DE69532245D1 - Imidazolderivat - Google Patents
ImidazolderivatInfo
- Publication number
- DE69532245D1 DE69532245D1 DE69532245T DE69532245T DE69532245D1 DE 69532245 D1 DE69532245 D1 DE 69532245D1 DE 69532245 T DE69532245 T DE 69532245T DE 69532245 T DE69532245 T DE 69532245T DE 69532245 D1 DE69532245 D1 DE 69532245D1
- Authority
- DE
- Germany
- Prior art keywords
- alkyl
- halogeno
- formula
- hydrogen
- imidazolderivat
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C07D233/58—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/84—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Virology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Dental Preparations (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP25749094 | 1994-09-26 | ||
JP25749094 | 1994-09-26 | ||
JP8469095 | 1995-03-15 | ||
JP8469095 | 1995-03-15 | ||
JP22720595 | 1995-08-12 | ||
JP22720595 | 1995-08-12 | ||
PCT/JP1995/001936 WO1996010019A1 (fr) | 1994-09-26 | 1995-09-25 | Derive imidazole |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69532245D1 true DE69532245D1 (en) | 2004-01-15 |
DE69532245T2 DE69532245T2 (de) | 2004-09-16 |
Family
ID=27304632
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69532245T Expired - Fee Related DE69532245T2 (de) | 1994-09-26 | 1995-09-25 | Imidazolderivat |
Country Status (20)
Country | Link |
---|---|
US (2) | US5910506A (de) |
EP (1) | EP0786455B1 (de) |
JP (1) | JP3155009B2 (de) |
KR (1) | KR100387157B1 (de) |
CN (1) | CN1093535C (de) |
AT (1) | ATE255564T1 (de) |
BR (1) | BR9509024A (de) |
CA (1) | CA2200316C (de) |
DE (1) | DE69532245T2 (de) |
DK (1) | DK0786455T3 (de) |
ES (1) | ES2211917T3 (de) |
FI (1) | FI971234A (de) |
HU (1) | HUT77357A (de) |
MX (1) | MX9702030A (de) |
NO (1) | NO308739B1 (de) |
PL (1) | PL183931B1 (de) |
PT (1) | PT786455E (de) |
RU (1) | RU2157368C2 (de) |
TW (1) | TW401404B (de) |
WO (1) | WO1996010019A1 (de) |
Families Citing this family (52)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69732230T2 (de) * | 1996-03-28 | 2005-12-22 | Shionogi & Co., Ltd. | Durch lymphe absorbierbare imidazolderivate |
KR100310888B1 (ko) * | 1996-04-04 | 2001-12-12 | 시오노 요시히코 | 이미다졸유도체를함유하는항-hiv조성물 |
DE69733716T2 (de) * | 1996-12-26 | 2006-04-20 | Shionogi & Co., Ltd. | Verfahren zur herstellung von imidazolderivaten |
EP0994106B1 (de) * | 1996-12-26 | 2004-03-17 | Shionogi & Co., Ltd. | Verfahren zur herstellung von carbamoylsubstituierten imidazolderivaten |
TWI232214B (en) * | 1998-04-16 | 2005-05-11 | Shionogi & Co | Preparation of aryl sulfenyl halide |
WO2000061109A1 (fr) | 1999-04-12 | 2000-10-19 | Shionogi & Co., Ltd. | Procede de production de composition medicamenteuse renfermant un compose medicamenteux hydrophobe basique |
GB0016787D0 (en) | 2000-07-07 | 2000-08-30 | Pfizer Ltd | Compounds useful in therapy |
JP2004518687A (ja) | 2001-01-31 | 2004-06-24 | ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー | アルコールをカルバモイル化する方法 |
