BR9712558A - Processo de preparação do ácido 2-hidróxi 4-metiltio butìrico e/ou do sal de amÈnio do ácido 2-hidróxi 4-metiltio butìrico por hidrólise enzimática de 2-hidróxi 4-metiltio butironitrila, solução aquosa, instalação para a realização do processo, e, plasmìdeo prpa-bcat3 - Google Patents

Processo de preparação do ácido 2-hidróxi 4-metiltio butìrico e/ou do sal de amÈnio do ácido 2-hidróxi 4-metiltio butìrico por hidrólise enzimática de 2-hidróxi 4-metiltio butironitrila, solução aquosa, instalação para a realização do processo, e, plasmìdeo prpa-bcat3

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Publication number
BR9712558A
BR9712558A BR9712558-0A BR9712558A BR9712558A BR 9712558 A BR9712558 A BR 9712558A BR 9712558 A BR9712558 A BR 9712558A BR 9712558 A BR9712558 A BR 9712558A
Authority
BR
Brazil
Prior art keywords
hydroxy
methylthio
butyric acid
preparation
ammonium salt
Prior art date
Application number
BR9712558-0A
Other languages
English (en)
Inventor
Olivier Favre-Bulle
Jerome Pierrard
Christophe David
Philippe Morel
Dominique Horbez
Original Assignee
Rhone Poulenc Nutrition Animal
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Nutrition Animal filed Critical Rhone Poulenc Nutrition Animal
Publication of BR9712558A publication Critical patent/BR9712558A/pt

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P11/00—Preparation of sulfur-containing organic compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/08—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer
    • C12N11/089—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/08—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer
    • C12N11/089—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • C12N11/096—Polyesters; Polyamides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Bakery Products And Manufacturing Methods Therefor (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

''PROCESSO DE PREPARAçãO DO áCIDO 2-HIDRóXI 4-METILTIO BUTìRICO E/OU DO SAL DE AMÈNIO DO áCIDO 2-HIDRóXI 4-METILTIO BUTìRICO POR HIDRóLISE ENZIMáTICA DE 2-HIDRóXI 4-METILTIO BUTIRONITRILA, SOLUçãO AQUOSA, INSTALAçãO PARA A REALIZAçãO DO PROCESSO, E, PLASMìDEO PRPABCAT3''. Esta invenção tem por objeto um processo de preparação do ácido 2-hidróxi 4-metiltio butírico e/ou do sal de amónio de ácido 2-hidróxi 4-metiltio butórico por hidrólise enzimática de 2-hidró 4-mtiltio butironitrila, caracterizado em que: a0 em uma primeira etapa, prepara-se um material biológico tendo uma cavidade nitrila, b) em uma segunda etapa, imobiliza-se o mesmo, c) em uma terceira etapa, coloca-se na presença de 2-hidróxi 4-metiltio butinitrila com o material biológico assim imobilizado, para obter o sal de amónio do ácido 2-hidróxi 4-metitio butírico, d) em uma quarta etapa, eventualmente, converte-se o sal obtido na etapa (c) ácido correspondente, e e) em uma quinta etapa, concentra-se o produto obtido na etapa c) ou d).
BR9712558-0A 1996-10-25 1997-10-24 Processo de preparação do ácido 2-hidróxi 4-metiltio butìrico e/ou do sal de amÈnio do ácido 2-hidróxi 4-metiltio butìrico por hidrólise enzimática de 2-hidróxi 4-metiltio butironitrila, solução aquosa, instalação para a realização do processo, e, plasmìdeo prpa-bcat3 BR9712558A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9613077A FR2755143B1 (fr) 1996-10-25 1996-10-25 Procede de preparation de l'acide 2-hydroxy-4-methylthio-butyrique par utilisation d'une nitrilase
PCT/FR1997/001913 WO1998018941A1 (fr) 1996-10-25 1997-10-24 Procede de preparation de l'acide 2-hydroxy 4-methylthio butyrique par utilisation d'une nitrilase

Publications (1)

Publication Number Publication Date
BR9712558A true BR9712558A (pt) 1999-10-19

Family

ID=9497056

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9712558-0A BR9712558A (pt) 1996-10-25 1997-10-24 Processo de preparação do ácido 2-hidróxi 4-metiltio butìrico e/ou do sal de amÈnio do ácido 2-hidróxi 4-metiltio butìrico por hidrólise enzimática de 2-hidróxi 4-metiltio butironitrila, solução aquosa, instalação para a realização do processo, e, plasmìdeo prpa-bcat3

Country Status (22)

