ES2182061T3 - 1 - (2 - desoxi - 2 - fluor-4- tio-beta-d arabinofuranosil)citosina. - Google Patents

1 - (2 - desoxi - 2 - fluor-4- tio-beta-d arabinofuranosil)citosina.

Info

Publication number
ES2182061T3
ES2182061T3 ES97916633T ES97916633T ES2182061T3 ES 2182061 T3 ES2182061 T3 ES 2182061T3 ES 97916633 T ES97916633 T ES 97916633T ES 97916633 T ES97916633 T ES 97916633T ES 2182061 T3 ES2182061 T3 ES 2182061T3
Authority
ES
Spain
Prior art keywords
beta
citosine
desoxi
arabinofuranosil
fluor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97916633T
Other languages
English (en)
Spanish (es)
Inventor
Yuichi Yoshimura
Kenji Kitano
Shinji Miura
Haruhiko Machida
Mikari Watanabe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yamasa Corp
Original Assignee
Yamasa Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamasa Corp filed Critical Yamasa Corp
Application granted granted Critical
Publication of ES2182061T3 publication Critical patent/ES2182061T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/32—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
ES97916633T 1996-04-09 1997-04-09 1 - (2 - desoxi - 2 - fluor-4- tio-beta-d arabinofuranosil)citosina. Expired - Lifetime ES2182061T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP11196896 1996-04-09
JP21508296 1996-07-26
JP27863196 1996-09-30

Publications (1)

Publication Number Publication Date
ES2182061T3 true ES2182061T3 (es) 2003-03-01

Family

ID=27312140

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97916633T Expired - Lifetime ES2182061T3 (es) 1996-04-09 1997-04-09 1 - (2 - desoxi - 2 - fluor-4- tio-beta-d arabinofuranosil)citosina.

Country Status (10)

Country Link
US (1) US6147058A (enExample)
EP (1) EP0841344B1 (enExample)
JP (1) JP3657008B2 (enExample)
AT (1) ATE224909T1 (enExample)
CA (1) CA2224155C (enExample)
DE (1) DE69715774T2 (enExample)
DK (1) DK0841344T3 (enExample)
ES (1) ES2182061T3 (enExample)
PT (1) PT841344E (enExample)
WO (1) WO1997038001A1 (enExample)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7138384B1 (en) 1997-08-29 2006-11-21 The Regents Of The University Of California Modulators of DNA cytosine-5 methyltransferase and methods for use thereof
EP1058686B1 (en) 1998-02-25 2006-11-02 Emory University 2'-fluoronucleosides
JP5379347B2 (ja) * 2003-09-18 2013-12-25 アイシス ファーマシューティカルズ， インコーポレーテッド ４’−チオヌクレオシドおよびオリゴマー化合物
US7524831B2 (en) * 2005-03-02 2009-04-28 Schering Corporation Treatments for Flaviviridae virus infection
US8329925B2 (en) * 2009-12-18 2012-12-11 Libramedicina, Inc. Process for preparing substituted 1-O-acyl-2-deoxy-2-fluoro-4-thio-beta-D-arabinofuranoses
EP2388257A1 (en) 2010-05-20 2011-11-23 LibraMedicina, Inc. Process for preparing substituted 1-O-acyl-2-deoxy-2-fluoro-4-thio-ß-D-arabinofuranoses
RU2600734C2 (ru) 2012-03-28 2016-10-27 Фуджифилм Корпорэйшн СОЛЬ 1-(2-ДЕЗОКСИ-2-ФТОР-4-ТИО-β-D-АРАБИНОФУРАНОЗИЛ)ЦИТОЗИНА
ES2718307T3 (es) * 2012-08-13 2019-07-01 Fujifilm Corp Intermedio para la síntesis de 1-(2-desoxi-2-fluoro-4-tio-beta-d-arabinofuranosil)citosina, intermedio para la síntesis de tionucleósido y métodos para producir estos intermedios
US10005779B2 (en) 2013-06-05 2018-06-26 Idenix Pharmaceuticals Llc 1′,4′-thio nucleosides for the treatment of HCV
CN106061959B (zh) * 2014-02-18 2018-11-09 富士胶片株式会社 四氢噻吩骨架型糖化合物的制造方法及四氢噻吩骨架型糖化合物
JP6351107B2 (ja) * 2014-02-18 2018-07-04 富士フイルム株式会社 チオラン骨格型糖化合物の製造方法およびチオラン骨格型糖化合物
JP6204223B2 (ja) 2014-02-19 2017-09-27 富士フイルム株式会社 チオピラノース化合物等の製造方法
TWI678373B (zh) * 2014-10-31 2019-12-01 日商富士軟片股份有限公司 硫代核苷衍生物或其鹽及醫藥組合物
CN109553651B (zh) * 2015-04-03 2021-08-06 四川科伦博泰生物医药股份有限公司 4’-硫代核苷的新型化合物及其制备方法、药物组合物和应用
JP6450356B2 (ja) * 2016-02-29 2019-01-09 富士フイルム株式会社 液状医薬製剤
MX392665B (es) 2016-08-31 2025-03-24 Fujifilm Corp Agente antitumoral, mejorador del efecto antitumoral, y kit antitumoral.
EA201990780A1 (ru) 2016-12-22 2019-11-29 Твердая форма соединения 4'-тио-2'-фторнуклеозид фосфамида и способ его получения и применения
US11266674B2 (en) 2017-09-01 2022-03-08 Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. Pharmaceutical composition for tumor treatment or prevention, method, and use thereof
WO2019146129A1 (ja) * 2018-01-29 2019-08-01 富士フイルム株式会社 イソクエン酸デヒドロゲナーゼ変異を有する腫瘍に対する医薬組成物および抗腫瘍剤ならびにその利用
WO2019146130A1 (ja) * 2018-01-29 2019-08-01 富士フイルム株式会社 胆道がん用抗腫瘍剤および胆道がんの処置方法
WO2019164010A1 (ja) * 2018-02-26 2019-08-29 富士フイルム株式会社 膀胱がん用抗腫瘍剤および膀胱がんの処置方法
CN111836628B (zh) 2018-03-13 2025-01-07 富士胶片株式会社 抗肿瘤剂、抗肿瘤效果增强剂及抗肿瘤用试剂盒
WO2020068657A1 (en) * 2018-09-25 2020-04-02 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services 2'-halogenated-4'-thio-2'-deoxy-5-azacytidine analogs and use thereof
CN112770731A (zh) * 2018-11-28 2021-05-07 四川科伦博泰生物医药股份有限公司 以4’-硫代核苷类化合物为活性成分的口服药物组合物、其制备方法及其用途
JP2022542697A (ja) * 2019-07-30 2022-10-06 ピノットバイオ，インコーポレイテッド 癌治療用ジヌクレオチド化合物及びその医薬用途
CN117794548A (zh) 2021-07-29 2024-03-29 富士胶片株式会社 针对bap1及pbrm1中的至少一个的功能下降的肿瘤的药物组合物及抗肿瘤剂

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE74701B1 (en) * 1989-10-04 1997-07-30 Univ Birmingham Further antiviral pyrimidine nucleosides
WO1996001834A1 (en) * 1994-07-12 1996-01-25 Yamasa Corporation 2'-deoxy-2'-(substituted or unsubstituted methylidene)-4'-thionucleoside
JPH0853490A (ja) * 1994-08-09 1996-02-27 Yamasa Shoyu Co Ltd ２’−デオキシ−２’，２’−ジハロゲノ−４’−チオヌクレオシド

Also Published As

Publication number Publication date
DK0841344T3 (da) 2002-12-23
DE69715774D1 (de) 2002-10-31
EP0841344A4 (enExample) 1998-05-13
EP0841344B1 (en) 2002-09-25
ATE224909T1 (de) 2002-10-15
WO1997038001A1 (en) 1997-10-16
EP0841344A1 (en) 1998-05-13
PT841344E (pt) 2003-02-28
DE69715774T2 (de) 2003-05-15
CA2224155A1 (en) 1997-10-16
JP3657008B2 (ja) 2005-06-08
US6147058A (en) 2000-11-14
CA2224155C (en) 2004-10-26

Similar Documents

Publication Publication Date Title
ES2182061T3 (es) 1 - (2 - desoxi - 2 - fluor-4- tio-beta-d arabinofuranosil)citosina.
ZA200309887B (en) Novel compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents.
AU5211686A (en) Pyrazolesulfonamide derivative, process for its production and herbicide containing it
ES2195510T3 (es) Derivados de imidazopiridina y procedimiento para prepararlos.
ATE201195T1 (de) Tricyclische verbindungen
PT1385518E (pt) Compostos de benzimidazolona
BG103778A (en) Process for preparing pyrazole derivatives
EP0714900A3 (de) Alkylhydrogenchlorsilane, Verfahren zu deren Herstellung und deren Verwendung
ATE277017T1 (de) 1,2-disubstituierte 1,4-dihydro-4-oxochinolin- verbindungen
ES2192852T3 (es) Proceso de obtencion de 3-aril-benzofuranonas.
AU2001282297A1 (en) Catalysts
FI955954A0 (fi) Thiolyhdisteitä
EP0782996A4 (en) METHOD FOR PRODUCING N-BIPHENYLMETHYLTHIADIAZOLINE DERIVATIVES OR THEIR SALTS, AND INTERMEDIATE COMPOUNDS REQUIRED THEREFOR
ATE223414T1 (de) Prozess zur herstellung von zwischebprodukten für imidazodeazepinen
EP0747350A4 (en) PROCESS FOR THE MANUFACTURE OF BIS (4-ALKYLTHIOPHENYLE) BISULFIDE
ATE206125T1 (de) Furoindolizine
EP0551632A3 (en) Process for the preparation of halogenoanthranilic acid
AU2407597A (en) Eyedrops
DE69601451D1 (de) UCK14-Verbindungen
ATE206699T1 (de) Uch-15-verbindungen
BR0016521B1 (pt) processo para produÇço de 2-nitroguanidinas 1,3-dissubstituÍdas.
FI904981A0 (fi) Nya inosin/guanosinderivat.
EP1007511A4 (en) PRODUCTION OF BETA MEHTYLCARBAPENEM INTERMEDIATE PRODUCTS