyclic compounds, some such new compounds and a process for the preparation of some of them |
| SK86198A3 (en) * | 1995-12-22 | 1999-02-11 | Schering Corp | Tricyclic amides useful for inhibition of g-protein function and for treatment of proliferative diseases |
-
1997
- 1997-09-11 SK SK335-99A patent/SK33599A3/sk unknown
- 1997-09-11 CN CN97199527A patent/CN1122031C/zh not_active Expired - Fee Related
- 1997-09-11 KR KR1019997002125A patent/KR20000036103A/ko not_active Application Discontinuation
- 1997-09-11 HU HU9904056A patent/HUP9904056A3/hu unknown
- 1997-09-11 AT AT97941478T patent/ATE209201T1/de not_active IP Right Cessation
- 1997-09-11 IL IL12892997A patent/IL128929A0/xx unknown
- 1997-09-11 EP EP97941478A patent/EP0931079B1/en not_active Expired - Lifetime
- 1997-09-11 ES ES97941478T patent/ES2163195T3/es not_active Expired - Lifetime
- 1997-09-11 BR BR9711477A patent/BR9711477A/pt unknown
- 1997-09-11 CA CA002264513A patent/CA2264513C/en not_active Expired - Fee Related
- 1997-09-11 TR TR1999/01205T patent/TR199901205T2/xx unknown
- 1997-09-11 DE DE69709774T patent/DE69709774T2/de not_active Expired - Fee Related
- 1997-09-11 WO PCT/US1997/015905 patent/WO1998011099A1/en not_active Application Discontinuation
- 1997-09-11 JP JP10513763A patent/JP2001500508A/ja not_active Ceased
- 1997-09-11 PL PL97332253A patent/PL332253A1/xx unknown
- 1997-09-11 AU AU43377/97A patent/AU4337797A/en not_active Abandoned
- 1997-09-11 CZ CZ99874A patent/CZ87499A3/cs unknown
- 1997-09-11 NZ NZ334437A patent/NZ334437A/xx unknown
- 1997-09-11 ID IDW990087A patent/ID22156A/id unknown
-
1999
- 1999-03-12 NO NO991229A patent/NO991229L/no not_active Application Discontinuation
- 1999-08-07 HK HK99103415A patent/HK1018443A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0931079A1 (en) | 1999-07-28 |
| CN1236364A (zh) | 1999-11-24 |
| JP2001500508A (ja) | 2001-01-16 |
| ID22156A (id) | 1999-09-09 |
| HK1018443A1 (en) | 1999-12-24 |
| DE69709774D1 (de) | 2002-02-21 |
| DE69709774T2 (de) | 2002-08-08 |
| PL332253A1 (en) | 1999-08-30 |
| ATE209201T1 (de) | 2001-12-15 |
| SK33599A3 (en) | 2000-03-13 |
| NO991229D0 (no) | 1999-03-12 |
| BR9711477A (pt) | 1999-08-24 |
| HUP9904056A2 (hu) | 2000-04-28 |
| AU4337797A (en) | 1998-04-02 |
| CA2264513A1 (en) | 1998-03-19 |
| TR199901205T2 (xx) | 1999-07-21 |
| NO991229L (no) | 1999-05-12 |
| NZ334437A (en) | 2000-09-29 |
| CA2264513C (en) | 2004-03-30 |
| IL128929A0 (en) | 2000-02-17 |
| HUP9904056A3 (en) | 2001-10-29 |
| CN1122031C (zh) | 2003-09-24 |
| CZ87499A3 (cs) | 1999-08-11 |
| KR20000036103A (ko) | 2000-06-26 |
| WO1998011099A1 (en) | 1998-03-19 |
| EP0931079B1 (en) | 2001-11-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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