ATE253638T1 - Verfahren zur herstellung von 2-hydroxy-4-methyl- thiobuttersäure mit einer nitrilase - Google Patents

Verfahren zur herstellung von 2-hydroxy-4-methyl- thiobuttersäure mit einer nitrilase

Info

Publication number
ATE253638T1
ATE253638T1 AT97912254T AT97912254T ATE253638T1 AT E253638 T1 ATE253638 T1 AT E253638T1 AT 97912254 T AT97912254 T AT 97912254T AT 97912254 T AT97912254 T AT 97912254T AT E253638 T1 ATE253638 T1 AT E253638T1
Authority
AT
Austria
Prior art keywords
hydroxy
iii
nitrilase
producing
methylthiobutyric acid
Prior art date
Application number
AT97912254T
Other languages
English (en)
Inventor
Olivier Favre-Bulle
Jerome Pierrard
Christophe David
Philippe Morel
Dominique Horbez
Original Assignee
Aventis Animal Nutrition Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Animal Nutrition Sa filed Critical Aventis Animal Nutrition Sa
Application granted granted Critical
Publication of ATE253638T1 publication Critical patent/ATE253638T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P11/00—Preparation of sulfur-containing organic compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/08—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer
    • C12N11/089—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/08—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer
    • C12N11/089—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • C12N11/096—Polyesters; Polyamides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Bakery Products And Manufacturing Methods Therefor (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
AT97912254T 1996-10-25 1997-10-24 Verfahren zur herstellung von 2-hydroxy-4-methyl- thiobuttersäure mit einer nitrilase ATE253638T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9613077A FR2755143B1 (fr) 1996-10-25 1996-10-25 Procede de preparation de l'acide 2-hydroxy-4-methylthio-butyrique par utilisation d'une nitrilase
PCT/FR1997/001913 WO1998018941A1 (fr) 1996-10-25 1997-10-24 Procede de preparation de l'acide 2-hydroxy 4-methylthio butyrique par utilisation d'une nitrilase

Publications (1)

Publication Number Publication Date
ATE253638T1 true ATE253638T1 (de) 2003-11-15

Family

ID=9497056

Family Applications (2)

Application Number Title Priority Date Filing Date
AT97912254T ATE253638T1 (de) 1996-10-25 1997-10-24 Verfahren zur herstellung von 2-hydroxy-4-methyl- thiobuttersäure mit einer nitrilase
AT03078492T ATE345384T1 (de) 1996-10-25 1997-10-24 Nitrilase und dafür kodierendes polynukleotid

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT03078492T ATE345384T1 (de) 1996-10-25 1997-10-24 Nitrilase und dafür kodierendes polynukleotid

Country Status (21)

Country Link
US (1) US6180359B1 (de)
EP (2) EP1411126B1 (de)
JP (1) JP4350801B2 (de)
KR (1) KR100557404B1 (de)
CN (1) CN1181204C (de)
AT (2) ATE253638T1 (de)
AU (1) AU738160B2 (de)
BR (1) BR9712558A (de)
CA (1) CA2268869A1 (de)
CZ (1) CZ298403B6 (de)
DE (2) DE69736961T2 (de)
DK (2) DK0934419T3 (de)
ES (2) ES2210504T3 (de)
FR (1) FR2755143B1 (de)
HU (1) HU226148B1 (de)
IL (3) IL129395A0 (de)
NZ (1) NZ335332A (de)
PL (1) PL190773B1 (de)
PT (2) PT934419E (de)
RU (1) RU2216594C2 (de)
WO (1) WO1998018941A1 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5905171A (en) 1995-06-22 1999-05-18 Novus International, Inc. Process for the preparation of 3-(methylthio)propanal
JPH10179183A (ja) * 1996-12-20 1998-07-07 Daicel Chem Ind Ltd カルボン酸の製造方法
WO1998031816A1 (en) 1997-01-17 1998-07-23 Regents Of The University Of Minnesota Dna molecules and protein displaying improved triazine compound degrading ability
FR2780416B1 (fr) * 1998-06-10 2002-12-20 Rhone Poulenc Nutrition Animal Procede industriel de production de proteines heterologues chez e. coli et souches utiles pour le procede
FR2787121B1 (fr) * 1998-12-11 2003-09-12 Aventis Cropscience Sa Nouvelle methode d'isolement et de selection de genes codant pour des enzymes, et milieu de culture approprie
FR2791668B1 (fr) * 1999-04-02 2001-05-04 Rhone Poulenc Animal Nutrition Procede de preparation d' beta-hydroxy acides
US6368804B1 (en) * 1999-07-12 2002-04-09 E. I. Du Pont De Nemours & Company Method for stabilizing nitrilase activity and preserving microbial cells
FR2800749B1 (fr) * 1999-11-08 2004-07-16 Rhone Poulenc Animal Nutrition Procede de modulation de la selective des nitrilases, nouvelles nitrilases obtenues par ce procede et leur utilisation
AU2001231155A1 (en) * 2000-01-25 2001-08-07 Hugh Mctavish Microbes and methods for remediation
EP1167521A1 (de) * 2000-06-30 2002-01-02 Aventis Animal Nutrition S.A. Beschichtete enzymenthaltende Katalysator
FR2824823A1 (fr) * 2001-05-21 2002-11-22 Aventis Animal Nutrition Sa Procede de preparation d'acides carboxyliques aliphatiques par hydrolyse enzymatique de composes nitriles aliphatiques
JP4884863B2 (ja) * 2006-07-18 2012-02-29 国立大学法人岐阜大学 ニトリラーゼおよびニトリラーゼを用いるカルボン酸の製造方法
JP5143838B2 (ja) * 2007-07-25 2013-02-13 日本曹達株式会社 α−ヒドロキシ酸アンモニウム塩からのα−ヒドロキシ酸の製造方法
EP2338987A1 (de) 2009-11-16 2011-06-29 ZYRUS Beteiligungsgesellschaft mbH & Co. Patente I KG Ganzzellen-Biokatalysator
CN103429748B (zh) * 2010-12-30 2016-01-06 代谢探索者公司 甲硫氨酸羟基类似物(mha)的发酵产生
CN102517274B (zh) * 2011-12-13 2013-12-25 重庆大学 一种制备固定化腈水解酶的方法
CN103933861B (zh) * 2013-08-02 2017-04-26 浙江赛特膜技术有限公司 一种双极膜电渗析制备蛋氨酸和氢氧化钠的方法
CN103497131B (zh) * 2013-10-08 2015-05-13 重庆紫光化工股份有限公司 2-羟基-4-甲硫基丁酸金属螯合物的制备方法
CA3025792A1 (en) * 2016-06-24 2017-12-28 Novus International Inc. Hydroxy methionine analog formulations suitable for specialty chemical applications
CN113274882B (zh) * 2021-06-09 2022-05-17 温州大学新材料与产业技术研究院 基于高温双极膜电渗析的己二酸铵废液回收方法及其装置
CN115975999B (zh) * 2022-12-07 2025-06-03 万华化学集团股份有限公司 一种腈水解酶及其在2-羟基-4-甲硫基丁酸合成中的应用
EP4600368A1 (de) 2024-02-09 2025-08-13 Adisseo France S.A.S. Verfahren zur enzymatischen herstellung einer amidverbindung

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5356385A (en) * 1976-10-29 1978-05-22 Ajinomoto Co Inc Preparation of immobilized
US4732851A (en) * 1982-03-16 1988-03-22 Purification Engineering, Inc. Immobilization of cells with a polyazetidine prepolymer
DK152764C (da) * 1985-06-14 1988-10-03 Novo Industri As Fremgangsmaade til fremstilling af et immobiliseret enzymprodukt
DE3542861A1 (de) * 1985-12-04 1987-06-11 Huels Chemische Werke Ag Verfahren zur gewinnung von l-aepfelsaeure
US4800162A (en) * 1987-04-01 1989-01-24 Sepracor, Inc. Method for resolution of steroisomers in multiphase and extractive membrane reactors
DK589389D0 (da) * 1989-11-23 1989-11-23 Novo Nordisk As Immobiliseret enzympraeparat
US5629190A (en) * 1992-08-10 1997-05-13 Rhone-Poulenc Chimie Polypeptides possessing a nitrilase activity and method of converting nitriles to carboxylates by means of said polypeptides
ATE195347T1 (de) * 1992-10-02 2000-08-15 Res Corp Technologies Inc Methoden der erhöhung der sekretion von überexpremierten proteinen
EP0782629B1 (de) * 1994-09-22 1998-12-02 Rhone-Poulenc Nutrition Animale Enzymatische hydrolyse von den 4-methylthiobutyronitrilen
US5763652A (en) * 1995-03-08 1998-06-09 Daicel Chemical Industries, Ltd. Process for producing a carboxylic acid

Also Published As

Publication number Publication date
CN1181204C (zh) 2004-12-22
IL173394A0 (en) 2006-06-11
PT934419E (pt) 2004-03-31
HUP9904513A3 (en) 2001-03-28
PL190773B1 (pl) 2006-01-31
IL129395A (en) 2006-06-11
BR9712558A (pt) 1999-10-19
DE69725999T2 (de) 2004-12-23
NZ335332A (en) 2000-11-24
ATE345384T1 (de) 2006-12-15
JP2001502908A (ja) 2001-03-06
US6180359B1 (en) 2001-01-30
RU2216594C2 (ru) 2003-11-20
DE69725999D1 (de) 2003-12-11
HUP9904513A2 (hu) 2000-05-28
HU226148B1 (en) 2008-05-28
DE69736961T2 (de) 2007-10-04
EP1411126B1 (de) 2006-11-15
HK1022170A1 (en) 2000-07-28
EP1411126A1 (de) 2004-04-21
ES2277027T3 (es) 2007-07-01
FR2755143B1 (fr) 1998-11-27
EP0934419A1 (de) 1999-08-11
IL129395A0 (en) 2000-02-17
AU738160B2 (en) 2001-09-13
CA2268869A1 (fr) 1998-05-07
DK1411126T3 (da) 2007-03-26
PT1411126E (pt) 2007-02-28
FR2755143A1 (fr) 1998-04-30
KR20000052732A (ko) 2000-08-25
DK0934419T3 (da) 2004-03-15
PL332958A1 (en) 1999-10-25
CZ145499A3 (cs) 1999-08-11
ES2210504T3 (es) 2004-07-01
CN1234074A (zh) 1999-11-03
KR100557404B1 (ko) 2006-03-07
AU4951397A (en) 1998-05-22
CZ298403B6 (cs) 2007-09-19
JP4350801B2 (ja) 2009-10-21
WO1998018941A1 (fr) 1998-05-07
EP0934419B1 (de) 2003-11-05
DE69736961D1 (de) 2006-12-28

Similar Documents

Publication Publication Date Title
ATE253638T1 (de) Verfahren zur herstellung von 2-hydroxy-4-methyl- thiobuttersäure mit einer nitrilase
DE59709121D1 (de) Verfahren zur herstellung von wasserstoffperoxid
DE3783081D1 (de) Verfahren zur herstellung von bernsteinsaeure durch anaerobe fermentation.
DE3688336D1 (de) Verfahren zur herstellung von organischen saeuren unter verwendung von mikroorganismen.
DE3882242D1 (de) Fermentationsverfahren zur herstellung von 2-keto-l-gulonsaeuren.
DE3762604D1 (de) Verfahren zur herstellung von waessrigen loesungen von freiem hydroxylamin.
AT380687B (de) Verfahren zur herstellung von n-phosphonometyl-glycin
DE3862306D1 (de) Verfahren zur elektrochemischen herstellung von carbonsaeuren.
ATE20735T1 (de) Verfahren zur herstellung von 2-cyanacrylaten aus 2,4-dicyanglutaraten.
DE3772847D1 (de) Verfahren zur herstellung von 2-methyl-1,4-naphthochinon.
DE3769973D1 (de) Verfahren zur herstellung von niedermolekularen alkalihuminaten.
AT364343B (de) Verfahren zur herstellung von alkoholischen phosphorsaeureloesungen aus einer waesserigen loesung oder suspension von sauren phosphaten, sowie vorrichtung zur durchfuehrung des verfahrens
ATE11525T1 (de) Verfahren zur herstellung von betahydroxybutans|ure.
ATE56204T1 (de) Verfahren zur herstellung von trockener alkansulfonsaeure.
ATE47861T1 (de) Verfahren zur herstellung von nphosphonomethylglycin.
DE3776173D1 (de) Verfahren zur herstellung von saeureamiden.
DE68910024D1 (de) Verfahren zur Herstellung von Methacrylsäure.
DE3484216D1 (de) Biosynthetische 2,5-diketogluconsaeurereduktase, verfahren, rekombinante zellen und expressionsvektoren fuer ihre herstellung und ihre verwendung zur bereitung von 2-keto-l-gulonsaeure.
ATE133204T1 (de) Verfahren zur kontinuierlichen umsetzung von cephalosporinderivaten zu glutaryl-7-amino- cephalosporansäurederivaten
ATE67986T1 (de) Verfahren zur herstellung von wasserstoffperoxid.
DE3685337D1 (de) Verfahren zur herstellung von amiden unter verwendung von mikroorganismen.
DE59309129D1 (de) Verfahren zur elektrochemischen herstellung von adipinsäure
DE58908961D1 (de) Verfahren zur Isolierung von 2-Keto-polyhydroxy-C6-carbonsäuren, insbesondere von 2-Keto-L-gulonsäure aus wässrigen Fermentationsausträgen.
DE3670074D1 (de) Verfahren zur herstellung von halogenierten benzolabkoemmlingen in gegenwart eines zeolith-katalysators.
DE3581885D1 (de) Verfahren zur herstellung des katalysators zur verwendung in der produktion der ungesaettigten carbonsaeuren.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 0934419

Country of ref document: EP

EEIH Change in the person of patent owner
REN Ceased due to non-payment of the annual fee