DE69715774T2 - 1-(2-deoxy-2-fluoro-4-thio-beta-d-arabinofuranosyl)-cytosine - Google Patents

1-(2-deoxy-2-fluoro-4-thio-beta-d-arabinofuranosyl)-cytosine

Info

Publication number
DE69715774T2
DE69715774T2 DE69715774T DE69715774T DE69715774T2 DE 69715774 T2 DE69715774 T2 DE 69715774T2 DE 69715774 T DE69715774 T DE 69715774T DE 69715774 T DE69715774 T DE 69715774T DE 69715774 T2 DE69715774 T2 DE 69715774T2
Authority
DE
Germany
Prior art keywords
compound
formula
group
compound represented
fluoro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69715774T
Other languages
German (de)
English (en)
Other versions
DE69715774D1 (de
Inventor
Kenji Kitano
Haruhiko Machida
Shinji Miura
Mikari Watanabe
Yuichi Yoshimura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yamasa Corp
Original Assignee
Yamasa Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamasa Corp filed Critical Yamasa Corp
Publication of DE69715774D1 publication Critical patent/DE69715774D1/de
Application granted granted Critical
Publication of DE69715774T2 publication Critical patent/DE69715774T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/32—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE69715774T 1996-04-09 1997-04-09 1-(2-deoxy-2-fluoro-4-thio-beta-d-arabinofuranosyl)-cytosine Expired - Lifetime DE69715774T2 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP11196896 1996-04-09
JP21508296 1996-07-26
JP27863196 1996-09-30
PCT/JP1997/001206 WO1997038001A1 (en) 1996-04-09 1997-04-09 1-(2-DEOXY-2-FLUORO-4-THIO-β-D-ARABINOFURANOSYL)CYTOSINES

Publications (2)

Publication Number Publication Date
DE69715774D1 DE69715774D1 (de) 2002-10-31
DE69715774T2 true DE69715774T2 (de) 2003-05-15

Family

ID=27312140

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69715774T Expired - Lifetime DE69715774T2 (de) 1996-04-09 1997-04-09 1-(2-deoxy-2-fluoro-4-thio-beta-d-arabinofuranosyl)-cytosine

Country Status (10)

Country Link
US (1) US6147058A (enExample)
EP (1) EP0841344B1 (enExample)
JP (1) JP3657008B2 (enExample)
AT (1) ATE224909T1 (enExample)
CA (1) CA2224155C (enExample)
DE (1) DE69715774T2 (enExample)
DK (1) DK0841344T3 (enExample)
ES (1) ES2182061T3 (enExample)
PT (1) PT841344E (enExample)
WO (1) WO1997038001A1 (enExample)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7138384B1 (en) 1997-08-29 2006-11-21 The Regents Of The University Of California Modulators of DNA cytosine-5 methyltransferase and methods for use thereof
EA200700564A1 (ru) * 1998-02-25 2007-08-31 Эмори Юниверсити 2`-фторнуклеозиды
WO2005027962A1 (en) * 2003-09-18 2005-03-31 Isis Pharmaceuticals, Inc. 4’-thionucleosides and oligomeric compounds
US7524831B2 (en) * 2005-03-02 2009-04-28 Schering Corporation Treatments for Flaviviridae virus infection
EP2388257A1 (en) * 2010-05-20 2011-11-23 LibraMedicina, Inc. Process for preparing substituted 1-O-acyl-2-deoxy-2-fluoro-4-thio-ß-D-arabinofuranoses
MY156954A (en) 2009-12-18 2016-04-15 Libramedicina Inc PROCESS FOR PREPARING SUBSTITUTED 1-O-ACYL-2-DEOXY-2-FLUORO-4-THIO-ß-D-ARABINOFURANOSES
KR101770246B1 (ko) 2012-03-28 2017-08-22 후지필름 가부시키가이샤 1-(2-디옥시-2-플루오로-4-티오-β-D-아라비노푸라노실)시토신의 염
HRP20190572T1 (hr) 2012-08-13 2019-05-17 Fujifilm Corporation POSREDNIK ZA SINTEZU 1-(2-DEOKSI-2 FLUORO-4-TIO-beta-D-ARABINOFURANOZIL) CITOZINA, POSREDNIK ZA SINTEZU TIONUKLEOZIDA, I METODE ZA PROIZVODNJU OVIH POSREDNIKA
EP3004130B1 (en) * 2013-06-05 2019-08-07 Idenix Pharmaceuticals LLC. 1',4'-thio nucleosides for the treatment of hcv
WO2015125781A1 (ja) * 2014-02-18 2015-08-27 富士フイルム株式会社 チオラン骨格型糖化合物の製造方法およびチオラン骨格型糖化合物
JP6351107B2 (ja) * 2014-02-18 2018-07-04 富士フイルム株式会社 チオラン骨格型糖化合物の製造方法およびチオラン骨格型糖化合物
JP6204223B2 (ja) 2014-02-19 2017-09-27 富士フイルム株式会社 チオピラノース化合物等の製造方法
TWI678373B (zh) * 2014-10-31 2019-12-01 日商富士軟片股份有限公司 硫代核苷衍生物或其鹽及醫藥組合物
CN106661077B (zh) * 2015-04-03 2019-02-12 四川科伦博泰生物医药股份有限公司 4’-硫代核苷的新型化合物及其制备方法、药物组合物和应用
JP6450356B2 (ja) * 2016-02-29 2019-01-09 富士フイルム株式会社 液状医薬製剤
RU2752172C2 (ru) * 2016-08-31 2021-07-23 Фуджифилм Корпорэйшн Противоопухолевый агент, усилитель противоопухолевого действия и противоопухолевый набор
EP3560944A4 (en) 2016-12-22 2020-08-26 Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. SOLID FORM OF 4'-THIO-2'-FLUORONUCLEOSIDE PHOSPHAMIDE COMPOUND, PROCESS FOR PREPARATION AND USE
US11266674B2 (en) 2017-09-01 2022-03-08 Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. Pharmaceutical composition for tumor treatment or prevention, method, and use thereof
WO2019146129A1 (ja) * 2018-01-29 2019-08-01 富士フイルム株式会社 イソクエン酸デヒドロゲナーゼ変異を有する腫瘍に対する医薬組成物および抗腫瘍剤ならびにその利用
MX2018002611A (es) 2018-01-29 2019-07-30 Fujifilm Corp Agente antitumoral para cancer del tracto biliar y metodo para tratar cancer del tracto biliar.
TW202000207A (zh) * 2018-02-26 2020-01-01 日商富士軟片股份有限公司 膀胱癌用抗腫瘤劑及膀胱癌的處置方法
TW202002989A (zh) * 2018-03-13 2020-01-16 日商富士軟片股份有限公司 抗腫瘤劑、抗腫瘤效果增強劑及抗腫瘤用試劑盒
WO2020068657A1 (en) * 2018-09-25 2020-04-02 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services 2'-halogenated-4'-thio-2'-deoxy-5-azacytidine analogs and use thereof
WO2020108343A1 (zh) * 2018-11-28 2020-06-04 四川科伦博泰生物医药股份有限公司 以4'-硫代核苷类化合物为活性成分的口服药物组合物、其制备方法及其用途
KR20220039748A (ko) * 2019-07-30 2022-03-29 주식회사 피노바이오 암 치료용 디뉴클레오티드 화합물 및 그의 의약 용도
JPWO2023008511A1 (enExample) 2021-07-29 2023-02-02

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE74701B1 (en) * 1989-10-04 1997-07-30 Univ Birmingham Further antiviral pyrimidine nucleosides
WO1996001834A1 (en) * 1994-07-12 1996-01-25 Yamasa Corporation 2'-deoxy-2'-(substituted or unsubstituted methylidene)-4'-thionucleoside
JPH0853490A (ja) * 1994-08-09 1996-02-27 Yamasa Shoyu Co Ltd ２’−デオキシ−２’，２’−ジハロゲノ−４’−チオヌクレオシド

Also Published As

Publication number Publication date
PT841344E (pt) 2003-02-28
EP0841344B1 (en) 2002-09-25
WO1997038001A1 (en) 1997-10-16
ES2182061T3 (es) 2003-03-01
ATE224909T1 (de) 2002-10-15
DE69715774D1 (de) 2002-10-31
DK0841344T3 (da) 2002-12-23
EP0841344A4 (enExample) 1998-05-13
JP3657008B2 (ja) 2005-06-08
CA2224155A1 (en) 1997-10-16
US6147058A (en) 2000-11-14
EP0841344A1 (en) 1998-05-13
CA2224155C (en) 2004-10-26

Similar Documents

Publication Publication Date Title
US6147058A (en) 1-(2-deoxy-2-fluoro-4-thio-beta-D-arabinofuranosyl)cytosine
DE3850571T2 (de) 2',3'-dideoxyribofuranoxid-derivate.
DE68923387T2 (de) 2',3'-Dideoxy-2',2'-difluornucleoside.
DE60005501T2 (de) 4'-c-ethynyl-pyrimidine nukleoside
JP5213194B2 (ja) ４’−ｃ−置換−２−ハロアデノシン誘導体
EP0316704B1 (de) Fluorcytidinderivate, deren Herstellung und Arzneimittel, die diese Derivate enthalten
US5393878A (en) Bicyclic nucleosides, oligonucleotides, process for their preparation and intermediates
DE69407419T2 (de) 2' oder 3' -deoxy- und 2' -dideoxy-beta-l-pentafuranonukleoside, verfahren zur herstellung und anwendung in der therapie, insbesondere als antivirale wirkstoffe
JP3530218B2 (ja) ▲ｎ４▼−アシル−５’−デオキシ−５−フルオロシチジン誘導体の新規製造法
DE2508312C2 (enExample)
JPWO1997038001A1 (ja) １−（２−デオキシ−２−フルオロ−４−チオ−β−Ｄ−アラビノフラノシル）シトシン
DE3751468T2 (de) Verfahren zur herstellung von oligonukleotiden und verbindungen zur bildung hochmolekularer schutzgruppen.
EP0003229A1 (de) Neues Verfahren zur Herstellung von Nucleosiden
US6103707A (en) 9-(2-deoxy-2-fluoro-4-thio-beta-D-arabinofuranosyl)purine derivatives
DE60204859T2 (de) Verfahren zur Herstellung von 2'-Halo-beta-L-arabino-furanosylnucleosiden
DE68918036T2 (de) Nukleosid-Derivate.
JP4202327B2 (ja) １−（２−デオキシ−２−フルオロ−４−チオ−β−Ｄ−アラビノフラノシル）シトシン
JPH0853490A (ja) ２’−デオキシ−２’，２’−ジハロゲノ−４’−チオヌクレオシド
DE68917060T2 (de) 2'-Methylidenpyrimidin-Nukleoside, ihre Verwendung und Verfahren zu ihrer Herstellung.
DE69119994T2 (de) Verfahren zur Herstellung von Desoxynukleosiden
DE60007848T2 (de) Herstellung von 2'-substitutierter rns
Kikuchi et al. Synthesis of 9-[2′, 3′-Dideoxy-2′, 3′-bis-C-hydroxymethyl-α-L-threofuranosyl] adenine and its 4′-Thio Analog as Potential Antiviral Agents
DE69719673T2 (de) D-pentofuranose-derivate und verfahren zu ihrer herstellung
EP0777673A2 (de) Alpha-d-pentofuranosid-derivate, verfahren zu deren herstellung und deren verwendung
AT394564B (de) Verfahren zur herstellung von 2-desoxy-d-threopentose und 2,3-didesoxy-3-fluor-d-erythro-pentosesowie von substituierten und unsubstituierten 2,3-didesoxy-3-fluor-d-erythro-pentofuranosen und deren verwendung

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Representative=s name: JUNG, SCHIRDEWAHN, GRUENBERG, SCHNEIDER PATENTANWAELTE

8328 Change in the person/name/address of the agent

Representative=s name: ADVOTEC. PATENT- UND RECHTSANWAELTE, 80538 MUENCHE

R082 Change of representative

Ref document number: 841344

Country of ref document: EP

Representative=s name: ADVOTEC. PATENT- UND RECHTSANWAELTE, 80538 MUENCHE