DE69723843T2 - Verwendung von clotrimazol und verwandte verbindungen zur behandlung von diarrhöe - Google Patents

Verwendung von clotrimazol und verwandte verbindungen zur behandlung von diarrhöe Download PDF

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Publication number
DE69723843T2
DE69723843T2 DE69723843T DE69723843T DE69723843T2 DE 69723843 T2 DE69723843 T2 DE 69723843T2 DE 69723843 T DE69723843 T DE 69723843T DE 69723843 T DE69723843 T DE 69723843T DE 69723843 T2 DE69723843 T2 DE 69723843T2
Authority
DE
Germany
Prior art keywords
group
phenyl
diarrhea
aromatic compound
clotrimazole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69723843T
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German (de)
English (en)
Other versions
DE69723843D1 (de
Inventor
I. Wayne LENCER
Carlo Brugnara
Seth Alper
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boston Children's Hospital
Original Assignee
Boston Children's Hospital
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boston Children's Hospital filed Critical Boston Children's Hospital
Application granted granted Critical
Publication of DE69723843D1 publication Critical patent/DE69723843D1/de
Publication of DE69723843T2 publication Critical patent/DE69723843T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/065—Diphenyl-substituted acyclic alcohols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4174—Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39508—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum from milk, i.e. lactoglobulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Mycology (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DE69723843T 1996-03-20 1997-03-20 Verwendung von clotrimazol und verwandte verbindungen zur behandlung von diarrhöe Expired - Lifetime DE69723843T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US621169 1996-03-20
US08/621,169 US5889038A (en) 1996-03-20 1996-03-20 Methods and products for treating diarrhea and scours: use of clotrimazole and related aromatic compounds
PCT/US1997/004244 WO1997034599A2 (en) 1996-03-20 1997-03-20 Use of clotrimazole and related compounds in the treatment of diarrhea

Publications (2)

Publication Number Publication Date
DE69723843D1 DE69723843D1 (de) 2003-09-04
DE69723843T2 true DE69723843T2 (de) 2004-03-04

Family

ID=24489031

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69723843T Expired - Lifetime DE69723843T2 (de) 1996-03-20 1997-03-20 Verwendung von clotrimazol und verwandte verbindungen zur behandlung von diarrhöe

Country Status (9)

Country Link
US (3) US5889038A (enExample)
EP (1) EP0910376B1 (enExample)
JP (2) JP2000506895A (enExample)
AT (1) ATE245981T1 (enExample)
DE (1) DE69723843T2 (enExample)
DK (1) DK0910376T3 (enExample)
ES (1) ES2199358T3 (enExample)
PT (1) PT910376E (enExample)
WO (1) WO1997034599A2 (enExample)

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US7048906B2 (en) * 1995-05-17 2006-05-23 Cedars-Sinai Medical Center Methods of diagnosing and treating small intestinal bacterial overgrowth (SIBO) and SIBO-related conditions
US5889038A (en) * 1996-03-20 1999-03-30 Children's Hospital Methods and products for treating diarrhea and scours: use of clotrimazole and related aromatic compounds
ATE314060T1 (de) 1996-03-20 2006-01-15 Harvard College Triarylmethanverbindungen zur behandlung von krebs, aktinischer keratose und kaposisarkom
US6667063B2 (en) * 1998-06-10 2003-12-23 Albert Crum Nutritional or therapeutic supplement and method
EP1465863B1 (en) 2002-01-04 2008-07-09 NeuroSearch A/S Potassium channel modulators
US20050175597A1 (en) * 2002-03-21 2005-08-11 Rawlin Grant T. Compositions containing labile bioactive materials and mammalian colostrum, methods of preparation and treatment
AU2003273141B2 (en) 2002-05-20 2009-05-07 Cedars-Sinai Medical Center Manipulation of the rate of gastrointestinal transit by modulating intestinal methane concentration
US10066254B2 (en) * 2002-05-20 2018-09-04 Cedars-Sinai Medical Center Diagnosis of constipation by analysis of methane concentration
WO2005027851A2 (en) * 2003-09-18 2005-03-31 Children's Medical Center Corporation Treatment of severe distal colitis
US20060013890A1 (en) * 2004-06-24 2006-01-19 Green Shawn J Dairy-derived anticholesterol immunoglobulin to lower dietary cholesterol in humans
US20070087002A1 (en) * 2005-10-14 2007-04-19 Green Shawn J Anticholesterol immunoglobulin to treat lipid raft diseases
PT2152663E (pt) 2007-06-04 2014-06-03 Univ Ben Gurion Compostos de triarilo e composições que compreendem os mesmos
WO2009027292A1 (en) 2007-08-24 2009-03-05 Neurosearch A/S Carbonylamino derivatives useful for the treatment of certain inflammatory disorders
KR101345860B1 (ko) 2011-10-25 2013-12-30 이화여자대학교 산학협력단 모다피닐 또는 이의 유도체를 포함하는 혈관질환 치료용 조성물
US9744208B2 (en) 2013-03-15 2017-08-29 Cedars-Sinai Medical Center Methods of diagnosis, selection, and treatment of diseases and conditions caused by or associated with methanogens
US9289418B2 (en) 2013-03-15 2016-03-22 Cedars-Sinai Medical Center Methods of diagnosis, selection, and treatment of diseases and conditions caused by or associated with methanogens
CN103266281B (zh) * 2013-05-24 2015-02-04 无锡鑫常钢管有限责任公司 一种超级双相不锈钢管及其生产工艺
EP3065723B1 (en) 2013-11-05 2020-09-23 Ben Gurion University of the Negev Research and Development Authority Compounds for the treatment of diabetes and disease complications arising from same
US9956292B2 (en) 2014-08-13 2018-05-01 Cedars-Sinai Medical Center Anti-methanogenic compositions and uses thereof
US10736871B2 (en) 2015-04-01 2020-08-11 Cedars-Sinai Medical Center Anti-methanogenic lovastatin analogs or derivatives and uses thereof
TW202042799A (zh) * 2019-01-16 2020-12-01 美國加利福尼亞大學董事會 治療酪胺酸激酶抑制劑引起之腹瀉的方法
JP6664637B1 (ja) * 2019-08-08 2020-03-13 株式会社 レオロジー機能食品研究所 ストレス低下用及び／又は体重回復用経口組成物、並びにプラズマローゲン含有組成物の製造方法

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US3965112A (en) * 1971-01-11 1976-06-22 John Wyeth & Brother Limited Imidazoline derivatives
CA1007568A (en) * 1973-12-13 1977-03-29 Canada Packers Limited Bovine immunoglobulin isolation process
US3917615A (en) * 1974-04-01 1975-11-04 Searle & Co 1,1-Diaryl-1-oxadiazol-alkylamines
US3998832A (en) * 1975-04-16 1976-12-21 G. D. Searle & Co. Anti-diarrheal compounds
US4284829A (en) * 1977-09-13 1981-08-18 Pfizer Inc. Hydroxyalkyl and oxoalkyl substituted phenols as analgesics and sedatives
US4806685A (en) 1985-08-05 1989-02-21 Gyogyszerkutato Inteezet/Pharmaceutical Research Institute 1,1,2-triphenylpropane and -propene derivatives
JPS62163662A (ja) * 1986-01-11 1987-07-20 Nippon Nousan Kogyo Kk 犬猫用ペツトフ−ド
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AU629559B2 (en) * 1988-08-04 1992-10-08 Thomas Julius Borody Oral antibody therapy for patients with lowered immune response and composition therefor
AU5254790A (en) * 1989-04-06 1990-10-11 Chugai Seiyaku Kabushiki Kaisha Process for preparing a therapeutic agent for rotavirus infection
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DE4130689A1 (de) * 1991-09-14 1993-03-18 Biotest Pharma Gmbh Verfahren zur herstellung eines leicht loeslichen getrockneten immunglobulin-praeparats aus kolostralmilch
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US5387600A (en) 1992-07-30 1995-02-07 Fuji Photo Film Co., Ltd. Treating arteriosclerosis using benzimidazole compositions
US5512591A (en) 1993-02-18 1996-04-30 President And Fellows Of Harvard College Treatments for diseases characterized by neovascularization
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FR2715068B1 (fr) * 1994-01-17 1996-04-19 Paul Vidal Procédé permettant de recueillir des doses de sérocolostrum bovin destinées à être administrées par voie orale à des veaux nouveau-nés ainsi que dispositif permettant la mise en Óoeuvre de ce procédé.
US5650425A (en) 1994-04-04 1997-07-22 Pharmos Corporation Permanently ionic derivatives of steroid hormones and their antagonists
AU2880595A (en) 1994-07-06 1996-01-25 Bo Arne Hofmann Use of pharmaceutical agents for restoring, alleviation, or treatment of immunodeficiency, including the alleviation or treatment of the immune dysfunction related to infection with human immunodeficiency viruses (hiv) or related viruses
WO1996008242A2 (en) * 1994-09-16 1996-03-21 Children's Medical Center Corporation Clotrimazole metabolites in the treatment of sickle cell disease
ATE314060T1 (de) 1996-03-20 2006-01-15 Harvard College Triarylmethanverbindungen zur behandlung von krebs, aktinischer keratose und kaposisarkom
US5889038A (en) * 1996-03-20 1999-03-30 Children's Hospital Methods and products for treating diarrhea and scours: use of clotrimazole and related aromatic compounds
WO1999025347A2 (en) 1997-11-14 1999-05-27 Neurosearch A/S Chemical compounds having ion channel blocking activity for the treatment of immune dysfunction

Also Published As

Publication number Publication date
JP2009007368A (ja) 2009-01-15
JP2000506895A (ja) 2000-06-06
US5889038A (en) 1999-03-30
EP0910376A2 (en) 1999-04-28
US20030119784A1 (en) 2003-06-26
WO1997034599A3 (en) 1998-02-12
WO1997034599A2 (en) 1997-09-25
EP0910376B1 (en) 2003-07-30
DK0910376T3 (da) 2003-11-17
PT910376E (pt) 2003-12-31
DE69723843D1 (de) 2003-09-04
ES2199358T3 (es) 2004-02-16
ATE245981T1 (de) 2003-08-15
US6495567B1 (en) 2002-12-17

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