PT841344E - 1-(2-desoxi-2-fluoro-4-tio-beta-d-arabinofuranosil) citosinas - Google Patents
1-(2-desoxi-2-fluoro-4-tio-beta-d-arabinofuranosil) citosinasInfo
- Publication number
- PT841344E PT841344E PT97916633T PT97916633T PT841344E PT 841344 E PT841344 E PT 841344E PT 97916633 T PT97916633 T PT 97916633T PT 97916633 T PT97916633 T PT 97916633T PT 841344 E PT841344 E PT 841344E
- Authority
- PT
- Portugal
- Prior art keywords
- arabinofuranosyl
- cytosines
- thio
- fluoro
- beta
- Prior art date
Links
- -1 2-DESOXY-2-FLUORO-4-THIO-BETA-D-ARABINOFURANOSYL Chemical class 0.000 title 1
- NIDPJRZOVFIBQB-PXBUCIJWSA-N 4-amino-1-[(2r,3s,4s,5r)-3-fluoro-4-hydroxy-5-(hydroxymethyl)thiolan-2-yl]pyrimidin-2-one Chemical class O=C1N=C(N)C=CN1[C@H]1[C@@H](F)[C@H](O)[C@@H](CO)S1 NIDPJRZOVFIBQB-PXBUCIJWSA-N 0.000 abstract 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical group OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 abstract 1
- 230000000259 anti-tumor effect Effects 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/32—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP11196896 | 1996-04-09 | ||
| JP21508296 | 1996-07-26 | ||
| JP27863196 | 1996-09-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT841344E true PT841344E (pt) | 2003-02-28 |
Family
ID=27312140
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT97916633T PT841344E (pt) | 1996-04-09 | 1997-04-09 | 1-(2-desoxi-2-fluoro-4-tio-beta-d-arabinofuranosil) citosinas |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6147058A (enExample) |
| EP (1) | EP0841344B1 (enExample) |
| JP (1) | JP3657008B2 (enExample) |
| AT (1) | ATE224909T1 (enExample) |
| CA (1) | CA2224155C (enExample) |
| DE (1) | DE69715774T2 (enExample) |
| DK (1) | DK0841344T3 (enExample) |
| ES (1) | ES2182061T3 (enExample) |
| PT (1) | PT841344E (enExample) |
| WO (1) | WO1997038001A1 (enExample) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7138384B1 (en) | 1997-08-29 | 2006-11-21 | The Regents Of The University Of California | Modulators of DNA cytosine-5 methyltransferase and methods for use thereof |
| US6348587B1 (en) * | 1998-02-25 | 2002-02-19 | Emory University | 2′-Fluoronucleosides |
| WO2005027962A1 (en) * | 2003-09-18 | 2005-03-31 | Isis Pharmaceuticals, Inc. | 4’-thionucleosides and oligomeric compounds |
| US7524831B2 (en) * | 2005-03-02 | 2009-04-28 | Schering Corporation | Treatments for Flaviviridae virus infection |
| SG181745A1 (en) * | 2009-12-18 | 2012-07-30 | Libramedicina Inc | PROCESS FOR PREPARING SUBSTITUTED 1-O-ACYL-2-DEOXY-2-FLUORO-4-THIO-ß-D-ARABINOFURANOSES |
| EP2388257A1 (en) | 2010-05-20 | 2011-11-23 | LibraMedicina, Inc. | Process for preparing substituted 1-O-acyl-2-deoxy-2-fluoro-4-thio-ß-D-arabinofuranoses |
| AU2013241341B2 (en) * | 2012-03-28 | 2016-09-08 | Fujifilm Corporation | Salt of 1-(2-deoxy-2-fluoro-4-thio-beta-D-arabinofuranosyl)cytosine |
| CN107011168B (zh) * | 2012-08-13 | 2020-06-09 | 富士胶片株式会社 | 胞嘧啶类的合成中间体和硫代核苷的合成中间体 |
| US10005779B2 (en) | 2013-06-05 | 2018-06-26 | Idenix Pharmaceuticals Llc | 1′,4′-thio nucleosides for the treatment of HCV |
| JP6351107B2 (ja) * | 2014-02-18 | 2018-07-04 | 富士フイルム株式会社 | チオラン骨格型糖化合物の製造方法およびチオラン骨格型糖化合物 |
| WO2015125781A1 (ja) | 2014-02-18 | 2015-08-27 | 富士フイルム株式会社 | チオラン骨格型糖化合物の製造方法およびチオラン骨格型糖化合物 |
| JP6204223B2 (ja) | 2014-02-19 | 2017-09-27 | 富士フイルム株式会社 | チオピラノース化合物等の製造方法 |
| TWI678373B (zh) * | 2014-10-31 | 2019-12-01 | 日商富士軟片股份有限公司 | 硫代核苷衍生物或其鹽及醫藥組合物 |
| CN109553651B (zh) * | 2015-04-03 | 2021-08-06 | 四川科伦博泰生物医药股份有限公司 | 4’-硫代核苷的新型化合物及其制备方法、药物组合物和应用 |
| JP6450356B2 (ja) * | 2016-02-29 | 2019-01-09 | 富士フイルム株式会社 | 液状医薬製剤 |
| CA3035334C (en) * | 2016-08-31 | 2022-05-10 | Fujifilm Corporation | Combination of paclitaxel and 1-(2-deoxy-2-fluoro-4-thio-beta-d-arabinofuranosyl)-cytosine as anti-tumor agent |
| EA201990780A1 (ru) | 2016-12-22 | 2019-11-29 | Твердая форма соединения 4'-тио-2'-фторнуклеозид фосфамида и способ его получения и применения | |
| EP3677267A4 (en) * | 2017-09-01 | 2021-06-02 | Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. | PHARMACEUTICAL COMPOSITION FOR TREATMENT OR PREVENTION OF TUMORS, METHOD AND USES THEREOF |
| CA3089728C (en) * | 2018-01-29 | 2023-01-10 | Fujifilm Corporation | Antitumor agent for biliary tract cancer and method for treating biliary tract cancer |
| MX2018002612A (es) * | 2018-01-29 | 2019-07-30 | Fujifilm Corp | Composicion farmaceutica para tumor que tiene mutacion de isocitrato deshidrogenada, agente antitumoral y uso del mismo. |
| TW202000207A (zh) * | 2018-02-26 | 2020-01-01 | 日商富士軟片股份有限公司 | 膀胱癌用抗腫瘤劑及膀胱癌的處置方法 |
| JP6974585B2 (ja) * | 2018-03-13 | 2021-12-01 | 富士フイルム株式会社 | 抗腫瘍剤、抗腫瘍効果増強剤及び抗腫瘍用キット |
| CN112888698A (zh) * | 2018-09-25 | 2021-06-01 | 美国政府(由卫生和人类服务部的部长所代表) | 2’-卤代-4’-硫代-2’-脱氧-5-氮杂胞苷类似物及其使用方法 |
| CN112770731A (zh) * | 2018-11-28 | 2021-05-07 | 四川科伦博泰生物医药股份有限公司 | 以4’-硫代核苷类化合物为活性成分的口服药物组合物、其制备方法及其用途 |
| JP2022542697A (ja) * | 2019-07-30 | 2022-10-06 | ピノットバイオ，インコーポレイテッド | 癌治療用ジヌクレオチド化合物及びその医薬用途 |
| KR20240028451A (ko) | 2021-07-29 | 2024-03-05 | 후지필름 가부시키가이샤 | Bap1 및 pbrm1 중 적어도 하나의 기능 저하를 갖는 종양에 대한 의약 조성물 및 항종양제 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE74701B1 (en) * | 1989-10-04 | 1997-07-30 | Univ Birmingham | Further antiviral pyrimidine nucleosides |
| US5811408A (en) * | 1994-07-12 | 1998-09-22 | Yamasa Corporation | 2'-deoxy-2'-(substituted or unsubstituted)methylidene-4'-thionucleosides |
| JPH0853490A (ja) * | 1994-08-09 | 1996-02-27 | Yamasa Shoyu Co Ltd | ２’−デオキシ−２’，２’−ジハロゲノ−４’−チオヌクレオシド |
-
1997
- 1997-04-09 EP EP97916633A patent/EP0841344B1/en not_active Expired - Lifetime
- 1997-04-09 US US08/973,529 patent/US6147058A/en not_active Expired - Lifetime
- 1997-04-09 JP JP52839997A patent/JP3657008B2/ja not_active Expired - Lifetime
- 1997-04-09 DE DE69715774T patent/DE69715774T2/de not_active Expired - Lifetime
- 1997-04-09 WO PCT/JP1997/001206 patent/WO1997038001A1/ja not_active Ceased
- 1997-04-09 DK DK97916633T patent/DK0841344T3/da active
- 1997-04-09 CA CA002224155A patent/CA2224155C/en not_active Expired - Lifetime
- 1997-04-09 ES ES97916633T patent/ES2182061T3/es not_active Expired - Lifetime
- 1997-04-09 PT PT97916633T patent/PT841344E/pt unknown
- 1997-04-09 AT AT97916633T patent/ATE224909T1/de active
Also Published As
| Publication number | Publication date |
|---|---|
| WO1997038001A1 (en) | 1997-10-16 |
| US6147058A (en) | 2000-11-14 |
| EP0841344B1 (en) | 2002-09-25 |
| DE69715774D1 (de) | 2002-10-31 |
| CA2224155C (en) | 2004-10-26 |
| EP0841344A1 (en) | 1998-05-13 |
| DK0841344T3 (da) | 2002-12-23 |
| DE69715774T2 (de) | 2003-05-15 |
| JP3657008B2 (ja) | 2005-06-08 |
| ATE224909T1 (de) | 2002-10-15 |
| CA2224155A1 (en) | 1997-10-16 |
| EP0841344A4 (enExample) | 1998-05-13 |
| ES2182061T3 (es) | 2003-03-01 |
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