WO2002068395A1 (en) * | 2001-02-23 | 2002-09-06 | K.U. Leuven Research & Development | Hiv inhibiting n-aminoimidazole derivatives |
JP3806090B2 (ja) | 2001-04-10 | 2006-08-09 | ファイザー・インク | Hiv関連疾患治療用のピラゾール誘導体 |
GB0113524D0 (en) * | 2001-06-04 | 2001-07-25 | Hoffmann La Roche | Pyrazole derivatives |
KR20040108756A (ko) | 2002-04-26 | 2004-12-24 | 길리애드 사이언시즈, 인코포레이티드 | 비뉴클레오사이드 역전사 효소 억제제 |
TW200423930A (en) | 2003-02-18 | 2004-11-16 | Hoffmann La Roche | Non-nucleoside reverse transcriptase inhibitors |
KR20050119652A (ko) | 2003-03-24 | 2005-12-21 | 에프. 호프만-라 로슈 아게 | 역전사 효소 저해제로서의 벤질-피리다진온 |
US7470724B2 (en) | 2003-04-25 | 2008-12-30 | Gilead Sciences, Inc. | Phosphonate compounds having immuno-modulatory activity |
US7432261B2 (en) | 2003-04-25 | 2008-10-07 | Gilead Sciences, Inc. | Anti-inflammatory phosphonate compounds |
US7452901B2 (en) | 2003-04-25 | 2008-11-18 | Gilead Sciences, Inc. | Anti-cancer phosphonate analogs |
US7407965B2 (en) | 2003-04-25 | 2008-08-05 | Gilead Sciences, Inc. | Phosphonate analogs for treating metabolic diseases |
US7427636B2 (en) | 2003-04-25 | 2008-09-23 | Gilead Sciences, Inc. | Inosine monophosphate dehydrogenase inhibitory phosphonate compounds |
EP1620109A2 (de) | 2003-04-25 | 2006-02-01 | Gilead Sciences, Inc. | Kinase inhbitor phosphonat konjugate |
WO2005002626A2 (en) | 2003-04-25 | 2005-01-13 | Gilead Sciences, Inc. | Therapeutic phosphonate compounds |
WO2004096285A2 (en) | 2003-04-25 | 2004-11-11 | Gilead Sciences, Inc. | Anti-infective phosphonate conjugates |
EA014685B1 (ru) | 2003-04-25 | 2010-12-30 | Джилид Сайэнс, Инк. | Фосфонатсодержащие антивирусные соединения (варианты) и фармацевтическая композиция на их основе |
WO2005016912A1 (en) * | 2003-08-19 | 2005-02-24 | Pfizer Inc. | An efficient microbial preparation of capravirine metabolites m4 and m5 |
EP1678322A2 (de) | 2003-10-24 | 2006-07-12 | Gilead Sciences, Inc. | Verfahren und zusammensetzungen zur identifizierung therapeutischer verbindungen |
WO2005044279A1 (en) | 2003-10-24 | 2005-05-19 | Gilead Sciences, Inc. | Purine nucleoside phosphonate conjugates |
WO2005044308A1 (en) | 2003-10-24 | 2005-05-19 | Gilead Sciences, Inc. | Phosphonate analogs of antimetabolites |
BRPI0417988A (pt) | 2003-12-22 | 2007-04-27 | Gilead Sciences Inc | análogos de fosfonato antivirais |
MXPA06011884A (es) * | 2004-04-14 | 2006-12-14 | Pfizer | Compuestos de imidazol unidos a azufre para el tratamiento del virus de inmunodeficiencia humana. |
ES2363160T3 (es) | 2004-07-27 | 2011-07-22 | Gilead Sciences, Inc. | Conjugados de fosfonato nucelosidico como agentes anti-vih. |
JP4993407B2 (ja) * | 2004-08-04 | 2012-08-08 | 大正製薬株式会社 | トリアゾール誘導体 |
US20080176919A1 (en) * | 2005-01-06 | 2008-07-24 | Pfizer Inc | Imidazole Derivatives As Enzyme Reverse Transcriptase Modulators |
RU2442779C2 (ru) * | 2005-12-01 | 2012-02-20 | Ф. Хоффманн-Ля Рош Аг | Производные 2,4,5-трифенилимидазолина как ингибиторы взаимодействия между белками p53 и mdm2, предназначенные для применения в качестве противораковых средств |
WO2007089018A1 (ja) * | 2006-02-03 | 2007-08-09 | Taisho Pharmaceutical Co., Ltd. | トリアゾール誘導体 |
RU2395499C2 (ru) | 2006-02-06 | 2010-07-27 | Тайсо Фармасьютикал Ко., Лтд. | Ингибитор связывания сфингозин-1-фосфата |
US7649098B2 (en) * | 2006-02-24 | 2010-01-19 | Lexicon Pharmaceuticals, Inc. | Imidazole-based compounds, compositions comprising them and methods of their use |
WO2007114338A1 (ja) | 2006-03-31 | 2007-10-11 | Takeda Pharmaceutical Company Limited | 酸分泌抑制薬 |
DK2057125T3 (da) | 2006-08-16 | 2011-05-16 | Hoffmann La Roche | Ikke-nucleosid revers transkriptase-inhibitorer |
PL2177512T3 (pl) | 2007-08-01 | 2012-09-28 | Taisho Pharmaceutical Co Ltd | Inhibitor wiązania S1P1 |
TW200920355A (en) * | 2007-09-06 | 2009-05-16 | Lexicon Pharmaceuticals Inc | Compositions and methods for treating immunological and inflammatory diseases and disorders |
KR101558011B1 (ko) * | 2007-09-28 | 2015-10-06 | 다케다 야쿠힌 고교 가부시키가이샤 | 양성자 펌프 억제제로서의 5-원 이종원자고리 화합물 |
RU2495878C2 (ru) | 2007-12-21 | 2013-10-20 | Ф.Хоффманн-Ля Рош Аг | Гетероциклические антивирусные соединения |
AP3347A (en) | 2008-07-08 | 2015-07-31 | Gilead Sciences Inc | Salts of HIV inhibitor compounds |
JP2012517479A (ja) * | 2009-02-12 | 2012-08-02 | エグゼリクシス, インコーポレイテッド | 糖尿病および肥満の処置においてtgr5アゴニストとして使用するためのトリアゾールおよびイミダゾール誘導体 |
BRPI1009090A2 (pt) | 2009-03-26 | 2016-03-01 | Takeda Pharmaceutical | composto, pró-droga, medicamento, métodos, e, uso do composto |
EP2508511A1 (de) * | 2011-04-07 | 2012-10-10 | Laboratoire Biodim | Inhibitoren der Virenreplikation, Verfahren zu deren Herstellung und deren therapeutische Verwendung |
AR091888A1 (es) * | 2012-07-24 | 2015-03-11 | Bial Portela & Ca Sa | Compuestos de urea y su uso como inhibidores de enzimas |
EP2716639A1 (de) | 2012-10-05 | 2014-04-09 | Laboratoire Biodim | Inhibitoren der Virenreplikation, Verfahren zu deren Herstellung und deren therapeutische Verwendung |
EP2716632A1 (de) | 2012-10-05 | 2014-04-09 | Laboratoire Biodim | Inhibitoren der Virenreplikation, Verfahren zu deren Herstellung und deren therapeutische Verwendung |
GB201602934D0 (en) | 2016-02-19 | 2016-04-06 | Cancer Res Inst Royal | Compounds |
EP3381905A1 (de) * | 2017-03-30 | 2018-10-03 | Institut National de la Sante et de la Recherche Medicale (INSERM) | Neuartige antivirale verbindungen |
ES2969496T3 (es) | 2017-08-01 | 2024-05-20 | Gilead Sciences Inc | Formas cristalinas de ((S)-((((2R,5R)-5-(6-amino-9H-purin-9-il)-4-fluoro-2,5-dihidrofuran-2- il)oxi)metil)(fenoxi)fosforil)-L-alaninato de etilo para tratar infecciones virales |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS63150266A (ja) * | 1986-12-12 | 1988-06-22 | Mitsui Petrochem Ind Ltd | ベンジルイミダゾ−ル誘導体 |
JPH0283373A (ja) * | 1988-05-19 | 1990-03-23 | Nippon Soda Co Ltd | 5員環の複素環化合物及びその製造方法 |
IL98319A (en) * | 1990-07-05 | 1997-04-15 | Roussel Uclaf | Sulphurous derivatives of imidazole, their preparation process, and pharmaceutical compositions containing them |
