DE69636626T2 - Biologische abbaubare multiblokhydrogene und ihre verwendung wie trägerstoffe fur kontrollierte freisetzung pharmakologisch activen werstoffe und gewebekontaktmaterialen - Google Patents

Biologische abbaubare multiblokhydrogene und ihre verwendung wie trägerstoffe fur kontrollierte freisetzung pharmakologisch activen werstoffe und gewebekontaktmaterialen Download PDF

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Publication number
DE69636626T2
DE69636626T2 DE69636626T DE69636626T DE69636626T2 DE 69636626 T2 DE69636626 T2 DE 69636626T2 DE 69636626 T DE69636626 T DE 69636626T DE 69636626 T DE69636626 T DE 69636626T DE 69636626 T2 DE69636626 T2 DE 69636626T2
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Prior art keywords
macromer
hydrophobic
composition
gel
poly
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Expired - Lifetime
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DE69636626T
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German (de)
English (en)
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DE69636626D1 (de
Inventor
P. Carbomedics Chandrashekhar Austin PATHAK
P. Shikha Bedford BARMAN
Michael C. Boston PHILBROOK
Amarpreet Bedford SAWHNEY
J. Arthur Boston COURY
Z. Luis Arlington AVILA
T. Mark Menlo Park KIERAS
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Genzyme Corp
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Genzyme Corp
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5138—Organic macromolecular compounds; Dendrimers obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1274—Non-vesicle bilayer structures, e.g. liquid crystals, tubules, cubic phases or cochleates; Sponge phases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7015—Drug-containing film-forming compositions, e.g. spray-on
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
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    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/60—Liquid-swellable gel-forming materials, e.g. super-absorbents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A61L24/0031—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A61L24/0042—Materials resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/046—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L71/00—Compositions of polyethers obtained by reactions forming an ether link in the main chain; Compositions of derivatives of such polymers
    • C08L71/02—Polyalkylene oxides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S424/00—Drug, bio-affecting and body treating compositions
    • Y10S424/13—Burn treatment
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S524/00—Synthetic resins or natural rubbers -- part of the class 520 series
    • Y10S524/916—Hydrogel compositions
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S525/00—Synthetic resins or natural rubbers -- part of the class 520 series
    • Y10S525/941—Polymer mixture containing block copolymer is mixed or reacted with chemical treating agent

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Surgery (AREA)
  • Polymers & Plastics (AREA)
  • Dispersion Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Preparation (AREA)
  • Macromonomer-Based Addition Polymer (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polyethers (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Polyurethanes Or Polyureas (AREA)
  • Steroid Compounds (AREA)
DE69636626T 1995-07-28 1996-07-26 Biologische abbaubare multiblokhydrogene und ihre verwendung wie trägerstoffe fur kontrollierte freisetzung pharmakologisch activen werstoffe und gewebekontaktmaterialen Expired - Lifetime DE69636626T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US172395P 1995-07-28 1995-07-28
US1723P 1995-07-28
PCT/US1996/012285 WO1997005185A2 (en) 1995-07-28 1996-07-26 Multiblock biodegradable hydrogels for use as controlled release agents for drugs delivery and tissue treatment agents

Publications (2)

Publication Number Publication Date
DE69636626D1 DE69636626D1 (de) 2006-11-23
DE69636626T2 true DE69636626T2 (de) 2007-08-30

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DE69636626T Expired - Lifetime DE69636626T2 (de) 1995-07-28 1996-07-26 Biologische abbaubare multiblokhydrogene und ihre verwendung wie trägerstoffe fur kontrollierte freisetzung pharmakologisch activen werstoffe und gewebekontaktmaterialen

Country Status (7)

Country Link
US (5) US6201065B1 (https=)
EP (1) EP0842209B1 (https=)
JP (2) JPH11510837A (https=)
AT (1) ATE342295T1 (https=)
CA (1) CA2228118A1 (https=)
DE (1) DE69636626T2 (https=)
WO (1) WO1997005185A2 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022069574A1 (de) * 2020-09-30 2022-04-07 Leibniz-Institut Für Neue Materialien Gemeinnützige Gmbh Neuartige hydrogele

Families Citing this family (288)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100266912B1 (ko) * 1992-02-28 2000-12-01 파라비 레이 조직접촉물질이며 방출조절운반체인 광중합성 생분해성 하이드로겔
JPH11510837A (ja) * 1995-07-28 1999-09-21 フォーカル，インコーポレイテッド 薬物送達のための制御された放出薬剤および組織処置薬剤としての使用のためのマルチブロック生分解性ヒドロゲル
US6696499B1 (en) * 1996-07-11 2004-02-24 Life Medical Sciences, Inc. Methods and compositions for reducing or eliminating post-surgical adhesion formation
US8003705B2 (en) * 1996-09-23 2011-08-23 Incept Llc Biocompatible hydrogels made with small molecule precursors
US20090324721A1 (en) * 1996-09-23 2009-12-31 Jack Kennedy Hydrogels Suitable For Use In Polyp Removal
US7009034B2 (en) * 1996-09-23 2006-03-07 Incept, Llc Biocompatible crosslinked polymers
AU4648697A (en) * 1996-09-23 1998-04-14 Chandrashekar Pathak Methods and devices for preparing protein concentrates
DE19640092A1 (de) * 1996-09-28 1998-04-16 Beiersdorf Ag Strukturen mit Lipid-Doppelmembranen, in deren lipophilen Bereich längerkettige Moleküle eintauchen oder durch hydrophobe Wechselwirkungen an solche Moleküle angedockt sind
US6039757A (en) * 1997-03-12 2000-03-21 Cardiosynopsis, Inc. In situ formed fenestrated stent
US6123667A (en) * 1997-03-20 2000-09-26 Focal, Inc. Retracting tissue using photoadhering adhesive
US6211249B1 (en) * 1997-07-11 2001-04-03 Life Medical Sciences, Inc. Polyester polyether block copolymers
US5837752A (en) * 1997-07-17 1998-11-17 Massachusetts Institute Of Technology Semi-interpenetrating polymer networks
EP1512395A1 (en) * 1997-07-18 2005-03-09 Azopax Therapeutics LLC Biodegradable macromers for the controlled release of biologically active substances
NZ502358A (en) * 1997-07-18 2002-11-26 Infimed Therapeutics Inc Hydrogel composition comprising a biologically active substance combined with a macromer
US5854382A (en) * 1997-08-18 1998-12-29 Meadox Medicals, Inc. Bioresorbable compositions for implantable prostheses
JP3786832B2 (ja) 1998-01-07 2006-06-14 デビオ ルシェルシュ ファルマシュティーク ソシエテ アノニム 分解性のヘテロ二官能性ポリ（エチレングリコール）アクリレート及びそれから誘導されるゲル及び複合体
US6872384B1 (en) 1998-02-23 2005-03-29 Life Medical Sciences, Inc. Treatment of trauma
US6367929B1 (en) 1998-03-02 2002-04-09 Johnson & Johnson Vision Care, Inc. Hydrogel with internal wetting agent
WO1999059638A2 (en) * 1998-05-15 1999-11-25 Chiron Corporation Compositions and methods for the delivery of nucleic acid molecules
AU5180199A (en) 1998-07-31 2000-02-21 First Water Limited Bioadhesive compositions and biomedical electrodes containing them
US6514534B1 (en) * 1998-08-14 2003-02-04 Incept Llc Methods for forming regional tissue adherent barriers and drug delivery systems
US7790192B2 (en) 1998-08-14 2010-09-07 Accessclosure, Inc. Apparatus and methods for sealing a vascular puncture
US6632457B1 (en) 1998-08-14 2003-10-14 Incept Llc Composite hydrogel drug delivery systems
US7347850B2 (en) * 1998-08-14 2008-03-25 Incept Llc Adhesion barriers applicable by minimally invasive surgery and methods of use thereof
US6818018B1 (en) 1998-08-14 2004-11-16 Incept Llc In situ polymerizable hydrogels
US6152943A (en) * 1998-08-14 2000-11-28 Incept Llc Methods and apparatus for intraluminal deposition of hydrogels
JP2002531217A (ja) * 1998-12-04 2002-09-24 チャンドラシェカー ピー． パサック， 生体適合性架橋ポリマー
US20080114092A1 (en) * 1998-12-04 2008-05-15 Incept Llc Adhesion barriers applicable by minimally invasive surgery and methods of use thereof
WO2000045868A1 (en) * 1999-02-05 2000-08-10 The Regents Of The University Of California Thermo-reversible polymer for intralumenal implant
NZ513686A (en) 1999-02-23 2001-09-28 Phairson Medical Inc Treatment of trauma
EP1168934B1 (en) * 1999-04-12 2008-02-13 Cornell Research Foundation, Inc. Hydrogel-forming system with hydrophobic and hydrophilic components
US6716445B2 (en) 1999-04-12 2004-04-06 Cornell Research Foundation, Inc. Hydrogel entrapping therapeutic agent and stent with coating comprising this
US6649702B1 (en) * 1999-05-19 2003-11-18 University Of Utah Research Foundation Stabilization and acoustic activation of polymeric micelles for drug delivery
US6579951B1 (en) * 1999-06-08 2003-06-17 Life Medical Sciences, Inc. Chain-extended or crosslinked polyethylene oxide/polypropylene oxide/polyethylene oxide block polymer with optional polyester blocks
AU769853B2 (en) 1999-06-11 2004-02-05 Atossa Genetics, Inc. Gel composition for filing a breast milk duct prior to surgical excision of the duct or other breast tissue
CN1220707C (zh) * 1999-09-01 2005-09-28 罗狄亚化学公司 包括含有至少一种水溶性嵌段和一种疏水嵌段的嵌段共聚物的凝胶化水性组合物
CA2391618A1 (en) * 1999-11-15 2001-05-21 Biocure, Inc. Degradable poly(vinyl alcohol) hydrogels
DE60041978D1 (de) 1999-11-15 2009-05-20 Biocure Inc Auf äussere bedingungen ansprechende polymere hohle partikel
US6710126B1 (en) 1999-11-15 2004-03-23 Bio Cure, Inc. Degradable poly(vinyl alcohol) hydrogels
WO2001041735A2 (en) * 1999-12-07 2001-06-14 Amgen Inc. Thermosensitive biodegradable hydrogels based on low molecular weight pluronics
AU4566001A (en) 2000-03-13 2001-09-24 Biocure Inc Embolic compositions
EP1263801B1 (en) * 2000-03-13 2006-05-24 BioCure, Inc. Tissue bulking and coating compositions
US6652883B2 (en) * 2000-03-13 2003-11-25 Biocure, Inc. Tissue bulking and coating compositions
US6951712B2 (en) * 2000-03-14 2005-10-04 Alnis Biosciences, Inc. Cryoprotective system comprising polymeric nano- or micro-particles
EP1272562A1 (en) * 2000-03-15 2003-01-08 CHENG, Yu-Ling Environment responsive gelling copolymer
US7193007B2 (en) 2000-03-15 2007-03-20 Yu-Ling Cheng Environment responsive gelling copolymer
US7160931B2 (en) 2000-03-15 2007-01-09 Yu-Ling Cheng Thermally reversible implant and filler
US7259139B1 (en) * 2000-05-26 2007-08-21 Frohwitter Means for maintenance and/or correction of glucose concentration in blood
EP1290052B1 (fr) * 2000-05-29 2006-05-03 Bio Merieux Polymere biocompatible pour la fixation de ligands biologiques
US8313504B2 (en) * 2000-09-18 2012-11-20 Cordis Corporation Foam matrix embolization device
US20040018228A1 (en) * 2000-11-06 2004-01-29 Afmedica, Inc. Compositions and methods for reducing scar tissue formation
FR2819416B1 (fr) * 2001-01-15 2004-12-17 Oreal Composition moussante tehrmogelifiante et mousse obtenue
EP1236507A3 (en) * 2001-02-28 2006-08-02 Dainippon Ink And Chemicals, Inc. Water absorbent material comprising polysaccharide derivatives
US6949251B2 (en) * 2001-03-02 2005-09-27 Stryker Corporation Porous β-tricalcium phosphate granules for regeneration of bone tissue
US6529759B1 (en) * 2001-03-08 2003-03-04 Electrical Geodesics, Inc. Method for mapping internal body tissue
US20020192286A1 (en) * 2001-03-27 2002-12-19 Macromed, Incorporated Biodegradable triblock copolymers as solubilizing agents for drugs and method of use thereof
US20040185101A1 (en) * 2001-03-27 2004-09-23 Macromed, Incorporated. Biodegradable triblock copolymers as solubilizing agents for drugs and method of use thereof
WO2002087586A1 (en) * 2001-04-26 2002-11-07 Control Delivery Systems, Inc. Sustained release drug delivery system containing codrugs
US20040022853A1 (en) * 2001-04-26 2004-02-05 Control Delivery Systems, Inc. Polymer-based, sustained release drug delivery system
ATE516759T1 (de) 2001-05-29 2011-08-15 Microvention Inc Verfahren zur herstellung von expandierbaren filamentösen embolisierungsvorrichtungen
US6939564B2 (en) * 2001-06-08 2005-09-06 Labopharm, Inc. Water-soluble stabilized self-assembled polyelectrolytes
US6730772B2 (en) 2001-06-22 2004-05-04 Venkatram P. Shastri Degradable polymers from derivatized ring-opened epoxides
KR100566911B1 (ko) 2001-06-25 2006-04-03 주식회사 삼양사 약물 전달체용 음이온기-함유 양친성 블록 공중합체 및 그의 양이온성 약물과의 복합체
WO2003006043A1 (en) * 2001-07-10 2003-01-23 Massachusetts Institute Of Technology Surfactant peptide nanostructures, and uses thereof
FR2829494B1 (fr) * 2001-07-13 2005-10-28 Rhodia Chimie Sa Compositions aqueuses comprenant un microgel chimique associe a un polymere pontant, preparation et utilisation
KR100527291B1 (ko) * 2001-07-14 2005-11-09 주식회사 삼양사 약물 전달체용 양이온기-함유 양친성 블록 공중합체 및그의 음이온성 약물과의 복합체
US8252040B2 (en) 2001-07-20 2012-08-28 Microvention, Inc. Aneurysm treatment device and method of use
US8715312B2 (en) 2001-07-20 2014-05-06 Microvention, Inc. Aneurysm treatment device and method of use
US7572288B2 (en) * 2001-07-20 2009-08-11 Microvention, Inc. Aneurysm treatment device and method of use
US20080063620A1 (en) * 2001-08-13 2008-03-13 Yissum Research Development Company Of The Hebrew University Of Jerusalem Novel reverse thermo-sensitive block copolymers
US20030082235A1 (en) * 2001-08-13 2003-05-01 Yissum Research Development Company Of The Hebrew University Of Jerusalem Novel reverse thermo-sensitive block copolymers
IN2014DN10834A (https=) * 2001-09-17 2015-09-04 Psivida Inc
US7223282B1 (en) * 2001-09-27 2007-05-29 Advanced Cardiovascular Systems, Inc. Remote activation of an implantable device
US6592899B2 (en) 2001-10-03 2003-07-15 Macromed Incorporated PLA/PLGA oligomers combined with block copolymers for enhancing solubility of a drug in water
US7842498B2 (en) 2001-11-08 2010-11-30 Bio-Rad Laboratories, Inc. Hydrophobic surface chip
US7491690B2 (en) * 2001-11-14 2009-02-17 Northwestern University Self-assembly and mineralization of peptide-amphiphile nanofibers
JP4346441B2 (ja) * 2001-11-15 2009-10-21 バイオマテラ インコーポレイテッド ゲルの調製方法
US7205337B2 (en) * 2001-12-21 2007-04-17 Isotis Orthobiologics, Inc. End-capped polymers and compositions containing such compounds
EP1456278B1 (en) * 2001-12-21 2006-03-08 IsoTis Orthobiologics, Inc. Compositions containing end-capped polyalkylene glycols
AU2003215280A1 (en) * 2002-02-15 2003-09-09 Northwestern University Self-assembly of peptide-amphiphile nanofibers under physiological conditions
ES2304501T3 (es) * 2002-02-15 2008-10-16 Nektar Therapeutics Al, Corporation Polimeros a base de oxido de alquileno degradables hidroliticamente.
US20030229333A1 (en) * 2002-02-22 2003-12-11 Control Delivery Systems, Inc. Methods for treating otic disorders
US8298606B2 (en) 2002-03-08 2012-10-30 The Regents Of The University Of California Methods and compositions for stabilizing the myocardium
US7985601B2 (en) * 2002-03-08 2011-07-26 The Regents Of The University Of California Tunable, semi-interpenetrating polymer networks (sIPNS) for medicine and biotechnology
US20070026518A1 (en) * 2005-03-29 2007-02-01 The Regents Of The University Of California Controlling stem cell destiny with tunable matrices
US7018655B2 (en) 2002-03-18 2006-03-28 Labopharm, Inc. Amphiphilic diblock, triblock and star-block copolymers and their pharmaceutical compositions
US20030180348A1 (en) * 2002-03-22 2003-09-25 Levinson R. Saul Transcellular drug delivery system
WO2003080119A1 (en) * 2002-03-26 2003-10-02 Yissum Research Development Company Of The Hebrew University Of Jerusalem Responsive biomedical composites
US7005143B2 (en) 2002-04-12 2006-02-28 3M Innovative Properties Company Gel materials, medical articles, and methods
US20030203032A1 (en) * 2002-04-25 2003-10-30 Schultz Clyde L. Growth factor delivery system for the healing of wounds and the prevention of inflammation and disease
WO2003090662A2 (en) * 2002-04-25 2003-11-06 Rapidheal, Inc. Growth factor delivery system for the healing of wounds and the prevention of inflammation and disease
US6923961B2 (en) * 2002-04-30 2005-08-02 Fziomed, Inc. Chemically activated carboxypolysaccharides and methods for use to inhibit adhesion formation and promote hemostasis
US20030204180A1 (en) * 2002-04-30 2003-10-30 Kimberly-Clark Worldwide, Inc. Temperature responsive delivery systems
US8273366B2 (en) * 2002-06-05 2012-09-25 University Of Florida Research Foundation, Incorporated Ophthalmic drug delivery system
US7649023B2 (en) * 2002-06-11 2010-01-19 Novartis Ag Biodegradable block copolymeric compositions for drug delivery
FR2840907B1 (fr) * 2002-06-14 2005-11-25 Polymerexpert Sa Polymere thermo-sensible ameliore susceptible de former des gels thermoreversibles a haut indice de viscosification
US7160551B2 (en) * 2002-07-09 2007-01-09 The Board Of Trustees Of The University Of Illinois Injectable system for controlled drug delivery
WO2004017915A2 (en) * 2002-08-20 2004-03-04 Exactech, Inc. Composition for the carrying and delivery of bone growth inducing material and methods for producing and applying the composition
WO2004018628A2 (en) 2002-08-21 2004-03-04 Northwestern University Charged peptide-amphiphile solutions & self-assembled peptide nanofiber networks formed therefrom
DE10238559A1 (de) * 2002-08-22 2004-03-04 Fresenius Medical Care Deutschland Gmbh Verfahren zur Immobilisierung von Hydrogel-bildenden Polymeren auf Polymersubstratoberflächen
US8673333B2 (en) * 2002-09-25 2014-03-18 The Johns Hopkins University Cross-linked polymer matrices, and methods of making and using same
US7862831B2 (en) * 2002-10-09 2011-01-04 Synthasome, Inc. Method and material for enhanced tissue-biomaterial integration
GB0222522D0 (en) 2002-09-27 2002-11-06 Controlled Therapeutics Sct Water-swellable polymers
US20050069572A1 (en) * 2002-10-09 2005-03-31 Jennifer Elisseeff Multi-layered polymerizing hydrogels for tissue regeneration
US6800663B2 (en) * 2002-10-18 2004-10-05 Alkermes Controlled Therapeutics Inc. Ii, Crosslinked hydrogel copolymers
EP1567559A4 (en) * 2002-11-12 2008-04-16 Polymer Technology Group Inc REGULATION OF MOLECULAR POLYMER SURFACE ARCHITECTURE USING AMPHIPATHIC TERMINAL GROUPS
US7554021B2 (en) 2002-11-12 2009-06-30 Northwestern University Composition and method for self-assembly and mineralization of peptide amphiphiles
US7683025B2 (en) 2002-11-14 2010-03-23 Northwestern University Synthesis and self-assembly of ABC triblock bola peptide amphiphiles
HUE033832T2 (en) 2002-11-15 2018-01-29 Idenix Pharmaceuticals Llc 2'-methyl nucleosides in combination with interferon and Flaviviridae mutation
US20040185013A1 (en) * 2003-01-30 2004-09-23 Burgio Paul A. Dental whitening compositions and methods
US20040151691A1 (en) * 2003-01-30 2004-08-05 Oxman Joel D. Hardenable thermally responsive compositions
US7223826B2 (en) * 2003-01-30 2007-05-29 3M Innovative Properties Company Amide-functional polymers, compositions, and methods
CN1446833A (zh) * 2003-02-08 2003-10-08 复旦大学 一种温敏性可降解微凝胶及其制备方法
WO2004072104A2 (en) * 2003-02-11 2004-08-26 Northwestern University Methods and materials for nanocrystalline surface coatings and attachment of peptide amphiphile nanofibers thereon
JP4909071B2 (ja) * 2003-03-24 2012-04-04 プルーローメッド， インコーポレイテッド 逆感熱性ポリマーを使用する一時的な塞栓形成
US9216106B2 (en) 2003-04-09 2015-12-22 Directcontact Llc Device and method for the delivery of drugs for the treatment of posterior segment disease
US20050074497A1 (en) * 2003-04-09 2005-04-07 Schultz Clyde L. Hydrogels used to deliver medicaments to the eye for the treatment of posterior segment diseases
US20050255144A1 (en) * 2003-04-09 2005-11-17 Directcontact Llc Methods and articles for the delivery of medicaments to the eye for the treatment of posterior segment diseases
FR2854071B1 (fr) * 2003-04-25 2009-01-30 Ethypharm Sa Procede de dispersion de substances hydrosolubles ou hydrophiles dans un fluide a pression supercritique
CA2523484A1 (en) * 2003-05-02 2004-11-11 Rimon Therapeutics Ltd. Thermally reversible implant
US20040249119A1 (en) * 2003-06-05 2004-12-09 Fox Martin Edward Novel mPEG propionaldehyde precursor
CA2531687C (en) 2003-07-18 2011-06-28 Yi Yan Yang Thermosensitive polymers for therapeutic use and methods of preparation
FR2862652B1 (fr) * 2003-11-24 2006-04-28 Rescoll Soc Procede d'obtention d'un gel thermoreversible a structure tridimensionnelle controlee et gel obtenu
GB2408510B (en) * 2003-11-28 2008-05-14 Ind Tech Res Inst Thermosensitive biodegradable copolymer
AU2004297211A1 (en) * 2003-12-05 2005-06-23 Northwestern University Branched peptide amphiphiles, related epitope compounds and self assembled structures thereof
ES2380340T3 (es) 2003-12-05 2012-05-10 Northwestern University Anfífilos peptídicos auto-ensamblantes y métodos relacionados para la administración de factores de crecimiento
EP1689369A2 (en) * 2003-12-09 2006-08-16 University of North Texas An aqueous dispersion of hydrogel nanoparticles with inverse thermoreversible gelation
GB0329654D0 (en) * 2003-12-23 2004-01-28 Smith & Nephew Tunable segmented polyacetal
US20050238678A1 (en) * 2004-03-05 2005-10-27 Janos Borbely Hydrogels from biopolymers
DE102004019504A1 (de) * 2004-04-22 2005-11-10 Celanese Ventures Gmbh Neue Hydrogele auf Basis von Polyvinylalkoholen und Polyvinylalkohol-Copolymeren
US7758654B2 (en) * 2004-05-20 2010-07-20 Kensey Nash Corporation Anti-adhesion device
US20050281866A1 (en) * 2004-05-24 2005-12-22 Genzyme Corporation Adherent polymeric compositions
CA2572363A1 (en) * 2004-06-29 2006-01-12 Biocure, Inc. Biomaterial
GB0417401D0 (en) 2004-08-05 2004-09-08 Controlled Therapeutics Sct Stabilised prostaglandin composition
WO2006039400A2 (en) 2004-09-29 2006-04-13 Mount Sinai School Of Medicine Of New York University Fsh and fsh receptor modulator compositions and methods for inhibiting osteoclastic bone resorption and bone loss in osteoporosis
CN101098703B (zh) * 2004-11-05 2011-08-03 费城儿童医院 用于分子治疗的生物降解连接剂
US20060110429A1 (en) * 2004-11-24 2006-05-25 Therakine Corporation Implant for intraocular drug delivery
US8128952B2 (en) * 2005-01-12 2012-03-06 Clemson University Research Foundation Ligand-mediated controlled drug delivery
CN101150954A (zh) * 2005-01-21 2008-03-26 西北大学 包封细胞的方法和组合物
WO2006086510A2 (en) * 2005-02-09 2006-08-17 Tyco Healthcare Group Lp Synthetic sealants
WO2006089119A2 (en) * 2005-02-18 2006-08-24 Cartilix, Inc. Biological adhesive
MX2007010771A (es) * 2005-03-04 2008-03-10 Univ Northwestern Anfifilos peptidicos para union a heparina angiogenicos.
US20060222596A1 (en) 2005-04-01 2006-10-05 Trivascular, Inc. Non-degradable, low swelling, water soluble radiopaque hydrogel polymer
US20060224095A1 (en) * 2005-04-05 2006-10-05 University Of New Hampshire Biocompatible polymeric vesicles self assembled from triblock copolymers
US8414907B2 (en) 2005-04-28 2013-04-09 Warsaw Orthopedic, Inc. Coatings on medical implants to guide soft tissue healing
US9119901B2 (en) 2005-04-28 2015-09-01 Warsaw Orthopedic, Inc. Surface treatments for promoting selective tissue attachment to medical impants
TWI411528B (zh) * 2005-05-12 2013-10-11 Clopay Plastic Prod Co 具有脆而不結塊之表層的彈性膜
GB0515625D0 (en) * 2005-07-29 2005-09-07 Univ Manchester Hydrogel particle
US20070031498A1 (en) * 2005-08-02 2007-02-08 Wright Medical Technology, Inc. Gel composition for cellular adhesion inhibition
US20070036842A1 (en) * 2005-08-15 2007-02-15 Concordia Manufacturing Llc Non-woven scaffold for tissue engineering
US7691946B2 (en) * 2005-09-30 2010-04-06 The United States Of America As Represented By The Secretary Of Agriculture Soy-based thermosensitive hydrogels for controlled release systems
US20070110788A1 (en) * 2005-11-14 2007-05-17 Hissong James B Injectable formulation capable of forming a drug-releasing device
US7432069B2 (en) * 2005-12-05 2008-10-07 Sontra Medical Corporation Biocompatible chemically crosslinked hydrogels for glucose sensing
US20070149641A1 (en) * 2005-12-28 2007-06-28 Goupil Dennis W Injectable bone cement
EP1978975B1 (en) * 2006-02-01 2014-12-24 Samyang Biopharmaceuticals Corporation Composition for inhibiting adhesion
US8795709B2 (en) 2006-03-29 2014-08-05 Incept Llc Superabsorbent, freeze dried hydrogels for medical applications
US8747870B2 (en) 2006-04-20 2014-06-10 University Of Utah Research Foundation Polymeric compositions and methods of making and using thereof
US20100285094A1 (en) * 2006-04-20 2010-11-11 University Of Utah Research Foundation Polymeric compositions and methods of making and using thereof
WO2007127198A2 (en) 2006-04-24 2007-11-08 Incept, Llc Protein crosslinkers, crosslinking methods and applications thereof
WO2007127785A2 (en) * 2006-04-25 2007-11-08 William Marsh Rice University Novel injectable macromonomers for the fabrication of hydrogels
US7872068B2 (en) * 2006-05-30 2011-01-18 Incept Llc Materials formable in situ within a medical device
US8273933B2 (en) * 2006-06-14 2012-09-25 Hewlett-Packard Development Company, L.P. Functionalized latex polymer and method of forming the same
EP2027729A2 (en) * 2006-06-15 2009-02-25 MicroVention, Inc. Embolization device constructed from expansible polymer
KR100773029B1 (ko) * 2006-06-16 2007-11-05 이화여자대학교 산학협력단 수용성 미셀을 형성하는 생분해성 고리형 삼합체 포스파젠-탁솔 컨쥬게이트 항암제 및 이의 제조방법
US8197499B2 (en) * 2006-06-21 2012-06-12 The Board Of Trustees Of The Leland Stanford Junior University Compositions and methods for joining non-conjoined lumens
US8608760B2 (en) * 2006-06-21 2013-12-17 The Board Of Trustees Of The Leland Stanford Junior University Compositions and methods for joining non-conjoined lumens
JP2009540965A (ja) * 2006-06-21 2009-11-26 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー 非結合管腔を接合するための組成物および方法
US8974542B2 (en) 2006-06-27 2015-03-10 University of Pittsburgh—of the Commonwealth System of Higher Education Biodegradable elastomeric patch for treating cardiac or cardiovascular conditions
GB0613333D0 (en) 2006-07-05 2006-08-16 Controlled Therapeutics Sct Hydrophilic polyurethane compositions
GB0613638D0 (en) * 2006-07-08 2006-08-16 Controlled Therapeutics Sct Polyurethane elastomers
MX2009000053A (es) * 2006-07-12 2009-02-23 Controlled Therapeutics Sct Polimero para el suministro de medicamentos con sal clorhidrato de clindamicina.
EP3047860B1 (en) 2006-07-20 2024-08-28 OrbusNeich Medical Pte. Ltd. Bioabsorbable polymeric composition for a medical device
WO2008033497A1 (en) * 2006-09-14 2008-03-20 The Research Foundation Of State University Of New York Nanostructured smart gel for time release drug delivery
MX2009003092A (es) * 2006-09-22 2009-05-08 Labopharm Inc Composiciones y metodos para suministro de farmaco dirigido a ph.
JP5277599B2 (ja) * 2006-09-29 2013-08-28 日油株式会社 生分解性ポリオキシアルキレン誘導体の製造方法
WO2008045904A2 (en) * 2006-10-10 2008-04-17 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Thermoresponsive, biodegradable, elastomeric material
GB0620685D0 (en) * 2006-10-18 2006-11-29 Controlled Therapeutics Sct Bioresorbable polymers
US8691321B2 (en) 2006-10-20 2014-04-08 Orbusneich Medical, Inc. Bioabsorbable polymeric composition and medical device background
US7959942B2 (en) 2006-10-20 2011-06-14 Orbusneich Medical, Inc. Bioabsorbable medical device with coating
US20080102123A1 (en) * 2006-10-27 2008-05-01 Schachter Deborah M Self-gelling tunable drug delivery system
EP1917971A1 (en) * 2006-10-27 2008-05-07 Société de Conseils de Recherches et d'Applications Scientifiques ( S.C.R.A.S.) Substained release formulations comprising very low molecular weight polymers
WO2008060557A2 (en) * 2006-11-14 2008-05-22 The Trustees Of The University Of Pennsylvania Efficient nuclear delivery of antisense oligonucleotides
JP2010519183A (ja) * 2007-02-06 2010-06-03 インセプト エルエルシー 生理溶液の溶出のためのタンパク質の沈殿を用いる重合
EP2120561A4 (en) 2007-02-19 2012-11-21 Plurogen Therapeutics Inc COMPOSITIONS FOR TREATING BIOFILMS, AND METHODS FOR THEIR USE
US20090227981A1 (en) * 2007-03-05 2009-09-10 Bennett Steven L Low-Swelling Biocompatible Hydrogels
US20090227689A1 (en) * 2007-03-05 2009-09-10 Bennett Steven L Low-Swelling Biocompatible Hydrogels
US20080279764A1 (en) * 2007-03-09 2008-11-13 Anthony Manganaro Method and composition for treating cancer
US8076295B2 (en) * 2007-04-17 2011-12-13 Nanotope, Inc. Peptide amphiphiles having improved solubility and methods of using same
KR100838809B1 (ko) * 2007-05-03 2008-06-17 성균관대학교산학협력단 겔강도가 우수한 온도 및 피에치 민감성 블록 공중합체 및이의 제조방법과 이를 이용한 약물전달체
US8133553B2 (en) 2007-06-18 2012-03-13 Zimmer, Inc. Process for forming a ceramic layer
US8309521B2 (en) 2007-06-19 2012-11-13 Zimmer, Inc. Spacer with a coating thereon for use with an implant device
EP2162101B1 (en) * 2007-06-25 2019-02-20 MicroVention, Inc. Self-expanding prosthesis
US9125807B2 (en) 2007-07-09 2015-09-08 Incept Llc Adhesive hydrogels for ophthalmic drug delivery
NZ582948A (en) * 2007-08-02 2012-04-27 Basf Se Polymer networks comprising active ingredients, process for their production, and their use
US8480651B2 (en) 2007-08-02 2013-07-09 Covidien Lp Cannula system
US8067028B2 (en) * 2007-08-13 2011-11-29 Confluent Surgical Inc. Drug delivery device
US8608049B2 (en) 2007-10-10 2013-12-17 Zimmer, Inc. Method for bonding a tantalum structure to a cobalt-alloy substrate
US8299316B2 (en) 2007-12-18 2012-10-30 Ethicon, Inc. Hemostatic device
US8629314B2 (en) 2007-12-18 2014-01-14 Ethicon, Inc. Surgical barriers having adhesion inhibiting properties
US8172861B2 (en) * 2007-12-20 2012-05-08 Tautona Group, L.P. Compositions and methods for joining non-conjoined lumens
WO2009086208A2 (en) 2007-12-21 2009-07-09 Microvention, Inc. Hydrogel filaments for biomedical uses
US8486528B2 (en) * 2008-01-22 2013-07-16 Gwangju Institute Of Science And Technology Temperature-sensitive nano-carriers
WO2009128934A1 (en) 2008-04-15 2009-10-22 Sarcode Corporation Topical lfa-1 antagonists for use in localized treatment of immune related disorders
KR20130097813A (ko) * 2008-04-21 2013-09-03 오토노미, 인코포레이티드 귀 질환 및 병태를 치료하기 위한 귀 조제물
US11969501B2 (en) 2008-04-21 2024-04-30 Dompé Farmaceutici S.P.A. Auris formulations for treating otic diseases and conditions
US8263704B2 (en) * 2008-04-23 2012-09-11 Tyco Healthcare Group Lp Bioabsorbable surgical composition
KR101534422B1 (ko) * 2008-05-14 2015-07-09 오토노미, 인코포레이티드 귀 질환 치료를 위한 제어 방출형 코르티코스테로이드 조성물 및 방법
WO2010011466A2 (en) 2008-06-27 2010-01-28 Otonomy, Inc. Controlled-release cns modulating compositions and methods for the treatment of otic disorders
US8496957B2 (en) * 2008-07-21 2013-07-30 Otonomy, Inc Controlled release auris sensory cell modulator compositions and methods for the treatment of otic disorders
US8784870B2 (en) 2008-07-21 2014-07-22 Otonomy, Inc. Controlled release compositions for modulating free-radical induced damage and methods of use thereof
AU2009274137B2 (en) * 2008-07-21 2013-10-31 Otonomy, Inc. Controlled release antimicrobial compositions and methods for the treatment of otic disorders
US8318817B2 (en) 2008-07-21 2012-11-27 Otonomy, Inc. Controlled release antimicrobial compositions and methods for the treatment of otic disorders
US8993068B2 (en) 2008-11-04 2015-03-31 The Trustees Of Columbia University In The City Of New York Heterobifunctional polymers and methods for layer-by-layer construction of multilayer films
US8563037B2 (en) * 2009-02-06 2013-10-22 Tautona Group, L.P. Compositions and methods for joining non-conjoined lumens
US8409606B2 (en) 2009-02-12 2013-04-02 Incept, Llc Drug delivery through hydrogel plugs
WO2010120830A1 (en) * 2009-04-13 2010-10-21 Northwestern University Novel peptide-based scaffolds for cartilage regeneration and methods for their use
US8757077B2 (en) 2009-04-30 2014-06-24 Technip France Spar mooring line sharing method and system
CA2977830C (en) 2009-05-04 2019-09-17 Incept, Llc Biomaterials for track and puncture closure
WO2010135449A1 (en) 2009-05-19 2010-11-25 Plurogen Therapeutics, Inc. Surface active agent compositions and methods for enhancing oxygenation, reducing bacteria and improving wound healing
US20090298953A1 (en) * 2009-07-09 2009-12-03 Iran Polymer And Petrochemical Institute Drug delivery system and method of making the same
WO2011038291A1 (en) 2009-09-24 2011-03-31 Microvention, Inc. Injectable hydrogel filaments for biomedical uses
WO2011040969A1 (en) * 2009-09-30 2011-04-07 Massachusetts Institute Of Technology Compositions and methods for the treatment of atherosclerosis and other related diseases
US20110081293A1 (en) 2009-10-07 2011-04-07 Sanford-Burnham Medical Research Institute Methods and compositions related to clot-binding lipid compounds
EP2493367B1 (en) * 2009-10-26 2019-03-13 Microvention, Inc. Embolization device constructed from expansile polymer
EP2498763A4 (en) 2009-11-09 2015-10-07 Spotlight Technology Partners Llc HYDROGELE ON POLYSACCHARIDBASIS
CN102695501A (zh) 2009-11-09 2012-09-26 聚光灯技术合伙有限责任公司 碎裂水凝胶
CN102741336B (zh) 2009-12-01 2014-03-19 株式会社普利司通 改性橡胶组合物和制备方法
US8383161B2 (en) 2009-12-15 2013-02-26 Incept, Llc Radioopaque covalently crosslinked hydrogel particle implants
WO2011085225A1 (en) * 2010-01-08 2011-07-14 Wake Forest University Health Sciences Delivery system
US8835395B2 (en) 2010-03-10 2014-09-16 Kansas State University Research Foundation Protein peptide hydrogels
US20110223156A1 (en) * 2010-03-11 2011-09-15 Raibekas Andrei A Reversible gel protein formulation
US8551531B2 (en) 2010-04-12 2013-10-08 The Curators Of The University Of Missouri Pentablock polymers
CA3048850A1 (en) 2010-05-11 2011-11-17 Howmedica Osteonics Corp. Organophosphorous, multivalent metal compounds, & polymer adhesive interpenetrating network compositions & methods
US9232805B2 (en) 2010-06-29 2016-01-12 Biocure, Inc. In-situ forming hydrogel wound dressings containing antimicrobial agents
WO2012024390A2 (en) 2010-08-17 2012-02-23 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Biohybrid composite scaffold
US8961501B2 (en) 2010-09-17 2015-02-24 Incept, Llc Method for applying flowable hydrogels to a cornea
WO2012047781A1 (en) * 2010-10-04 2012-04-12 Church & Dwight Co., Inc. Multi-purposed dentifrice
KR101983402B1 (ko) 2011-03-07 2019-05-28 웨이크 포리스트 유니버시티 헬스 사이언시즈 전달 시스템
US9006345B2 (en) 2011-03-25 2015-04-14 The Trustees Of Columbia University In The City Of New York Heterotrifunctional molecules and methods for the synthesis of dendrimeric materials
BR112013024863A2 (pt) 2011-03-28 2016-12-20 Yissum Res Dev Co formulação injetável de liberação sustentada
WO2012145431A2 (en) 2011-04-18 2012-10-26 Microvention, Inc. Embolic devices
CN106729771A (zh) 2011-04-21 2017-05-31 加利福尼亚大学董事会 官能化磁性纳米颗粒及在淀粉样沉积物和神经原纤维缠结成像中用途
EP2707077B1 (en) 2011-05-11 2017-10-04 Microvention, Inc. Device for occluding a lumen
WO2012158527A2 (en) 2011-05-13 2012-11-22 Howmedica Osteonics Organophosphorous & multivalent metal compound compositions & methods
US9943592B2 (en) 2011-05-26 2018-04-17 Kansas State University Research Foundation Vaccine adjuvants from self-assembling peptides
US10226417B2 (en) 2011-09-16 2019-03-12 Peter Jarrett Drug delivery systems and applications
EP2766407B1 (en) * 2011-10-12 2018-06-27 The Curators Of The University Of Missouri Pentablock polymers
US8936784B2 (en) 2011-10-17 2015-01-20 Poly-Med, Inc. Absorbable in situ gel-forming system, method of making and use thereof
CA2852386C (en) * 2011-10-17 2019-05-21 Poly-Med, Inc. Absorbable in situ gel-forming system, method of making and use thereof
US20130101547A1 (en) 2011-10-19 2013-04-25 Allergan, Inc. Thermoresponsive compositions for dermatological use and methods thereof
EP4556010A3 (en) 2011-11-30 2025-07-23 Emory University Jak inhibitors for use in the prevention or treatment of a viral disease caused by a coronaviridae
US9011884B2 (en) 2012-04-18 2015-04-21 Microvention, Inc. Embolic devices
US9205175B2 (en) 2012-07-27 2015-12-08 Drexel University Thermosensitive and crosslinkable polymer composite for three-dimensional soft tissue scaffold printing
US9395468B2 (en) 2012-08-27 2016-07-19 Ocular Dynamics, Llc Contact lens with a hydrophilic layer
US8633296B1 (en) 2012-09-12 2014-01-21 International Business Machines Corporation Composite hydrogels for delivery of biologically active materials
US9421221B2 (en) 2012-11-12 2016-08-23 Warsaw Orthopedic, Inc. Compositions and methods for inhibiting adhesion formation
US9474767B2 (en) 2012-11-12 2016-10-25 Warsaw Orthopedic, Inc. Compositions and methods for inhibiting bone growth
US9707323B2 (en) 2012-11-12 2017-07-18 Warsaw Orthopedic, Inc. Devices and methods for inhibiting adhesion formation
DE102012223416A1 (de) * 2012-12-17 2014-07-03 Polymaterials Ag Kettenverlängerte Poloxamere, daraus gebildete thermoreversible Hydrogele mit biologischen Materialien, und medizinische Anwendungen derselben
MX2015011820A (es) * 2013-03-14 2016-01-25 Genzyme Corp Composiciones termosensibles para crecimiento oseo.
WO2014186669A1 (en) 2013-05-16 2014-11-20 The Curators Of The University Of Missouri Drug loading pentablock polymers
US9486405B2 (en) 2013-08-27 2016-11-08 Otonomy, Inc. Methods for the treatment of pediatric otic disorders
US9566296B2 (en) 2013-11-08 2017-02-14 Warsaw Orthopedic, Inc. Multi-layered anti-adhesion device
CN105917270A (zh) 2013-11-15 2016-08-31 视觉力学有限责任公司 具有亲水层的接触透镜
WO2015138919A1 (en) 2014-03-14 2015-09-17 The University Of North Carolina At Chapel Hill Small molecules for inhibiting male fertility
WO2015153996A1 (en) 2014-04-03 2015-10-08 Micro Vention, Inc. Embolic devices
CN110433326A (zh) 2014-04-29 2019-11-12 微仙美国有限公司 包含活性剂的聚合物
WO2015167751A1 (en) 2014-04-29 2015-11-05 Microvention, Inc. Polymers
JP6774947B2 (ja) 2014-12-09 2020-10-28 タンジブル サイエンス インコーポレイテッド 生体適合性層を有する医療デバイスコーティング
WO2016118644A1 (en) 2015-01-20 2016-07-28 Plurogen Therapeutics, Llc Compositions and methods of treating microbes
EP3269755B1 (en) * 2015-03-10 2025-08-13 The University of Tokyo Process for producing low-concentration gel using gel-precursor clusters, and gel obtained by said production process
EP4279064A3 (en) 2015-05-12 2024-02-28 Incept, LLC Drug delivery from hydrogels
WO2016201250A1 (en) 2015-06-11 2016-12-15 Microvention, Inc. Expansile device for implantation
CR20180128A (es) * 2015-08-05 2018-04-24 Childrens Medical Center Composiciones con potenciadores de permeación para suministro de fármacos
US20170173209A1 (en) * 2015-12-18 2017-06-22 Rousseau Research, Inc. Wound closure compositions and method
US9868870B2 (en) 2016-03-16 2018-01-16 International Business Machines Corporation Hydrogel compositions for direct-write printing applications
US11040004B2 (en) 2016-09-16 2021-06-22 Otonomy, Inc. Otic gel formulations for treating otitis externa
US11911532B2 (en) 2017-03-29 2024-02-27 The Regents Of The University Of Colorado, A Body Corporate Reverse thermal gels and their use as vascular embolic repair agents
US10457772B2 (en) 2017-09-08 2019-10-29 International Business Machines Corporation Preparation of robust polythioaminal carriers
SE541313C2 (en) * 2017-10-13 2019-06-25 Amferia Ab Amphiphilic antimicrobial hydrogel
CN112533986B (zh) 2018-07-31 2023-07-11 国立大学法人东京大学 具有海绵状多孔结构的高分子凝胶
CN109400816B (zh) * 2018-08-24 2020-10-30 哈尔滨工业大学 一种可紫外光固化的变色凝胶树脂及其合成方法和凝胶的变色、褪色方法
CA3111385A1 (en) 2018-09-06 2020-03-12 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Sustained-release injectable antibiotical formulation
US20220040136A1 (en) 2018-10-09 2022-02-10 University Of Rochester Treatment of vulvovaginal disorders
AU2021316104A1 (en) * 2020-07-31 2023-02-16 Massachusetts Institute Of Technology Compositions including solid forms of polypeptides and related methods
WO2023220717A2 (en) * 2022-05-12 2023-11-16 The General Hospital Corporation Nanoparticle doped polyethylene glycol based gels and medical devices for drug delivery
AU2024220563A1 (en) 2023-02-16 2025-08-14 University Of Rochester Improving glymphatic-lymphatic efflux
WO2025255023A1 (en) * 2024-06-03 2025-12-11 Ocular Therapeutix, Inc. Sustained release prodrug implant

Family Cites Families (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1595369C3 (de) * 1966-12-15 1973-10-04 Badische Anilin- & Soda-Fabrik Ag, 6700 Ludwigshafen Derivate von Blockcopolymerisaten des Äthylenoxids und des 1,2-Propylends und Verfahren zu deren Herstellung
US4189609A (en) 1974-08-19 1980-02-19 Basf Wyandotte Corporation Multi-block coupled polyoxyalkylene copolymer surfactants
US3931337A (en) 1974-08-19 1976-01-06 Basf Wyandotte Corporation Multi-block polyacetal copolymer surfactants
DE2536121A1 (de) 1974-08-19 1976-03-04 Basf Wyandotte Corp Oberflaechenaktive block-polyoxyalkylencopolymere
US3954886A (en) 1974-11-22 1976-05-04 Basf Wyandotte Corporation Alkali stable polyoxyethylene acetal surfactants
US3931148A (en) 1974-12-23 1976-01-06 Basf Wyandotte Corporation Hydroxyalkylamino glycosides and process of preparation
US4191820A (en) 1978-01-03 1980-03-04 Basf Wyandotte Corporation Process for preparing polyalkylene polyamine polyethers
US4178434A (en) 1978-01-03 1979-12-11 Basf Wyandotte Corporation Amine-coupled polyepichlorohydrin and polyamines derived therefrom
US4281199A (en) 1978-06-03 1981-07-28 Basf Wyandotte Corporation Polyalkylene polyamine ether derivatives of polyoxyalkylene compounds
US4261704A (en) 1979-06-22 1981-04-14 Basf Wyandotte Corporation Polyoxyalkylene polyamine detergent compositions
US4287078A (en) 1980-01-28 1981-09-01 Basf Wyandotte Corporation Surfactants derived from the reaction product of polyoxyalkylene polyols and polyglycidyl ethers and glycol-based antifreeze using same
US4314000A (en) 1980-11-03 1982-02-02 Basf Wyandotte Corporation Fiber lubricants yielding low residues upon oxidation
US4408084A (en) 1981-01-09 1983-10-04 Basf Wyandotte Corporation Non-ionic surfactants containing acetal groups
US4504418A (en) 1981-01-09 1985-03-12 Basf Wyandotte Corporation Non-ionic surface-active agents coupled with carbonates or carboxylic esters
US4519950A (en) 1981-01-16 1985-05-28 Basf Wyandotte Corporation Acetal group-containing non-ionic surfactants
ATE37983T1 (de) 1982-04-22 1988-11-15 Ici Plc Mittel mit verzoegerter freigabe.
US4452973A (en) 1982-11-12 1984-06-05 American Cyanamid Company Poly(glycolic acid)/poly(oxyethylene) triblock copolymers and method of manufacturing the same
US4888176A (en) 1984-05-21 1989-12-19 Massachusetts Institute Of Technology Controlled drug delivery high molecular weight polyanhydrides
US4757128A (en) 1986-08-01 1988-07-12 Massachusetts Institute Of Technology High molecular weight polyanhydride and preparation thereof
US4818542A (en) 1983-11-14 1989-04-04 The University Of Kentucky Research Foundation Porous microspheres for drug delivery and methods for making same
US4741337A (en) 1985-07-17 1988-05-03 Ethicon, Inc. Surgical fastener made from glycolide-rich polymer blends
US5160745A (en) 1986-05-16 1992-11-03 The University Of Kentucky Research Foundation Biodegradable microspheres as a carrier for macromolecules
US4716203A (en) 1986-09-05 1987-12-29 American Cyanamid Company Diblock and triblock copolymers
IT1198449B (it) 1986-10-13 1988-12-21 F I D I Farmaceutici Italiani Esteri di alcoli polivalenti di acido ialuronico
US4789724A (en) 1986-10-17 1988-12-06 Massachusetts Institute Of Technology Preparation of anhydride copolymers
IL82834A (en) 1987-06-09 1990-11-05 Yissum Res Dev Co Biodegradable polymeric materials based on polyether glycols,processes for the preparation thereof and surgical artiicles made therefrom
US4857311A (en) 1987-07-31 1989-08-15 Massachusetts Institute Of Technology Polyanhydrides with improved hydrolytic degradation properties
US5296627A (en) 1988-06-20 1994-03-22 Ppg Industries, Inc. Ethylenically unsaturated poly(alkyleneoxy) surfactants
US5213580A (en) 1988-08-24 1993-05-25 Endoluminal Therapeutics, Inc. Biodegradable polymeric endoluminal sealing process
US5328471A (en) 1990-02-26 1994-07-12 Endoluminal Therapeutics, Inc. Method and apparatus for treatment of focal disease in hollow tubular organs and other tissue lumens
US4938763B1 (en) 1988-10-03 1995-07-04 Atrix Lab Inc Biodegradable in-situ forming implants and method of producing the same
US4987744A (en) 1990-01-26 1991-01-29 Union Carbide Industrial Gases Technology Corporation Cryogenic distillation with unbalanced heat pump
US5078994A (en) 1990-04-12 1992-01-07 Eastman Kodak Company Microgel drug delivery system
EP0544671A4 (en) 1990-04-18 1993-09-15 The University Of Utah Colonic-targeted oral drug-dosage forms based on crosslinked hydrogels containing azobonds and exhibiting ph-dependent swelling
US5219564A (en) 1990-07-06 1993-06-15 Enzon, Inc. Poly(alkylene oxide) amino acid copolymers and drug carriers and charged copolymers based thereon
US5145518A (en) 1990-06-27 1992-09-08 Xerox Corporation Inks containing block copolymer micelles
US5512091A (en) 1990-08-13 1996-04-30 Steiner; Carol A. Associative polymer hydrogels
US5410016A (en) 1990-10-15 1995-04-25 Board Of Regents, The University Of Texas System Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
CA2101773A1 (en) 1991-01-31 1992-08-01 Toyoichi Tanaka Interpenetrating-polymer network phase-transition gels
GB9112267D0 (en) 1991-06-07 1991-07-24 Biocompatibles Ltd Polymeric coating
CA2087125A1 (en) * 1992-01-23 1993-07-24 Mridula Nair Chemically fixed micelles
US5417983A (en) 1992-02-19 1995-05-23 Sagami Chemical Research Center Drug release controlling material responsive to changes in temperature
SE9200564L (sv) 1992-02-26 1993-03-15 Perstorp Ab Dendritisk makromolekyl av polyestertyp, foerfarande foer framstaellning daerav samt anvaendning daerav
US5573934A (en) * 1992-04-20 1996-11-12 Board Of Regents, The University Of Texas System Gels for encapsulation of biological materials
KR100266912B1 (ko) 1992-02-28 2000-12-01 파라비 레이 조직접촉물질이며 방출조절운반체인 광중합성 생분해성 하이드로겔
KR940003548U (ko) 1992-08-14 1994-02-21 김형술 세탁물 건조기
ATE173171T1 (de) 1993-03-23 1998-11-15 Focal Inc Gerät und methode für den lokalen auftrag von polymermaterial auf gewebe
TW272976B (https=) 1993-08-06 1996-03-21 Ciba Geigy Ag
US5525657A (en) 1994-10-11 1996-06-11 Basf Corporation Latex composition employing specifically defined ethylene oxide/propylene oxide block copolymer surfactant and hydrophobic defoaming agent
JPH11510837A (ja) * 1995-07-28 1999-09-21 フォーカル，インコーポレイテッド 薬物送達のための制御された放出薬剤および組織処置薬剤としての使用のためのマルチブロック生分解性ヒドロゲル
US5702717A (en) 1995-10-25 1997-12-30 Macromed, Inc. Thermosensitive biodegradable polymers based on poly(ether-ester)block copolymers
KR100704597B1 (ko) 2003-02-19 2007-04-09 후지쯔 가부시끼가이샤 패킷 스케줄링

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022069574A1 (de) * 2020-09-30 2022-04-07 Leibniz-Institut Für Neue Materialien Gemeinnützige Gmbh Neuartige hydrogele

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