PT841344E - 1-(2-desoxi-2-fluoro-4-tio-beta-d-arabinofuranosil) citosinas - Google Patents
1-(2-desoxi-2-fluoro-4-tio-beta-d-arabinofuranosil) citosinasInfo
- Publication number
- PT841344E PT841344E PT97916633T PT97916633T PT841344E PT 841344 E PT841344 E PT 841344E PT 97916633 T PT97916633 T PT 97916633T PT 97916633 T PT97916633 T PT 97916633T PT 841344 E PT841344 E PT 841344E
- Authority
- PT
- Portugal
- Prior art keywords
- arabinofuranosyl
- cytosines
- thio
- fluoro
- beta
- Prior art date
Links
- -1 2-DESOXY-2-FLUORO-4-THIO-BETA-D-ARABINOFURANOSYL Chemical class 0.000 title 1
- NIDPJRZOVFIBQB-PXBUCIJWSA-N 4-amino-1-[(2r,3s,4s,5r)-3-fluoro-4-hydroxy-5-(hydroxymethyl)thiolan-2-yl]pyrimidin-2-one Chemical class O=C1N=C(N)C=CN1[C@H]1[C@@H](F)[C@H](O)[C@@H](CO)S1 NIDPJRZOVFIBQB-PXBUCIJWSA-N 0.000 abstract 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical group OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 abstract 1
- 230000000259 anti-tumor effect Effects 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/32—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP11196896 | 1996-04-09 | ||
| JP21508296 | 1996-07-26 | ||
| JP27863196 | 1996-09-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT841344E true PT841344E (pt) | 2003-02-28 |
Family
ID=27312140
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT97916633T PT841344E (pt) | 1996-04-09 | 1997-04-09 | 1-(2-desoxi-2-fluoro-4-tio-beta-d-arabinofuranosil) citosinas |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6147058A (enExample) |
| EP (1) | EP0841344B1 (enExample) |
| JP (1) | JP3657008B2 (enExample) |
| AT (1) | ATE224909T1 (enExample) |
| CA (1) | CA2224155C (enExample) |
| DE (1) | DE69715774T2 (enExample) |
| DK (1) | DK0841344T3 (enExample) |
| ES (1) | ES2182061T3 (enExample) |
| PT (1) | PT841344E (enExample) |
| WO (1) | WO1997038001A1 (enExample) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7138384B1 (en) | 1997-08-29 | 2006-11-21 | The Regents Of The University Of California | Modulators of DNA cytosine-5 methyltransferase and methods for use thereof |
| EP1058686B1 (en) | 1998-02-25 | 2006-11-02 | Emory University | 2'-fluoronucleosides |
| JP5379347B2 (ja) * | 2003-09-18 | 2013-12-25 | アイシス ファーマシューティカルズ， インコーポレーテッド | ４’−チオヌクレオシドおよびオリゴマー化合物 |
| US7524831B2 (en) * | 2005-03-02 | 2009-04-28 | Schering Corporation | Treatments for Flaviviridae virus infection |
| US8329925B2 (en) * | 2009-12-18 | 2012-12-11 | Libramedicina, Inc. | Process for preparing substituted 1-O-acyl-2-deoxy-2-fluoro-4-thio-beta-D-arabinofuranoses |
| EP2388257A1 (en) | 2010-05-20 | 2011-11-23 | LibraMedicina, Inc. | Process for preparing substituted 1-O-acyl-2-deoxy-2-fluoro-4-thio-ß-D-arabinofuranoses |
| RU2600734C2 (ru) | 2012-03-28 | 2016-10-27 | Фуджифилм Корпорэйшн | СОЛЬ 1-(2-ДЕЗОКСИ-2-ФТОР-4-ТИО-β-D-АРАБИНОФУРАНОЗИЛ)ЦИТОЗИНА |
| ES2718307T3 (es) * | 2012-08-13 | 2019-07-01 | Fujifilm Corp | Intermedio para la síntesis de 1-(2-desoxi-2-fluoro-4-tio-beta-d-arabinofuranosil)citosina, intermedio para la síntesis de tionucleósido y métodos para producir estos intermedios |
| US10005779B2 (en) | 2013-06-05 | 2018-06-26 | Idenix Pharmaceuticals Llc | 1′,4′-thio nucleosides for the treatment of HCV |
| CN106061959B (zh) * | 2014-02-18 | 2018-11-09 | 富士胶片株式会社 | 四氢噻吩骨架型糖化合物的制造方法及四氢噻吩骨架型糖化合物 |
| JP6351107B2 (ja) * | 2014-02-18 | 2018-07-04 | 富士フイルム株式会社 | チオラン骨格型糖化合物の製造方法およびチオラン骨格型糖化合物 |
| JP6204223B2 (ja) | 2014-02-19 | 2017-09-27 | 富士フイルム株式会社 | チオピラノース化合物等の製造方法 |
| TWI678373B (zh) * | 2014-10-31 | 2019-12-01 | 日商富士軟片股份有限公司 | 硫代核苷衍生物或其鹽及醫藥組合物 |
| CN109553651B (zh) * | 2015-04-03 | 2021-08-06 | 四川科伦博泰生物医药股份有限公司 | 4’-硫代核苷的新型化合物及其制备方法、药物组合物和应用 |
| JP6450356B2 (ja) * | 2016-02-29 | 2019-01-09 | 富士フイルム株式会社 | 液状医薬製剤 |
| MX392665B (es) | 2016-08-31 | 2025-03-24 | Fujifilm Corp | Agente antitumoral, mejorador del efecto antitumoral, y kit antitumoral. |
| EA201990780A1 (ru) | 2016-12-22 | 2019-11-29 | Твердая форма соединения 4'-тио-2'-фторнуклеозид фосфамида и способ его получения и применения | |
| US11266674B2 (en) | 2017-09-01 | 2022-03-08 | Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. | Pharmaceutical composition for tumor treatment or prevention, method, and use thereof |
| WO2019146129A1 (ja) * | 2018-01-29 | 2019-08-01 | 富士フイルム株式会社 | イソクエン酸デヒドロゲナーゼ変異を有する腫瘍に対する医薬組成物および抗腫瘍剤ならびにその利用 |
| WO2019146130A1 (ja) * | 2018-01-29 | 2019-08-01 | 富士フイルム株式会社 | 胆道がん用抗腫瘍剤および胆道がんの処置方法 |
| WO2019164010A1 (ja) * | 2018-02-26 | 2019-08-29 | 富士フイルム株式会社 | 膀胱がん用抗腫瘍剤および膀胱がんの処置方法 |
| CN111836628B (zh) | 2018-03-13 | 2025-01-07 | 富士胶片株式会社 | 抗肿瘤剂、抗肿瘤效果增强剂及抗肿瘤用试剂盒 |
| WO2020068657A1 (en) * | 2018-09-25 | 2020-04-02 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | 2'-halogenated-4'-thio-2'-deoxy-5-azacytidine analogs and use thereof |
| CN112770731A (zh) * | 2018-11-28 | 2021-05-07 | 四川科伦博泰生物医药股份有限公司 | 以4’-硫代核苷类化合物为活性成分的口服药物组合物、其制备方法及其用途 |
| JP2022542697A (ja) * | 2019-07-30 | 2022-10-06 | ピノットバイオ，インコーポレイテッド | 癌治療用ジヌクレオチド化合物及びその医薬用途 |
| CN117794548A (zh) | 2021-07-29 | 2024-03-29 | 富士胶片株式会社 | 针对bap1及pbrm1中的至少一个的功能下降的肿瘤的药物组合物及抗肿瘤剂 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE74701B1 (en) * | 1989-10-04 | 1997-07-30 | Univ Birmingham | Further antiviral pyrimidine nucleosides |
| WO1996001834A1 (en) * | 1994-07-12 | 1996-01-25 | Yamasa Corporation | 2'-deoxy-2'-(substituted or unsubstituted methylidene)-4'-thionucleoside |
| JPH0853490A (ja) * | 1994-08-09 | 1996-02-27 | Yamasa Shoyu Co Ltd | ２’−デオキシ−２’，２’−ジハロゲノ−４’−チオヌクレオシド |
-
1997
- 1997-04-09 DE DE69715774T patent/DE69715774T2/de not_active Expired - Lifetime
- 1997-04-09 PT PT97916633T patent/PT841344E/pt unknown
- 1997-04-09 US US08/973,529 patent/US6147058A/en not_active Expired - Lifetime
- 1997-04-09 DK DK97916633T patent/DK0841344T3/da active
- 1997-04-09 WO PCT/JP1997/001206 patent/WO1997038001A1/ja not_active Ceased
- 1997-04-09 CA CA002224155A patent/CA2224155C/en not_active Expired - Lifetime
- 1997-04-09 JP JP52839997A patent/JP3657008B2/ja not_active Expired - Lifetime
- 1997-04-09 EP EP97916633A patent/EP0841344B1/en not_active Expired - Lifetime
- 1997-04-09 AT AT97916633T patent/ATE224909T1/de active
- 1997-04-09 ES ES97916633T patent/ES2182061T3/es not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DK0841344T3 (da) | 2002-12-23 |
| DE69715774D1 (de) | 2002-10-31 |
| EP0841344A4 (enExample) | 1998-05-13 |
| EP0841344B1 (en) | 2002-09-25 |
| ATE224909T1 (de) | 2002-10-15 |
| WO1997038001A1 (en) | 1997-10-16 |
| EP0841344A1 (en) | 1998-05-13 |
| ES2182061T3 (es) | 2003-03-01 |
| DE69715774T2 (de) | 2003-05-15 |
| CA2224155A1 (en) | 1997-10-16 |
| JP3657008B2 (ja) | 2005-06-08 |
| US6147058A (en) | 2000-11-14 |
| CA2224155C (en) | 2004-10-26 |
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