DE69632224T2 - Reduzierung von Gelation von Fettsäureacylierten Proteinen unter Nutzung von Zitratpuffer - Google Patents

Reduzierung von Gelation von Fettsäureacylierten Proteinen unter Nutzung von Zitratpuffer Download PDF

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Publication number
DE69632224T2
DE69632224T2 DE69632224T DE69632224T DE69632224T2 DE 69632224 T2 DE69632224 T2 DE 69632224T2 DE 69632224 T DE69632224 T DE 69632224T DE 69632224 T DE69632224 T DE 69632224T DE 69632224 T2 DE69632224 T2 DE 69632224T2
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DE
Germany
Prior art keywords
fatty acid
acylated
protein
insulin
solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69632224T
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German (de)
English (en)
Other versions
DE69632224D1 (de
Inventor
Jeffrey Clayton Indianapolis Baker
Jose M. Martinsville Hanquier
Warren E. Indianapolis Shrader
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Eli Lilly and Co
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Eli Lilly and Co
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Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of DE69632224D1 publication Critical patent/DE69632224D1/de
Application granted granted Critical
Publication of DE69632224T2 publication Critical patent/DE69632224T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Fats And Perfumes (AREA)
DE69632224T 1995-06-07 1996-05-31 Reduzierung von Gelation von Fettsäureacylierten Proteinen unter Nutzung von Zitratpuffer Expired - Fee Related DE69632224T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/484,545 US5631347A (en) 1995-06-07 1995-06-07 Reducing gelation of a fatty acid-acylated protein
US484545 1995-06-07

Publications (2)

Publication Number Publication Date
DE69632224D1 DE69632224D1 (de) 2004-05-27
DE69632224T2 true DE69632224T2 (de) 2005-04-14

Family

ID=23924602

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69632224T Expired - Fee Related DE69632224T2 (de) 1995-06-07 1996-05-31 Reduzierung von Gelation von Fettsäureacylierten Proteinen unter Nutzung von Zitratpuffer

Country Status (10)

Country Link
US (1) US5631347A (enExample)
EP (1) EP0747390B1 (enExample)
JP (1) JP3962430B2 (enExample)
AT (1) ATE264867T1 (enExample)
AU (1) AU5951596A (enExample)
CA (1) CA2223531A1 (enExample)
DE (1) DE69632224T2 (enExample)
DK (1) DK0747390T3 (enExample)
ES (1) ES2218569T3 (enExample)
WO (1) WO1996040188A1 (enExample)

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US7196059B2 (en) * 2001-09-07 2007-03-27 Biocon Limited Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
US7312192B2 (en) * 2001-09-07 2007-12-25 Biocon Limited Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US6913903B2 (en) * 2001-09-07 2005-07-05 Nobex Corporation Methods of synthesizing insulin polypeptide-oligomer conjugates, and proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
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US7601688B2 (en) 2002-06-13 2009-10-13 Biocon Limited Methods of reducing hypoglycemic episodes in the treatment of diabetes mellitus
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CN1882356B (zh) 2003-11-20 2015-02-25 诺沃挪第克公司 对于生产和用于注射装置中是最佳的含有丙二醇的肽制剂
CN103223160B (zh) 2004-07-19 2015-02-18 比奥孔有限公司 胰岛素-低聚物共轭物,制剂及其用途
ES2442223T3 (es) 2004-08-31 2014-02-10 Novo Nordisk A/S Uso de tris(hidroximetil) aminometano para la estabilización de péptidos, polipéptidos y proteínas
CN106137952B (zh) 2004-11-12 2020-11-17 诺和诺德公司 促胰岛素肽的稳定制剂
BRPI0710503A2 (pt) * 2006-04-07 2011-08-16 Merrion Res Iii Ltd uso de uma composição farmacêutica, composição farmacêutica, e, forma de dosagem oral
CA2654566A1 (en) * 2006-06-09 2007-12-21 Merrion Research Iii Limited Solid oral dosage form containing an enhancer
PT2203181T (pt) * 2007-10-16 2018-05-10 Biocon Ltd Uma composição farmacêutica sólida para administração por via oral e o seu processo de fabrico
WO2009137080A1 (en) * 2008-05-07 2009-11-12 Merrion Research Iii Limited Compositions of gnrh related compounds and processes of preparation
US20100215743A1 (en) * 2009-02-25 2010-08-26 Leonard Thomas W Composition and drug delivery of bisphosphonates
CN102770152B (zh) 2009-11-25 2016-07-06 阿瑞斯根股份有限公司 肽类的粘膜递送
US20110182985A1 (en) * 2010-01-28 2011-07-28 Coughlan David C Solid Pharmaceutical Composition with Enhancers and Methods of Preparing thereof
WO2011120033A1 (en) * 2010-03-26 2011-09-29 Merrion Research Iii Limited Pharmaceutical compositions of selective factor xa inhibitors for oral administration
KR20140026354A (ko) 2011-01-07 2014-03-05 메리온 리서치 Ⅲ 리미티드 경구 투여용 철의 제약 조성물
US9155775B1 (en) 2015-01-28 2015-10-13 Teva Pharmaceutical Industries, Ltd. Process for manufacturing glatiramer acetate product
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IL294520A (en) 2020-02-18 2022-09-01 Novo Nordisk As Pharmaceutical formulations

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Also Published As

Publication number Publication date
ATE264867T1 (de) 2004-05-15
ES2218569T3 (es) 2004-11-16
EP0747390B1 (en) 2004-04-21
DE69632224D1 (de) 2004-05-27
JP3962430B2 (ja) 2007-08-22
WO1996040188A1 (en) 1996-12-19
AU5951596A (en) 1996-12-30
EP0747390A2 (en) 1996-12-11
US5631347A (en) 1997-05-20
JPH11506739A (ja) 1999-06-15
EP0747390A3 (en) 1997-06-04
DK0747390T3 (da) 2004-07-26
CA2223531A1 (en) 1996-12-19

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee