DE69532245D1 - Imidazolderivat - Google Patents

Imidazolderivat

Info

Publication number
DE69532245D1
DE69532245D1 DE69532245T DE69532245T DE69532245D1 DE 69532245 D1 DE69532245 D1 DE 69532245D1 DE 69532245 T DE69532245 T DE 69532245T DE 69532245 T DE69532245 T DE 69532245T DE 69532245 D1 DE69532245 D1 DE 69532245D1
Authority
DE
Germany
Prior art keywords
alkyl
halogeno
formula
hydrogen
imidazolderivat
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69532245T
Other languages
English (en)
Other versions
DE69532245T2 (de
Inventor
Hirohiko Sugimoto
Tamio Fujiwara
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Application granted granted Critical
Publication of DE69532245D1 publication Critical patent/DE69532245D1/de
Publication of DE69532245T2 publication Critical patent/DE69532245T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4151,2-Diazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/58Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/84Sulfur atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Dental Preparations (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
DE69532245T 1994-09-26 1995-09-25 Imidazolderivat Expired - Fee Related DE69532245T2 (de)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
JP25749094 1994-09-26
JP25749094 1994-09-26
JP8469095 1995-03-15
JP8469095 1995-03-15
JP22720595 1995-08-12
JP22720595 1995-08-12
PCT/JP1995/001936 WO1996010019A1 (fr) 1994-09-26 1995-09-25 Derive imidazole

Publications (2)

Publication Number Publication Date
DE69532245D1 true DE69532245D1 (en) 2004-01-15
DE69532245T2 DE69532245T2 (de) 2004-09-16

Family

ID=27304632

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69532245T Expired - Fee Related DE69532245T2 (de) 1994-09-26 1995-09-25 Imidazolderivat

Country Status (20)

Country Link
US (2) US5910506A (de)
EP (1) EP0786455B1 (de)
JP (1) JP3155009B2 (de)
KR (1) KR100387157B1 (de)
CN (1) CN1093535C (de)
AT (1) ATE255564T1 (de)
BR (1) BR9509024A (de)
CA (1) CA2200316C (de)
DE (1) DE69532245T2 (de)
DK (1) DK0786455T3 (de)
ES (1) ES2211917T3 (de)
FI (1) FI971234A (de)
HU (1) HUT77357A (de)
MX (1) MX9702030A (de)
NO (1) NO308739B1 (de)
PL (1) PL183931B1 (de)
PT (1) PT786455E (de)
RU (1) RU2157368C2 (de)
TW (1) TW401404B (de)
WO (1) WO1996010019A1 (de)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69732230T2 (de) * 1996-03-28 2005-12-22 Shionogi & Co., Ltd. Durch lymphe absorbierbare imidazolderivate
KR100310888B1 (ko) * 1996-04-04 2001-12-12 시오노 요시히코 이미다졸유도체를함유하는항-hiv조성물
DE69733716T2 (de) * 1996-12-26 2006-04-20 Shionogi & Co., Ltd. Verfahren zur herstellung von imidazolderivaten
EP0994106B1 (de) * 1996-12-26 2004-03-17 Shionogi & Co., Ltd. Verfahren zur herstellung von carbamoylsubstituierten imidazolderivaten
TWI232214B (en) * 1998-04-16 2005-05-11 Shionogi & Co Preparation of aryl sulfenyl halide
WO2000061109A1 (fr) 1999-04-12 2000-10-19 Shionogi & Co., Ltd. Procede de production de composition medicamenteuse renfermant un compose medicamenteux hydrophobe basique
GB0016787D0 (en) 2000-07-07 2000-08-30 Pfizer Ltd Compounds useful in therapy
JP2004518687A (ja) 2001-01-31 2004-06-24 ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー アルコールをカルバモイル化する方法
WO2002068395A1 (en) * 2001-02-23 2002-09-06 K.U. Leuven Research & Development Hiv inhibiting n-aminoimidazole derivatives
JP3806090B2 (ja) 2001-04-10 2006-08-09 ファイザー・インク Hiv関連疾患治療用のピラゾール誘導体
GB0113524D0 (en) * 2001-06-04 2001-07-25 Hoffmann La Roche Pyrazole derivatives
KR20040108756A (ko) 2002-04-26 2004-12-24 길리애드 사이언시즈, 인코포레이티드 비뉴클레오사이드 역전사 효소 억제제
TW200423930A (en) 2003-02-18 2004-11-16 Hoffmann La Roche Non-nucleoside reverse transcriptase inhibitors
KR20050119652A (ko) 2003-03-24 2005-12-21 에프. 호프만-라 로슈 아게 역전사 효소 저해제로서의 벤질-피리다진온
US7470724B2 (en) 2003-04-25 2008-12-30 Gilead Sciences, Inc. Phosphonate compounds having immuno-modulatory activity
US7432261B2 (en) 2003-04-25 2008-10-07 Gilead Sciences, Inc. Anti-inflammatory phosphonate compounds
US7452901B2 (en) 2003-04-25 2008-11-18 Gilead Sciences, Inc. Anti-cancer phosphonate analogs
US7407965B2 (en) 2003-04-25 2008-08-05 Gilead Sciences, Inc. Phosphonate analogs for treating metabolic diseases
US7427636B2 (en) 2003-04-25 2008-09-23 Gilead Sciences, Inc. Inosine monophosphate dehydrogenase inhibitory phosphonate compounds
EP1620109A2 (de) 2003-04-25 2006-02-01 Gilead Sciences, Inc. Kinase inhbitor phosphonat konjugate
WO2005002626A2 (en) 2003-04-25 2005-01-13 Gilead Sciences, Inc. Therapeutic phosphonate compounds
WO2004096285A2 (en) 2003-04-25 2004-11-11 Gilead Sciences, Inc. Anti-infective phosphonate conjugates
EA014685B1 (ru) 2003-04-25 2010-12-30 Джилид Сайэнс, Инк. Фосфонатсодержащие антивирусные соединения (варианты) и фармацевтическая композиция на их основе
WO2005016912A1 (en) * 2003-08-19 2005-02-24 Pfizer Inc. An efficient microbial preparation of capravirine metabolites m4 and m5
EP1678322A2 (de) 2003-10-24 2006-07-12 Gilead Sciences, Inc. Verfahren und zusammensetzungen zur identifizierung therapeutischer verbindungen
WO2005044279A1 (en) 2003-10-24 2005-05-19 Gilead Sciences, Inc. Purine nucleoside phosphonate conjugates
WO2005044308A1 (en) 2003-10-24 2005-05-19 Gilead Sciences, Inc. Phosphonate analogs of antimetabolites
BRPI0417988A (pt) 2003-12-22 2007-04-27 Gilead Sciences Inc análogos de fosfonato antivirais
MXPA06011884A (es) * 2004-04-14 2006-12-14 Pfizer Compuestos de imidazol unidos a azufre para el tratamiento del virus de inmunodeficiencia humana.
ES2363160T3 (es) 2004-07-27 2011-07-22 Gilead Sciences, Inc. Conjugados de fosfonato nucelosidico como agentes anti-vih.
JP4993407B2 (ja) * 2004-08-04 2012-08-08 大正製薬株式会社 トリアゾール誘導体
US20080176919A1 (en) * 2005-01-06 2008-07-24 Pfizer Inc Imidazole Derivatives As Enzyme Reverse Transcriptase Modulators
RU2442779C2 (ru) * 2005-12-01 2012-02-20 Ф. Хоффманн-Ля Рош Аг Производные 2,4,5-трифенилимидазолина как ингибиторы взаимодействия между белками p53 и mdm2, предназначенные для применения в качестве противораковых средств
WO2007089018A1 (ja) * 2006-02-03 2007-08-09 Taisho Pharmaceutical Co., Ltd. トリアゾール誘導体
RU2395499C2 (ru) 2006-02-06 2010-07-27 Тайсо Фармасьютикал Ко., Лтд. Ингибитор связывания сфингозин-1-фосфата
US7649098B2 (en) * 2006-02-24 2010-01-19 Lexicon Pharmaceuticals, Inc. Imidazole-based compounds, compositions comprising them and methods of their use
WO2007114338A1 (ja) 2006-03-31 2007-10-11 Takeda Pharmaceutical Company Limited 酸分泌抑制薬
DK2057125T3 (da) 2006-08-16 2011-05-16 Hoffmann La Roche Ikke-nucleosid revers transkriptase-inhibitorer
PL2177512T3 (pl) 2007-08-01 2012-09-28 Taisho Pharmaceutical Co Ltd Inhibitor wiązania S1P1
TW200920355A (en) * 2007-09-06 2009-05-16 Lexicon Pharmaceuticals Inc Compositions and methods for treating immunological and inflammatory diseases and disorders
KR101558011B1 (ko) * 2007-09-28 2015-10-06 다케다 야쿠힌 고교 가부시키가이샤 양성자 펌프 억제제로서의 5-원 이종원자고리 화합물
RU2495878C2 (ru) 2007-12-21 2013-10-20 Ф.Хоффманн-Ля Рош Аг Гетероциклические антивирусные соединения
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JP2012517479A (ja) * 2009-02-12 2012-08-02 エグゼリクシス, インコーポレイテッド 糖尿病および肥満の処置においてtgr5アゴニストとして使用するためのトリアゾールおよびイミダゾール誘導体
BRPI1009090A2 (pt) 2009-03-26 2016-03-01 Takeda Pharmaceutical composto, pró-droga, medicamento, métodos, e, uso do composto
EP2508511A1 (de) * 2011-04-07 2012-10-10 Laboratoire Biodim Inhibitoren der Virenreplikation, Verfahren zu deren Herstellung und deren therapeutische Verwendung
AR091888A1 (es) * 2012-07-24 2015-03-11 Bial Portela & Ca Sa Compuestos de urea y su uso como inhibidores de enzimas
EP2716639A1 (de) 2012-10-05 2014-04-09 Laboratoire Biodim Inhibitoren der Virenreplikation, Verfahren zu deren Herstellung und deren therapeutische Verwendung
EP2716632A1 (de) 2012-10-05 2014-04-09 Laboratoire Biodim Inhibitoren der Virenreplikation, Verfahren zu deren Herstellung und deren therapeutische Verwendung
GB201602934D0 (en) 2016-02-19 2016-04-06 Cancer Res Inst Royal Compounds
EP3381905A1 (de) * 2017-03-30 2018-10-03 Institut National de la Sante et de la Recherche Medicale (INSERM) Neuartige antivirale verbindungen
ES2969496T3 (es) 2017-08-01 2024-05-20 Gilead Sciences Inc Formas cristalinas de ((S)-((((2R,5R)-5-(6-amino-9H-purin-9-il)-4-fluoro-2,5-dihidrofuran-2- il)oxi)metil)(fenoxi)fosforil)-L-alaninato de etilo para tratar infecciones virales

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JPS63150266A (ja) * 1986-12-12 1988-06-22 Mitsui Petrochem Ind Ltd ベンジルイミダゾ−ル誘導体
JPH0283373A (ja) * 1988-05-19 1990-03-23 Nippon Soda Co Ltd 5員環の複素環化合物及びその製造方法
IL98319A (en) * 1990-07-05 1997-04-15 Roussel Uclaf Sulphurous derivatives of imidazole, their preparation process, and pharmaceutical compositions containing them
TW235963B (de) * 1992-01-16 1994-12-11 Shionogi & Co
DE10230797C2 (de) * 2001-07-16 2003-09-25 Dieter Reif Befestigungsklammer zur Verbindung von Holzbauteilen

Also Published As

Publication number Publication date
CN1093535C (zh) 2002-10-30
US6147097A (en) 2000-11-14
BR9509024A (pt) 1997-09-30
CA2200316C (en) 2004-09-21
PL320009A1 (en) 1997-09-01
KR970706260A (ko) 1997-11-03
PL183931B1 (pl) 2002-08-30
DE69532245T2 (de) 2004-09-16
EP0786455A4 (de) 1998-12-30
NO308739B1 (no) 2000-10-23
AU4788896A (en) 1996-04-19
DK0786455T3 (da) 2004-03-29
FI971234A0 (fi) 1997-03-25
NO971306D0 (no) 1997-03-20
HUT77357A (hu) 1998-03-30
EP0786455A1 (de) 1997-07-30
PT786455E (pt) 2004-02-27
FI971234A (fi) 1997-05-23
WO1996010019A1 (fr) 1996-04-04
EP0786455B1 (de) 2003-12-03
NO971306L (no) 1997-05-21
KR100387157B1 (ko) 2003-09-29
CN1158609A (zh) 1997-09-03
MX9702030A (es) 1997-06-28
ATE255564T1 (de) 2003-12-15
US5910506A (en) 1999-06-08
ES2211917T3 (es) 2004-07-16
RU2157368C2 (ru) 2000-10-10
CA2200316A1 (en) 1996-04-04
JP3155009B2 (ja) 2001-04-09
TW401404B (en) 2000-08-11
AU706095B2 (en) 1999-06-10

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