Country Link
US (1) US6180359B1 (pt)
EP (2) EP1411126B1 (pt)
JP (1) JP4350801B2 (pt)
KR (1) KR100557404B1 (pt)
CN (1) CN1181204C (pt)
AT (2) ATE345384T1 (pt)
AU (1) AU738160B2 (pt)
BR (1) BR9712558A (pt)
CA (1) CA2268869A1 (pt)
CZ (1) CZ298403B6 (pt)
DE (2) DE69736961T2 (pt)
DK (2) DK0934419T3 (pt)
ES (2) ES2210504T3 (pt)
FR (1) FR2755143B1 (pt)
HK (1) HK1022170A1 (pt)
HU (1) HU226148B1 (pt)
IL (3) IL129395A0 (pt)
NZ (1) NZ335332A (pt)
PL (1) PL190773B1 (pt)
PT (2) PT1411126E (pt)
RU (1) RU2216594C2 (pt)
WO (1) WO1998018941A1 (pt)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5905171A (en) * 1995-06-22 1999-05-18 Novus International, Inc. Process for the preparation of 3-(methylthio)propanal
JPH10179183A (ja) * 1996-12-20 1998-07-07 Daicel Chem Ind Ltd カルボン酸の製造方法
US6265201B1 (en) 1997-01-17 2001-07-24 Regents Of The University Of Minnesota DNA molecules and protein displaying improved triazine compound degrading ability
FR2780416B1 (fr) * 1998-06-10 2002-12-20 Rhone Poulenc Nutrition Animal Procede industriel de production de proteines heterologues chez e. coli et souches utiles pour le procede
FR2787121B1 (fr) * 1998-12-11 2003-09-12 Aventis Cropscience Sa Nouvelle methode d'isolement et de selection de genes codant pour des enzymes, et milieu de culture approprie
FR2791668B1 (fr) * 1999-04-02 2001-05-04 Rhone Poulenc Animal Nutrition Procede de preparation d' beta-hydroxy acides
US6368804B1 (en) * 1999-07-12 2002-04-09 E. I. Du Pont De Nemours & Company Method for stabilizing nitrilase activity and preserving microbial cells
FR2800749B1 (fr) * 1999-11-08 2004-07-16 Rhone Poulenc Animal Nutrition Procede de modulation de la selective des nitrilases, nouvelles nitrilases obtenues par ce procede et leur utilisation
AU2001231155A1 (en) 2000-01-25 2001-08-07 Hugh Mctavish Microbes and methods for remediation
EP1167521A1 (en) * 2000-06-30 2002-01-02 Aventis Animal Nutrition S.A. Coated enzyme-containing catalyst
FR2824823A1 (fr) * 2001-05-21 2002-11-22 Aventis Animal Nutrition Sa Procede de preparation d'acides carboxyliques aliphatiques par hydrolyse enzymatique de composes nitriles aliphatiques
JP4884863B2 (ja) * 2006-07-18 2012-02-29 国立大学法人岐阜大学 ニトリラーゼおよびニトリラーゼを用いるカルボン酸の製造方法
WO2009013909A1 (ja) * 2007-07-25 2009-01-29 Nippon Soda Co., Ltd. α－ヒドロキシ酸アンモニウム塩からのα－ヒドロキシ酸の製造方法
EP2338987A1 (en) 2009-11-16 2011-06-29 ZYRUS Beteiligungsgesellschaft mbH & Co. Patente I KG Whole cell biocatalyst
MX342139B (es) 2010-12-30 2016-09-14 Metabolic Explorer Sa Produccion fermentativa de analogo de hidroximetionina (mha).
CN102517274B (zh) * 2011-12-13 2013-12-25 重庆大学 一种制备固定化腈水解酶的方法
CN103933861B (zh) * 2013-08-02 2017-04-26 浙江赛特膜技术有限公司 一种双极膜电渗析制备蛋氨酸和氢氧化钠的方法
CN103497131B (zh) * 2013-10-08 2015-05-13 重庆紫光化工股份有限公司 2-羟基-4-甲硫基丁酸金属螯合物的制备方法
MY198309A (en) * 2016-06-24 2023-08-22 Novus Int Inc Hydroxy methionine analog formulations suibtable for specialty chemical applications
CN113274882B (zh) * 2021-06-09 2022-05-17 温州大学新材料与产业技术研究院 基于高温双极膜电渗析的己二酸铵废液回收方法及其装置

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5356385A (en) * 1976-10-29 1978-05-22 Ajinomoto Co Inc Preparation of immobilized
US4732851A (en) * 1982-03-16 1988-03-22 Purification Engineering, Inc. Immobilization of cells with a polyazetidine prepolymer
DK152764C (da) * 1985-06-14 1988-10-03 Novo Industri As Fremgangsmaade til fremstilling af et immobiliseret enzymprodukt
DE3542861A1 (de) * 1985-12-04 1987-06-11 Huels Chemische Werke Ag Verfahren zur gewinnung von l-aepfelsaeure
US4800162A (en) * 1987-04-01 1989-01-24 Sepracor, Inc. Method for resolution of steroisomers in multiphase and extractive membrane reactors
DK589389D0 (da) * 1989-11-23 1989-11-23 Novo Nordisk As Immobiliseret enzympraeparat
US5629190A (en) * 1992-08-10 1997-05-13 Rhone-Poulenc Chimie Polypeptides possessing a nitrilase activity and method of converting nitriles to carboxylates by means of said polypeptides
WO1994008012A1 (en) * 1992-10-02 1994-04-14 Research Corporation Technologies, Inc. Methods for increasing secretion of overexpressed proteins
US5814497A (en) * 1994-09-22 1998-09-29 Rhone-Poulenc Nutrition Animale Enzymatic hydrolysis of racemic a-substituted 4-methylthiobutyronitriles using a nitrilase from alcaligenes faecalis, gordona terrae or rhodococcus sp
SG59966A1 (en) * 1995-03-08 1999-02-22 Daicel Chem Process for producing a carboxylic acid

Also Published As

Publication number Publication date
CZ145499A3 (cs) 1999-08-11
IL173394A0 (en) 2006-06-11
IL129395A (en) 2006-06-11
CN1181204C (zh) 2004-12-22
DE69725999D1 (de) 2003-12-11
HK1022170A1 (en) 2000-07-28
ATE253638T1 (de) 2003-11-15
NZ335332A (en) 2000-11-24
FR2755143A1 (fr) 1998-04-30
WO1998018941A1 (fr) 1998-05-07
DE69725999T2 (de) 2004-12-23
ATE345384T1 (de) 2006-12-15
CZ298403B6 (cs) 2007-09-19
HUP9904513A2 (hu) 2000-05-28
HUP9904513A3 (en) 2001-03-28
EP1411126A1 (fr) 2004-04-21
CA2268869A1 (fr) 1998-05-07
DK1411126T3 (da) 2007-03-26
ES2277027T3 (es) 2007-07-01
JP2001502908A (ja) 2001-03-06
PL190773B1 (pl) 2006-01-31
PL332958A1 (en) 1999-10-25
CN1234074A (zh) 1999-11-03
IL129395A0 (en) 2000-02-17
JP4350801B2 (ja) 2009-10-21
EP1411126B1 (fr) 2006-11-15
AU4951397A (en) 1998-05-22
EP0934419B1 (fr) 2003-11-05
PT1411126E (pt) 2007-02-28
DE69736961T2 (de) 2007-10-04
HU226148B1 (en) 2008-05-28
FR2755143B1 (fr) 1998-11-27
ES2210504T3 (es) 2004-07-01
RU2216594C2 (ru) 2003-11-20
AU738160B2 (en) 2001-09-13
PT934419E (pt) 2004-03-31
KR100557404B1 (ko) 2006-03-07
US6180359B1 (en) 2001-01-30
KR20000052732A (ko) 2000-08-25
EP0934419A1 (fr) 1999-08-11
DK0934419T3 (da) 2004-03-15
DE69736961D1 (de) 2006-12-28

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Legal Events

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B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B25G Requested change of headquarter approved

Owner name: RHONE-POULENC NUTRITION ANIMALE (FR)

Free format text: ALTERADA A SEDE DO TITULAR CONFORME REQUERIDO NA PETICAO NO 020050016290/RJ DE 09/03/2005.

B25D Requested change of name of applicant approved

Owner name: RHONE-POULENC ANIMAL NUTRITION S.A. (FR)

Free format text: ALTERADO DE: RHONE-POULENC NUTRITION ANIMALE

B25D Requested change of name of applicant approved

Owner name: AVENTIS ANIMAL NUTRITION S.A. (FR)

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B25A Requested transfer of rights approved

Owner name: ADISSEO IRELAND LIMITED (IE)

Free format text: TRANSFERIDO DE: AVENTIS ANIMAL NUTRITION S.A.

B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: EM FACE DO ACIMA EXPOSTO E COM BASE NO ARTIGO 8O COMBINADO COM O ARTIGO 13 E DE ACORDO COM O ARTIGO 37 DA LPI 9.279/96, DECIDIMOS PELO INDEFERIMENTO DO PRESENTE PEDIDO.

B12B Appeal against refusal [chapter 12.2 patent gazette]