DE69728544T2 - Totalsynthese von acylfulvenen mit antitumorwirkung - Google Patents

Totalsynthese von acylfulvenen mit antitumorwirkung Download PDF

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Publication number
DE69728544T2
DE69728544T2 DE69728544T DE69728544T DE69728544T2 DE 69728544 T2 DE69728544 T2 DE 69728544T2 DE 69728544 T DE69728544 T DE 69728544T DE 69728544 T DE69728544 T DE 69728544T DE 69728544 T2 DE69728544 T2 DE 69728544T2
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DE
Germany
Prior art keywords
formula
compound
alkyl
pharmaceutically acceptable
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69728544T
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German (de)
English (en)
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DE69728544D1 (de
Inventor
C. Trevor MCMORRIS
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California
Original Assignee
University of California
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Filing date
Publication date
Application filed by University of California filed Critical University of California
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Publication of DE69728544D1 publication Critical patent/DE69728544D1/de
Publication of DE69728544T2 publication Critical patent/DE69728544T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C35/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C35/22—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system
    • C07C35/37—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system with a hydroxy group on a condensed system having three rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/723—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups polycyclic
    • C07C49/727—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups polycyclic a keto group being part of a condensed ring system
    • C07C49/737—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups polycyclic a keto group being part of a condensed ring system having three rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/93—Spiro compounds
    • C07C2603/94—Spiro compounds containing "free" spiro atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Electric Double-Layer Capacitors Or The Like (AREA)
  • Organic Insulating Materials (AREA)
  • Inorganic Insulating Materials (AREA)
DE69728544T 1996-08-08 1997-08-05 Totalsynthese von acylfulvenen mit antitumorwirkung Expired - Lifetime DE69728544T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/689,461 US5723632A (en) 1996-08-08 1996-08-08 Total synthesis of antitumor acylfulvenes
US689461 1996-08-08
PCT/US1997/013644 WO1998005669A1 (en) 1996-08-08 1997-08-05 Total synthesis of antitumor acylfulvenes

Publications (2)

Publication Number Publication Date
DE69728544D1 DE69728544D1 (de) 2004-05-13
DE69728544T2 true DE69728544T2 (de) 2004-09-16

Family

ID=24768581

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69728544T Expired - Lifetime DE69728544T2 (de) 1996-08-08 1997-08-05 Totalsynthese von acylfulvenen mit antitumorwirkung

Country Status (12)

Country Link
US (6) US5723632A (US06252093-20010626-C00008.png)
EP (2) EP0918776B1 (US06252093-20010626-C00008.png)
JP (1) JP4267702B2 (US06252093-20010626-C00008.png)
AT (1) ATE263771T1 (US06252093-20010626-C00008.png)
AU (1) AU3744397A (US06252093-20010626-C00008.png)
CA (1) CA2262648A1 (US06252093-20010626-C00008.png)
DE (1) DE69728544T2 (US06252093-20010626-C00008.png)
DK (1) DK0918776T3 (US06252093-20010626-C00008.png)
ES (1) ES2215234T3 (US06252093-20010626-C00008.png)
HK (1) HK1019878A1 (US06252093-20010626-C00008.png)
PT (1) PT918776E (US06252093-20010626-C00008.png)
WO (1) WO1998005669A1 (US06252093-20010626-C00008.png)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5932553A (en) * 1996-07-18 1999-08-03 The Regents Of The University Of California Illudin analogs useful as antitumor agents
US5723632A (en) * 1996-08-08 1998-03-03 Mgi Pharma, Inc. Total synthesis of antitumor acylfulvenes
US7141603B2 (en) * 1999-02-19 2006-11-28 The Regents Of The University California Antitumor agents
US6025328A (en) * 1998-02-20 2000-02-15 The Regents Of The University Of California Antitumor agents
US6635490B1 (en) * 2000-05-25 2003-10-21 Noble Laboratories Procedure for the simultaneous quantitative and qualitative analysis of both flavonoid glycosides and steroidal glycosides
EP1330459B1 (en) * 2000-10-02 2006-08-02 Emory University Triptolide analogs for the treatment of autoimmune and inflammatory disorders
US7015247B2 (en) * 2000-10-12 2006-03-21 Alvin Guttag Ibuprofen-aspirin, hydroxymethylacylfulvene analogs and L-sugar illudin analogs
US6436916B1 (en) 2000-10-12 2002-08-20 Alvin Guttag Ibuprofen-aspirin and hydroxymethylacylfulvene analogs
ATE487744T1 (de) * 2001-06-22 2010-11-15 Borealis Tech Oy Metallocenkatalysatoren mit einer in 4-, 5-, 6- oder 7-stellung mit siloxy oder germyloxy substitutierten indenylgruppe
US7718385B2 (en) * 2003-10-17 2010-05-18 The Johns Hopkins University Bioactivation of alkylating agents for cancer treatment
ATE527998T1 (de) * 2005-08-03 2011-10-15 Univ California Illudin-analoga als krebsmittel
US8883790B2 (en) 2006-10-12 2014-11-11 Astex Therapeutics Limited Pharmaceutical combinations
EP2073803B1 (en) 2006-10-12 2018-09-19 Astex Therapeutics Limited Pharmaceutical combinations
CA2685726A1 (en) * 2007-05-03 2008-11-13 Emory University Fulvene and fulvalene analogs and their use in treating cancers
GB0715576D0 (en) * 2007-08-09 2007-09-19 Syngenta Ltd Novel herbicides
WO2009089285A2 (en) * 2008-01-07 2009-07-16 Emory University Branched diepoxide compounds for the treatment of inflammatory disorders
US10285955B2 (en) 2014-04-10 2019-05-14 Af Chemicals, Llc Affinity medicant conjugate
US11135182B2 (en) 2014-04-10 2021-10-05 Af Chemicals, Llc Affinity medicant conjugates
JP2017518359A (ja) 2014-04-10 2017-07-06 エイエフ ケミカルス, エルエルシーAf Chemicals, Llc 親和性薬物コンジュゲート
CN104650160A (zh) * 2015-01-13 2015-05-27 济南大学 卡培他滨关键中间体1,2,3-o-三乙酰基-5-脱氧-d-核糖的合成新方法
BR112021006710A2 (pt) 2018-09-04 2021-08-10 Lantern Pharma Inc. composto análogos de iludina, usos dos mesmos e métodos para sintetizar os mesmos
EP3667323A1 (en) 2018-12-11 2020-06-17 Kelner, Michael Methods, compositions and devices for treating cancer with illudofulvenes
US11591295B2 (en) 2019-11-25 2023-02-28 Af Chemicals Llc Affinity illudofulvene conjugates

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4559157A (en) * 1983-04-21 1985-12-17 Creative Products Resource Associates, Ltd. Cosmetic applicator useful for skin moisturizing
LU84979A1 (fr) * 1983-08-30 1985-04-24 Oreal Composition cosmetique ou pharmaceutique sous forme aqueuse ou anhydre dont la phase grasse contient un polyether oligomere et polyethers oligomeres nouveaux
US4612302A (en) * 1983-11-14 1986-09-16 Brigham And Women's Hospital Clinical use of somatostatin analogues
US4684620A (en) * 1984-09-04 1987-08-04 Gibson-Stephens Neuropharmaceuticals, Inc. Cyclic polypeptides having mu-receptor specificity
JPS62234040A (ja) * 1986-04-02 1987-10-14 Kyowa Hakko Kogyo Co Ltd Ｄｃ１０４３物質
US4853371A (en) * 1986-06-17 1989-08-01 The Administrators Of The Tulane Educational Fund Therapeutic somatostatin analogs
US4820508A (en) * 1987-06-23 1989-04-11 Neutrogena Corporation Skin protective composition
US4992478A (en) * 1988-04-04 1991-02-12 Warner-Lambert Company Antiinflammatory skin moisturizing composition and method of preparing same
US4938949A (en) * 1988-09-12 1990-07-03 University Of New York Treatment of damaged bone marrow and dosage units therefor
JPH05503077A (ja) * 1989-10-03 1993-05-27 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 抗腫瘍剤としてのイルージンアナログ
US5439936A (en) * 1989-10-03 1995-08-08 The Regents Of The University Of California Method of treating certain tumors using illudin analogs
GB9017024D0 (en) * 1990-08-03 1990-09-19 Erba Carlo Spa New linker for bioactive agents
KR100331667B1 (ko) * 1993-04-27 2002-11-08 스미스클라인 비참 코포레이션 엔도텔린수용체길항제
US5708163A (en) * 1994-03-15 1998-01-13 Sloan-Kettering Institute Of Cancer Research Synthesis of the breast tumor-associated antigen defined by monoclonalantibody MBRL and uses thereof
US6303120B1 (en) * 1994-03-15 2001-10-16 Memorial Sloan-Kettering Institute For Cancer Research Synthesis of glycoconjugates of the lewis y epitope and uses thereof
US5932553A (en) * 1996-07-18 1999-08-03 The Regents Of The University Of California Illudin analogs useful as antitumor agents
US5723632A (en) * 1996-08-08 1998-03-03 Mgi Pharma, Inc. Total synthesis of antitumor acylfulvenes
US6025328A (en) 1998-02-20 2000-02-15 The Regents Of The University Of California Antitumor agents

Also Published As

Publication number Publication date
US6717017B2 (en) 2004-04-06
US6469184B2 (en) 2002-10-22
US5856580A (en) 1999-01-05
US6252093B1 (en) 2001-06-26
ES2215234T3 (es) 2004-10-01
WO1998005669A1 (en) 1998-02-12
ATE263771T1 (de) 2004-04-15
US5723632A (en) 1998-03-03
CA2262648A1 (en) 1998-02-12
AU3744397A (en) 1998-02-25
EP1454890A2 (en) 2004-09-08
US20010029303A1 (en) 2001-10-11
EP0918776B1 (en) 2004-04-07
PT918776E (pt) 2004-07-30
HK1019878A1 (en) 2000-03-03
EP0918776A1 (en) 1999-06-02
US20030050495A1 (en) 2003-03-13
JP2000515552A (ja) 2000-11-21
DE69728544D1 (de) 2004-05-13
EP1454890A3 (en) 2004-11-10
JP4267702B2 (ja) 2009-05-27
US6160184A (en) 2000-12-12
EP1454890A8 (en) 2004-11-03
DK0918776T3 (da) 2004-07-12

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