DE69725999D1 - Verfahren zur herstellung von 2-hydroxy-4-methyl-thiobuttersäure mit einer nitrilase - Google Patents

Verfahren zur herstellung von 2-hydroxy-4-methyl-thiobuttersäure mit einer nitrilase

Info

Publication number
DE69725999D1
DE69725999D1 DE69725999T DE69725999T DE69725999D1 DE 69725999 D1 DE69725999 D1 DE 69725999D1 DE 69725999 T DE69725999 T DE 69725999T DE 69725999 T DE69725999 T DE 69725999T DE 69725999 D1 DE69725999 D1 DE 69725999D1
Authority
DE
Germany
Prior art keywords
hydroxy
nitrilase
iii
acid
thiobutteric
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69725999T
Other languages
English (en)
Other versions
DE69725999T2 (de
Inventor
Olivier Favre-Bulle
Jerome Pierrard
Christophe David
Philippe Morel
Dominique Horbez
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Adisseo Ireland Ltd
Original Assignee
Aventis Animal Nutrition SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Animal Nutrition SA filed Critical Aventis Animal Nutrition SA
Publication of DE69725999D1 publication Critical patent/DE69725999D1/de
Application granted granted Critical
Publication of DE69725999T2 publication Critical patent/DE69725999T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P11/00—Preparation of sulfur-containing organic compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/08—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer
    • C12N11/089—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/08—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer
    • C12N11/089—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • C12N11/096—Polyesters; Polyamides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Bakery Products And Manufacturing Methods Therefor (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE69725999T 1996-10-25 1997-10-24 Verfahren zur herstellung von 2-hydroxy-4-methyl-thiobuttersäure mit einer nitrilase Expired - Fee Related DE69725999T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR9613077A FR2755143B1 (fr) 1996-10-25 1996-10-25 Procede de preparation de l'acide 2-hydroxy-4-methylthio-butyrique par utilisation d'une nitrilase
FR9613077 1996-10-25
PCT/FR1997/001913 WO1998018941A1 (fr) 1996-10-25 1997-10-24 Procede de preparation de l'acide 2-hydroxy 4-methylthio butyrique par utilisation d'une nitrilase

Publications (2)

Publication Number Publication Date
DE69725999D1 true DE69725999D1 (de) 2003-12-11
DE69725999T2 DE69725999T2 (de) 2004-12-23

Family

ID=9497056

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69736961T Expired - Fee Related DE69736961T2 (de) 1996-10-25 1997-10-24 Nitrilase und dafür kodierendes Polynukleotid
DE69725999T Expired - Fee Related DE69725999T2 (de) 1996-10-25 1997-10-24 Verfahren zur herstellung von 2-hydroxy-4-methyl-thiobuttersäure mit einer nitrilase

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69736961T Expired - Fee Related DE69736961T2 (de) 1996-10-25 1997-10-24 Nitrilase und dafür kodierendes Polynukleotid

Country Status (22)

Country Link
US (1) US6180359B1 (de)
EP (2) EP1411126B1 (de)
JP (1) JP4350801B2 (de)
KR (1) KR100557404B1 (de)
CN (1) CN1181204C (de)
AT (2) ATE345384T1 (de)
AU (1) AU738160B2 (de)
BR (1) BR9712558A (de)
CA (1) CA2268869A1 (de)
CZ (1) CZ298403B6 (de)
DE (2) DE69736961T2 (de)
DK (2) DK0934419T3 (de)
ES (2) ES2210504T3 (de)
FR (1) FR2755143B1 (de)
HK (1) HK1022170A1 (de)
HU (1) HU226148B1 (de)
IL (3) IL129395A0 (de)
NZ (1) NZ335332A (de)
PL (1) PL190773B1 (de)
PT (2) PT1411126E (de)
RU (1) RU2216594C2 (de)
WO (1) WO1998018941A1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5905171A (en) * 1995-06-22 1999-05-18 Novus International, Inc. Process for the preparation of 3-(methylthio)propanal
JPH10179183A (ja) * 1996-12-20 1998-07-07 Daicel Chem Ind Ltd カルボン酸の製造方法
US6265201B1 (en) 1997-01-17 2001-07-24 Regents Of The University Of Minnesota DNA molecules and protein displaying improved triazine compound degrading ability
FR2780416B1 (fr) * 1998-06-10 2002-12-20 Rhone Poulenc Nutrition Animal Procede industriel de production de proteines heterologues chez e. coli et souches utiles pour le procede
FR2787121B1 (fr) * 1998-12-11 2003-09-12 Aventis Cropscience Sa Nouvelle methode d'isolement et de selection de genes codant pour des enzymes, et milieu de culture approprie
FR2791668B1 (fr) * 1999-04-02 2001-05-04 Rhone Poulenc Animal Nutrition Procede de preparation d' beta-hydroxy acides
US6368804B1 (en) * 1999-07-12 2002-04-09 E. I. Du Pont De Nemours & Company Method for stabilizing nitrilase activity and preserving microbial cells
FR2800749B1 (fr) * 1999-11-08 2004-07-16 Rhone Poulenc Animal Nutrition Procede de modulation de la selective des nitrilases, nouvelles nitrilases obtenues par ce procede et leur utilisation
AU2001231155A1 (en) 2000-01-25 2001-08-07 Hugh Mctavish Microbes and methods for remediation
EP1167521A1 (de) * 2000-06-30 2002-01-02 Aventis Animal Nutrition S.A. Beschichtete enzymenthaltende Katalysator
FR2824823A1 (fr) * 2001-05-21 2002-11-22 Aventis Animal Nutrition Sa Procede de preparation d'acides carboxyliques aliphatiques par hydrolyse enzymatique de composes nitriles aliphatiques
JP4884863B2 (ja) * 2006-07-18 2012-02-29 国立大学法人岐阜大学 ニトリラーゼおよびニトリラーゼを用いるカルボン酸の製造方法
WO2009013909A1 (ja) * 2007-07-25 2009-01-29 Nippon Soda Co., Ltd. α－ヒドロキシ酸アンモニウム塩からのα－ヒドロキシ酸の製造方法
EP2338987A1 (de) 2009-11-16 2011-06-29 ZYRUS Beteiligungsgesellschaft mbH & Co. Patente I KG Ganzzellen-Biokatalysator
MX342139B (es) 2010-12-30 2016-09-14 Metabolic Explorer Sa Produccion fermentativa de analogo de hidroximetionina (mha).
CN102517274B (zh) * 2011-12-13 2013-12-25 重庆大学 一种制备固定化腈水解酶的方法
CN103933861B (zh) * 2013-08-02 2017-04-26 浙江赛特膜技术有限公司 一种双极膜电渗析制备蛋氨酸和氢氧化钠的方法
CN103497131B (zh) * 2013-10-08 2015-05-13 重庆紫光化工股份有限公司 2-羟基-4-甲硫基丁酸金属螯合物的制备方法
MY198309A (en) * 2016-06-24 2023-08-22 Novus Int Inc Hydroxy methionine analog formulations suibtable for specialty chemical applications
CN113274882B (zh) * 2021-06-09 2022-05-17 温州大学新材料与产业技术研究院 基于高温双极膜电渗析的己二酸铵废液回收方法及其装置

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5356385A (en) * 1976-10-29 1978-05-22 Ajinomoto Co Inc Preparation of immobilized
US4732851A (en) * 1982-03-16 1988-03-22 Purification Engineering, Inc. Immobilization of cells with a polyazetidine prepolymer
DK152764C (da) * 1985-06-14 1988-10-03 Novo Industri As Fremgangsmaade til fremstilling af et immobiliseret enzymprodukt
DE3542861A1 (de) * 1985-12-04 1987-06-11 Huels Chemische Werke Ag Verfahren zur gewinnung von l-aepfelsaeure
US4800162A (en) * 1987-04-01 1989-01-24 Sepracor, Inc. Method for resolution of steroisomers in multiphase and extractive membrane reactors
DK589389D0 (da) * 1989-11-23 1989-11-23 Novo Nordisk As Immobiliseret enzympraeparat
US5629190A (en) * 1992-08-10 1997-05-13 Rhone-Poulenc Chimie Polypeptides possessing a nitrilase activity and method of converting nitriles to carboxylates by means of said polypeptides
WO1994008012A1 (en) * 1992-10-02 1994-04-14 Research Corporation Technologies, Inc. Methods for increasing secretion of overexpressed proteins
US5814497A (en) * 1994-09-22 1998-09-29 Rhone-Poulenc Nutrition Animale Enzymatic hydrolysis of racemic a-substituted 4-methylthiobutyronitriles using a nitrilase from alcaligenes faecalis, gordona terrae or rhodococcus sp
SG59966A1 (en) * 1995-03-08 1999-02-22 Daicel Chem Process for producing a carboxylic acid

Also Published As

Publication number Publication date
CZ145499A3 (cs) 1999-08-11
IL173394A0 (en) 2006-06-11
IL129395A (en) 2006-06-11
CN1181204C (zh) 2004-12-22
HK1022170A1 (en) 2000-07-28
ATE253638T1 (de) 2003-11-15
NZ335332A (en) 2000-11-24
FR2755143A1 (fr) 1998-04-30
WO1998018941A1 (fr) 1998-05-07
DE69725999T2 (de) 2004-12-23
ATE345384T1 (de) 2006-12-15
CZ298403B6 (cs) 2007-09-19
HUP9904513A2 (hu) 2000-05-28
HUP9904513A3 (en) 2001-03-28
EP1411126A1 (de) 2004-04-21
CA2268869A1 (fr) 1998-05-07
DK1411126T3 (da) 2007-03-26
ES2277027T3 (es) 2007-07-01
JP2001502908A (ja) 2001-03-06
PL190773B1 (pl) 2006-01-31
PL332958A1 (en) 1999-10-25
CN1234074A (zh) 1999-11-03
IL129395A0 (en) 2000-02-17
JP4350801B2 (ja) 2009-10-21
EP1411126B1 (de) 2006-11-15
BR9712558A (pt) 1999-10-19
AU4951397A (en) 1998-05-22
EP0934419B1 (de) 2003-11-05
PT1411126E (pt) 2007-02-28
DE69736961T2 (de) 2007-10-04
HU226148B1 (en) 2008-05-28
FR2755143B1 (fr) 1998-11-27
ES2210504T3 (es) 2004-07-01
RU2216594C2 (ru) 2003-11-20
AU738160B2 (en) 2001-09-13
PT934419E (pt) 2004-03-31
KR100557404B1 (ko) 2006-03-07
US6180359B1 (en) 2001-01-30
KR20000052732A (ko) 2000-08-25
EP0934419A1 (de) 1999-08-11
DK0934419T3 (da) 2004-03-15
DE69736961D1 (de) 2006-12-28

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Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: ADISSEO IRELAND LTD., DUBLIN, IE

8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee