JP3962430B2 - 脂肪酸アシル化蛋白質のゲル化削減法 - Google Patents

脂肪酸アシル化蛋白質のゲル化削減法 Download PDF

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Publication number
JP3962430B2
JP3962430B2 JP50083397A JP50083397A JP3962430B2 JP 3962430 B2 JP3962430 B2 JP 3962430B2 JP 50083397 A JP50083397 A JP 50083397A JP 50083397 A JP50083397 A JP 50083397A JP 3962430 B2 JP3962430 B2 JP 3962430B2
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JP
Japan
Prior art keywords
insulin
acylated
fatty
fatty acid
protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP50083397A
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English (en)
Japanese (ja)
Other versions
JPH11506739A (ja
JPH11506739A5 (enExample
Inventor
ベイカー，ジェフリー・クレイトン
ハンキエ，ジョゼ・エム
シュレーダー，ウォーレン・イー
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Eli Lilly and Co
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Eli Lilly and Co
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Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of JPH11506739A publication Critical patent/JPH11506739A/ja
Publication of JPH11506739A5 publication Critical patent/JPH11506739A5/ja
Application granted granted Critical
Publication of JP3962430B2 publication Critical patent/JP3962430B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Fats And Perfumes (AREA)
JP50083397A 1995-06-07 1996-06-04 脂肪酸アシル化蛋白質のゲル化削減法 Expired - Fee Related JP3962430B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/484,545 1995-06-07
US08/484,545 US5631347A (en) 1995-06-07 1995-06-07 Reducing gelation of a fatty acid-acylated protein
PCT/US1996/007965 WO1996040188A1 (en) 1995-06-07 1996-06-04 Reducing gelation of a fatty acid-acylated protein

Publications (3)

Publication Number Publication Date
JPH11506739A JPH11506739A (ja) 1999-06-15
JPH11506739A5 JPH11506739A5 (enExample) 2004-07-22
JP3962430B2 true JP3962430B2 (ja) 2007-08-22

Family

ID=23924602

Family Applications (1)

Application Number Title Priority Date Filing Date
JP50083397A Expired - Fee Related JP3962430B2 (ja) 1995-06-07 1996-06-04 脂肪酸アシル化蛋白質のゲル化削減法

Country Status (10)

Country Link
US (1) US5631347A (enExample)
EP (1) EP0747390B1 (enExample)
JP (1) JP3962430B2 (enExample)
AT (1) ATE264867T1 (enExample)
AU (1) AU5951596A (enExample)
CA (1) CA2223531A1 (enExample)
DE (1) DE69632224T2 (enExample)
DK (1) DK0747390T3 (enExample)
ES (1) ES2218569T3 (enExample)
WO (1) WO1996040188A1 (enExample)

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US6828297B2 (en) 2001-06-04 2004-12-07 Nobex Corporation Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6713452B2 (en) 2001-06-04 2004-03-30 Nobex Corporation Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
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US7312192B2 (en) * 2001-09-07 2007-12-25 Biocon Limited Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US7166571B2 (en) * 2001-09-07 2007-01-23 Biocon Limited Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US7030082B2 (en) * 2001-09-07 2006-04-18 Nobex Corporation Pharmaceutical compositions of drug-oligomer conjugates and methods of treating disease therewith
ATE446971T1 (de) * 2001-09-07 2009-11-15 Biocon Ltd Verfahren zur synthese von insulinpolypeptid- oligomer-konjugaten und proinsulinpolypeptid- oligomer-konjugaten und verfahren zu deren synthese
US6913903B2 (en) * 2001-09-07 2005-07-05 Nobex Corporation Methods of synthesizing insulin polypeptide-oligomer conjugates, and proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US6770625B2 (en) 2001-09-07 2004-08-03 Nobex Corporation Pharmaceutical compositions of calcitonin drug-oligomer conjugates and methods of treating diseases therewith
US7196059B2 (en) * 2001-09-07 2007-03-27 Biocon Limited Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
AU2003236521A1 (en) 2002-06-13 2003-12-31 Nobex Corporation Methods of reducing hypoglycemic episodes in the treatment of diabetes mellitus
JP4936884B2 (ja) 2003-06-03 2012-05-23 ノボ・ノルデイスク・エー／エス 安定化された薬学的ペプチド組成物
WO2004105790A1 (en) 2003-06-03 2004-12-09 Novo Nordisk A/S Stabilized pharmaceutical peptide compositions
CN102784386A (zh) 2003-11-20 2012-11-21 诺沃挪第克公司 对于生产和用于注射装置中是最佳的含有丙二醇的肽制剂
BRPI0513508B1 (pt) 2004-07-19 2021-06-01 Biocon Limited Conjugados de insulina-oligômero, formulações e usos desses
US8710181B2 (en) 2004-08-31 2014-04-29 Novo Nordisk A/S Use of tris(hydroxymethyl) aminomethane for the stabilization of peptides, polypeptides and proteins
JP5175103B2 (ja) 2004-11-12 2013-04-03 ノヴォ ノルディスク アー／エス 安定なペプチド製剤
US7704977B2 (en) * 2006-04-07 2010-04-27 Merrion Research Iii Limited Solid oral dosage form containing an enhancer
US20070292512A1 (en) * 2006-06-09 2007-12-20 Merrion Research Ii Limited Solid Oral Dosage Form Containing an Enhancer
PL2203181T3 (pl) * 2007-10-16 2018-07-31 Biocon Limited Podawana doustnie stała kompozycja farmaceutyczna i jej sposób
JP5671451B2 (ja) * 2008-05-07 2015-02-18 メリオン・リサーチ・Ｉｉｉ・リミテッド ＧｎＲＨ関連化合物の組成物および調製プロセス
WO2010099255A1 (en) * 2009-02-25 2010-09-02 Merrion Research Iii Limited Composition and drug delivery of bisphosphonates
AU2010323117B2 (en) 2009-11-25 2015-09-03 Capsugel Belgium Nv Mucosal delivery compositions comprising a peptide complexed with a crown comppound and/or a counter ion
US20110182985A1 (en) * 2010-01-28 2011-07-28 Coughlan David C Solid Pharmaceutical Composition with Enhancers and Methods of Preparing thereof
WO2011120033A1 (en) * 2010-03-26 2011-09-29 Merrion Research Iii Limited Pharmaceutical compositions of selective factor xa inhibitors for oral administration
US8802114B2 (en) 2011-01-07 2014-08-12 Merrion Research Iii Limited Pharmaceutical compositions of iron for oral administration
US9155775B1 (en) 2015-01-28 2015-10-13 Teva Pharmaceutical Industries, Ltd. Process for manufacturing glatiramer acetate product
CN107205948B (zh) 2015-01-29 2021-12-14 诺和诺德股份有限公司 包含glp-1激动剂和肠溶衣的片剂
US11180739B2 (en) * 2017-02-27 2021-11-23 Duke University In vivo protein N-acylation
JP6633777B2 (ja) 2017-08-24 2020-01-22 ノヴォ ノルディスク アー／エス Ｇｌｐ−１組成物及びその使用
AU2021208601B2 (en) 2020-02-18 2025-06-05 Novo Nordisk A/S Glp-1 compositions and uses thereof

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Also Published As

Publication number Publication date
US5631347A (en) 1997-05-20
DE69632224D1 (de) 2004-05-27
DE69632224T2 (de) 2005-04-14
EP0747390A3 (en) 1997-06-04
JPH11506739A (ja) 1999-06-15
CA2223531A1 (en) 1996-12-19
ATE264867T1 (de) 2004-05-15
AU5951596A (en) 1996-12-30
ES2218569T3 (es) 2004-11-16
DK0747390T3 (da) 2004-07-26
EP0747390A2 (en) 1996-12-11
WO1996040188A1 (en) 1996-12-19
EP0747390B1 (en) 2004-04-21

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