DE69732120D1 - Trizyklische inhibitoren der farnesyl protein transferase - Google Patents
Trizyklische inhibitoren der farnesyl protein transferaseInfo
- Publication number
- DE69732120D1 DE69732120D1 DE69732120T DE69732120T DE69732120D1 DE 69732120 D1 DE69732120 D1 DE 69732120D1 DE 69732120 T DE69732120 T DE 69732120T DE 69732120 T DE69732120 T DE 69732120T DE 69732120 D1 DE69732120 D1 DE 69732120D1
- Authority
- DE
- Germany
- Prior art keywords
- protein transferase
- farnesyl protein
- tricyclic inhibitors
- compounds
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 102000004357 Transferases Human genes 0.000 title abstract 2
- 108090000992 Transferases Proteins 0.000 title abstract 2
- JXBSHSBNOVLGHF-BUJBXKITSA-N (6E,10E)-2,6,10-trimethyldodeca-2,6,10-triene Chemical compound C\C=C(/C)CC\C=C(/C)CCC=C(C)C JXBSHSBNOVLGHF-BUJBXKITSA-N 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 230000002159 abnormal effect Effects 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 125000004030 farnesyl group Chemical group [H]C([*])([H])C([H])=C(C([H])([H])[H])C([H])([H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 210000004881 tumor cell Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Cereal-Derived Products (AREA)
- Enzymes And Modification Thereof (AREA)
- Dental Preparations (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US71332396A | 1996-09-13 | 1996-09-13 | |
| US713323 | 1996-09-13 | ||
| PCT/US1997/015907 WO1998011093A1 (en) | 1996-09-13 | 1997-09-11 | Tricyclic inhibitors of farnesyl protein transferase |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69732120D1 true DE69732120D1 (de) | 2005-02-03 |
| DE69732120T2 DE69732120T2 (de) | 2005-12-08 |
Family
ID=24865689
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69732120T Expired - Fee Related DE69732120T2 (de) | 1996-09-13 | 1997-09-11 | Trizyklische inhibitoren der farnesyl protein transferase |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP0929545B1 (de) |
| JP (1) | JP2001500510A (de) |
| KR (1) | KR20000036120A (de) |
| CN (1) | CN1104427C (de) |
| AT (1) | ATE286046T1 (de) |
| AU (1) | AU4337997A (de) |
| BR (1) | BR9712831A (de) |
| CA (1) | CA2266016C (de) |
| CZ (1) | CZ84399A3 (de) |
| DE (1) | DE69732120T2 (de) |
| ES (1) | ES2235252T3 (de) |
| HU (1) | HUP0000121A2 (de) |
| ID (1) | ID21699A (de) |
| IL (1) | IL128928A0 (de) |
| NO (1) | NO991234L (de) |
| NZ (1) | NZ334453A (de) |
| PL (1) | PL332242A1 (de) |
| SK (1) | SK33899A3 (de) |
| TR (1) | TR199901276T2 (de) |
| WO (1) | WO1998011093A1 (de) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LT3962B (en) | 1993-12-21 | 1996-05-27 | Albright & Wilson | Funcional fluids |
| US5939416A (en) * | 1997-06-17 | 1999-08-17 | Schering Corporation | Benzo (5,6) cycloheptapyridine compounds useful as farnesyl protein transferase inhibitors |
| WO1999037619A1 (en) | 1998-01-21 | 1999-07-29 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
| US6509346B2 (en) | 1998-01-21 | 2003-01-21 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
| US6329385B1 (en) | 1998-01-21 | 2001-12-11 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
| US6613905B1 (en) | 1998-01-21 | 2003-09-02 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
| US6288083B1 (en) | 1998-09-04 | 2001-09-11 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
| US6503926B2 (en) | 1998-09-04 | 2003-01-07 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
| US7271176B2 (en) | 1998-09-04 | 2007-09-18 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use thereof |
| US7541365B2 (en) | 2001-11-21 | 2009-06-02 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
| TWI291467B (en) | 2002-11-13 | 2007-12-21 | Millennium Pharm Inc | CCR1 antagonists and methods of use therefor |
| US8679096B2 (en) | 2007-06-21 | 2014-03-25 | Board Of Regents Of The University Of Nebraska | Multifunctional operational component for robotic devices |
| TW200902007A (en) * | 2007-05-25 | 2009-01-16 | Astrazeneca Ab | Spirocyclopropyl piperidine derivatives |
| US8343171B2 (en) | 2007-07-12 | 2013-01-01 | Board Of Regents Of The University Of Nebraska | Methods and systems of actuation in robotic devices |
| CA2695615A1 (en) | 2007-08-15 | 2009-02-19 | Board Of Regents Of The University Of Nebraska | Medical inflation, attachment, and delivery devices and related methods |
| EP4275634A3 (de) | 2011-06-10 | 2024-01-10 | Board of Regents of the University of Nebraska | Verfahren, systeme und vorrichtungen in zusammenhang mit chirurgischen endeffektoren |
| CA2841459C (en) | 2011-07-11 | 2020-07-28 | Board Of Regents Of The University Of Nebraska | Robotic surgical devices, systems, and related methods |
| WO2013106569A2 (en) | 2012-01-10 | 2013-07-18 | Board Of Regents Of The University Of Nebraska | Methods, systems, and devices for surgical access and insertion |
| WO2014011238A2 (en) | 2012-05-01 | 2014-01-16 | Board Of Regents Of The University Of Nebraska | Single site robotic device and related systems and methods |
| JP6228196B2 (ja) | 2012-06-22 | 2017-11-08 | ボード オブ リージェンツ オブ ザ ユニバーシティ オブ ネブラスカ | ローカル制御ロボット手術デバイス |
| WO2014025399A1 (en) | 2012-08-08 | 2014-02-13 | Board Of Regents Of The University Of Nebraska | Robotic surgical devices, systems, and related methods |
| US9770305B2 (en) | 2012-08-08 | 2017-09-26 | Board Of Regents Of The University Of Nebraska | Robotic surgical devices, systems, and related methods |
| WO2014160086A2 (en) | 2013-03-14 | 2014-10-02 | Board Of Regents Of The University Of Nebraska | Methods, systems, and devices relating to robotic surgical devices, end effectors, and controllers |
| US9888966B2 (en) | 2013-03-14 | 2018-02-13 | Board Of Regents Of The University Of Nebraska | Methods, systems, and devices relating to force control surgical systems |
| EP3970604A1 (de) | 2013-03-15 | 2022-03-23 | Board of Regents of the University of Nebraska | Robotische chirurgische vorrichtungen und systeme |
| JP6479790B2 (ja) | 2013-07-17 | 2019-03-06 | ボード オブ リージェンツ オブ ザ ユニバーシティ オブ ネブラスカ | ロボット外科的デバイス、システムおよび関連する方法 |
| WO2016040946A1 (en) | 2014-09-12 | 2016-03-17 | Board Of Regents Of University Of Nebraska | Quick-release end effectors and related systems and methods |
| JP6608928B2 (ja) | 2014-11-11 | 2019-11-20 | ボード オブ リージェンツ オブ ザ ユニバーシティ オブ ネブラスカ | 小型の関節デザインを備えるロボットデバイスおよび関連するシステムおよび方法 |
| WO2017024081A1 (en) | 2015-08-03 | 2017-02-09 | Board Of Regents Of The University Of Nebraska | Robotic surgical devices systems and related methods |
| CA3024623A1 (en) | 2016-05-18 | 2017-11-23 | Virtual Incision Corporation | Robotic surgical devices, systems and related methods |
| EP3503829A4 (de) | 2016-08-25 | 2020-04-15 | Board of Regents of the University of Nebraska | Schnell lösbare werkzeugkopplung sowie zugehörige systeme und verfahren |
| US10702347B2 (en) | 2016-08-30 | 2020-07-07 | The Regents Of The University Of California | Robotic device with compact joint design and an additional degree of freedom and related systems and methods |
| WO2018098319A1 (en) | 2016-11-22 | 2018-05-31 | Board Of Regents Of The University Of Nebraska | Improved gross positioning device and related systems and methods |
| CN110462259B (zh) | 2016-11-29 | 2022-10-28 | 虚拟切割有限公司 | 具有用户存在检测的用户控制器及相关系统和方法 |
| WO2018112199A1 (en) | 2016-12-14 | 2018-06-21 | Virtual Incision Corporation | Releasable attachment device for coupling to medical devices and related systems and methods |
| CN111417333B (zh) | 2017-09-27 | 2023-08-29 | 虚拟切割有限公司 | 具有跟踪相机技术的机器人手术设备及相关系统和方法 |
| US11013564B2 (en) | 2018-01-05 | 2021-05-25 | Board Of Regents Of The University Of Nebraska | Single-arm robotic device with compact joint design and related systems and methods |
| WO2020146348A1 (en) | 2019-01-07 | 2020-07-16 | Virtual Incision Corporation | Robotically assisted surgical system and related devices and methods |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4826853A (en) * | 1986-10-31 | 1989-05-02 | Schering Corporation | 6,11-Dihydro-11-(N-substituted-4-piperidylidene)-5H-benzo(5,6)cyclohepta(1,2-B)pyridines and compositions and methods of use |
| US5089496A (en) * | 1986-10-31 | 1992-02-18 | Schering Corporation | Benzo[5,6]cycloheptapyridine compounds, compositions and method of treating allergies |
| JPH0676403B2 (ja) * | 1991-01-18 | 1994-09-28 | エスエス製薬株式会社 | 新規なベンゾ［５，６ シクロヘプタ［１，２−ｂ ピリジン誘導体及びこれを含有する抗アレルギー剤 |
| JP2875392B2 (ja) * | 1993-10-15 | 1999-03-31 | シェーリング コーポレイション | Ｇ−タンパク質機能の阻害および増殖性疾患の治療に有用な三環式スルホンアミド化合物 |
| TW308594B (de) * | 1993-10-15 | 1997-06-21 | Schering Corp | |
| US5719148A (en) * | 1993-10-15 | 1998-02-17 | Schering Corporation | Tricyclic amide and urea compounds useful for inhibition of g-protein function and for treatment of proliferative diseases |
| IL111235A (en) * | 1993-10-15 | 2001-03-19 | Schering Plough Corp | Medicinal preparations for inhibiting protein G activity and for the treatment of malignant diseases, containing tricyclic compounds, some such new compounds and a process for the preparation of some of them |
| US5700806A (en) * | 1995-03-24 | 1997-12-23 | Schering Corporation | Tricyclic amide and urea compounds useful for inhibition of G-protein function and for treatment of proliferative diseases |
| IL117798A (en) * | 1995-04-07 | 2001-11-25 | Schering Plough Corp | Tricyclic compounds useful for inhibiting the function of protein - G and for the treatment of malignant diseases, and pharmaceutical preparations containing them |
| TW350844B (en) * | 1995-12-22 | 1999-01-21 | Schering Corp | Tricyclic amides useful to inhibition of G-protein function and for treatment of proliferative diseases |
-
1997
- 1997-09-11 BR BR9712831-7A patent/BR9712831A/pt unknown
- 1997-09-11 DE DE69732120T patent/DE69732120T2/de not_active Expired - Fee Related
- 1997-09-11 AT AT97941480T patent/ATE286046T1/de not_active IP Right Cessation
- 1997-09-11 ES ES97941480T patent/ES2235252T3/es not_active Expired - Lifetime
- 1997-09-11 NZ NZ334453A patent/NZ334453A/xx unknown
- 1997-09-11 WO PCT/US1997/015907 patent/WO1998011093A1/en active IP Right Grant
- 1997-09-11 CN CN97199598A patent/CN1104427C/zh not_active Expired - Fee Related
- 1997-09-11 HU HU0000121A patent/HUP0000121A2/hu unknown
- 1997-09-11 JP JP10513765A patent/JP2001500510A/ja not_active Ceased
- 1997-09-11 TR TR1999/01276T patent/TR199901276T2/xx unknown
- 1997-09-11 EP EP97941480A patent/EP0929545B1/de not_active Expired - Lifetime
- 1997-09-11 PL PL97332242A patent/PL332242A1/xx unknown
- 1997-09-11 CA CA002266016A patent/CA2266016C/en not_active Expired - Fee Related
- 1997-09-11 IL IL12892897A patent/IL128928A0/xx unknown
- 1997-09-11 SK SK338-99A patent/SK33899A3/sk unknown
- 1997-09-11 CZ CZ99843A patent/CZ84399A3/cs unknown
- 1997-09-11 KR KR1019997002149A patent/KR20000036120A/ko not_active Application Discontinuation
- 1997-09-11 AU AU43379/97A patent/AU4337997A/en not_active Abandoned
- 1997-11-09 ID IDW990086A patent/ID21699A/id unknown
-
1999
- 1999-03-12 NO NO991234A patent/NO991234L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| WO1998011093A1 (en) | 1998-03-19 |
| ES2235252T3 (es) | 2005-07-01 |
| KR20000036120A (ko) | 2000-06-26 |
| CA2266016A1 (en) | 1998-03-19 |
| HUP0000121A2 (hu) | 2001-04-28 |
| DE69732120T2 (de) | 2005-12-08 |
| CN1237165A (zh) | 1999-12-01 |
| NZ334453A (en) | 2000-08-25 |
| EP0929545A1 (de) | 1999-07-21 |
| CN1104427C (zh) | 2003-04-02 |
| ATE286046T1 (de) | 2005-01-15 |
| JP2001500510A (ja) | 2001-01-16 |
| NO991234L (no) | 1999-05-12 |
| PL332242A1 (en) | 1999-08-30 |
| NO991234D0 (no) | 1999-03-12 |
| CA2266016C (en) | 2004-06-01 |
| EP0929545B1 (de) | 2004-12-29 |
| BR9712831A (pt) | 1999-11-16 |
| AU4337997A (en) | 1998-04-02 |
| CZ84399A3 (cs) | 1999-11-17 |
| ID21699A (id) | 1999-07-15 |
| SK33899A3 (en) | 2000-02-14 |
| IL128928A0 (en) | 2000-02-17 |
| TR199901276T2 (xx) | 1999-09-21 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE69732120D1 (de) | Trizyklische inhibitoren der farnesyl protein transferase | |
| NO991235L (no) | Forbindelser anvendelige for inhibering av farnesylproteintransferase | |
| DE69709774D1 (de) | Substituierte benzocycloheptapyridine derivate verwendbar als farnesyl-protein transferase inhibitoren | |
| NO991231D0 (no) | Forbindelser for inhibering av farnesylproteintransferase | |
| DE69724130D1 (de) | Substituierte benzocycloheptapyridine derivate verwendbar als farnesyl protein transferase inhibitoren |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |