PT841344E - 1-(2-desoxi-2-fluoro-4-tio-beta-d-arabinofuranosil) citosinas - Google Patents
1-(2-desoxi-2-fluoro-4-tio-beta-d-arabinofuranosil) citosinasInfo
- Publication number
- PT841344E PT841344E PT97916633T PT97916633T PT841344E PT 841344 E PT841344 E PT 841344E PT 97916633 T PT97916633 T PT 97916633T PT 97916633 T PT97916633 T PT 97916633T PT 841344 E PT841344 E PT 841344E
- Authority
- PT
- Portugal
- Prior art keywords
- arabinofuranosyl
- cytosines
- thio
- fluoro
- beta
- Prior art date
Links
- -1 2-DESOXY-2-FLUORO-4-THIO-BETA-D-ARABINOFURANOSYL Chemical class 0.000 title 1
- NIDPJRZOVFIBQB-PXBUCIJWSA-N 4-amino-1-[(2r,3s,4s,5r)-3-fluoro-4-hydroxy-5-(hydroxymethyl)thiolan-2-yl]pyrimidin-2-one Chemical class O=C1N=C(N)C=CN1[C@H]1[C@@H](F)[C@H](O)[C@@H](CO)S1 NIDPJRZOVFIBQB-PXBUCIJWSA-N 0.000 abstract 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical group OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 abstract 1
- 230000000259 anti-tumor effect Effects 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/32—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP11196896 | 1996-04-09 | ||
| JP21508296 | 1996-07-26 | ||
| JP27863196 | 1996-09-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT841344E true PT841344E (pt) | 2003-02-28 |
Family
ID=27312140
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT97916633T PT841344E (pt) | 1996-04-09 | 1997-04-09 | 1-(2-desoxi-2-fluoro-4-tio-beta-d-arabinofuranosil) citosinas |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6147058A (enExample) |
| EP (1) | EP0841344B1 (enExample) |
| JP (1) | JP3657008B2 (enExample) |
| AT (1) | ATE224909T1 (enExample) |
| CA (1) | CA2224155C (enExample) |
| DE (1) | DE69715774T2 (enExample) |
| DK (1) | DK0841344T3 (enExample) |
| ES (1) | ES2182061T3 (enExample) |
| PT (1) | PT841344E (enExample) |
| WO (1) | WO1997038001A1 (enExample) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7138384B1 (en) | 1997-08-29 | 2006-11-21 | The Regents Of The University Of California | Modulators of DNA cytosine-5 methyltransferase and methods for use thereof |
| KR100954390B1 (ko) * | 1998-02-25 | 2010-04-26 | 에모리 유니버시티 | 2'-플루오로뉴클레오사이드 |
| JP5379347B2 (ja) * | 2003-09-18 | 2013-12-25 | アイシス ファーマシューティカルズ， インコーポレーテッド | ４’−チオヌクレオシドおよびオリゴマー化合物 |
| US7524831B2 (en) * | 2005-03-02 | 2009-04-28 | Schering Corporation | Treatments for Flaviviridae virus infection |
| SG181745A1 (en) | 2009-12-18 | 2012-07-30 | Libramedicina Inc | PROCESS FOR PREPARING SUBSTITUTED 1-O-ACYL-2-DEOXY-2-FLUORO-4-THIO-ß-D-ARABINOFURANOSES |
| EP2388257A1 (en) | 2010-05-20 | 2011-11-23 | LibraMedicina, Inc. | Process for preparing substituted 1-O-acyl-2-deoxy-2-fluoro-4-thio-ß-D-arabinofuranoses |
| KR101770246B1 (ko) * | 2012-03-28 | 2017-08-22 | 후지필름 가부시키가이샤 | 1-(2-디옥시-2-플루오로-4-티오-β-D-아라비노푸라노실)시토신의 염 |
| HUE044412T2 (hu) | 2012-08-13 | 2019-10-28 | Fujifilm Corp | Intermedier l-(2-deoxi-2-fluor-4-tio-beta-D-arabinofuranozil)-citozin szintézisére, intermedier tionukleozid szintézisére és eljárások ezen intermedierek elõállítására |
| WO2014197578A1 (en) * | 2013-06-05 | 2014-12-11 | Idenix Pharmaceuticals, Inc. | 1',4'-thio nucleosides for the treatment of hcv |
| EP3109245B1 (en) | 2014-02-18 | 2018-01-03 | FUJIFILM Corporation | Method for producting thiolane skeleton-type glycoconjugate, and thiolane skeleton-type glycoconjugate |
| JP6351107B2 (ja) * | 2014-02-18 | 2018-07-04 | 富士フイルム株式会社 | チオラン骨格型糖化合物の製造方法およびチオラン骨格型糖化合物 |
| JP6204223B2 (ja) | 2014-02-19 | 2017-09-27 | 富士フイルム株式会社 | チオピラノース化合物等の製造方法 |
| TWI678373B (zh) | 2014-10-31 | 2019-12-01 | 日商富士軟片股份有限公司 | 硫代核苷衍生物或其鹽及醫藥組合物 |
| CN109553651B (zh) * | 2015-04-03 | 2021-08-06 | 四川科伦博泰生物医药股份有限公司 | 4’-硫代核苷的新型化合物及其制备方法、药物组合物和应用 |
| JP6450356B2 (ja) * | 2016-02-29 | 2019-01-09 | 富士フイルム株式会社 | 液状医薬製剤 |
| AU2017319260B2 (en) * | 2016-08-31 | 2020-01-30 | Fujifilm Corporation | Anti-tumor agent, anti-tumor effect enhancer, and anti-tumor kit |
| CN109952307B (zh) | 2016-12-22 | 2022-03-25 | 四川科伦博泰生物医药股份有限公司 | 4’-硫代-2’-氟代核苷磷酰胺化合物的固体形式及其制备方法和用途 |
| WO2019042226A1 (zh) * | 2017-09-01 | 2019-03-07 | 四川科伦博泰生物医药股份有限公司 | 用于肿瘤治疗或预防的药物组合物、方法及其用途 |
| MX2018002612A (es) * | 2018-01-29 | 2019-07-30 | Fujifilm Corp | Composicion farmaceutica para tumor que tiene mutacion de isocitrato deshidrogenada, agente antitumoral y uso del mismo. |
| TW201932119A (zh) | 2018-01-29 | 2019-08-16 | 日商富士軟片股份有限公司 | 膽道癌用抗腫瘤劑和膽道癌的處理方法 |
| TW202000207A (zh) * | 2018-02-26 | 2020-01-01 | 日商富士軟片股份有限公司 | 膀胱癌用抗腫瘤劑及膀胱癌的處置方法 |
| EP3766502A4 (en) * | 2018-03-13 | 2021-05-05 | FUJIFILM Corporation | ANTITUMOR DRUG, ANTITUMOR ENHANCER AND ANTITUMOR KIT |
| WO2020068657A1 (en) * | 2018-09-25 | 2020-04-02 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | 2'-halogenated-4'-thio-2'-deoxy-5-azacytidine analogs and use thereof |
| CN112770731A (zh) * | 2018-11-28 | 2021-05-07 | 四川科伦博泰生物医药股份有限公司 | 以4’-硫代核苷类化合物为活性成分的口服药物组合物、其制备方法及其用途 |
| WO2021020879A1 (en) * | 2019-07-30 | 2021-02-04 | Pinotbio, Inc. | Dinucleotide compounds for treating cancers and medical uses thereof |
| EP4378466A4 (en) | 2021-07-29 | 2024-11-20 | FUJIFILM Corporation | PHARMACEUTICAL COMPOSITION AND ANTI-TUMOOR AGENT FOR TUMORS WITH AT LEAST ONE IMPAIRED BAP1 OR PBRM1 FUNCTION |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE74701B1 (en) * | 1989-10-04 | 1997-07-30 | Univ Birmingham | Further antiviral pyrimidine nucleosides |
| WO1996001834A1 (en) * | 1994-07-12 | 1996-01-25 | Yamasa Corporation | 2'-deoxy-2'-(substituted or unsubstituted methylidene)-4'-thionucleoside |
| JPH0853490A (ja) * | 1994-08-09 | 1996-02-27 | Yamasa Shoyu Co Ltd | ２’−デオキシ−２’，２’−ジハロゲノ−４’−チオヌクレオシド |
-
1997
- 1997-04-09 ES ES97916633T patent/ES2182061T3/es not_active Expired - Lifetime
- 1997-04-09 CA CA002224155A patent/CA2224155C/en not_active Expired - Lifetime
- 1997-04-09 PT PT97916633T patent/PT841344E/pt unknown
- 1997-04-09 DE DE69715774T patent/DE69715774T2/de not_active Expired - Lifetime
- 1997-04-09 WO PCT/JP1997/001206 patent/WO1997038001A1/ja not_active Ceased
- 1997-04-09 AT AT97916633T patent/ATE224909T1/de active
- 1997-04-09 EP EP97916633A patent/EP0841344B1/en not_active Expired - Lifetime
- 1997-04-09 JP JP52839997A patent/JP3657008B2/ja not_active Expired - Lifetime
- 1997-04-09 DK DK97916633T patent/DK0841344T3/da active
- 1997-04-09 US US08/973,529 patent/US6147058A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP0841344A4 (enExample) | 1998-05-13 |
| WO1997038001A1 (en) | 1997-10-16 |
| CA2224155A1 (en) | 1997-10-16 |
| US6147058A (en) | 2000-11-14 |
| EP0841344B1 (en) | 2002-09-25 |
| DK0841344T3 (da) | 2002-12-23 |
| JP3657008B2 (ja) | 2005-06-08 |
| ATE224909T1 (de) | 2002-10-15 |
| DE69715774T2 (de) | 2003-05-15 |
| DE69715774D1 (de) | 2002-10-31 |
| EP0841344A1 (en) | 1998-05-13 |
| ES2182061T3 (es) | 2003-03-01 |
| CA2224155C (en) | 2004-10-26 |
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