TW235963B (de) * | 1992-01-16 | 1994-12-11 | Shionogi & Co | |
DE10230797C2 (de) * | 2001-07-16 | 2003-09-25 | Dieter Reif | Befestigungsklammer zur Verbindung von Holzbauteilen |
-
1995
- 1995-09-25 DE DE69532245T patent/DE69532245T2/de not_active Expired - Fee Related
- 1995-09-25 MX MX9702030A patent/MX9702030A/es not_active IP Right Cessation
- 1995-09-25 CN CN95195260A patent/CN1093535C/zh not_active Expired - Fee Related
- 1995-09-25 WO PCT/JP1995/001936 patent/WO1996010019A1/ja active IP Right Grant
- 1995-09-25 BR BR9509024A patent/BR9509024A/pt not_active IP Right Cessation
- 1995-09-25 CA CA002200316A patent/CA2200316C/en not_active Expired - Fee Related
- 1995-09-25 HU HU9701899A patent/HUT77357A/hu not_active Application Discontinuation
- 1995-09-25 EP EP95932231A patent/EP0786455B1/de not_active Expired - Lifetime
- 1995-09-25 ES ES95932231T patent/ES2211917T3/es not_active Expired - Lifetime
- 1995-09-25 AT AT95932231T patent/ATE255564T1/de not_active IP Right Cessation
- 1995-09-25 RU RU97106829/04A patent/RU2157368C2/ru not_active IP Right Cessation
- 1995-09-25 DK DK95932231T patent/DK0786455T3/da active
- 1995-09-25 PL PL95320009A patent/PL183931B1/pl not_active IP Right Cessation
- 1995-09-25 PT PT95932231T patent/PT786455E/pt unknown
- 1995-09-25 JP JP51159896A patent/JP3155009B2/ja not_active Expired - Fee Related
- 1995-09-25 KR KR1019970701989A patent/KR100387157B1/ko not_active IP Right Cessation
- 1995-09-25 US US08/809,624 patent/US5910506A/en not_active Expired - Fee Related
- 1995-09-29 TW TW084110183A patent/TW401404B/zh not_active IP Right Cessation
-
1997
- 1997-03-20 NO NO971306A patent/NO308739B1/no unknown
- 1997-03-25 FI FI971234A patent/FI971234A/fi unknown
-
1998
- 1998-12-04 US US09/205,289 patent/US6147097A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CN1093535C (zh) | 2002-10-30 |
US6147097A (en) | 2000-11-14 |
BR9509024A (pt) | 1997-09-30 |
CA2200316C (en) | 2004-09-21 |
PL320009A1 (en) | 1997-09-01 |
KR970706260A (ko) | 1997-11-03 |
PL183931B1 (pl) | 2002-08-30 |
DE69532245T2 (de) | 2004-09-16 |
EP0786455A4 (de) | 1998-12-30 |
NO308739B1 (no) | 2000-10-23 |
AU4788896A (en) | 1996-04-19 |
DK0786455T3 (da) | 2004-03-29 |
FI971234A0 (fi) | 1997-03-25 |
NO971306D0 (no) | 1997-03-20 |
HUT77357A (hu) | 1998-03-30 |
EP0786455A1 (de) | 1997-07-30 |
PT786455E (pt) | 2004-02-27 |
FI971234A (fi) | 1997-05-23 |
WO1996010019A1 (fr) | 1996-04-04 |
EP0786455B1 (de) | 2003-12-03 |
NO971306L (no) | 1997-05-21 |
KR100387157B1 (ko) | 2003-09-29 |
CN1158609A (zh) | 1997-09-03 |
MX9702030A (es) | 1997-06-28 |
ATE255564T1 (de) | 2003-12-15 |
US5910506A (en) | 1999-06-08 |
ES2211917T3 (es) | 2004-07-16 |
RU2157368C2 (ru) | 2000-10-10 |
CA2200316A1 (en) | 1996-04-04 |
JP3155009B2 (ja) | 2001-04-09 |
TW401404B (en) | 2000-08-11 |
AU706095B2 (en) | 1999-06-10 |
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