DE69426292D1 - Stabilisierung von mit organischen lösungsmittel behandelten polypeptiden mit einem hilfsstoff - Google Patents

Stabilisierung von mit organischen lösungsmittel behandelten polypeptiden mit einem hilfsstoff

Info

Publication number
DE69426292D1
DE69426292D1 DE69426292T DE69426292T DE69426292D1 DE 69426292 D1 DE69426292 D1 DE 69426292D1 DE 69426292 T DE69426292 T DE 69426292T DE 69426292 T DE69426292 T DE 69426292T DE 69426292 D1 DE69426292 D1 DE 69426292D1
Authority
DE
Germany
Prior art keywords
pct
stabilization
organic solvent
auxiliary substance
polypeptides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69426292T
Other languages
English (en)
Other versions
DE69426292T2 (de
Inventor
Jeffrey L Cleland
Andrew J S Jones
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genentech Inc
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Application granted granted Critical
Publication of DE69426292D1 publication Critical patent/DE69426292D1/de
Publication of DE69426292T2 publication Critical patent/DE69426292T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DE69426292T 1993-02-23 1994-02-17 Stabilisierung von mit organischen lösungsmittel behandelten polypeptiden mit einem hilfsstoff Expired - Lifetime DE69426292T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2142193A 1993-02-23 1993-02-23
PCT/US1994/001666 WO1994019020A1 (en) 1993-02-23 1994-02-17 Excipient stabilization of polypeptides treated with organic solvents

Publications (2)

Publication Number Publication Date
DE69426292D1 true DE69426292D1 (de) 2000-12-21
DE69426292T2 DE69426292T2 (de) 2001-05-17

Family

ID=21804127

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69426292T Expired - Lifetime DE69426292T2 (de) 1993-02-23 1994-02-17 Stabilisierung von mit organischen lösungsmittel behandelten polypeptiden mit einem hilfsstoff

Country Status (17)

Country Link
US (3) US5589167A (de)
EP (1) EP0686045B1 (de)
JP (1) JP3698721B2 (de)
CN (1) CN1108823C (de)
AT (1) ATE197550T1 (de)
AU (1) AU685784B2 (de)
CZ (1) CZ296649B6 (de)
DE (1) DE69426292T2 (de)
DK (1) DK0686045T3 (de)
ES (1) ES2153418T3 (de)
GR (1) GR3035383T3 (de)
IL (1) IL108713A (de)
NZ (1) NZ262634A (de)
PT (1) PT686045E (de)
RU (1) RU2143889C1 (de)
WO (1) WO1994019020A1 (de)
ZA (1) ZA941239B (de)

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WO1994019020A1 (en) 1994-09-01
GR3035383T3 (en) 2001-05-31
IL108713A (en) 1999-12-22
ZA941239B (en) 1995-08-23
AU685784B2 (en) 1998-01-29
JP3698721B2 (ja) 2005-09-21
US5804557A (en) 1998-09-08
IL108713A0 (en) 1994-05-30
DK0686045T3 (da) 2001-03-05
RU2143889C1 (ru) 2000-01-10
NZ262634A (en) 1997-02-24
PT686045E (pt) 2001-04-30
US5753219A (en) 1998-05-19
DE69426292T2 (de) 2001-05-17
ES2153418T3 (es) 2001-03-01
JPH08507064A (ja) 1996-07-30
CZ296649B6 (cs) 2006-05-17
US5589167A (en) 1996-12-31
CZ212795A3 (en) 1996-02-14
ATE197550T1 (de) 2000-12-15
CN1108823C (zh) 2003-05-21
EP0686045B1 (de) 2000-11-15
AU6241294A (en) 1994-09-14
CN1118143A (zh) 1996-03-06
EP0686045A1 (de) 1995-12-13

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