DE3484216D1 - Biosynthetische 2,5-diketogluconsaeurereduktase, verfahren, rekombinante zellen und expressionsvektoren fuer ihre herstellung und ihre verwendung zur bereitung von 2-keto-l-gulonsaeure. - Google Patents

Biosynthetische 2,5-diketogluconsaeurereduktase, verfahren, rekombinante zellen und expressionsvektoren fuer ihre herstellung und ihre verwendung zur bereitung von 2-keto-l-gulonsaeure.

Info

Publication number
DE3484216D1
DE3484216D1 DE8484304277T DE3484216T DE3484216D1 DE 3484216 D1 DE3484216 D1 DE 3484216D1 DE 8484304277 T DE8484304277 T DE 8484304277T DE 3484216 T DE3484216 T DE 3484216T DE 3484216 D1 DE3484216 D1 DE 3484216D1
Authority
DE
Germany
Prior art keywords
acid
biosynthetic
keto
preparing
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8484304277T
Other languages
English (en)
Inventor
David Aaron Estell
David Richard Light
William Harry Rastetter
Robert Alan Lazarus
Jeffrey Veach Miller
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genentech Inc
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/620,652 external-priority patent/US4758514A/en
Priority claimed from US06/620,651 external-priority patent/US4757012A/en
Application filed by Genentech Inc filed Critical Genentech Inc
Application granted granted Critical
Publication of DE3484216D1 publication Critical patent/DE3484216D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01274—2,5-Didehydrogluconate reductase (1.1.1.274), i.e. 2,5-diketo-D-gluconic acid reductase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/58—Aldonic, ketoaldonic or saccharic acids
    • C12P7/60—2-Ketogulonic acid
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00—Technologies for the production of fuel of non-fossil origin
    • Y02E50/10—Biofuels, e.g. bio-diesel

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DE8484304277T 1983-06-28 1984-06-25 Biosynthetische 2,5-diketogluconsaeurereduktase, verfahren, rekombinante zellen und expressionsvektoren fuer ihre herstellung und ihre verwendung zur bereitung von 2-keto-l-gulonsaeure. Expired - Fee Related DE3484216D1 (de)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US50840983A 1983-06-28 1983-06-28
US50862883A 1983-06-28 1983-06-28
US50841083A 1983-06-28 1983-06-28
US62058584A 1984-06-14 1984-06-14
US06/620,652 US4758514A (en) 1983-06-28 1984-06-14 Ascorbic acid intermediates and process enzymes
US06/620,651 US4757012A (en) 1983-06-28 1984-06-14 Ascorbic acid intermediates and process enzymes

Publications (1)

Publication Number Publication Date
DE3484216D1 true DE3484216D1 (de) 1991-04-11

Family

ID=27560082

Family Applications (2)

Application Number Title Priority Date Filing Date
DE8787202624T Expired - Lifetime DE3485981T2 (de) 1983-06-28 1984-06-25 Biosynthetische 2,5-diketoglukonsaeure-reduktase, verfahren, rekombinante zellen und expressionsvektoren zu deren herstellung und ihre verwendung zur herstellung von 2-keto-l-gulonsaeure.
DE8484304277T Expired - Fee Related DE3484216D1 (de) 1983-06-28 1984-06-25 Biosynthetische 2,5-diketogluconsaeurereduktase, verfahren, rekombinante zellen und expressionsvektoren fuer ihre herstellung und ihre verwendung zur bereitung von 2-keto-l-gulonsaeure.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE8787202624T Expired - Lifetime DE3485981T2 (de) 1983-06-28 1984-06-25 Biosynthetische 2,5-diketoglukonsaeure-reduktase, verfahren, rekombinante zellen und expressionsvektoren zu deren herstellung und ihre verwendung zur herstellung von 2-keto-l-gulonsaeure.

Country Status (12)

Country Link
EP (2) EP0305608B1 (de)
JP (2) JPS6070073A (de)
AR (1) AR243606A1 (de)
AT (1) ATE61409T1 (de)
AU (1) AU594921B2 (de)
BR (1) BR8403146A (de)
CA (1) CA1339107C (de)
DE (2) DE3485981T2 (de)
DK (1) DK175702B1 (de)
IE (1) IE57551B1 (de)
IL (5) IL89241A (de)
NZ (2) NZ208687A (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60118186A (ja) * 1983-11-17 1985-06-25 Shionogi & Co Ltd ２・５−ジケト−ｄ−グルコン酸リダクタ−ゼ
US5008193A (en) * 1984-06-14 1991-04-16 Genentech, Inc. Ascorbic acid intermediates and process enzymes
EP0231354B1 (de) * 1985-08-02 1992-07-15 Biogen, Inc. Herstellung eines vitamin-c-vorläufers mittels genetisch modifizierter organismen
GB8519536D0 (en) * 1985-08-02 1985-09-11 Biogen Nv Vitamin c precursor
US5082785A (en) * 1987-01-30 1992-01-21 Hoffmann-La Roche Inc. Biosynthesis of 2 keto-l-gulonic acid
US5376544A (en) * 1992-09-08 1994-12-27 Rutgers The State University Of New Jersey Enzymes for the production of 2-keto-L-gulonic acid
JPH08188578A (ja) 1994-11-11 1996-07-23 Takeda Chem Ind Ltd Ｌ−アスコルビン酸の製造方法
CN1119414C (zh) * 1997-12-30 2003-08-27 中国科学院上海生物工程研究中心 突变的2,5二酮基－d－葡萄糖酸还原酶及其基因工程表达
EP4061873A1 (de) 2019-11-19 2022-09-28 Solvay Specialty Polymers USA, LLC Verfahren zur herstellung eines polysulfon (psu)-polymers

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5021559B2 (de) * 1973-03-22 1975-07-23
JPS5135487A (en) * 1974-09-20 1976-03-25 Shionogi Seiyaku Kk 22 keto ll guronsan no seizohoho
US4245049A (en) * 1980-01-21 1981-01-13 Pfizer Inc. Preparation of 2-keto-L-gulonic acid
JPS6041596B2 (ja) * 1980-08-14 1985-09-18 塩野義製薬株式会社 ２，５−ジケト−ｄ−グルコン酸の製造方法
US4543331A (en) * 1982-03-05 1985-09-24 Shionogi & Co., Ltd. Fermentative or enzymatic production of 2-keto-L-gulonic acid
JPS58162298A (ja) * 1982-03-05 1983-09-26 Shionogi & Co Ltd ２−ケト−ｌ−グロン酸の製造方法
JPS60118186A (ja) * 1983-11-17 1985-06-25 Shionogi & Co Ltd ２・５−ジケト−ｄ−グルコン酸リダクタ−ゼ

Also Published As

Publication number Publication date
JPH0586186B2 (de) 1993-12-10
AR243606A1 (es) 1993-08-31
ATE61409T1 (de) 1991-03-15
JPS6070073A (ja) 1985-04-20
NZ208687A (en) 1991-07-26
BR8403146A (pt) 1985-02-12
NZ223397A (en) 1995-03-28
DK175702B1 (da) 2005-01-24
CA1339107C (en) 1997-07-29
IL89241A (en) 1990-08-31
JPH0614771A (ja) 1994-01-25
IL89241A0 (en) 1989-09-10
IL72225A (en) 1990-08-31
DE3485981T2 (de) 1993-06-09
EP0305608A1 (de) 1989-03-08
IL89242A (en) 1990-08-31
EP0132308A1 (de) 1985-01-30
IE841629L (en) 1984-12-28
DE3485981D1 (de) 1992-12-17
AU594921B2 (en) 1990-03-22
EP0305608B1 (de) 1992-11-11
DK310784A (da) 1984-12-29
EP0132308B1 (de) 1991-03-06
IL89242A0 (en) 1989-09-10
IE57551B1 (en) 1992-12-16
IL72225A0 (en) 1984-10-31
AU2983284A (en) 1985-01-03
DK310784D0 (da) 1984-06-26
JPH0740936B2 (ja) 1995-05-10

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8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee